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Conserved domains on  [gi|1907152199|ref|XP_036019224|]
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5'-3' DNA helicase ZGRF1 isoform X7 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DNA2 COG1112
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
393-741 1.74e-70

Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];


:

Pssm-ID: 440729 [Multi-domain]  Cd Length: 819  Bit Score: 247.73  E-value: 1.74e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 393 YSLHAGSDNESEQLKELNALLKEELTPIERVY--VRKSIEQHKLGTNRvLLKQVRVVGVTCAACA-FPCLNDLKFPVVVL 469
Cdd:COG1112   483 SLLEELIEEHPEELEKLIAELREAARLRRALRreLKKRRELRKLLWDA-LLELAPVVGMTPASVArLLPLGEGSFDLVII 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 470 DECSQMTEPASLLPIARfqCEKLILVGDPKQLPPTIQGSDAA--HENGLEQTLFDRLclmactskmlqvtagcrlcgwmK 547
Cdd:COG1112   562 DEASQATLAEALGALAR--AKRVVLVGDPKQLPPVVFGEEAEevAEEGLDESLLDRL----------------------L 617

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 548 DEEGHKPVLLRTQYRCHPAISAIANDLFYEGSLVNGISERERSPVLEWLPtLCFYNVTGAEQvERENSFVNVAEATFTLK 627
Cdd:COG1112   618 ARLPERGVMLREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARRLADPDSP-LVFIDVDGVYE-RRGGSRTNPEEAEAVVE 695

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 628 LIQSLMASGVESCMIGVITLYKSQMYKICNLLSAVDVGHPDvkAVQVSTVDAFQGAEKEITILSCVRT------RQVGFI 701
Cdd:COG1112   696 LVRELLEDGPDGESIGVITPYRAQVALIRELLREALGDGLE--PVFVGTVDRFQGDERDVIIFSLVYSndedvpRNFGFL 773

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1907152199 702 -DSEKRMNVALTRGRRHLLIVGSLSCL---RKNRLWGRVIQHCE 741
Cdd:COG1112   774 nGGPRRLNVAVSRARRKLIVVGSRELLdsdPSTPALKRLLEYLE 817
zf-GRF pfam06839
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ...
 9-53 2.26e-13

GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.


:

Pssm-ID: 462017  Cd Length: 45  Bit Score: 64.73  E-value: 2.26e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907152199   9 PSCHHNQPAKLVMVKKEGPNKGRLFYTCDKSKDNQCKFFKWLEEV 53
Cdd:pfam06839   1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
 
Name Accession Description Interval E-value
DNA2 COG1112
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
393-741 1.74e-70

Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];


Pssm-ID: 440729 [Multi-domain]  Cd Length: 819  Bit Score: 247.73  E-value: 1.74e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 393 YSLHAGSDNESEQLKELNALLKEELTPIERVY--VRKSIEQHKLGTNRvLLKQVRVVGVTCAACA-FPCLNDLKFPVVVL 469
Cdd:COG1112   483 SLLEELIEEHPEELEKLIAELREAARLRRALRreLKKRRELRKLLWDA-LLELAPVVGMTPASVArLLPLGEGSFDLVII 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 470 DECSQMTEPASLLPIARfqCEKLILVGDPKQLPPTIQGSDAA--HENGLEQTLFDRLclmactskmlqvtagcrlcgwmK 547
Cdd:COG1112   562 DEASQATLAEALGALAR--AKRVVLVGDPKQLPPVVFGEEAEevAEEGLDESLLDRL----------------------L 617

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 548 DEEGHKPVLLRTQYRCHPAISAIANDLFYEGSLVNGISERERSPVLEWLPtLCFYNVTGAEQvERENSFVNVAEATFTLK 627
Cdd:COG1112   618 ARLPERGVMLREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARRLADPDSP-LVFIDVDGVYE-RRGGSRTNPEEAEAVVE 695

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 628 LIQSLMASGVESCMIGVITLYKSQMYKICNLLSAVDVGHPDvkAVQVSTVDAFQGAEKEITILSCVRT------RQVGFI 701
Cdd:COG1112   696 LVRELLEDGPDGESIGVITPYRAQVALIRELLREALGDGLE--PVFVGTVDRFQGDERDVIIFSLVYSndedvpRNFGFL 773

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1907152199 702 -DSEKRMNVALTRGRRHLLIVGSLSCL---RKNRLWGRVIQHCE 741
Cdd:COG1112   774 nGGPRRLNVAVSRARRKLIVVGSRELLdsdPSTPALKRLLEYLE 817
AAA_12 pfam13087
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 516-723 2.48e-62

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.


