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Conserved domains on  [gi|1907154496|ref|XP_036019652|]
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low-density lipoprotein receptor-related protein 8 isoform X22 [Mus musculus]

Protein Classification

LY and Ldl_recept_b domain-containing protein( domain architecture ID 10819178)

protein containing domains LDLa, FXa_inhibition, LY, and Ldl_recept_b

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 472-512 2.47e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.47e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907154496 472 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 512
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 410-451 1.42e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 1.42e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907154496  410 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 451
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 41-75 1.59e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.59e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907154496  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 496-538 7.60e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 7.60e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907154496  496 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 538
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 79-111 3.60e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.60e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154496   79 TCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 165-199 8.65e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 8.65e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907154496 165 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 199
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 559-599 2.77e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 2.77e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907154496 559 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 599
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 260-294 1.54e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.54e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907154496 260 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 294
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 121-157 6.86e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 6.86e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907154496 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:cd00112     1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
203-239 2.10e-06

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 2.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907154496 203 STCEgPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQ 239
Cdd:pfam00057   1 STCS-PNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
296-326 1.25e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.25e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154496  296 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 326
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 365-400 1.08e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 1.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907154496  365 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 400
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 617-654 1.31e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 1.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907154496 617 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 654
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 472-512 2.47e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.47e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907154496 472 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 512
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 410-451 1.42e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 1.42e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907154496  410 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 451
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 41-75 1.59e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.59e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907154496  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 496-538 7.60e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 7.60e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907154496  496 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 538
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 40-72 2.58e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 2.58e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154496   40 ECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDE 72
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 453-495 3.05e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 3.05e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907154496  453 TLFSRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKAGLNGADR 495
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 79-111 3.60e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.60e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154496   79 TCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 430-469 4.67e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.24  E-value: 4.67e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907154496 430 HIYWTDSGNK-TISVATTDGRRRCTLFSRELSEPRAIAVDP 469
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 165-199 8.65e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 8.65e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907154496 165 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 199
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 80-111 1.99e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.99e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907154496  80 CADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
164-199 3.98e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.98e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907154496 164 PCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 199
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
41-75 8.79e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 8.79e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907154496  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 165-196 1.77e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 1.77e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907154496  165 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDE 196
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 559-599 2.77e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 2.77e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907154496 559 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 599
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 413-597 3.19e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 3.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 413 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCT-----LFSRELSEPRAIAVDPlRGFMYWSDWG------F 481
Cdd:cd05819    51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGnhriqkF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 482 QAK---IEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGNrkMLIFSTDF-----LSHPFG 553
Cdd:cd05819   129 DPDgefLTTFGSGGSGPGQFNG-----PTGVAVD-SDGNIYVADTGNHRIQVFDPDGNF--LTTFGSTGtgpgqFNYPTG 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907154496 554 VAVFED-KVFWTDLENEAIFSANRLNGLEIAI-----LAENLNNPHDIVI 597
Cdd:cd05819   201 IAVDSDgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
78-111 8.04e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 8.04e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907154496  78 RTCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 516-558 1.48e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.48e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907154496 516 QRLYWVDSKLHQ-LSSIDFNGGNRKMLIfsTDFLSHPFGVAVFE 558
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 260-294 1.54e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.54e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907154496 260 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 294
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 121-157 6.86e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 6.86e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907154496 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:cd00112     1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
203-239 2.10e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 2.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907154496 203 STCEgPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQ 239
Cdd:pfam00057   1 STCS-PNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
428-579 8.41e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 8.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 428 HKHIYWTDSGNKTISV-ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKagLNGADRQTLvsDNI--- 503
Cdd:COG3391    79 GRRLYVANSGSGRVSViDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSG-NGRVSV--IDTATGKVV--ATIpvg 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 504 EWPNGITLDLLSQRLYWVDSKLHQLSSI--DFNGGNRKmLIFSTDFLSHPFGVAVFED--KVFWTDLENEaifSANRLNG 579
Cdd:COG3391   152 AGPHGIAVDPDGKRLYVANSGSNTVSVIvsVIDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGGSN 227
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 207-237 1.09e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.96  E-value: 1.09e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907154496 207 GPRRFQCKSGECVDGGKVCDDQRDCRDWSDE 237
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
296-326 1.25e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.25e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154496  296 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 326
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 204-237 1.34e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 1.34e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907154496  204 TCeGPRRFQCKSGECVDGGKVCDDQRDCRDWSDE 237
Cdd:smart00192   1 TC-PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 120-154 3.51e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 3.51e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907154496  120 ECPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 154
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
121-157 3.72e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.47  E-value: 3.72e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907154496 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 296-329 4.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 4.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907154496 296 DIDECQDPDACS--QICVNYKGYFKCECHPGYEMDT 329
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGRN 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 365-400 1.08e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 1.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907154496  365 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 400
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 617-654 1.31e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 1.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907154496 617 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 654
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 472-512 2.47e-14

