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Conserved domains on  [gi|1907170420|ref|XP_036021667|]
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voltage-dependent L-type calcium channel subunit alpha-1C isoform X10 [Mus musculus]

Protein Classification

voltage-dependent L-type calcium channel subunit alpha-1( domain architecture ID 11999372)

voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1271-1568 1.48e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 228.31  E-value: 1.48e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1271 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG-YFSDPWNVFDFLIVIGSI 1348
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1349 IDVILSETNHYFcdawntfdalivvgsivdiaitevhpaehtqcspsmsaeensriSITFFRLFRVMRLVKLLSRGEGIR 1428
Cdd:pfam00520   81 ISLVLSSVGSLS--------------------------------------------GLRVLRLLRLLRLLRLIRRLEGLR 116
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1429 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1508
Cdd:pfam00520  117 TLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID 196
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1509 GKkcapesepsnstegetpcGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1568
Cdd:pfam00520  197 GK------------------GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
153-446 2.03e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 227.92  E-value: 2.03e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  153 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 232
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  233 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  313 AIIGLELFMGKMHKtcynqegiidvpaeedpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 392
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907170420  393 EGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 446
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
553-794 8.58e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 183.24  E-value: 8.58e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  553 SNVFYWLVIFLVFLNTLTIASEHYNQP-HWLTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFIVCGGI 630
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  631 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 709
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  710 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 789
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 1907170420  790 ESLTS 794
Cdd:pfam00520  234 TERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
932-1229 1.73e-49

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 176.30  E-value: 1.73e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  932 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDivfttiftieialkilgnadYVFTSIFTLEIILKMTAYGAF 1011
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILD--------------------YVFTGIFTLEMLLKIIAAGFK 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1012 LHkgsFCRNYFNILDLLVVSVSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1090
Cdd:pfam00520   61 KR---YFRSPWNILDFVVVLPSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1091 LLQFMFACIGVQLFKGKLYTCSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGW 1170
Cdd:pfam00520  138 LFLFIFAIIGYQLFGGKLKTWENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGW 187
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907170420 1171 PELLYRSIDSHTEDKGPIYnyrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1229
Cdd:pfam00520  188 GDIMYDTIDGKGEFWAYIY---------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1640-1714 3.15e-38

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 430200  Cd Length: 77  Bit Score: 137.72  E-value: 3.15e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907170420 1640 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1714
Cdd:pfam08763    1 TATLFALIRTALSIKMApaGEMDQADAELRKIIKKIWPLLSKKMLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C super family cl25181
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1734-2169 1.83e-35

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


The actual alignment was detected with superfamily member pfam16885:

Pssm-ID: 435629 [Multi-domain]  Cd Length: 356  Bit Score: 139.68  E-value: 1.83e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1734 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkEAVSAASEDDIFRRAgglfgNHVTYyqSDSRGNFPQTfatQRPLHINK 1813
Cdd:pfam16885    1 AGLRTLQDLGPEMRQALTCDLEEEEE------GAEEEQEGDDEEASA-----APETP--KDPIGSQPPS---RSRISVSL 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1814 TGNNQADTESPSHEklvDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHgpplspavRVQEAawkls 1893
Cdd:pfam16885   65 PVGDRLPDSLPSDD---DGGAPNSRQPSGGQSGSHTHRRSSGVLMFTIPEEGSSQPKGTKGQ--------DKQDE----- 128
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1894 skrchsresqgatvNQEIFPDETRSVRmSEEAEYCSEPSLLSTdmfsyqedeHRqltcPEEDKREIQPsPKRSFLRSASL 1973
Cdd:pfam16885  129 --------------EEEVPVQDQLAYL-DEQAGTPSRPVLLPP---------HR----PQRYVNGHHY-PRRRLLPPTPA 179
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1974 GRRASFHLECLKRQkdqggdiSQKTALPLHLVHHQAlavaGLSPLLqRSHSPTTfprpcptppvTPGSRGRPLRPiPTLR 2053
Cdd:pfam16885  180 GRKPSFTIQCLRRQ-------GSCDDLPIPGTYHRG----GNSGPS-RAQGSWA----------TPPQRGRLLYA-PLLL 236
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 2054 LEGAESSEKLNSSFPSihcsswSEETTACsgsssmarrarpvsLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQD 2133
Cdd:pfam16885  237 VEEGAAGEGYLGKSPG------PLRTFTC--------------LHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARD 296
                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1907170420 2134 PKFIEVTTQELADACDMTIEEMENAADNILSGGAQQ 2169
Cdd:pfam16885  297 PKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 332
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1577-1630 5.65e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 435642  Cd Length: 54  Bit Score: 116.22  E-value: 5.65e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907170420 1577 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1630
Cdd:pfam16905    1 EFVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1271-1568 1.48e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 228.31  E-value: 1.48e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1271 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG-YFSDPWNVFDFLIVIGSI 1348
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1349 IDVILSETNHYFcdawntfdalivvgsivdiaitevhpaehtqcspsmsaeensriSITFFRLFRVMRLVKLLSRGEGIR 1428
Cdd:pfam00520   81 ISLVLSSVGSLS--------------------------------------------GLRVLRLLRLLRLLRLIRRLEGLR 116
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1429 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1508
Cdd:pfam00520  117 TLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID 196
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1509 GKkcapesepsnstegetpcGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1568
Cdd:pfam00520  197 GK------------------GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
153-446 2.03e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 227.92  E-value: 2.03e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  153 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 232
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  233 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  313 AIIGLELFMGKMHKtcynqegiidvpaeedpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 392
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907170420  393 EGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 446
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
553-794 8.58e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 183.24  E-value: 8.58e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  553 SNVFYWLVIFLVFLNTLTIASEHYNQP-HWLTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFIVCGGI 630
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  631 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 709
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  710 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 789
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 1907170420  790 ESLTS 794
Cdd:pfam00520  234 TERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
932-1229 1.73e-49

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 176.30  E-value: 1.73e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  932 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDivfttiftieialkilgnadYVFTSIFTLEIILKMTAYGAF 1011
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILD--------------------YVFTGIFTLEMLLKIIAAGFK 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1012 LHkgsFCRNYFNILDLLVVSVSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1090
Cdd:pfam00520   61 KR---YFRSPWNILDFVVVLPSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1091 LLQFMFACIGVQLFKGKLYTCSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGW 1170
Cdd:pfam00520  138 LFLFIFAIIGYQLFGGKLKTWENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGW 187
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907170420 1171 PELLYRSIDSHTEDKGPIYnyrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1229
Cdd:pfam00520  188 GDIMYDTIDGKGEFWAYIY---------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1640-1714 3.15e-38

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 430200  Cd Length: 77  Bit Score: 137.72  E-value: 3.15e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907170420 1640 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1714
Cdd:pfam08763    1 TATLFALIRTALSIKMApaGEMDQADAELRKIIKKIWPLLSKKMLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1734-2169 1.83e-35

