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Conserved domains on  [gi|1907165018|ref|XP_036021211|]
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brain protein I3 isoform X1 [Mus musculus]

Protein Classification

BRI3 family protein( domain architecture ID 8734)

BRI3 (brain protein I3) family protein is a DUF2367 domain-containing protein; similar to human brain protein I3 that participates in tumor necrosis factor-alpha (TNF)-induced cell death

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF2367 super family cl10861
Uncharacterized conserved protein (DUF2367); This is a highly conserved family of proteins ...
29-82 2.06e-10

Uncharacterized conserved protein (DUF2367); This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. The function is unknown. Several members are putatively assigned as brain protein i3 but this was not validated.


The actual alignment was detected with superfamily member pfam10164:

Pssm-ID: 431102  Cd Length: 104  Bit Score: 52.60  E-value: 2.06e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907165018  29 GYGAIPTAPPPPPYPYLVTGIPTSHPRV--------YNIHSRTVTRYPANSIVVVGGCPVCR 82
Cdd:pfam10164   1 GYGAIPTAPPQYLITYVVTQAPPPYQYPdgpavsqqPQQTTYTIVVQPTQSVVVVGGCPACR 62
 
Name Accession Description Interval E-value
DUF2367 pfam10164
Uncharacterized conserved protein (DUF2367); This is a highly conserved family of proteins ...
29-82 2.06e-10

Uncharacterized conserved protein (DUF2367); This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. The function is unknown. Several members are putatively assigned as brain protein i3 but this was not validated.


Pssm-ID: 431102  Cd Length: 104  Bit Score: 52.60  E-value: 2.06e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907165018  29 GYGAIPTAPPPPPYPYLVTGIPTSHPRV--------YNIHSRTVTRYPANSIVVVGGCPVCR 82
Cdd:pfam10164   1 GYGAIPTAPPQYLITYVVTQAPPPYQYPdgpavsqqPQQTTYTIVVQPTQSVVVVGGCPACR 62
 
Name Accession Description Interval E-value
DUF2367 pfam10164
Uncharacterized conserved protein (DUF2367); This is a highly conserved family of proteins ...
29-82 2.06e-10

Uncharacterized conserved protein (DUF2367); This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. The function is unknown. Several members are putatively assigned as brain protein i3 but this was not validated.


Pssm-ID: 431102  Cd Length: 104  Bit Score: 52.60  E-value: 2.06e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907165018  29 GYGAIPTAPPPPPYPYLVTGIPTSHPRV--------YNIHSRTVTRYPANSIVVVGGCPVCR 82
Cdd:pfam10164   1 GYGAIPTAPPQYLITYVVTQAPPPYQYPdgpavsqqPQQTTYTIVVQPTQSVVVVGGCPACR 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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