BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  15 FSTALRSLINNPQYSDICFVVGQERQEVFAHRCLLACRCNFFQRLLGPGV-----PSPVVLSTVPAEAFLAVLEFLYTNS 89
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPqkestQSPLVLSDIEPEVFRAVLEFIYTNC 80

                          90
                  ....*....|....*....
gi 1907157837  90 VKLHQHSVLEVLTTAVEYG 108
Cdd:cd18294    81 VTLSNHTVIEVLAAAVEYG 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  15 FSTALRSLINNPQYSDICFVVGQERQEVFAHRCLLACRCNFFQRLLGPGV-----PSPVVLSTVPAEAFLAVLEFLYTNS 89
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPqkestQSPLVLSDIEPEVFRAVLEFIYTNC 80

                          90
                  ....*....|....*....
gi 1907157837  90 VKLHQHSVLEVLTTAVEYG 108
Cdd:cd18294    81 VTLSNHTVIEVLAAAVEYG 99

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  24 NNPQYSDICFVVGQerQEVFAHRCLLACRCNFFQRLLGPGVP----SPVVLSTVPAEAFLAVLEFLYTNSVKLHQhSVLE 99
Cdd:pfam00651   6 EQGELCDVTLVVGD--KEFRAHKAVLAACSPYFKALFSGQESessvSEITLDDVSPEDFEALLEFMYTGKLISEE-NVDD 82

                  ....*...
gi 1907157837 100 VLTTAVEY 107
Cdd:pfam00651  83 LLAAADKL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  15 FSTALRSLINNPQYSDICFVVGQERQEVFAHRCLLACRCNFFQRLLGPGV-----PSPVVLSTVPAEAFLAVLEFLYTNS 89
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPqkestQSPLVLSDIEPEVFRAVLEFIYTNC 80

                          90
                  ....*....|....*....
gi 1907157837  90 VKLHQHSVLEVLTTAVEYG 108
Cdd:cd18294    81 VTLSNHTVIEVLAAAVEYG 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  28 YSDICFVVGqeRQEVFAHRCLLACRCNFFQRLLGPGV----PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTT 103
Cdd:cd18186     1 LCDVTLVVG--GREFPAHRAVLAARSPYFRAMFSSGMkessSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAA 78

                  ....
gi 1907157837 104 AVEY 107
Cdd:cd18186    79 ADKL 82

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907157837  20 RSLINNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLLGPG----VPSPVVLSTVPAEAFLAVLEFLYTNSVKL 92
Cdd:cd18300     1 KLFLNKGLFSDVTFIV--EDGTIPAHKALLVARCDVMAAMFGGNfresSAKEVELPGVSKETFLALLEYLYTDQAPI 75

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837   30 DICFVVGQerQEVFAHRCLLACRCNFFQRLL----GPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTAV 105
Cdd:smart00225   1 DVTLVVGG--KKFHAHKAVLAAHSPYFKALFssdfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                   ..
gi 1907157837  106 EY 107
Cdd:smart00225  79 YL 80

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  24 NNPQYSDICFVVGQerQEVFAHRCLLACRCNFFQRLLGPGVP----SPVVLSTVPAEAFLAVLEFLYTNSVKLHQhSVLE 99
Cdd:pfam00651   6 EQGELCDVTLVVGD--KEFRAHKAVLAACSPYFKALFSGQESessvSEITLDDVSPEDFEALLEFMYTGKLISEE-NVDD 82

                  ....*...
gi 1907157837 100 VLTTAVEY 107
Cdd:pfam00651  83 LLAAADKL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  22 LINNPQYSDICFVVGQER--------QEVFAHRCLLACRCNFFQRLLGPGVPSP---VVLSTVPAEAFLAVLEFLYTNSV 90
Cdd:cd18346    16 LFNNELLSDVRFVVGKGRprgpgpgaQRIPAHRFVLAAGSAVFDAMFNGGMATTsaeIELPDVEPAAFLALLRFLYSDEV 95

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1907157837  91 KLHQHSVLEVLTTAVEYGLEELRELCLEFVVKVL 124
Cdd:cd18346    96 QIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHL 129

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  16 STALRSLINNPQ--YSDICFVVGQERQeVFAHRCLLACRCNFFQRLLG------------PGVPSPVVLSTVPAEAFLAV 81
Cdd:cd18310     4 SSDLENLLDSPDlfYSDAEIIVEGGRP-VPVHRCILAARSPFFRDIFAsakaegantkpkLELRELIPGGIVGYDAFMLV 82