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 435629 [Multi-domain]  Cd Length: 356  Bit Score: 139.68  E-value: 1.83e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1734 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkEAVSAASEDDIFRRAgglfgNHVTYyqSDSRGNFPQTfatQRPLHINK 1813
Cdd:pfam16885    1 AGLRTLQDLGPEMRQALTCDLEEEEE------GAEEEQEGDDEEASA-----APETP--KDPIGSQPPS---RSRISVSL 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1814 TGNNQADTESPSHEklvDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHgpplspavRVQEAawkls 1893
Cdd:pfam16885   65 PVGDRLPDSLPSDD---DGGAPNSRQPSGGQSGSHTHRRSSGVLMFTIPEEGSSQPKGTKGQ--------DKQDE----- 128
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1894 skrchsresqgatvNQEIFPDETRSVRmSEEAEYCSEPSLLSTdmfsyqedeHRqltcPEEDKREIQPsPKRSFLRSASL 1973
Cdd:pfam16885  129 --------------EEEVPVQDQLAYL-DEQAGTPSRPVLLPP---------HR----PQRYVNGHHY-PRRRLLPPTPA 179
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1974 GRRASFHLECLKRQkdqggdiSQKTALPLHLVHHQAlavaGLSPLLqRSHSPTTfprpcptppvTPGSRGRPLRPiPTLR 2053
Cdd:pfam16885  180 GRKPSFTIQCLRRQ-------GSCDDLPIPGTYHRG----GNSGPS-RAQGSWA----------TPPQRGRLLYA-PLLL 236
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 2054 LEGAESSEKLNSSFPSihcsswSEETTACsgsssmarrarpvsLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQD 2133
Cdd:pfam16885  237 VEEGAAGEGYLGKSPG------PLRTFTC--------------LHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARD 296
                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1907170420 2134 PKFIEVTTQELADACDMTIEEMENAADNILSGGAQQ 2169
Cdd:pfam16885  297 PKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 332
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1577-1630 5.65e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 435642  Cd Length: 54  Bit Score: 116.22  E-value: 5.65e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907170420 1577 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1630
Cdd:pfam16905    1 EFVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1692-1722 3.30e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 65.32  E-value: 3.30e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1907170420  1692 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 1722
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1271-1568 1.48e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 228.31  E-value: 1.48e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1271 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKPKG-YFSDPWNVFDFLIVIGSI 1348
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1349 IDVILSETNHYFcdawntfdalivvgsivdiaitevhpaehtqcspsmsaeensriSITFFRLFRVMRLVKLLSRGEGIR 1428
Cdd:pfam00520   81 ISLVLSSVGSLS--------------------------------------------GLRVLRLLRLLRLLRLIRRLEGLR 116
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1429 TLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMP 1508
Cdd:pfam00520  117 TLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID 196
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1509 GKkcapesepsnstegetpcGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1568
Cdd:pfam00520  197 GK------------------GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
153-446 2.03e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 227.92  E-value: 2.03e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  153 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 232
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  233 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 312
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  313 AIIGLELFMGKMHKtcynqegiidvpaeedpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 392
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907170420  393 EGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 446
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
553-794 8.58e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 183.24  E-value: 8.58e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  553 SNVFYWLVIFLVFLNTLTIASEHYNQP-HWLTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFIVCGGI 630
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  631 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 709
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  710 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 789
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 1907170420  790 ESLTS 794
Cdd:pfam00520  234 TERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
932-1229 1.73e-49

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 176.30  E-value: 1.73e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  932 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDivfttiftieialkilgnadYVFTSIFTLEIILKMTAYGAF 1011
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILD--------------------YVFTGIFTLEMLLKIIAAGFK 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1012 LHkgsFCRNYFNILDLLVVSVSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1090
Cdd:pfam00520   61 KR---YFRSPWNILDFVVVLPSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1091 LLQFMFACIGVQLFKGKLYTCSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGW 1170
Cdd:pfam00520  138 LFLFIFAIIGYQLFGGKLKTWENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGW 187
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907170420 1171 PELLYRSIDSHTEDKGPIYnyrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1229
Cdd:pfam00520  188 GDIMYDTIDGKGEFWAYIY---------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1640-1714 3.15e-38

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 430200  Cd Length: 77  Bit Score: 137.72  E-value: 3.15e-38
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907170420 1640 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1714
Cdd:pfam08763    1 TATLFALIRTALSIKMApaGEMDQADAELRKIIKKIWPLLSKKMLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1734-2169 1.83e-35

