NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907132220|ref|XP_036017440|]
View 

protein PAT1 homolog 1 isoform X1 [Mus musculus]

Protein Classification

PAT1 family protein( domain architecture ID 1001013)

PAT1 family protein similar to Saccharomyces cerevisiae DNA topoisomerase 2-associated protein PAT1, an activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation

Gene Ontology:  GO:0003723

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 166-538 1.62e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.66  E-value: 1.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 166 PNSSLLGHPFPPNVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPSFRaffs 245
Cdd:pfam09770 214 PAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFH---- 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 246 apppatPPPQQHPPGPGPHLQNLR---------PQAPMFRADTTHLHPQHRR---LLHQRQLQSRNQH--------RNLN 305
Cdd:pfam09770 290 ------QQPPPVPVQPTQILQNPNrlsaarvgyPQNPQPGVQPAPAHQAHRQqgsFGRQAPIITHPQQlaqlseeeKAAY 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 306 GTGDRGGHQSSHQDHL-RKDpyANLMLQREKDWVSKIQMMQL---------QSTDPYL-DDFYYQNYfekleklsaaEEI 374
Cdd:pfam09770 364 LDEEAKRAKRNHKIFLlSKD--NGLMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYYQVY----------SQI 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 375 QGdGPKKE---------RTKLItpQ------------------VAKLEhayQPVQ----------------FEGSLGKLT 411
Cdd:pfam09770 432 RG-GPRQHpsqplsnfaQTYLF--QtgsrqggmrrqgrgaenhMQRME---QQVQraveaaknkpknkqlvIEGSLGKIS 505

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 412 VSSVNNPRKMI---------DAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDE 482
Cdd:pfam09770 506 FSNAKTPKPLLnikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTEDSDPELIE 585

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907132220 483 RKHKICSMYDNLRGKL---------PGQERPsddH-FVQIMCIRKGKRMVARILPFLSTEQAADIL 538
Cdd:pfam09770 586 KHMEWRSTLQALNAKLwqelkvhepIGSTTP---HpFIAFLSHPKGKKAIPRIFRHLSQEQRTTIL 648
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 166-538 1.62e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.66  E-value: 1.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 166 PNSSLLGHPFPPNVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPSFRaffs 245
Cdd:pfam09770 214 PAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFH---- 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 246 apppatPPPQQHPPGPGPHLQNLR---------PQAPMFRADTTHLHPQHRR---LLHQRQLQSRNQH--------RNLN 305
Cdd:pfam09770 290 ------QQPPPVPVQPTQILQNPNrlsaarvgyPQNPQPGVQPAPAHQAHRQqgsFGRQAPIITHPQQlaqlseeeKAAY 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 306 GTGDRGGHQSSHQDHL-RKDpyANLMLQREKDWVSKIQMMQL---------QSTDPYL-DDFYYQNYfekleklsaaEEI 374
Cdd:pfam09770 364 LDEEAKRAKRNHKIFLlSKD--NGLMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYYQVY----------SQI 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 375 QGdGPKKE---------RTKLItpQ------------------VAKLEhayQPVQ----------------FEGSLGKLT 411
Cdd:pfam09770 432 RG-GPRQHpsqplsnfaQTYLF--QtgsrqggmrrqgrgaenhMQRME---QQVQraveaaknkpknkqlvIEGSLGKIS 505

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 412 VSSVNNPRKMI---------DAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDE 482
Cdd:pfam09770 506 FSNAKTPKPLLnikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTEDSDPELIE 585

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907132220 483 RKHKICSMYDNLRGKL---------PGQERPsddH-FVQIMCIRKGKRMVARILPFLSTEQAADIL 538
Cdd:pfam09770 586 KHMEWRSTLQALNAKLwqelkvhepIGSTTP---HpFIAFLSHPKGKKAIPRIFRHLSQEQRTTIL 648
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 166-538 1.62e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.66  E-value: 1.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 166 PNSSLLGHPFPPNVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPSFRaffs 245
Cdd:pfam09770 214 PAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFH---- 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 246 apppatPPPQQHPPGPGPHLQNLR---------PQAPMFRADTTHLHPQHRR---LLHQRQLQSRNQH--------RNLN 305
Cdd:pfam09770 290 ------QQPPPVPVQPTQILQNPNrlsaarvgyPQNPQPGVQPAPAHQAHRQqgsFGRQAPIITHPQQlaqlseeeKAAY 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 306 GTGDRGGHQSSHQDHL-RKDpyANLMLQREKDWVSKIQMMQL---------QSTDPYL-DDFYYQNYfekleklsaaEEI 374
Cdd:pfam09770 364 LDEEAKRAKRNHKIFLlSKD--NGLMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYYQVY----------SQI 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 375 QGdGPKKE---------RTKLItpQ------------------VAKLEhayQPVQ----------------FEGSLGKLT 411
Cdd:pfam09770 432 RG-GPRQHpsqplsnfaQTYLF--QtgsrqggmrrqgrgaenhMQRME---QQVQraveaaknkpknkqlvIEGSLGKIS 505

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132220 412 VSSVNNPRKMI---------DAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDE 482
Cdd:pfam09770 506 FSNAKTPKPLLnikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTEDSDPELIE 585

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907132220 483 RKHKICSMYDNLRGKL---------PGQERPsddH-FVQIMCIRKGKRMVARILPFLSTEQAADIL 538
Cdd:pfam09770 586 KHMEWRSTLQALNAKLwqelkvhepIGSTTP---HpFIAFLSHPKGKKAIPRIFRHLSQEQRTTIL 648
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH