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Conserved domains on  [gi|1907129954|ref|XP_036017042|]
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rotatin isoform X3 [Mus musculus]

Protein Classification

RTTN_N domain-containing protein( domain architecture ID 10631620)

RTTN_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RTTN_N pfam14726
Rotatin, an armadillo repeat protein, centriole functioning; Rotatin and its homologs such as ...
 16-112 1.21e-44

Rotatin, an armadillo repeat protein, centriole functioning; Rotatin and its homologs such as Ana3 in Drosophila are found to be essential for centriole function. A deficiency of rotatin in mice leads to randomized heart tube looping, defects in embryonic turning, and abnormal expression of HNF3beta, lefty, and nodal. Thus it is required for left-right and axial patterning. Ana3 - the Drosophila homolog - is present in centrioles and basal bodies, is required for the structural integrity of both centrioles and basal bodies and for centriole cohesion. Rotatin also localizes to centrioles and basal bodies and appears to be essential for cilia function. This family represents the N-terminal domain.


:

Pssm-ID: 464283  Cd Length: 97  Bit Score: 156.58  E-value: 1.21e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129954   16 EIRERALKSILCKIEHNLICYADLIQERLLFLHLLEWFNFPSVPMKEEVLNLLSRLVKYSPAVQHLIDLGAVEFLSKLRP 95
Cdd:pfam14726    1 EIRVRALENILFKLEHGLISEEDLVQEKLLLKQLLEWFNFPPVPMPEEVLALLLRLLKHPYAAQILRKIGAVRFLSKLRD 80

                           90
                   ....*....|....*..
gi 1907129954   96 NVEPVIQAEIDGILDGL 112
Cdd:pfam14726   81 NVEPHLQAEIDELLDQL 97
 
Name Accession Description Interval E-value
RTTN_N pfam14726
Rotatin, an armadillo repeat protein, centriole functioning; Rotatin and its homologs such as ...
 16-112 1.21e-44

Rotatin, an armadillo repeat protein, centriole functioning; Rotatin and its homologs such as Ana3 in Drosophila are found to be essential for centriole function. A deficiency of rotatin in mice leads to randomized heart tube looping, defects in embryonic turning, and abnormal expression of HNF3beta, lefty, and nodal. Thus it is required for left-right and axial patterning. Ana3 - the Drosophila homolog - is present in centrioles and basal bodies, is required for the structural integrity of both centrioles and basal bodies and for centriole cohesion. Rotatin also localizes to centrioles and basal bodies and appears to be essential for cilia function. This family represents the N-terminal domain.


Pssm-ID: 464283  Cd Length: 97  Bit Score: 156.58  E-value: 1.21e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129954   16 EIRERALKSILCKIEHNLICYADLIQERLLFLHLLEWFNFPSVPMKEEVLNLLSRLVKYSPAVQHLIDLGAVEFLSKLRP 95
Cdd:pfam14726    1 EIRVRALENILFKLEHGLISEEDLVQEKLLLKQLLEWFNFPPVPMPEEVLALLLRLLKHPYAAQILRKIGAVRFLSKLRD 80

                           90
                   ....*....|....*..
gi 1907129954   96 NVEPVIQAEIDGILDGL 112
Cdd:pfam14726   81 NVEPHLQAEIDELLDQL 97
 
Name Accession Description Interval E-value
RTTN_N pfam14726
Rotatin, an armadillo repeat protein, centriole functioning; Rotatin and its homologs such as ...
 16-112 1.21e-44

Rotatin, an armadillo repeat protein, centriole functioning; Rotatin and its homologs such as Ana3 in Drosophila are found to be essential for centriole function. A deficiency of rotatin in mice leads to randomized heart tube looping, defects in embryonic turning, and abnormal expression of HNF3beta, lefty, and nodal. Thus it is required for left-right and axial patterning. Ana3 - the Drosophila homolog - is present in centrioles and basal bodies, is required for the structural integrity of both centrioles and basal bodies and for centriole cohesion. Rotatin also localizes to centrioles and basal bodies and appears to be essential for cilia function. This family represents the N-terminal domain.


Pssm-ID: 464283  Cd Length: 97  Bit Score: 156.58  E-value: 1.21e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907129954   16 EIRERALKSILCKIEHNLICYADLIQERLLFLHLLEWFNFPSVPMKEEVLNLLSRLVKYSPAVQHLIDLGAVEFLSKLRP 95
Cdd:pfam14726    1 EIRVRALENILFKLEHGLISEEDLVQEKLLLKQLLEWFNFPPVPMPEEVLALLLRLLKHPYAAQILRKIGAVRFLSKLRD 80

                           90
                   ....*....|....*..
gi 1907129954   96 NVEPVIQAEIDGILDGL 112
Cdd:pfam14726   81 NVEPHLQAEIDELLDQL 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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