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Conserved domains on  [gi|1907152262|ref|XP_036019240|]
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fibronectin type III domain-containing protein 3B isoform X5 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
563-852 2.59e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.90  E-value: 2.59e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  563 PLIKGPVTSHGFSVKWDAPKDNGGSEILKYLLEIT-DGTSEDVPASESGCEVSEYSVEMTEPENVASEVYHGPELEcTVG 641
Cdd:COG3401    119 SPAVGTATTATAVAGGAATAGTYALGAGLYGVDGAnASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVD-GGG 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  642 NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPgqcRAP---RVSFTPDGCVLVGWEspASPGADISEYRLEWGEDE 718
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP---SAPtglTATADTPGSVTLSWD--PVTESDATGYRVYRSNSG 272

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  719 Q-SLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPAG-AGPYSELVHCQTPASAPDPVSTLCVLEEEPPSahpdspsvcL 796
Cdd:COG3401    273 DgPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSS---------I 343

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152262  797 VLNWEEpcNNGSEILAYNI----DLGDSCITVG---NTTTHVMKNLLPETTYRIRIQAINEIG 852
Cdd:COG3401    344 TLSWTA--SSDADVTGYNVyrstSGGGTYTKIAetvTTTSYTDTGLTPGTTYYYKVTAVDAAG 404
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 463-552 1.13e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  463 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 538
Cdd:cd00063      1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1907152262  539 EGKSCPSEVLVCTT 552
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
739-973 1.39e-11

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.49  E-value: 1.39e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  739 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 818
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  819 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 890
Cdd:COG3401    270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  891 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 964
Cdd:COG3401    349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                   ....*....
gi 1907152262  965 PTLKAPRVT 973
Cdd:COG3401    422 SGESLTASV 430
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 6.78e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 6.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907152262  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
924-1056 5.18e-08

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 5.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  924 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1000
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152262 1001 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1056
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-455 4.94e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 4.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  382 PECPFPPKLAHRSKSSLTLQW-----------------KGKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARNDI 442
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWtppeddggpitgyvveyREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1907152262  443 GTSGYSQEVVCYT 455
Cdd:cd00063     81 GESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
563-852 2.59e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.90  E-value: 2.59e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  563 PLIKGPVTSHGFSVKWDAPKDNGGSEILKYLLEIT-DGTSEDVPASESGCEVSEYSVEMTEPENVASEVYHGPELEcTVG 641
Cdd:COG3401    119 SPAVGTATTATAVAGGAATAGTYALGAGLYGVDGAnASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVD-GGG 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  642 NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPgqcRAP---RVSFTPDGCVLVGWEspASPGADISEYRLEWGEDE 718
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP---SAPtglTATADTPGSVTLSWD--PVTESDATGYRVYRSNSG 272

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  719 Q-SLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPAG-AGPYSELVHCQTPASAPDPVSTLCVLEEEPPSahpdspsvcL 796
Cdd:COG3401    273 DgPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSS---------I 343

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152262  797 VLNWEEpcNNGSEILAYNI----DLGDSCITVG---NTTTHVMKNLLPETTYRIRIQAINEIG 852
Cdd:COG3401    344 TLSWTA--SSDADVTGYNVyrstSGGGTYTKIAetvTTTSYTDTGLTPGTTYYYKVTAVDAAG 404
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 557-672 1.57e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.91  E-value: 1.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  557 PGPPTRPLIKgPVTSHGFSVKWDAPKDNGGsEILKYLLEITDGTSEDvpasesgcevseysvemtePENVASEVyhGPEL 636
Cdd:cd00063      1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGD-------------------WKEVEVTP--GSET 57

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1907152262  637 ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 672
Cdd:cd00063     58 SYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
558-665 6.03e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 6.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  558 GPPTRPLIKgPVTSHGFSVKWDAPKDnGGSEILKYLLEITDGTSEDVPasesgcevseysVEMTEPenvasevyhGPELE 637
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPW------------NEITVP---------GTTTS 57

