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Conserved domains on  [gi|1907202397|ref|XP_036017673|]
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ribose-phosphate pyrophosphokinase 2 isoform X3 [Mus musculus]

Protein Classification

ribose-phosphate pyrophosphokinase-like domain-containing protein( domain architecture ID 10619030)

ribose-phosphate pyrophosphokinase-like domain-containing protein which contains the N-terminal domain of ribose-phosphate pyrophosphokinase and phosphoribosyl pyrophosphate synthetase-associated proteins, which play roles in 5-phospho-ribosyl-1(alpha)-pyrophosphate (PRPP) synthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 189-250 3.03e-38

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 131.77  E-value: 3.03e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907202397 189 SVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDK 250
Cdd:pfam13793  38 YVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAKRITAVIPYFGYARQDRKDK 99
 
Name Accession Description Interval E-value
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 189-250 3.03e-38

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 131.77  E-value: 3.03e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907202397 189 SVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDK 250
Cdd:pfam13793  38 YVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAKRITAVIPYFGYARQDRKDK 99
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 189-253 2.25e-32

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 122.09  E-value: 2.25e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907202397 189 SVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKVGE 253
Cdd:COG0462    41 YVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRASARRITAVIPYYGYARQDRKFRPRE 105
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
189-250 4.85e-30

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 115.99  E-value: 4.85e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907202397 189 SVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDK 250
Cdd:PRK01259   38 SVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAGRITAVIPYFGYARQDRKAR 99
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 190-255 3.16e-28

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 111.22  E-value: 3.16e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907202397 190 VEIGESVRGEDVYII-QSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKVGEGL 255
Cdd:TIGR01251  39 VRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSREPI 105
 
Name Accession Description Interval E-value
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 189-250 3.03e-38

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 131.77  E-value: 3.03e-38
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907202397 189 SVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDK 250
Cdd:pfam13793  38 YVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAKRITAVIPYFGYARQDRKDK 99
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 189-253 2.25e-32

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 122.09  E-value: 2.25e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907202397 189 SVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKVGE 253
Cdd:COG0462    41 YVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRASARRITAVIPYYGYARQDRKFRPRE 105
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
189-250 4.85e-30

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 115.99  E-value: 4.85e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907202397 189 SVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDK 250
Cdd:PRK01259   38 SVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAGRITAVIPYFGYARQDRKAR 99
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 190-255 3.16e-28

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 111.22  E-value: 3.16e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907202397 190 VEIGESVRGEDVYII-QSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKVGEGL 255
Cdd:TIGR01251  39 VRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSREPI 105
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
190-248 7.46e-24

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 99.25  E-value: 7.46e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907202397 190 VEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKK 248
Cdd:PRK03092   28 VRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPYARQDKK 86
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 190-248 7.04e-23

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 96.30  E-value: 7.04e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907202397 190 VEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKK 248
Cdd:PLN02369   30 VQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYFGYARADRK 88
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 190-248 2.30e-21

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 92.50  E-value: 2.30e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907202397 190 VEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKK 248
Cdd:PRK02812   60 VQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASARQITAVIPYYGYARADRK 118
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 190-247 1.29e-20

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 90.57  E-value: 1.29e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907202397 190 VEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDK 247
Cdd:PRK02458   48 INIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRASANTVNVVLPYFGYARQDR 105
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 189-248 4.68e-20

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 90.32  E-value: 4.68e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202397 189 SVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKK 248
Cdd:PTZ00145  157 SMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRASAKKITAVIPYYGYARQDRK 216
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
188-248 2.25e-19

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 86.91  E-value: 2.25e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907202397 188 ESVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKK 248
Cdd:PRK04923   43 VQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRASAASVTAVIPYFGYSRQDRR 103
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
190-253 3.76e-18

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 83.30  E-value: 3.76e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907202397 190 VEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKVGE 253
Cdd:PRK02269   44 VNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASAESINVVMPYYGYARQDRKARSRE 107
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 194-250 5.70e-17

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 80.35  E-value: 5.70e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907202397 194 ESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDK 250
Cdd:PRK00553   52 ESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSAKSITAILPYYGYARQDRKTA 108
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 190-253 4.73e-13

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 68.40  E-value: 4.73e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907202397 190 VEIGESVRGEDVYIIQSGCGEiNDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKVGE 253
Cdd:PRK00934   38 VRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKSITLVIPYLGYARQDKRFKPGE 100
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 190-255 3.17e-09

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 57.65  E-value: 3.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202397 190 VEIGESVRGEDVYIIQ---------SGCGE-----INDNLMELLIMINACKiASSSRVTAVIPCFPYARQDKKDKVgEGL 255
Cdd:PRK06827   69 GEILESVRGKDIYILQdvgnysvtyNMFGEknhmsPDDHFQDLKRTIDAIR-GKARRITVIMPFLYESRQHKRKGR-ESL 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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