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Conserved domains on  [gi|1907126015|ref|XP_036016674|]
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uncharacterized protein LOC70081 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-52 4.28e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.30  E-value: 4.28e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907126015  13 ITFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
201-436 4.83e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 201 HQRIHTGEKPYKCSECDKSFTQKGSLSIHQMYHTGKEPYKCSECSKCFAQKCWFRKHQRIHTGEKPYKCSECGKSFTQKG 280
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 281 SLSIHQMYHTG-------KKPYKCSECEKCFIQVGDLRRHER--IHTGE--KPYKCNE--CDKCFRYKSSLRSHQRIHTG 347
Cdd:COG5048   269 SSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 348 EKPYKCSECEKYFSHKGSL------SIHQRIHTGEKPYKC---SECDKFFTQKGSLNVHQRVHTGEKP--YKCSECDKCF 416
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLnneppqSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         250       260
                  ....*....|....*....|
gi 1907126015 417 SYKGDLRKHQRIHTGERTLQ 436
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLL 448
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-52 4.28e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.30  E-value: 4.28e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907126015  13 ITFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
14-55 2.54e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.88  E-value: 2.54e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907126015   14 TFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFVENH 55
Cdd:smart00349   2 TFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 9.15e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 9.15e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907126015  13 ITFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
201-436 4.83e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 201 HQRIHTGEKPYKCSECDKSFTQKGSLSIHQMYHTGKEPYKCSECSKCFAQKCWFRKHQRIHTGEKPYKCSECGKSFTQKG 280
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 281 SLSIHQMYHTG-------KKPYKCSECEKCFIQVGDLRRHER--IHTGE--KPYKCNE--CDKCFRYKSSLRSHQRIHTG 347
Cdd:COG5048   269 SSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 348 EKPYKCSECEKYFSHKGSL------SIHQRIHTGEKPYKC---SECDKFFTQKGSLNVHQRVHTGEKP--YKCSECDKCF 416
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLnneppqSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         250       260
                  ....*....|....*....|
gi 1907126015 417 SYKGDLRKHQRIHTGERTLQ 436
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLL 448
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-334 7.98e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 7.98e-05
                          10        20
                  ....*....|....*....|....*.
gi 1907126015 309 DLRRHERIHTGEKPYKCNECDKCFRY 334
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-52 4.28e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.30  E-value: 4.28e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907126015  13 ITFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
14-55 2.54e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.88  E-value: 2.54e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907126015   14 TFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFVENH 55
Cdd:smart00349   2 TFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-51 9.15e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 9.15e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907126015  13 ITFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
201-436 4.83e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 201 HQRIHTGEKPYKCSECDKSFTQKGSLSIHQMYHTGKEPYKCSECSKCFAQKCWFRKHQRIHTGEKPYKCSECGKSFTQKG 280
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 281 SLSIHQMYHTG-------KKPYKCSECEKCFIQVGDLRRHER--IHTGE--KPYKCNE--CDKCFRYKSSLRSHQRIHTG 347
Cdd:COG5048   269 SSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 348 EKPYKCSECEKYFSHKGSL------SIHQRIHTGEKPYKC---SECDKFFTQKGSLNVHQRVHTGEKP--YKCSECDKCF 416
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLnneppqSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         250       260
                  ....*....|....*....|
gi 1907126015 417 SYKGDLRKHQRIHTGERTLQ 436
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLL 448
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-334 7.98e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 7.98e-05
                          10        20
                  ....*....|....*....|....*.
gi 1907126015 309 DLRRHERIHTGEKPYKCNECDKCFRY 334
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-388 1.18e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 238 PYKCSECSKCFAQKCWFRKHQR--IHTGE--KPYKCSE--CGKSFTQKGSLSIHQMYHTGKKPYKCSECEKCFIQVGDL- 310
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLn 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 311 -RRHERI--HTGEKPYKCNECD--KCF-----RYKSSLRSHQRIHTGEKPYKCSECEKYFSHKGSLSIHQRIHTGEKPYK 380
Cdd:COG5048   369 nEPPQSLqqYKDLKNDKKSETLsnSCIrnfkrDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                  ....*...
gi 1907126015 381 CSECDKFF 388
Cdd:COG5048   449 CSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-222 2.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.88e-04
                          10        20
                  ....*....|....*....|....*
gi 1907126015 198 FRKHQRIHTGEKPYKCSECDKSFTQ 222
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-278 3.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.34e-04
                          10        20
                  ....*....|....*....|....*
gi 1907126015 254 FRKHQRIHTGEKPYKCSECGKSFTQ 278
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-362 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907126015 337 SLRSHQRIHTGEKPYKCSECEKYFSH 362
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 207-290 1.21e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 207 GEKPYKCS--ECDKSFTQKGSLSIHQMYhtgkepykcSECSKCFAQKCWFRKHQRIHTGEKPYKCSECGKSFTQKGSLSI 284
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1907126015 285 HQMYHT 290
Cdd:COG5189   417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
393-418 1.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907126015 393 SLNVHQRVHTGEKPYKCSECDKCFSY 418
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-390 1.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907126015 365 SLSIHQRIHTGEKPYKCSECDKFFTQ 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-361 3.04e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 209 KPYKCSECDKSFTQKGSLSIHQ--MYHTGK--EPYKCSE--CSKCFAQKCWFRKHQRIHTGEKPYKC--SECGKSFTQ-- 278
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 279 --KGSLSIHQMYHTGKKPYKCSECEKCFIQVGD---LRRHERIHTGEKP--YKCNECDKCFRYKSSLRSHQRIHTGEKPY 351
Cdd:COG5048   368 nnEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRdsnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|
gi 1907126015 352 KCSECEKYFS 361
Cdd:COG5048   448 LCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
180-437 3.62e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 180 KKPYKCSECAKCFAQKCWFRKHQRIHTGEKPYKCS--ECDKSFTQKGSLSIHQMYHTGKEPYKCSECSKCFAQKCWFRKH 257
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 258 QRIHTGE-KPYKCSECGKSFTQKG---------SLSIHQMYHTGKKPYKCSECEKCFIQ-------------VGDLRRHE 314
Cdd:COG5048   111 SSSSSNSnDNNLLSSHSLPPSSRDpqlpdllsiSNLRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpssNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907126015 315 RIHTGEKPYKCNECDKCFRYKSSLRSHQRIHTGEKPYKCSECekYFSHKGSLSIHQRIHTGEKPYKCSECDKFFTQKGSL 394
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907126015 395 NVHQRVHTG---------EKPYKCSECDKCFSYKGDLRKHQR--IHTGERTLQM 437
Cdd:COG5048   269 SSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPF 322
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 323-345 4.15e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.15e-03
                          10        20
                  ....*....|....*....|...
gi 1907126015 323 YKCNECDKCFRYKSSLRSHQRIH 345
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 407-429 5.25e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.25e-03
                          10        20
                  ....*....|....*....|...
gi 1907126015 407 YKCSECDKCFSYKGDLRKHQRIH 429
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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