                           90       100
                   ....*....|....*....|....*...
gi 1907152262  638 CTVGNLLPGTVYRFRVRALNDGGYGPYS 665
Cdd:pfam00041   58 VTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 463-552 1.13e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  463 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 538
Cdd:cd00063      1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1907152262  539 EGKSCPSEVLVCTT 552
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
739-973 1.39e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.49  E-value: 1.39e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  739 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 818
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  819 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 890
Cdd:COG3401    270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  891 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 964
Cdd:COG3401    349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                   ....*....
gi 1907152262  965 PTLKAPRVT 973
Cdd:COG3401    422 SGESLTASV 430
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 557-662 1.59e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 1.59e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262   557 PGPPTRPLIKgPVTSHGFSVKWDAPKDNGGseilkylleitdgtsedvpasesGCEVSEYSVEMTEPENVASEVYHGP-E 635
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPDDGI-----------------------TGYIVGYRVEYREEGSEWKEVNVTPsS 56

                            90       100
                    ....*....|....*....|....*..
gi 1907152262   636 LECTVGNLLPGTVYRFRVRALNDGGYG 662
Cdd:smart00060   57 TSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 6.78e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 6.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907152262  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
924-1056 5.18e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 5.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  924 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1000
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152262 1001 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1056
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 283-363 7.54e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 7.54e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262   283 EKPQVSNIQARAVVLSWAPPVglscgPHGGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    .
gi 1907152262   363 N 363
Cdd:smart00060   79 G 79
fn3 pfam00041
Fibronectin type III domain;
285-367 4.53e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  285 PQVSNIQARAVVLSWAPPVGLScGPhgglsfPYSYEVALS--DKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GP------ITGYEVEYRpkNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*
gi 1907152262  363 NSVKG 367
Cdd:pfam00041   78 GGGEG 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 964-1037 8.16e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 8.16e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152262  964 PPTLKAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVYK--GEEATFQISGLQSNTDYRFRVCA 1037
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 460-542 9.30e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 9.30e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262   460 PQMPLAPRLVRAGVTWITLQWSRPEGCSPEE-VITYTLDIQEDENDSHFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNM 538
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1907152262   539 EGKS 542
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 880-959 7.19e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 7.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  880 GPQSLKLKWgdSNSKTHAAGDMVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYT 956
Cdd:cd00063     13 TSTSVTLSW--TPPEDDGGPITGYVVEYREKGSgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90


                   ...
gi 1907152262  957 FST 959
Cdd:cd00063     91 VTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 964-1037 1.13e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.13e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152262   964 PPTLKAPRVTQLEGNSCEIFWEtvPPMRGDPVSYVLQVLV---GRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVCA 1037
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWE--PPPDDGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
964-1037 1.62e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.62e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152262  964 PPTlkAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVY--KGEEATFQISGLQSNTDYRFRVCA 1037
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
465-545 1.88e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  465 APRLVRA---GVTWITLQWSRPEGCSpEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNMEG 540
Cdd:pfam00041    2 APSNLTVtdvTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1907152262  541 KSCPS 545
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 878-949 1.66e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.36  E-value: 1.66e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152262   878 ASGPQSLKLKWGDSNSKTHAAGDMVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAMSEAGEG 949
Cdd:smart00060   11 DVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-455 4.94e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 4.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  382 PECPFPPKLAHRSKSSLTLQW-----------------KGKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARNDI 442
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWtppeddggpitgyvveyREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1907152262  443 GTSGYSQEVVCYT 455
Cdd:cd00063     81 GESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
563-852 2.59e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.90  E-value: 2.59e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  563 PLIKGPVTSHGFSVKWDAPKDNGGSEILKYLLEIT-DGTSEDVPASESGCEVSEYSVEMTEPENVASEVYHGPELEcTVG 641
Cdd:COG3401    119 SPAVGTATTATAVAGGAATAGTYALGAGLYGVDGAnASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVD-GGG 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  642 NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPgqcRAP---RVSFTPDGCVLVGWEspASPGADISEYRLEWGEDE 718
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP---SAPtglTATADTPGSVTLSWD--PVTESDATGYRVYRSNSG 272