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 67.57  E-value: 2.47e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907154496 472 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLD 512
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 410-451 1.42e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.62  E-value: 1.42e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907154496  410 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRR 451
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 41-75 1.59e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.59e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907154496  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 496-538 7.60e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.61  E-value: 7.60e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907154496  496 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNR 538
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 40-72 2.58e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 2.58e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154496   40 ECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDE 72
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 453-495 3.05e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.07  E-value: 3.05e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907154496  453 TLFSRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKAGLNGADR 495
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 79-111 3.60e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.60e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154496   79 TCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 430-469 4.67e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.24  E-value: 4.67e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907154496 430 HIYWTDSGNK-TISVATTDGRRRCTLFSRELSEPRAIAVDP 469
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 165-199 8.65e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 8.65e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907154496 165 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 199
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 80-111 1.99e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 1.99e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907154496  80 CADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
164-199 3.98e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.64  E-value: 3.98e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907154496 164 PCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGC 199
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
41-75 8.79e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.48  E-value: 8.79e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907154496  41 CEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDC 75
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 165-196 1.77e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.71  E-value: 1.77e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907154496  165 CRENEFQCGDGTCVLAIKRCNQERDCPDGSDE 196
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 559-599 2.77e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.24  E-value: 2.77e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907154496 559 DKVFWTDLENEAIFSANRLNGLEI-AILAENLNNPHDIVIFH 599
Cdd:pfam00058   1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 413-597 3.19e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 3.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 413 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCT-----LFSRELSEPRAIAVDPlRGFMYWSDWG------F 481
Cdd:cd05819    51 DGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASfggsgDGDGEFNGPRGIAVDS-SGNIYVADTGnhriqkF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 482 QAK---IEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGNrkMLIFSTDF-----LSHPFG 553
Cdd:cd05819   129 DPDgefLTTFGSGGSGPGQFNG-----PTGVAVD-SDGNIYVADTGNHRIQVFDPDGNF--LTTFGSTGtgpgqFNYPTG 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907154496 554 VAVFED-KVFWTDLENEAIFSANRLNGLEIAI-----LAENLNNPHDIVI 597
Cdd:cd05819   201 IAVDSDgNIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAV 250
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 413-597 4.04e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.40  E-value: 4.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 413 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMY-----------W 476
Cdd:cd05819     4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFGSFgsgdgQFNEPAGVAVDS-DGNLYvadtgnhriqkF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 477 SDWGfqAKIEKAGLNGADRQTLVSdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNGGnrkmLIF-------STDFLS 549
Cdd:cd05819    82 DPDG--NFLASFGGSGDGDGEFNG-----PRGIAVD-SSGNIYVADTGNHRIQKFDPDGE----FLTtfgsggsGPGQFN 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907154496 550 HPFGVAVF-EDKVFWTDLENEAI--FSAnrlNGLEIAILAEN------LNNPHDIVI 597
Cdd:cd05819   150 GPTGVAVDsDGNIYVADTGNHRIqvFDP---DGNFLTTFGSTgtgpgqFNYPTGIAV 203
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
78-111 8.04e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 8.04e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907154496  78 RTCADSDFTCDNGHCIPERWKCDGEEECPDGSDE 111
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 516-558 1.48e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 1.48e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907154496 516 QRLYWVDSKLHQ-LSSIDFNGGNRKMLIfsTDFLSHPFGVAVFE 558
Cdd:pfam00058   1 GRLYWTDSSLRAsISSADLNGSDRKTLF--TDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 260-294 1.54e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.01  E-value: 1.54e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907154496 260 CLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTC 294
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 121-157 6.86e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 6.86e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907154496 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:cd00112     1 CPPNEFRCA--NGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
203-239 2.10e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.93  E-value: 2.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907154496 203 STCEgPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQ 239
Cdd:pfam00057   1 STCS-PNEFQCGSGECIPRSWVCDGDPDCGDGSDEEN 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
428-579 8.41e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 8.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 428 HKHIYWTDSGNKTISV-ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWGfQAKIEKagLNGADRQTLvsDNI--- 503
Cdd:COG3391    79 GRRLYVANSGSGRVSViDLATGKVVATI--PVGGGPRGLAVDPDGGRLYVADSG-NGRVSV--IDTATGKVV--ATIpvg 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 504 EWPNGITLDLLSQRLYWVDSKLHQLSSI--DFNGGNRKmLIFSTDFLSHPFGVAVFED--KVFWTDLENEaifSANRLNG 579
Cdd:COG3391   152 AGPHGIAVDPDGKRLYVANSGSNTVSVIvsVIDTATGK-VVATIPVGGGPVGVAVSPDgrRLYVANRGSN---TSNGGSN 227
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 207-237 1.09e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.96  E-value: 1.09e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907154496 207 GPRRFQCKSGECVDGGKVCDDQRDCRDWSDE 237
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
296-326 1.25e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.25e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1907154496  296 DIDECQDPDACSQ--ICVNYKGYFKCECHPGYE 326
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 204-237 1.34e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 42.62  E-value: 1.34e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907154496  204 TCeGPRRFQCKSGECVDGGKVCDDQRDCRDWSDE 237
Cdd:smart00192   1 TC-PPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 413-565 1.88e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 47.31  E-value: 1.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 413 DEQLHSPEGLAVDwVHKHIYWTDSGNKTISVATTDGRRRcTLF------SRELSEPRAIAVDPlRGFMYWSDWG------ 480
Cdd:cd05819    98 DGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFL-TTFgsggsgPGQFNGPTGVAVDS-DGNIYVADTGnhriqv 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 481 ------FQAKIEKAGLNGADRQTlvsdniewPNGITLDlLSQRLYWVDSKLHQLSSIDFNG------GNRkmlIFSTDFL 548
Cdd:cd05819   175 fdpdgnFLTTFGSTGTGPGQFNY--------PTGIAVD-SDGNIYVADSGNNRVQVFDPDGagfggnGNF---LGSDGQF 242

