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Conserved domains on  [gi|1907153589|ref|XP_036019409|]
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chemokine (C-C motif) ligand 27b isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 94-154 2.75e-07

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


:

Pssm-ID: 459650  Cd Length: 60  Bit Score: 45.72  E-value: 2.75e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907153589  94 TSCCTQLYRQPLPsrlLRRIVHMELQEADGDCHLQAVVLHLAR-RSVCVHPQNRSLARWLER 154
Cdd:pfam00048   1 SDCCLRYSSKPIP---LKRVKSYEIQPASSSCPKPAVIFLTKKgRQVCADPKAKWVQRLIKK 59
 
Name Accession Description Interval E-value
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 94-154 2.75e-07

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 45.72  E-value: 2.75e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907153589  94 TSCCTQLYRQPLPsrlLRRIVHMELQEADGDCHLQAVVLHLAR-RSVCVHPQNRSLARWLER 154
Cdd:pfam00048   1 SDCCLRYSSKPIP---LKRVKSYEIQPASSSCPKPAVIFLTKKgRQVCADPKAKWVQRLIKK 59
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 96-145 9.89e-06

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 41.55  E-value: 9.89e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907153589  96 CCTQLYRQPLPSRllrRIVHMELQEADGDCHLQAVVLHLAR-RSVCVHPQN 145
Cdd:cd00169     1 CCLKYTSKPIPPK---NIKSYRVQEAGGHCSIPAVIFTTKKgRKVCADPKE 48
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 93-159 6.00e-04

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 36.45  E-value: 6.00e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907153589   93 STSCCTQLYRQPLPsrlLRRIVHmeLQEADGDCHLQAVVLHLAR-RSVCVHPQnrslARWLERQGKRL 159
Cdd:smart00199   1 PLRCCLSYTSKKIP---LKRIKS--YYPTSSHCPKPAVIFTTKKgRKVCADPK----AKWVQRYIKKL 59
 
Name Accession Description Interval E-value
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 94-154 2.75e-07

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 45.72  E-value: 2.75e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907153589  94 TSCCTQLYRQPLPsrlLRRIVHMELQEADGDCHLQAVVLHLAR-RSVCVHPQNRSLARWLER 154
Cdd:pfam00048   1 SDCCLRYSSKPIP---LKRVKSYEIQPASSSCPKPAVIFLTKKgRQVCADPKAKWVQRLIKK 59
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 96-145 9.89e-06

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 41.55  E-value: 9.89e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907153589  96 CCTQLYRQPLPSRllrRIVHMELQEADGDCHLQAVVLHLAR-RSVCVHPQN 145
Cdd:cd00169     1 CCLKYTSKPIPPK---NIKSYRVQEAGGHCSIPAVIFTTKKgRKVCADPKE 48
Chemokine_CC_DCCL cd01119
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ...
 96-160 1.79e-04

Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238539  Cd Length: 61  Bit Score: 38.15  E-value: 1.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907153589  96 CCTQLYRQPLPSRLLRrivHMELQEADGDCHLQAVVLHLAR-RSVCVHPQNrslaRWLERQGKRLQ 160
Cdd:cd01119     3 CCLSYTQHPIPWRVLR---GYTYQEISESCDIPAIIFHTRRgRKVCADPKQ----DWVKRAIQLLS 61
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 93-159 6.00e-04

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 36.45  E-value: 6.00e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907153589   93 STSCCTQLYRQPLPsrlLRRIVHmeLQEADGDCHLQAVVLHLAR-RSVCVHPQnrslARWLERQGKRL 159
Cdd:smart00199   1 PLRCCLSYTSKKIP---LKRIKS--YYPTSSHCPKPAVIFTTKKgRKVCADPK----AKWVQRYIKKL 59
Chemokine_CC cd00272
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 96-160 6.29e-04

Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.


Pssm-ID: 238170  Cd Length: 57  Bit Score: 36.45  E-value: 6.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907153589  96 CCTQLYRQPLPSRLLRRivhmeLQEADGDCHLQAVVLHLAR-RSVCVHPQNrslaRWLERQGKRLQ 160
Cdd:cd00272     1 CCLSYSKKRIPLRVLKS-----YRRTSSSCSKPAVIFKTKRgREVCADPKQ----KWVQRYMKLLD 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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