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  719 Q-SLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPAG-AGPYSELVHCQTPASAPDPVSTLCVLEEEPPSahpdspsvcL 796
Cdd:COG3401    273 DgPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSS---------I 343

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152262  797 VLNWEEpcNNGSEILAYNI----DLGDSCITVG---NTTTHVMKNLLPETTYRIRIQAINEIG 852
Cdd:COG3401    344 TLSWTA--SSDADVTGYNVyrstSGGGTYTKIAetvTTTSYTDTGLTPGTTYYYKVTAVDAAG 404
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 557-672 1.57e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.91  E-value: 1.57e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  557 PGPPTRPLIKgPVTSHGFSVKWDAPKDNGGsEILKYLLEITDGTSEDvpasesgcevseysvemtePENVASEVyhGPEL 636
Cdd:cd00063      1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGD-------------------WKEVEVTP--GSET 57

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1907152262  637 ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITT 672
Cdd:cd00063     58 SYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
432-706 1.11e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.51  E-value: 1.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  432 YTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRPEGcspEEVITYTLDIQEDENDShFHPKY 511
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE---SDATGYRVYRSNSGDGP-FTKVA 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  512 TGEDLTCTVKNLKRSTQYKFRLTASNMEG-KSCPSEVLVCTTSPDRPGPPTrPLIKGPVTSHGFSVKWDAPKDNGgseIL 590
Cdd:COG3401    281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS-GLTATAVGSSSITLSWTASSDAD---VT 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  591 KYLLEITDGTSedvpasesgcevseysvemTEPENVASEVyhgPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSE 669
Cdd:COG3401    357 GYNVYRSTSGG-------------------GTYTKIAETV---TTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVS 414

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1907152262  670 ITTAAGPPGQcRAPRVSFTPDGCVLVGWESPASPGAD 706
Cdd:COG3401    415 ATTASAASGE-SLTASVDAVPLTDVAGATAAASAASN 450
fn3 pfam00041
Fibronectin type III domain;
558-665 6.03e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 6.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  558 GPPTRPLIKgPVTSHGFSVKWDAPKDnGGSEILKYLLEITDGTSEDVPasesgcevseysVEMTEPenvasevyhGPELE 637
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYRPKNSGEPW------------NEITVP---------GTTTS 57

                           90       100
                   ....*....|....*....|....*...
gi 1907152262  638 CTVGNLLPGTVYRFRVRALNDGGYGPYS 665
Cdd:pfam00041   58 VTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 463-552 1.13e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  463 PLAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNM 538
Cdd:cd00063      1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1907152262  539 EGKSCPSEVLVCTT 552
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
739-973 1.39e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.49  E-value: 1.39e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  739 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVSTLcvleeeppSAHPDSPSVcLVLNWEEpcNNGSEILAYNIDLG 818
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGL--------TATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  819 DSC------ITVGNTTTHVMKNLLPETTYRIRIQAINEIGV-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWgD 890
Cdd:COG3401    270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSW-T 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  891 SNSKTHAAGDMVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTkSVP 964
Cdd:COG3401    349 ASSDADVTGYNVY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTA-SAA 421


                   ....*....
gi 1907152262  965 PTLKAPRVT 973
Cdd:COG3401    422 SGESLTASV 430
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
837-1057 1.45e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.49  E-value: 1.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  837 PETTYRIRIQAINEIGVGPFSQFIKAKTRPLPPSPPRL-ECAASGPQSLKLKWgDSNSKTHAAGDMVYtlQLEDRNKRFI 915
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGlTATADTPGSVTLSW-DPVTESDATGYRVY--RSNSGDGPFT 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  916 SIYRGPSHTYKVQRLTEFTCYSFRIQAMSEAG-EGPYSETYTFSTTKSVPPTLKAPRVTQLEGNSCEIFWETVPPmrGDP 994
Cdd:COG3401    278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADV 355