                          90
                  ....*....|.
gi 1907157837  82 LEFLYTNSVKL 92
Cdd:cd18310    83 LSYLYSGRLRL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  22 LINNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLL--GPGVPSP--VVLSTVPAEAFLAVLEFLYTNSVKLH---Q 94
Cdd:cd18297     6 YVNNPEMSDVTFLV--EGRPFYAHKIVLVTASDRFKSMLssGSTEAQTpvIEIPDIRYDIFQLMMQYLYTGGVESLdvaQ 83

                          90
                  ....*....|
gi 1907157837  95 HSVLEVLTTA 104
Cdd:cd18297    84 DDALELLRAA 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  22 LINNPQYSDICFVVGQER--QEVFAHRCLLACRCNFFQRLLGPGV---PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHS 96
Cdd:cd18282     1 MFNNELMADVHFIVGPPGgtQRIPAHKYVLATGSSVFYAMFYGGLaenKNEIEIPDVEPAAFLNLLRYLYCDEIDLEPDT 80

                          90
                  ....*....|.
gi 1907157837  97 VLEVLTTAVEY 107
Cdd:cd18282    81 VLATLYAAKKY 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  22 LINNPQYSDICFVVGQ--ERQEVFAHRCLLACRCNFFQRLLGPGVPSP---VVLSTVPAEAFLAVLEFLYTNSVKLHQHS 96
Cdd:cd18347    16 LFNNEVLSDVHFLVGKglGSQRIPAHRFVLAVGSAVFDAMFNGGMATTsteIELPDVEPAAFLALLKFLYSDEVQIGPET 95

                          90       100
                  ....*....|....*....|....*...
gi 1907157837  97 VLEVLTTAVEYGLEELRELCLEFVVKVL 124
Cdd:cd18347    96 VMTTLYTAKKYAVPALEAHCVEFLKKNL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  18 ALRSLINNPQYSDICFVVGQErqEVFAHRCLLACRCNFFQRLL------GPGVPSPVVLSTVPAEAFLAVLEFLYTNSVK 91
Cdd:cd18245     4 ALNSFREEPHLCDATLVVGGE--EIPVQKNVLAAASPYFRAKLnynppkDDGSTYKIELEGISVEVMEEILDYIYTGQIK 81

                          90
                  ....*....|...
gi 1907157837  92 LHQHSVLEVLTTA 104
Cdd:cd18245    82 LSEDNIQDIVQAA 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  19 LRSLINNPQYSDICFVVgQERQEVFAHRCLLACRC----------NFFQRLLGPGVPSPVVLSTVPAEAFLAVLEFLYTN 88
Cdd:cd18288     9 FSAMVNNPHLSDVQFQT-DSGEVLYAHSFVLYARCplliqmvhseGFSVEEEGGVTTRRVLLGDVSGEAARCFLQYLYTA 87

                          90       100
                  ....*....|....*....|
gi 1907157837  89 SVKLHQHSVLEVLTTAVEYG 108
Cdd:cd18288    88 DTGLPPGLSPHVSELADRFG 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  19 LRSLINNPQYSDICFVVGQerQEVFAHRCLLACRCNFFQRLL-----GPGVPSPVVLSTVP--AEAFLAVLEFLYTNSVK 91
Cdd:cd18292     8 IAQLYNNEELSDIVLRVGG--KVFHAHRLILAKSSDVFRVMLsndwwSESKQSEIELVEDPecAAVFEKFLRYLYTGQIS 85

                          90
                  ....*....|....*..
gi 1907157837  92 LHQHSVLEVLTTAVEYG 108
Cdd:cd18292    86 VNLETALPLLMLADKYN 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  20 RSLINNPQYSDICFVVGQerQEVFAHRCLLACRCNFFQRLLGPGVpSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSV-- 97
Cdd:cd18303    10 ASLFDKELYSDITIKLAD--KSIPAHKFVLAARSEKWSNENLAST-NELDLSDISYEVVLALLRWLYTDELDLTLDDEfl 86

                          90
                  ....*....|....
gi 1907157837  98 LEVLTTAVEYGLEE 111
Cdd:cd18303    87 LELMKAAKRFQLTD 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907157837  44 AHRCLLACRCNFFQRLL-----GPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18330    32 AHRNILFANSGYFRALLihyiqDSGRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAA 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  17 TALRSLINNPQYSDICFVVGQerQEVFAHRCLLACRCNF----FQRLLGPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKL 92
Cdd:cd18306     7 AKLNALRKNRQFCDVILQVGG--HEIPAHRAVLACASPYlfelFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEV 84