                         170
                  ....*....|....*...
gi 1907154496 549 SHPFGVAVFED-KVFWTD 565
Cdd:cd05819   243 NRPSGLAVDSDgNLYVAD 260
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 120-154 3.51e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 41.46  E-value: 3.51e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907154496  120 ECPAEKLSCGptSHKCVPASWRCDGEKDCEGGADE 154
Cdd:smart00192   1 TCPPGEFQCD--NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
121-157 3.72e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.47  E-value: 3.72e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907154496 121 CPAEKLSCGptSHKCVPASWRCDGEKDCEGGADEAGC 157
Cdd:pfam00057   3 CSPNEFQCG--SGECIPRSWVCDGDPDCGDGSDEENC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 296-329 4.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 4.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907154496 296 DIDECQDPDACS--QICVNYKGYFKCECHPGYEMDT 329
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYTGRN 36
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 415-571 7.25e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 45.35  E-value: 7.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 415 QLHSPEGLAVDWVHkHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPLrGFMYWSD-WGFqaKIEKA 488
Cdd:cd14956    11 QFKDPRGIAVDADD-NVYVADARNGRIQVFDKDGTFLRRFGTTgdgpgQFGRPRGLAVDKD-GWLYVADyWGD--RIQVF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 489 GLNGADRQTL-VSDNIE----WPNGITLDllSQRLYWVdsklhqlssIDFngGNRKMLIFSTD--FLS------------ 549
Cdd:cd14956    87 TLTGELQTIGgSSGSGPgqfnAPRGVAVD--ADGNLYV---------ADF--GNQRIQKFDPDgsFLRqwggtgiepgsf 153