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907152262  995 VSYVLQVLVGRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVcacrRCVDTSQELSGAFSPSAA 1057
Cdd:COG3401    356 TGYNVYRSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKV----TAVDAAGNESAPSEEVSA 415
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 677-766 4.10e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 4.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  677 PGQCRAPRVSFTPDGCVLVGWESPASPGADISEYRLEW---GEDEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPA 753
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrekGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1907152262  754 GAGPYSELVHCQT 766
Cdd:cd00063     81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 557-662 1.59e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 1.59e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262   557 PGPPTRPLIKgPVTSHGFSVKWDAPKDNGGseilkylleitdgtsedvpasesGCEVSEYSVEMTEPENVASEVYHGP-E 635
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPDDGI-----------------------TGYIVGYRVEYREEGSEWKEVNVTPsS 56

                            90       100
                    ....*....|....*....|....*..
gi 1907152262   636 LECTVGNLLPGTVYRFRVRALNDGGYG 662
Cdd:smart00060   57 TSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
785-857 3.42e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.42  E-value: 3.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  785 PSAHPDSPSVcLVLNWEEPCNNGSEILAYNIDLGD--------SCITVGNTTTHVMKNLLPETTYRIRIQAINEIGVGPF 856
Cdd:pfam00041    6 LTVTDVTSTS-LTVSWTPPPDGNGPITGYEVEYRPknsgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84


                   .
gi 1907152262  857 S 857
Cdd:pfam00041   85 S 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
350-676 3.83e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.79  E-value: 3.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  350 PATDYHVRVYAVYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQW---KGKRNSGFR--QCFFGSQKHCKL- 423
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWdpvTESDATGYRvyRSNSGDGPFTKVa 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  424 ---------TKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSRPegcSPEEVIT 493
Cdd:COG3401    281 tvtttsytdTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTAS---SDADVTG 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  494 YTLDiQEDENDSHFHP-KYTGEDLTCTVKNLKRSTQYKFRLTASNMEG-KSCPSEVLVCTTSPDRPGPPT---RPLIKGP 568
Cdd:COG3401    358 YNVY-RSTSGGGTYTKiAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLtasVDAVPLT 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  569 VTSHGFSVKWDAPKDNGGSEILKYLLEIT------------DGTSEDVPASESGCEVSEYsVEMTEPENVASEVYHGPEL 636
Cdd:COG3401    437 DVAGATAAASAASNPGVSAAVLADGGDTGnavpftttsstvTATTTDTTTANLSVTTGSL-VGGSGASSVTNSVSVIGAS 515

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1907152262  637 ECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP 676
Cdd:COG3401    516 AAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTT 555
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 796-864 5.86e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 5.86e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907152262  796 LVLNWEEPCNNGSEILAYNI----DLGDSCITV----GNTTTHVMKNLLPETTYRIRIQAINEIGVGPFSQFIKAKT 864
Cdd:cd00063     17 VTLSWTPPEDDGGPITGYVVeyreKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 6.78e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 6.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  283 EKPQVSNIQARAVVLSWAPPVGLSCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAV 361
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907152262  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
924-1056 5.18e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 5.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  924 TYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMRGDpvSYVLQ 1000
Cdd:COG3401    193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTESDAT--GYRVY 267