                          90
                  ....*....|....*.
gi 1907157837  93 HQHSVLEVLTTAVEYG 108
Cdd:cd18306    85 PADLVKSVYSAAKKLK 100

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907157837  19 LRSLINNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLL-GPGVPSP---VVLSTVPAEAFLAVLEFLY 86
Cdd:cd18286     8 LLQLFLNGEDSDITIKV--DGKTFKAHRCILCARSSYFAAMLsGSWAESNsseITLTGVSHAAVSFVLLFIY 77

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  28 YSDICFVVgqerqevfaHRCLLACRCNFFQRLL----GPGVPSPVVLSTVP--AEAFLAVLEFLYTNSVKLHQHSV--LE 99
Cdd:cd18283     9 FQGTCFPV---------HRAILSARCPFFRDLLssspGYGAEIPVDLPTAGidVPMFSALLRYLYTGEFGSEDSRSqnLD 79

                  ..
gi 1907157837 100 VL 101
Cdd:cd18283    80 VL 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  37 QERQEVF-------------AHRCLLACRCNFFQRLLGPGV-----PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVL 98
Cdd:cd18199    12 QRKQDFFcdcsiivegrifkAHRNVLFASSGYFRMLLSHYIqdtgrPSTASFDVFSSDAFSIILDFVYSGKLSLTSQNVI 91

                  ....*.
gi 1907157837  99 EVLTTA 104
Cdd:cd18199    92 EVMSAA 97

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  38 ERQEVFAHRCLLACRCNFFQRLLGPGVPSP---VVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18315     9 EGGSLKAHKLVLAAASPYFAALLKETPPDEhpvIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  37 QERQEVF-------------AHRCLLACRCNFFQRLLGPGV-----PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVL 98
Cdd:cd18329    15 QRKQELFcdcsilvegqvfkAHRNVLFASSGYFKMLLSQNAketgqPTVATFDVFSPDTFTIILDFVYSGKLSLTSQNVI 94

                  ....*.
gi 1907157837  99 EVLTTA 104
Cdd:cd18329    95 EVMSAA 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907157837  27 QYSDICFVVgqERQEVFAHRCLLACRCNFFQRLLGPGVPSPVVL-STVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18289    28 LYCDVSIVV--KGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELpATVPPACFQQILSFCYTGKLTMAASEQLVVMYTA 104

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907157837  26 PQYSDICFVVGQERqeVFAHRCLLACRCNFFQRLLGPGVPSPVVLS-----TVPA-EAFLAVLEFLYTNSVKL 92
Cdd:cd18309    18 GDFCDITLLLDGHP--IPAHKAILAARCSYFEAMFRSFMPEDNTVNisigeMVPSrQAFDSLLRYIYYGDVTM 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  24 NNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLLGPGV----PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLE 99
Cdd:cd18326    21 TQGLLCDVVILV--EGREFPTHRSVLAACSQYFKKLFTSGAvvdqQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGD 98

                  ....*
gi 1907157837 100 VLTTA 104
Cdd:cd18326    99 ILSAA 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  29 SDICFVVGqeRQEVFAHRCLL-ACRCNFFQRLLGPGVPSPVVLSTVP---AEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18215    20 TDVVLVVG--REQFRAHKTVLmACSGLFYSIFTDQLKNNVSVINLDPeiePEGFRILLDFMYTSRLNLREGNIMAVMATA 97

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157837  44 AHRCLLACRCNFFQRLLGPGV----PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTAVEYGLEELRELCLEF 119
Cdd:cd18263    27 VHRVILAAGSDYFRAMFTSGMkestQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQLQISGALALCLDF 106

                  ....*.
gi 1907157837 120 VVKVLD 125
Cdd:cd18263   107 LQREIS 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907157837  19 LRSLINNPQYSDICFVVGQErqEVFAHRCLLACRCNFFQ-RLLGP---GVPSPVVLSTVPAEAFLAVLEFLYTNS 89
Cdd:cd18280     5 FGALLESEEGADVTFNVDGE--KFRAHKLVLAARSPVFRsMLFGPmreENEGEIVIEDVEPPVFKALLHFIYKDE 77