                         170       180
                  ....*....|....*....|....
gi 1907154496 550 -HPFGVAVFEDKVFW-TDLENEAI 571
Cdd:cd14956   154 nYPRGVAVDPDGTLYvADTYNDRI 177
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 365-400 1.08e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 40.28  E-value: 1.08e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907154496  365 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMD 400
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 380-556 1.17e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.88  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 380 ATNRIYWCDLSYRKIYSAHMDkasipDEQVVLIDEQLHSPEGLAVD-----WVhkhiywTDSGNKTISVATTDGRRR--C 452
Cdd:COG3386    17 PDGRLYWVDIPGGRIHRYDPD-----GGAVEVFAEPSGRPNGLAFDpdgrlLV------ADHGRGLVRFDPADGEVTvlA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 453 TLFSRELSEPRAIAVDPlRGFMYWSDwgFQAKIEKAGL---NGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 529
Cdd:COG3386    86 DEYGKPLNRPNDGVVDP-DGRLYFTD--MGEYLPTGALyrvDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIY 162

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1907154496 530 SIDFNG----GNRKMLIFSTDFLSHPFGVAV 556
Cdd:COG3386   163 RFDLDAdgtlGNRRVFADLPDGPGGPDGLAV 193
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 413-600 2.67e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 43.43  E-value: 2.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 413 DEQLHSPEGLAVDWvhKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMYWSDWGFQaKIEK 487
Cdd:cd14963     6 GDPLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPgtgpgEFKYPYGIAVDS-DGNIYVADLYNG-RIQV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 488 AGLNGADRQTLVSD----NIEWPNGITLDllSQRLYWVDSKLHQLSSIDFNGgnRKMLIFST--DF---LSHPFGVAVFE 558
Cdd:cd14963    82 FDPDGKFLKYFPEKkdrvKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG--KLLLEFGKpgSEpgeLSYPNGIAVDE 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907154496 559 DK-VFWTDLENEAI--FSAN-----RLNGLEIAilAENLNNP------------------HDIVIFHE 600
Cdd:cd14963   158 DGnIYVADSGNGRIqvFDKNgkfikELNGSPDG--KSGFVNPrgiavdpdgnlyvvdnlsHRVYVFDE 223
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 336-526 4.72e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.96  E-value: 4.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 336 AVAGKSPSLIF---TNRHEVRRIDLVKRDYSRLIP----MLKNVVALDVEVAtNRIYWCDLSYRKIYsaHMDkasiPDEQ 408
Cdd:cd14962    16 GVAADGRGRIYvadTGRGAVFVFDLPNGKVFVIGNagpnRFVSPIGVAIDAN-GNLYVSDAELGKVF--VFD----RDGK 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 409 VV-LIDE--QLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSR-----ELSEPRAIAVDPlRGFMYWSDwG 480
Cdd:cd14962    89 FLrAIGAgaLFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRgsgpgEFNLPTDLAVDR-DGNLYVTD-T 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907154496 481 FQAKIEKAGLNGADRQT-----LVSDNIEWPNGITLDlLSQRLYWVDSKLH 526
Cdd:cd14962   167 MNFRVQIFDADGKFLRSfgergDGPGSFARPKGIAVD-SEGNIYVVDAAFD 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 382-426 8.12e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 8.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907154496 382 NRIYWCDLSYR-KIYSAHMDKASipdeQVVLIDEQLHSPEGLAVDW 426
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSD----RKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
347-480 1.23e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154496 347 TNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYsahmdKASIPDEQVVLIDEQLHSPEGLAVDW 426
Cdd:COG3391    87 SGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVS-----VIDTATGKVVATIPVGAGPHGIAVDP 161

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907154496 427 VHKHIYWTDSGNKTISV-----ATTDGRRRCTLfsRELSEPRAIAVDPLRGFMYWSDWG 480
Cdd:COG3391   162 DGKRLYVANSGSNTVSVivsviDTATGKVVATI--PVGGGPVGVAVSPDGRRLYVANRG 218
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 617-654 1.31e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.84  E-value: 1.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907154496 617 NGGCEYLCLPAPQisshspKYTCACPDTMWLGPDMKRC 654
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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