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152262 1001 VLVGRDSEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1056
Cdd:COG3401    268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 283-363 7.54e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 7.54e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262   283 EKPQVSNIQARAVVLSWAPPVglscgPHGGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    .
gi 1907152262   363 N 363
Cdd:smart00060   79 G 79
fn3 pfam00041
Fibronectin type III domain;
285-367 4.53e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  285 PQVSNIQARAVVLSWAPPVGLScGPhgglsfPYSYEVALS--DKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYAVY 362
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGN-GP------ITGYEVEYRpkNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*
gi 1907152262  363 NSVKG 367
Cdd:pfam00041   78 GGGEG 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 771-854 4.69e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 4.69e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262   771 PDPVSTLCVLEEEPPSahpdspsvcLVLNWEEP--CNNGSEILAYNIDLGDS------CITVGNTTTHVMKNLLPETTYR 842
Cdd:smart00060    1 PSPPSNLRVTDVTSTS---------VTLSWEPPpdDGITGYIVGYRVEYREEgsewkeVNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 1907152262   843 IRIQAINEIGVG 854
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 964-1037 8.16e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 8.16e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152262  964 PPTLKAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVYK--GEEATFQISGLQSNTDYRFRVCA 1037
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 460-542 9.30e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 9.30e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262   460 PQMPLAPRLVRAGVTWITLQWSRPEGCSPEE-VITYTLDIQEDENDSHFHPKyTGEDLTCTVKNLKRSTQYKFRLTASNM 538
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1907152262   539 EGKS 542
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 677-756 1.71e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 1.71e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262   677 PGQCRAPRVSFTPDGCVLVGWESPASPGAD--ISEYRLEWGE-DEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPA 753
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1907152262   754 GAG 756
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 880-959 7.19e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.57  E-value: 7.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  880 GPQSLKLKWgdSNSKTHAAGDMVYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQAMSEAGEGPYSETYT 956
Cdd:cd00063     13 TSTSVTLSW--TPPEDDGGPITGYVVEYREKGSgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVT 90


                   ...
gi 1907152262  957 FST 959
Cdd:cd00063     91 VTT 93
fn3 pfam00041
Fibronectin type III domain;
693-759 1.05e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.05e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  693 VLVGWESPASPGADISEYRLEW---GEDEQSLELVYHGPDTCFEMRDLLPAAQYCCRLQAFNPAGAGPYS 759
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 964-1037 1.13e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.13e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907152262   964 PPTLKAPRVTQLEGNSCEIFWEtvPPMRGDPVSYVLQVLV---GRDSEYKQVYKGEEAT-FQISGLQSNTDYRFRVCA 1037
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWE--PPPDDGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
964-1037 1.62e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.62e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907152262  964 PPTlkAPRVTQLEGNSCEIFWETVPPMRGDPVSYVLQVLVGRDSEYKQVY--KGEEATFQISGLQSNTDYRFRVCA 1037
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
465-545 1.88e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  465 APRLVRA---GVTWITLQWSRPEGCSpEEVITYTLDIQE-DENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNMEG 540
Cdd:pfam00041    2 APSNLTVtdvTSTSLTVSWTPPPDGN-GPITGYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1907152262  541 KSCPS 545
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 878-949 1.66e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 38.36  E-value: 1.66e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907152262   878 ASGPQSLKLKWGDSNSKTHAAGDMVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQAMSEAGEG 949
Cdd:smart00060   11 DVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3_4 pfam16794
Fibronectin-III type domain;
559-667 2.92e-03

Fibronectin-III type domain;


Pssm-ID: 465273 [Multi-domain]  Cd Length: 101  Bit Score: 38.48  E-value: 2.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  559 PPTRPLIKGPVTSHGFSVKWDAPK-DNGGSEILKYLLEITDGTSEDVPASESGCEVSEY---SVEMTepenvasevyhgp 634
Cdd:pfam16794    2 PPQKPTLKLARVPTGIVLSWNMPDlDPKYAPVESYHLFAYQENTSTTPSTDSWKKIGDVkalPLPMA------------- 68

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1907152262  635 eleCTVGNLLPGTVYRFRVRALND-GGYGPYSDV 667
Cdd:pfam16794   69 ---CTLSQFKAGQRYYFAVRAVDIhGRYGPFSDP 99
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-455 4.94e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 4.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907152262  382 PECPFPPKLAHRSKSSLTLQW-----------------KGKRNSGFRQC--FFGSQKHCKLTKLCPAMGYTFRLAARNDI 442
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWtppeddggpitgyvveyREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1907152262  443 GTSGYSQEVVCYT 455
Cdd:cd00063     81 GESPPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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