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Conserved domains on  [gi|1907140534|ref|XP_036018189|]
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putative sodium-coupled neutral amino acid transporter 11 isoform X1 [Mus musculus]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
32-398 2.73e-44

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 159.39  E-value: 2.73e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534  32 GKSSQSAAVFNVVNSVIGSGIIGLPYSMKQAGFPLGILLLFLVSYITDFSLVLLIK-----GGALSGTDSYQSLVNKTFG 106
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRcskevPVTGKRNKSYGDLGYRLLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 107 FPGYLLLSTLQFMYPF----------------IVD--PGGWFISRHFIIVVSTVTCtLPLSLYRDIAKLGKISFISTILT 168
Cdd:pfam01490  81 PKGRLLILFAILLNLFgvcisylifagdnlpaIFDsfFDTCPISLVYFIIIFGLIF-IPLSFIPNLSALSILSLLAAVSS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 169 TVILGIVmtrAISLGPNIPKTDNAWV-------FAKPNAIQAIGVMSFAFICHHNCFLVYGSLEEPTVAK-WRRIIHTSI 240
Cdd:pfam01490 160 LYYIVIL---VLSVAEGIVLTAQGVGhlgsktnIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFKaMTKILLTAI 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 241 LVSVFICVLFATCGYFTFTGFTQGDLFENYCRSDDLVTFGRFCYGITVILTYPIECFVTREVIANVFF-----------G 309
Cdd:pfam01490 237 IIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFrkeapfgasgkN 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 310 GTLSSVFHTVLAVLIVTAATLVSLMIECLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRT-------HSDKIMACVMF 382
Cdd:pfam01490 317 NPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLKKTKKKsqeklwkPDILDVICIVI 396
                         410
                  ....*....|....*.
gi 1907140534 383 pvGAVVMVVGFVMAIT 398
Cdd:pfam01490 397 --GLLLMAYGVAGLIL 410
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
32-398 2.73e-44

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 159.39  E-value: 2.73e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534  32 GKSSQSAAVFNVVNSVIGSGIIGLPYSMKQAGFPLGILLLFLVSYITDFSLVLLIK-----GGALSGTDSYQSLVNKTFG 106
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRcskevPVTGKRNKSYGDLGYRLLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 107 FPGYLLLSTLQFMYPF----------------IVD--PGGWFISRHFIIVVSTVTCtLPLSLYRDIAKLGKISFISTILT 168
Cdd:pfam01490  81 PKGRLLILFAILLNLFgvcisylifagdnlpaIFDsfFDTCPISLVYFIIIFGLIF-IPLSFIPNLSALSILSLLAAVSS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 169 TVILGIVmtrAISLGPNIPKTDNAWV-------FAKPNAIQAIGVMSFAFICHHNCFLVYGSLEEPTVAK-WRRIIHTSI 240
Cdd:pfam01490 160 LYYIVIL---VLSVAEGIVLTAQGVGhlgsktnIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFKaMTKILLTAI 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 241 LVSVFICVLFATCGYFTFTGFTQGDLFENYCRSDDLVTFGRFCYGITVILTYPIECFVTREVIANVFF-----------G 309
Cdd:pfam01490 237 IIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFrkeapfgasgkN 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 310 GTLSSVFHTVLAVLIVTAATLVSLMIECLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRT-------HSDKIMACVMF 382
Cdd:pfam01490 317 NPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLKKTKKKsqeklwkPDILDVICIVI 396
                         410
                  ....*....|....*.
gi 1907140534 383 pvGAVVMVVGFVMAIT 398
Cdd:pfam01490 397 --GLLLMAYGVAGLIL 410
PTZ00206 PTZ00206
amino acid transporter; Provisional
37-359 3.33e-08

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 55.26  E-value: 3.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534  37 SAAVFNVVNSVIGSGIIGLPYSMKQAGFPLGILLLFLVSYITDFSLVLLIKGGALSGTDSYQSLVNKTFGFPGYLLLSTL 116
Cdd:PTZ00206   63 AASAFNIASSTVGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAADKTNIRTYEGVARVLLGPWGSYYVAAT 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 117 QFMYPF------IVDPGGWFIS----------------RHFIIVVSTVTCTLPLSLYRDIAKLGKISFI--STILTTVIL 172
Cdd:PTZ00206  143 RAFHGFsacvayVISVGDILSAtlkgtnapdflkqksgNRLLTSLMWLCFMLPLVIPRHIDSLRYVSTIavSFMVYLVIV 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 173 GIVMTRAISLGPNIP-----KTDNAWV--FAKPN-AIQAIGVMSFAFICHHNCFLVYGSLEEPTVAKWRRIIHTSILVSV 244
Cdd:PTZ00206  223 IVVHSCMNGLPENIKnvsvgKDDNAEIilFNSGNrAIEGLGVFIFAYVFQITAYEVYMDMTNRSVGKFVLASTIAMGMCF 302
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 245 FICVLFATCGYFTFTGFTQGDLFENYcrsdDLVTFGRFCYGITVIL-----TYPIECFVTREVIANVFFGGTLSSVF--H 317
Cdd:PTZ00206  303 TMYVLTAFFGYMDFGRNVTGSVLLMY----DPVNEPAIMVGFVGVLvklfvSYALLGMACRNALYDVIGWDARKVAFwkH 378
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1907140534 318 TVLAVLIVTAATLVSLMIECLGIVLELNGVLCAAPLIFIIPS 359
Cdd:PTZ00206  379 CIAVVTLSVVMLLCGLFIPKINTVLGFAGSISGGLLGFILPA 420
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
32-398 2.73e-44