Pssm-ID: 463780 [Multi-domain]  Cd Length: 196  Bit Score: 207.79  E-value: 2.48e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 516 LEQTLFDRLCLMActskmlqvtagcrlcgwmkdeeGHKPVLLRTQYRCHPAISAIANDLFYEGSLVNGISERERS-PVLE 594
Cdd:pfam13087   1 LDRSLFERLQELG----------------------PSAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAERPlPDDF 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 595 WLPT----LCFYNVTGAEQ--VERENSFVNVAEATFTLKLIQSLMASGV-ESCMIGVITLYKSQMYKICNLLSAVDVGHP 667
Cdd:pfam13087  59 HLPDplgpLVFIDVDGSEEeeSDGGTSYSNEAEAELVVQLVEKLIKSGPeEPSDIGVITPYRAQVRLIRKLLKRKLGGKL 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152199 668 DVKavqVSTVDAFQGAEKEITILSCVRTRQ---VGFIDSEKRMNVALTRGRRHLLIVGS 723
Cdd:pfam13087 139 EIE---VNTVDGFQGREKDVIIFSCVRSNEkggIGFLSDPRRLNVALTRAKRGLIIVGN 194
SF1_C_Upf1 cd18808
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ...
 563-741 5.92e-57

C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350195 [Multi-domain]  Cd Length: 184  Bit Score: 192.83  E-value: 5.92e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 563 CHPAISAIANDLFYEGSLVNGISERERSPVLEWLPT---LCFYNVTGAEQVERE-NSFVNVAEATFTLKLIQSLMASGVE 638
Cdd:cd18808     1 MHPEISEFPSKLFYEGKLKAGVSVAARLNPPPLPGPskpLVFVDVSGGEEREESgTSKSNEAEAELVVELVKYLLKSGVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 639 SCMIGVITLYKSQMYKICNLLSAVDVGHPDVKavqVSTVDAFQGAEKEITILSCVRTRQ----VGFIDSEKRMNVALTRG 714
Cdd:cd18808    81 PSSIGVITPYRAQVALIRELLRKRGGLLEDVE---VGTVDNFQGREKDVIILSLVRSNEsggsIGFLSDPRRLNVALTRA 157

                         170       180
                  ....*....|....*....|....*..
gi 1907152199 715 RRHLLIVGSLSCLRKNRLWGRVIQHCE 741
Cdd:cd18808   158 KRGLIIVGNPDTLSKDPLWKKLLEYLE 184
zf-GRF pfam06839
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ...
 9-53 2.26e-13

GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.


Pssm-ID: 462017  Cd Length: 45  Bit Score: 64.73  E-value: 2.26e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907152199   9 PSCHHNQPAKLVMVKKEGPNKGRLFYTCDKSKDNQCKFFKWLEEV 53
Cdd:pfam06839   1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
 
Name Accession Description Interval E-value
DNA2 COG1112
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
393-741 1.74e-70

Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];


Pssm-ID: 440729 [Multi-domain]  Cd Length: 819  Bit Score: 247.73  E-value: 1.74e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 393 YSLHAGSDNESEQLKELNALLKEELTPIERVY--VRKSIEQHKLGTNRvLLKQVRVVGVTCAACA-FPCLNDLKFPVVVL 469
Cdd:COG1112   483 SLLEELIEEHPEELEKLIAELREAARLRRALRreLKKRRELRKLLWDA-LLELAPVVGMTPASVArLLPLGEGSFDLVII 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 470 DECSQMTEPASLLPIARfqCEKLILVGDPKQLPPTIQGSDAA--HENGLEQTLFDRLclmactskmlqvtagcrlcgwmK 547
Cdd:COG1112   562 DEASQATLAEALGALAR--AKRVVLVGDPKQLPPVVFGEEAEevAEEGLDESLLDRL----------------------L 617

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 548 DEEGHKPVLLRTQYRCHPAISAIANDLFYEGSLVNGISERERSPVLEWLPtLCFYNVTGAEQvERENSFVNVAEATFTLK 627
Cdd:COG1112   618 ARLPERGVMLREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARRLADPDSP-LVFIDVDGVYE-RRGGSRTNPEEAEAVVE 695

