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Conserved domains on  [gi|1907131555|ref|XP_036017297|]
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AH receptor-interacting protein isoform X1 [Mus musculus]

Protein Classification

FKBP-type peptidyl-prolyl cis-trans isomerase( domain architecture ID 139723)

FKBP-type peptidyl-prolyl cis-trans isomerase acts as a PPIase that accelerates the folding of proteins

CATH:  3.10.50.40
EC:  5.2.1.8
Gene Ontology:  GO:0003755
SCOP:  4001062

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C super family cl19519
FKBP-type peptidyl-prolyl cis-trans isomerase;
29-90 5.86e-09

FKBP-type peptidyl-prolyl cis-trans isomerase;


The actual alignment was detected with superfamily member pfam00254:

Pssm-ID: 473184  Cd Length: 94  Bit Score: 52.58  E-value: 5.86e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907131555  29 QDGTKATFHFR-TLHsdnEGSVIDDSRTRGKPMELIVGKKFKLPVWETIVCTMREGEIAQFLC 90
Cdd:pfam00254   6 KKGDRVTVHYTgTLE---DGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTI 65
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 186-309 5.45e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.98  E-value: 5.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131555 186 GNRLYREGQVKEAAAKYYDAIAClknlqmkeqpgSPDWIQLdlqitplLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNV 265
Cdd:COG3914   119 GNLLLALGRLEEALAALRRALAL-----------NPDFAEA-------YLNLGEALRRLGRLEEAIAALRRALELDPDNA 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907131555 266 KAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRAL 309
Cdd:COG3914   181 EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL 224
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
29-90 5.86e-09

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 52.58  E-value: 5.86e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907131555  29 QDGTKATFHFR-TLHsdnEGSVIDDSRTRGKPMELIVGKKFKLPVWETIVCTMREGEIAQFLC 90
Cdd:pfam00254   6 KKGDRVTVHYTgTLE---DGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTI 65
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 13-90 2.67e-06

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 45.17  E-value: 2.67e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907131555  13 IQKRVIQEGRGELPdfQDGTKATFHFRTLHSDneGSVIDDSRTRGKPMELIVGKKFKLPVWETIVCTMREGEIAQFLC 90
Cdd:COG0545     1 LQYKVLKEGTGAKP--KAGDTVTVHYTGTLLD--GTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVI 74
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 186-309 5.45e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.98  E-value: 5.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131555 186 GNRLYREGQVKEAAAKYYDAIAClknlqmkeqpgSPDWIQLdlqitplLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNV 265
Cdd:COG3914   119 GNLLLALGRLEEALAALRRALAL-----------NPDFAEA-------YLNLGEALRRLGRLEEAIAALRRALELDPDNA 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907131555 266 KAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRAL 309
Cdd:COG3914   181 EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL 224
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 10-65 2.29e-03

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 38.63  E-value: 2.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131555  10 EDGIQKRVIQEGRGELPDFQDGTKATFHFRTLhsdnEGSVIDDSRTRGKPMELIVG 65
Cdd:PRK11570  101 ESGLQFRVLTQGEGAIPARTDRVRVHYTGKLI----DGTVFDSSVARGEPAEFPVN 152
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
29-90 5.86e-09

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 52.58  E-value: 5.86e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907131555  29 QDGTKATFHFR-TLHsdnEGSVIDDSRTRGKPMELIVGKKFKLPVWETIVCTMREGEIAQFLC 90
Cdd:pfam00254   6 KKGDRVTVHYTgTLE---DGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTI 65
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 13-90 2.67e-06

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 45.17  E-value: 2.67e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907131555  13 IQKRVIQEGRGELPdfQDGTKATFHFRTLHSDneGSVIDDSRTRGKPMELIVGKKFKLPVWETIVCTMREGEIAQFLC 90
Cdd:COG0545     1 LQYKVLKEGTGAKP--KAGDTVTVHYTGTLLD--GTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVI 74
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 186-309 5.45e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.98  E-value: 5.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131555 186 GNRLYREGQVKEAAAKYYDAIAClknlqmkeqpgSPDWIQLdlqitplLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNV 265
Cdd:COG3914   119 GNLLLALGRLEEALAALRRALAL-----------NPDFAEA-------YLNLGEALRRLGRLEEAIAALRRALELDPDNA 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1907131555 266 KAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRAL 309
Cdd:COG3914   181 EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFAL 224
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
261-301 1.85e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.13  E-value: 1.85e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907131555 261 YDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPV 301
Cdd:COG4785    69 LPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEA 109
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 10-65 2.29e-03

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 38.63  E-value: 2.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131555  10 EDGIQKRVIQEGRGELPDFQDGTKATFHFRTLhsdnEGSVIDDSRTRGKPMELIVG 65
Cdd:PRK11570  101 ESGLQFRVLTQGEGAIPARTDRVRVHYTGKLI----DGTVFDSSVARGEPAEFPVN 152
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
189-299 4.51e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.06  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131555 189 LYREGQVKEAAAKYYDAIACLKNLqmkeqpgspdwIQLDLQITPLLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNVKAY 268
Cdd:COG0457    45 LYNLGLAYLRLGRYEEALADYEQA-----------LELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL 113

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1907131555 269 FKRGKAHAAVWNAQEAQADFAKVLELDPALA 299
Cdd:COG0457   114 YNLGLALLELGRYDEAIEAYERALELDPDDA 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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