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 159.39  E-value: 2.73e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534  32 GKSSQSAAVFNVVNSVIGSGIIGLPYSMKQAGFPLGILLLFLVSYITDFSLVLLIK-----GGALSGTDSYQSLVNKTFG 106
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRcskevPVTGKRNKSYGDLGYRLLG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 107 FPGYLLLSTLQFMYPF----------------IVD--PGGWFISRHFIIVVSTVTCtLPLSLYRDIAKLGKISFISTILT 168
Cdd:pfam01490  81 PKGRLLILFAILLNLFgvcisylifagdnlpaIFDsfFDTCPISLVYFIIIFGLIF-IPLSFIPNLSALSILSLLAAVSS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 169 TVILGIVmtrAISLGPNIPKTDNAWV-------FAKPNAIQAIGVMSFAFICHHNCFLVYGSLEEPTVAK-WRRIIHTSI 240
Cdd:pfam01490 160 LYYIVIL---VLSVAEGIVLTAQGVGhlgsktnIKLAGTFLAIGIIVFAFEGHAVLLPIQNEMKNPSKFKaMTKILLTAI 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 241 LVSVFICVLFATCGYFTFTGFTQGDLFENYCRSDDLVTFGRFCYGITVILTYPIECFVTREVIANVFF-----------G 309
Cdd:pfam01490 237 IIATVLYILIGLVGYLAFGDNVKGNILLNLPKSAWLIDIANLLLVLHVILSFPLQLFPIRQIVENLLFrkeapfgasgkN 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 310 GTLSSVFHTVLAVLIVTAATLVSLMIECLGIVLELNGVLCAAPLIFIIPSACYLKLSEEPRT-------HSDKIMACVMF 382
Cdd:pfam01490 317 NPKSKLLRVVIRSGLVVITYLIAISVPFFGDLLSLVGATSCAPLSFILPPLFHLKLKKTKKKsqeklwkPDILDVICIVI 396
                         410
                  ....*....|....*.
gi 1907140534 383 pvGAVVMVVGFVMAIT 398
Cdd:pfam01490 397 --GLLLMAYGVAGLIL 410
PTZ00206 PTZ00206
amino acid transporter; Provisional
37-359 3.33e-08

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 55.26  E-value: 3.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534  37 SAAVFNVVNSVIGSGIIGLPYSMKQAGFPLGILLLFLVSYITDFSLVLLIKGGALSGTDSYQSLVNKTFGFPGYLLLSTL 116
Cdd:PTZ00206   63 AASAFNIASSTVGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAADKTNIRTYEGVARVLLGPWGSYYVAAT 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 117 QFMYPF------IVDPGGWFIS----------------RHFIIVVSTVTCTLPLSLYRDIAKLGKISFI--STILTTVIL 172
Cdd:PTZ00206  143 RAFHGFsacvayVISVGDILSAtlkgtnapdflkqksgNRLLTSLMWLCFMLPLVIPRHIDSLRYVSTIavSFMVYLVIV 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 173 GIVMTRAISLGPNIP-----KTDNAWV--FAKPN-AIQAIGVMSFAFICHHNCFLVYGSLEEPTVAKWRRIIHTSILVSV 244
Cdd:PTZ00206  223 IVVHSCMNGLPENIKnvsvgKDDNAEIilFNSGNrAIEGLGVFIFAYVFQITAYEVYMDMTNRSVGKFVLASTIAMGMCF 302
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907140534 245 FICVLFATCGYFTFTGFTQGDLFENYcrsdDLVTFGRFCYGITVIL-----TYPIECFVTREVIANVFFGGTLSSVF--H 317
Cdd:PTZ00206  303 TMYVLTAFFGYMDFGRNVTGSVLLMY----DPVNEPAIMVGFVGVLvklfvSYALLGMACRNALYDVIGWDARKVAFwkH 378
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1907140534 318 TVLAVLIVTAATLVSLMIECLGIVLELNGVLCAAPLIFIIPS 359
Cdd:PTZ00206  379 CIAVVTLSVVMLLCGLFIPKINTVLGFAGSISGGLLGFILPA 420
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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