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 628 LIQSLMASGVESCMIGVITLYKSQMYKICNLLSAVDVGHPDvkAVQVSTVDAFQGAEKEITILSCVRT------RQVGFI 701
Cdd:COG1112   696 LVRELLEDGPDGESIGVITPYRAQVALIRELLREALGDGLE--PVFVGTVDRFQGDERDVIIFSLVYSndedvpRNFGFL 773

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1907152199 702 -DSEKRMNVALTRGRRHLLIVGSLSCL---RKNRLWGRVIQHCE 741
Cdd:COG1112   774 nGGPRRLNVAVSRARRKLIVVGSRELLdsdPSTPALKRLLEYLE 817
AAA_12 pfam13087
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 516-723 2.48e-62

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.


Pssm-ID: 463780 [Multi-domain]  Cd Length: 196  Bit Score: 207.79  E-value: 2.48e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 516 LEQTLFDRLCLMActskmlqvtagcrlcgwmkdeeGHKPVLLRTQYRCHPAISAIANDLFYEGSLVNGISERERS-PVLE 594
Cdd:pfam13087   1 LDRSLFERLQELG----------------------PSAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAERPlPDDF 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 595 WLPT----LCFYNVTGAEQ--VERENSFVNVAEATFTLKLIQSLMASGV-ESCMIGVITLYKSQMYKICNLLSAVDVGHP 667
Cdd:pfam13087  59 HLPDplgpLVFIDVDGSEEeeSDGGTSYSNEAEAELVVQLVEKLIKSGPeEPSDIGVITPYRAQVRLIRKLLKRKLGGKL 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152199 668 DVKavqVSTVDAFQGAEKEITILSCVRTRQ---VGFIDSEKRMNVALTRGRRHLLIVGS 723
Cdd:pfam13087 139 EIE---VNTVDGFQGREKDVIIFSCVRSNEkggIGFLSDPRRLNVALTRAKRGLIIVGN 194
SF1_C_Upf1 cd18808
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ...
 563-741 5.92e-57

C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350195 [Multi-domain]  Cd Length: 184  Bit Score: 192.83  E-value: 5.92e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 563 CHPAISAIANDLFYEGSLVNGISERERSPVLEWLPT---LCFYNVTGAEQVERE-NSFVNVAEATFTLKLIQSLMASGVE 638
Cdd:cd18808     1 MHPEISEFPSKLFYEGKLKAGVSVAARLNPPPLPGPskpLVFVDVSGGEEREESgTSKSNEAEAELVVELVKYLLKSGVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 639 SCMIGVITLYKSQMYKICNLLSAVDVGHPDVKavqVSTVDAFQGAEKEITILSCVRTRQ----VGFIDSEKRMNVALTRG 714
Cdd:cd18808    81 PSSIGVITPYRAQVALIRELLRKRGGLLEDVE---VGTVDNFQGREKDVIILSLVRSNEsggsIGFLSDPRRLNVALTRA 157

                         170       180
                  ....*....|....*....|....*..
gi 1907152199 715 RRHLLIVGSLSCLRKNRLWGRVIQHCE 741
Cdd:cd18808   158 KRGLIIVGNPDTLSKDPLWKKLLEYLE 184
DEXXQc_DNA2 cd18041
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses ...
 275-525 4.97e-30

DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350799 [Multi-domain]  Cd Length: 203  Bit Score: 117.72  E-value: 4.97e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 275 RLNKDQATALIQIaqMMAsqgsdEDalepfghslpITVIHGVFGAGKSYLLAVvilfLVELFEKCdsgtvGNarpwKVLV 354
Cdd:cd18041     1 GLNKDQRQAIKKV--LNA-----KD----------YALILGMPGTGKTTTIAA----LVRILVAL-----GK----SVLL 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 355 SSSTNVAVDRVLLGLLSLGFEkFIRVGSVRKIAKPVLPYSLHAGSDNEseqlkelnallkeeltpiervyvrKSIEQHKL 434
Cdd:cd18041    51 TSYTHSAVDNILLKLKKFGVN-FLRLGRLKKIHPDVQEFTLEAILKSC------------------------KSVEELES 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 435 gtnrvLLKQVRVVGVTCAACAFPCLNDLKFPVVVLDECSQMTEPASLLPIARfqCEKLILVGDPKQLPPTIQgSDAAHEN 514
Cdd:cd18041   106 -----KYESVSVVATTCLGINHPIFRRRTFDYCIVDEASQITLPICLGPLRL--AKKFVLVGDHYQLPPLVK-SREAREL 177

                         250
                  ....*....|.
gi 1907152199 515 GLEQTLFDRLC 525
Cdd:cd18041   178 GMDESLFKRLS 188
DEXXQc_UPF1 cd18039
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ...
 309-562 6.24e-28

DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350797 [Multi-domain]  Cd Length: 234  Bit Score: 112.73  E-value: 6.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 309 PITVIHGVFGAGKSyllaVVILFLVELFEKCDSGtvgnarpwKVLVSSSTNVAVDRVLLGLLSLGFeKFIRVGSVRK--I 386
Cdd:cd18039    17 PLSLIQGPPGTGKT----VTSATIVYHLVKQGNG--------PVLVCAPSNVAVDQLTEKIHQTGL-KVVRLCAKSReaV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 387 AKPVLPYSLHAGSDNESE-QLKELNALLKEELTPIERVYVRKSIEQhKLGTNRVLLKQVRVVGVTCAACAFPCLNDLKFP 465
Cdd:cd18039    84 ESPVSFLALHNQVRNLDSaEKLELLKLLKLETGELSSADEKRYRKL-KRKAERELLRNADVICCTCVGAGDPRLSKMKFR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 466 VVVLDECSQMTEPASLLPIARfQCEKLILVGDPKQLPPTIQGSDAAhENGLEQTLFDRLCLMactskmlqvtagcrlcgw 545
Cdd:cd18039   163 TVLIDEATQATEPECLIPLVH-GAKQVILVGDHCQLGPVVMCKKAA-KAGLSQSLFERLVQL------------------ 222

                         250
                  ....*....|....*..
gi 1907152199 546 mkdeeGHKPVLLRTQYR 562
Cdd:cd18039   223 -----GIRPIRLQVQYR 234
AAA_11 pfam13086
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 309-505 6.47e-26

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.


Pssm-ID: 404072 [Multi-domain]  Cd Length: 248  Bit Score: 107.43  E-value: 6.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 309 PITVIHGVFGAGKSYLLAVVILFLVElfekcDSGTVGNARPwKVLVSSSTNVAVDRVLLGLLSLGFE---KFIRVGSVRK 385
Cdd:pfam13086  14 HFTLIQGPPGTGKTTTIVELIRQLLS-----YPATSAAAGP-RILVCAPSNAAVDNILERLLRKGQKygpKIVRIGHPAA 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 386 IAKPVLPYSL-----------------HAGSDNESEQLKELNALLKEELTPIERVYV---------------------RK 427
Cdd:pfam13086  88 ISEAVLPVSLdylvesklnneedaqivKDISKELEKLAKALRAFEKEIIVEKLLKSRnkdkskleqerrklrserkelRK 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907152199 428 SIEQHKLGTNRVLLKQVRVVGVTCAACAFPCLNDL-KFPVVVLDECSQMTEPASLLPIaRFQCEKLILVGDPKQLPPTI 505
Cdd:pfam13086 168 ELRRREQSLEREILDEAQIVCSTLSGAGSRLLSSLaNFDVVIIDEAAQALEPSTLIPL-LRGPKKVVLVGDPKQLPPTV 245
DEXXQc_SMUBP2 cd18044
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, ...
 309-524 1.30e-25

DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, or IGHMBP2) is a 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. It is a DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence (5'-GGGCT-3') related to the immunoglobulin mu chain switch region. The IGHMBP2 gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). It is also thought to play a role in frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) and major depressive disorder (MDD). SMUBP2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350802 [Multi-domain]  Cd Length: 191  Bit Score: 104.61  E-value: 1.30e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 309 PITVIHGVFGAGKSYLLAVVILFLVElfekcdsgtvgnaRPWKVLVSSSTNVAVDRVLLGLLSLGfEKFIRVGSVRKIAK 388
Cdd:cd18044    18 DVALIHGPPGTGKTTTVVEIILQAVK-------------RGEKVLACAPSNIAVDNLVERLVALK-VKVVRIGHPARLLE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 389 PVLPYSLHAgsdneseqlkelnallkeeltpiervyvrksieqhklgtnrvlLKQVRVVGVTC-AACAFPCLNDLKFPVV 467
Cdd:cd18044    84 SVLDHSLDA-------------------------------------------LVAAQVVLATNtGAGSRQLLPNELFDVV 120

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907152199 468 VLDECSQMTEPASLLPIARFQceKLILVGDPKQLPPTIQgSDAAHENGLEQTLFDRL 524
Cdd:cd18044   121 VIDEAAQALEASCWIPLLKAR--RCILAGDHKQLPPTIL-SDKAARGGLGVTLFERL 174
DEXXQc_SETX cd18042
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ...
 276-562 2.22e-24

DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438712 [Multi-domain]  Cd Length: 218  Bit Score: 101.91  E-value: 2.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 276 LNKDQATALIQIAQMMAsqgsdedalepfghslPITVIHGVFGAGKSY-LLAVVILFLVELFEK------------CDSG 342
Cdd:cd18042     1 LNESQLEAIASALQNSP----------------GITLIQGPPGTGKTKtIVGILSVLLAGKYRKyyekvkkklrklQRNL 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 343 TVGNARPwKVLVSSSTNVAVDRVLLGLLSLGFEKFIRVGSVRKIAkpvlpyslhagsdneseqlkelnallkeeltpieR 422
Cdd:cd18042    65 NNKKKKN-RILVCAPSNAAVDEIVLRLLSEGFLDGDGRSYKPNVV----------------------------------R 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 423 VyVRKSIEQHklgtnrvLLKQVRVVGVTCAACAFPCLN--DLKFPVVVLDECSQMTEPASLLPIaRFQCEKLILVGDPKQ 500
Cdd:cd18042   110 V-GRQELRAS-------ILNEADIVCTTLSSSGSDLLEslPRGFDTVIIDEAAQAVELSTLIPL-RLGCKRLILVGDPKQ 180

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907152199 501 LPPTIQGSDAAhENGLEQTLFDRLClmactskmlqvtagcrlcgwmkdEEGHKPVLLRTQYR 562
Cdd:cd18042   181 LPATVFSKVAQ-KLGYDRSLFERLQ-----------------------LAGYPVLMLTTQYR 218
DEXXQc_Upf1-like cd17934
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ...
 310-562 1.76e-22

DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438708 [Multi-domain]  Cd Length: 121  Bit Score: 93.45  E-value: 1.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 310 ITVIHGVFGAGKSYLLAVVILFLVElfekcdsgtvgNARPWKVLVSSSTNVAVDRVllgllslgfekfirvgsvrkiakp 389
Cdd:cd17934     1 ISLIQGPPGTGKTTTIAAIVLQLLK-----------GLRGKRVLVTAQSNVAVDNV------------------------ 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 390 vlpyslhagsdneseqlkelnallkeeltpiervyvrksieqhklgtnrvllkqvrvvgvtcaacafpclndlkfPVVVL 469
Cdd:cd17934    46 ---------------------------------------------------------------------------DVVII 50

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 470 DECSQMTEPASLLPIARfqCEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRLCLMACTskmlqvtagcrlcgwmkde 549
Cdd:cd17934    51 DEASQITEPELLIALIR--AKKVVLVGDPKQLPPVVQEDHAALLGLSFILSLLLLFRLLLP------------------- 109

                         250
                  ....*....|...
gi 1907152199 550 eGHKPVLLRTQYR 562
Cdd:cd17934   110 -GSPKVMLDTQYR 121
DEXXc_HELZ2-C cd18040
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ...
 276-536 6.26e-18

C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350798 [Multi-domain]  Cd Length: 271  Bit Score: 84.50  E-value: 6.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 276 LNKDQATALIQiaqmmasqgsdedALEPfghslPITVIHGVFGAGKSYLLAVVILFLVELFEKCDSGTVGNARPWKVLVS 355
Cdd:cd18040     2 LNPSQNHAVRT-------------ALTK-----PFTLIQGPPGTGKTVTGVHIAYWFAKQNREIQSVSGEGDGGPCVLYC 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 356 SSTNVAVDRVLLGLLSLGFEKFIRVGSvRKIAKPVLPY------------------------SLH----AGSDNESEQLK 407
Cdd:cd18040    64 GPSNKSVDVVAELLLKVPGLKILRVYS-EQIETTEYPIpneprhpnkksereskpnselssiTLHhrirQPSNPHSQQIK 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 408 ELNALLKEELTPIERvyvrKSIEQHK---LGTNRVLLKQVRVVGVTCAACAFPCLNdLKFPV--VVLDECSQMTEPASLL 482
Cdd:cd18040   143 AFEARFERTQEKITE----EDIKTYKiliWEARFEELETVDVILCTCSEAASQKMR-THANVkqCIVDECGMCTEPESLI 217

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907152199 483 PI-ARFQCEKLILVGDPKQLPPTIQgSDAAHENGLEQTLFDRLCLMACtskMLQV 536
Cdd:cd18040   218 PIvSAPRAEQVVLIGDHKQLRPVVQ-NKEAQKLGLGRSLFERYAEKAC---MLDT 268
DEXXQc_Helz-like cd18038
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ...
 275-526 1.10e-15

DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350796 [Multi-domain]  Cd Length: 229  Bit Score: 76.89  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 275 RLNKDQATALIQIAQMMASQGsdedalePFghslpitVIHGVFGAGKSYLLAVVILFLVELFEKCdsgtvgnarpwKVLV 354
Cdd:cd18038     1 ELNDEQKLAVRNIVTGTSRPP-------PY-------IIFGPPGTGKTVTLVEAILQVLRQPPEA-----------RILV 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 355 SSSTNVAVDRVLLGLLslgfekfirvgsvRKIAKPVLPYSLHAGSDNESEQLKELNALLKEELtpiERVYVRKSIEQhkl 434
Cdd:cd18038    56 CAPSNSAADLLAERLL-------------NALVTKREILRLNAPSRDRASVPPELLPYCNSKA---EGTFRLPSLEE--- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 435 gtnrvlLKQVRVVGVTCAACAFpcLNDLKFPV-----VVLDECSQMTEPASLLPIARFQCEK--LILVGDPKQLPPTIQg 507
Cdd:cd18038   117 ------LKKYRIVVCTLMTAGR--LVQAGVPNghfthIFIDEAGQATEPEALIPLSELASKNtqIVLAGDPKQLGPVVR- 187

                         250
                  ....*....|....*....
gi 1907152199 508 SDAAHENGLEQTLFDRLCL 526
Cdd:cd18038   188 SPLARKYGLGKSLLERLME 206
EEXXEc_NFX1 cd17936
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that ...
 297-536 4.70e-15

EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that represses class II MHC (major histocompatibility complex) gene expression. NFX1 binds a conserved cis-acting element, termed the X-box, in promoters of human class II MHC genes. The Cys-rich region contains several NFX1-type zinc finger domains. Frequently, a R3H domain is present in the C-terminus, and a RING finger domain and a PAM2 motif are present in the N-terminus. The lack of R3H and PAM2 motifs in the plant proteins indicates functional differences. Plant NFX1-like proteins are proposed to modulate growth and survival by coordinating reactive oxygen species, salicylic acid, further biotic stress and abscisic acid responses. A common feature of all members may be E3 ubiquitin ligase, due to the presence of a RING finger domain, as well as DNA binding. NFX1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350694 [Multi-domain]  Cd Length: 178  Bit Score: 73.73  E-value: 4.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 297 DEDALEPFGHSL--PITVIHGVFGAGKSYLlAVVILFLveLFEKCDSGTVGnarpwKVLVSSSTNVAVDRVLLGLLSLGF 374
Cdd:cd17936     3 DPSQLEALKHALtsELALIQGPPGTGKTFL-GVKLVRA--LLQNQDLSITG-----PILVVCYTNHALDQFLEGLLDFGP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 375 EKFIRVGsvrkiakpvlpyslhagsdneseqlkelnallkeeltpiervyvrksieqhklgtnrvllkqVRVVGVTCAAC 454
Cdd:cd17936    75 TKIVRLG--------------------------------------------------------------ARVIGMTTTGA 92

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 455 A--FPCLNDLKFPVVVLDECSQMTEP---ASLLPiarfQCEKLILVGDPKQLPPTIQG-SDAAHENGLEQTLFDRLCLMA 528
Cdd:cd17936    93 AkyRELLQALGPKVVIVEEAAEVLEAhilAALTP----STEHLILIGDHKQLRPKVNVyELTAKKYNLDVSLFERLVKNG 168


                  ....*...
gi 1907152199 529 CTSKMLQV 536
Cdd:cd17936   169 LPFVTLNV 176
zf-GRF pfam06839
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ...
 9-53 2.26e-13

GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.


Pssm-ID: 462017  Cd Length: 45  Bit Score: 64.73  E-value: 2.26e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907152199   9 PSCHHNQPAKLVMVKKEGPNKGRLFYTCDKSKDNQCKFFKWLEEV 53
Cdd:pfam06839   1 PLCPCGQRAVLLTVRKTGPNPGRQFYKCPVGREKQCGFFQWADEV 45
DEXXQc_Mov10L1 cd18078
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ...
 276-524 9.02e-11

DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350836 [Multi-domain]  Cd Length: 230  Bit Score: 62.77  E-value: 9.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 276 LNKDQATALIQIaqmmasqgsdedaLEPFGHSLPItVIHGVFGAGKSYLLAVVILFLVELFEKCdsgtvgnarpwKVLVS 355
Cdd:cd18078     2 LNELQKEAVKRI-------------LGGECRPLPY-ILFGPPGTGKTVTIIEAILQVVYNLPRS-----------RILVC 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 356 SSTNVAVDRVLLGLLSlgfEKFIRVGsvrkiakpvlpyslhagsdneseQLKELNALLKEELT--PIERVYVRKSIEQHK 433
Cdd:cd18078    57 APSNSAADLVTSRLHE---SKVLKPG-----------------------DMVRLNAVNRFESTviDARKLYCRLGEDLSK 110

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 434 LGTNRVLLKQVRVVGVtcaacafpcLNDLKFPV-----VVLDECSQMTEPASLLPIARFQCE--KLILVGDPKQLPPTIQ 506
Cdd:cd18078   111 ASRHRIVISTCSTAGL---------LYQMGLPVghfthVFVDEAGQATEPESLIPLGLISSRdgQIILAGDPMQLGPVIK 181

                         250
                  ....*....|....*...
gi 1907152199 507 gSDAAHENGLEQTLFDRL 524
Cdd:cd18078   182 -SRLASAYGLGVSFLERL 198
SF1_C cd18786
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ...
 642-722 7.06e-09

C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350173 [Multi-domain]  Cd Length: 89  Bit Score: 53.60  E-value: 7.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 642 IGVITLYKSQMYKICNLLSAVDVGHPDVKAVQVSTVDAFQGAEKEITILSCVRTrqvgFIDSEKRMNVALTRGRRHLLIV 721
Cdd:cd18786    13 GVVLTPYHRDRAYLNQYLQGLSLDEFDLQLVGAITIDSSQGLTFDVVTLYLPTA----NSLTPRRLYVALTRARKRLVIY 88


                  .
gi 1907152199 722 G 722
Cdd:cd18786    89 D 89
EEXXQc_AQR cd17935
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ...
 445-572 9.40e-08

EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350693 [Multi-domain]  Cd Length: 207  Bit Score: 53.20  E-value: 9.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 445 RVVGVTCAACAFPcLNDL-----KFPVVVLDECSQMTEPASLLPIA--RFQCE-----KLILVGDPKQLPPTIQGSDAAH 512
Cdd:cd17935    88 KIIAMTCTHAALK-RGELvelgfKYDNILMEEAAQILEIETFIPLLlqNPEDGpnrlkRLIMIGDHHQLPPVIKNMAFQK 166

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 513 ENGLEQTLFDRLclmactskmlqvtagCRLcgwmkdeeGHKPVLLRTQYRCHPAISAIAN 572
Cdd:cd17935   167 YSNMEQSLFTRL---------------VRL--------GVPTVDLDAQGRARASISSLYN 203
DEXXQc_SF1 cd18043
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ...
 459-505 3.62e-07

DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350801 [Multi-domain]  Cd Length: 127  Bit Score: 49.89  E-value: 3.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907152199 459 LNDLKFPVVVLDECSQMTEPASLLPIARfqCEKLILVGDPKQLPPTI 505
Cdd:cd18043    76 LNRNLFDLVIFDEASQIPIEEALPALFR--GKQVVVVGDDKQLPPSI 120
CoV_Nsp13-helicase cd21718
helicase domain of coronavirus non-structural protein 13; This model represents the helicase ...
 459-721 2.94e-06

helicase domain of coronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from alpha-, beta-, gamma-, and deltacoronavirus, including pathogenic human viruses such as Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV2 (also called 2019 novel CoV or 2019-nCoV), and Middle East respiratory syndrome-related (MERS) CoV. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.


Pssm-ID: 409652 [Multi-domain]  Cd Length: 341  Bit Score: 50.22  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 459 LNDLKFPVVVLDECSQMTEPASLLPIARFQCEKLILVGDPKQLP-PTIQGSdaahENGLEQTLFDRLCLMACTSKmlqvt 537
Cdd:cd21718   113 LPECSADIVVVDEVSMCTNYDLSVVNARLKYKHIVYVGDPAQLPaPRTLLT----EGSLEPKDYNVVTRLMVGSG----- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 538 agcrlcgwmkdeeghKPVLLRTQYRCHPAISAIANDLFYEGSL--VNGISErerspvlewlptlCFYNVTGAEQVEREN- 614
Cdd:cd21718   184 ---------------PDVFLSKCYRCPKEIVDTVSKLVYDNKLkaIKPKSR-------------QCFKTFGKGDVRHDNg 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 615 SFVNVAEatftLKLIQSLMASGVESCMIGVITLYKSQMYKICNLLsavdvghpdvkAVQVSTVDAFQGAEKEITILsCVr 694
Cdd:cd21718   236 SAINRPQ----LEFVKRFLDRNPRWRKAVFISPYNAMNNRASRLL-----------GLSTQTVDSSQGSEYDYVIF-CQ- 298

                         250       260
                  ....*....|....*....|....*..
gi 1907152199 695 TRQVGFIDSEKRMNVALTRGRRHLLIV 721
Cdd:cd21718   299 TTDTAHALNINRFNVAITRAKHGILVI 325
DExxQc_SF1-N cd17914
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ...
 462-524 5.80e-06

DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438706 [Multi-domain]  Cd Length: 121  Bit Score: 45.94  E-value: 5.80e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907152199 462 LKFPVVVLDECSQMTEPASLLPIARF-QCEKLILVGDPKQLPPTIQGSDAAhENGLEQTLFDRL 524
Cdd:cd17914    45 AQLDNILVDEAAQILEPETSRLIDLAlDQGRVILVGDHDQLGPVWRGAVLA-KICNEQSLFTRL 107
DEXSc_RecD-like cd17933
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ...
 460-503 2.57e-05

DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350691 [Multi-domain]  Cd Length: 155  Bit Score: 44.85  E-value: 2.57e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907152199 460 NDLKFPVVVLDECSQMTEP--ASLLPIARFQCeKLILVGDPKQLPP 503
Cdd:cd17933    86 NPLDADLLIVDEASMVDTRlmAALLSAIPAGA-RLILVGDPDQLPS 130
DEXXQc_HELZ cd18077
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that ...
 275-524 1.57e-04

DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. HELZ is a member of the family I class of RNA helicases of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350835 [Multi-domain]  Cd Length: 226  Bit Score: 44.01  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 275 RLNKDQATALIQIAQmmasqgsdedalePFGHSLPITVIHGVFGAGKSYLLAVVILFLVElfekcDSGTvgnarpwKVLV 354
Cdd:cd18077     1 RLNAKQKEAVLAITT-------------PLSIQLPPVLLIGPFGTGKTFTLAQAVKHILQ-----QPET-------RILI 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 355 SSSTNVAVDRVLLGLLslgfEKFIRVGSVRkiAKPVLPYsLHAGSDNESEQLKELNALLKEELTpiERVYVRKSIEQHkl 434
Cdd:cd18077    56 CTHSNSAADLYIKEYL----HPYVETGNPR--ARPLRVY-YRNRWVKTVHPVVQKYCLIDEHGT--FRMPTREDVMRH-- 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152199 435 gtnrvllkqvRVVGVTCAACAFPCLNDLK---FPVVVLDECSQMTEPASLLPIA-RFQCEKLILVGDPKQLPPTIQgSDA 510
Cdd:cd18077   125 ----------RVVVVTLSTSQYLCQLDLEpgfFTHILLDEAAQAMECEAIMPLAlATKSTRIVLAGDHMQLSPEVY-SEF 193

                         250
                  ....*....|....
gi 1907152199 511 AHENGLEQTLFDRL 524
Cdd:cd18077   194 ARERNLHISLLERL 207
RecD COG0507
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ...
 466-503 6.61e-04

ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440273 [Multi-domain]  Cd Length: 514  Bit Score: 43.04  E-value: 6.61e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907152199 466 VVVLDECSQMTEP--ASLLPIARFQCEKLILVGDPKQLPP 503
Cdd:COG0507   221 LLVVDEASMVDTRlmAALLEALPRAGARLILVGDPDQLPS 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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