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 435629 [Multi-domain]  Cd Length: 356  Bit Score: 139.68  E-value: 1.83e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1734 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkEAVSAASEDDIFRRAgglfgNHVTYyqSDSRGNFPQTfatQRPLHINK 1813
Cdd:pfam16885    1 AGLRTLQDLGPEMRQALTCDLEEEEE------GAEEEQEGDDEEASA-----APETP--KDPIGSQPPS---RSRISVSL 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1814 TGNNQADTESPSHEklvDSTFTPSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHgpplspavRVQEAawkls 1893
Cdd:pfam16885   65 PVGDRLPDSLPSDD---DGGAPNSRQPSGGQSGSHTHRRSSGVLMFTIPEEGSSQPKGTKGQ--------DKQDE----- 128
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1894 skrchsresqgatvNQEIFPDETRSVRmSEEAEYCSEPSLLSTdmfsyqedeHRqltcPEEDKREIQPsPKRSFLRSASL 1973
Cdd:pfam16885  129 --------------EEEVPVQDQLAYL-DEQAGTPSRPVLLPP---------HR----PQRYVNGHHY-PRRRLLPPTPA 179
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1974 GRRASFHLECLKRQkdqggdiSQKTALPLHLVHHQAlavaGLSPLLqRSHSPTTfprpcptppvTPGSRGRPLRPiPTLR 2053
Cdd:pfam16885  180 GRKPSFTIQCLRRQ-------GSCDDLPIPGTYHRG----GNSGPS-RAQGSWA----------TPPQRGRLLYA-PLLL 236
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 2054 LEGAESSEKLNSSFPSihcsswSEETTACsgsssmarrarpvsLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQD 2133
Cdd:pfam16885  237 VEEGAAGEGYLGKSPG------PLRTFTC--------------LHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARD 296
                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1907170420 2134 PKFIEVTTQELADACDMTIEEMENAADNILSGGAQQ 2169
Cdd:pfam16885  297 PKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 332
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1577-1630 5.65e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 435642  Cd Length: 54  Bit Score: 116.22  E-value: 5.65e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907170420 1577 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1630
Cdd:pfam16905    1 EFVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1692-1722 3.30e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 65.32  E-value: 3.30e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1907170420  1692 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 1722
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
1299-1561 7.78e-09

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 60.44  E-value: 7.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1299 LFKIAMNILNMLFTGLFTVEMILKLIAFKPKgYFSDPWNVFDFLIVIGSIIDVILSetnhyfcdAWNTFDALIVVGSIVD 1378
Cdd:pfam08016  207 LFILLCEIVFVVFFLYFVVEEILKIRKHRPS-YLRSVWNLLDLAIVILSVVLIVLN--------IYRDFLVDRLIKSVEA 277
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1379 iaiTEVHPAEHTQCSPSMSAEENSRISITFF---RLFRVMRLVK---LLSRgegirtllwTFIKSFQALPYVALLIVMLF 1452
Cdd:pfam08016  278 ---SPVTFIDFDRVAQLDNLYRIILAFLVFLtwlKLFKVLRFNKtmsLFTK---------TLSRAWKDLAGFALMFVIFF 345
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420 1453 FIYAVIGMQVFGkialndtteiNRNNNFQTFPQAVLLLFR-CATGEAWQDImlacmpgkkcapESepsnstegetpCGSS 1531
Cdd:pfam08016  346 FAYAQFGYLLFG----------TQAPNFSNFVKSILTLFRtILGDFGYNEI------------FS-----------GNRV 392
                          250       260       270
                   ....*....|....*....|....*....|
gi 1907170420 1532 FAVFYFISFYMLCAFLIINLFVAVIMDNFD 1561
Cdd:pfam08016  393 LGPLLFLTFVFLVIFILLNLFLAIINDSYV 422
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
193-434 2.90e-03

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 42.33  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  193 EYLFLIIFTVEAFLKVIAYGLLFHPN--AYLRNGWNLLDFIIVVVGLFSAILE--QATKADG----ANALGGKGAGFD-- 262
Cdd:pfam08016  209 ILLCEIVFVVFFLYFVVEEILKIRKHrpSYLRSVWNLLDLAIVILSVVLIVLNiyRDFLVDRliksVEASPVTFIDFDrv 288
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  263 ---------VKALRAFRV-LRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFmgkmhktcynqe 332
Cdd:pfam08016  289 aqldnlyriILAFLVFLTwLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLF------------ 356
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907170420  333 giidvpaeedpspcaletghgrqcqnGTvckpgwdgpkhGITNFDNFAFAMLTVFQ-CITMEGWTDVLYwmqdaMGYELP 411
Cdd:pfam08016  357 --------------------------GT-----------QAPNFSNFVKSILTLFRtILGDFGYNEIFS-----GNRVLG 394
                          250       260
                   ....*....|....*....|...
gi 1907170420  412 WVYFVSLVIFGSFFVLNLVLGVL 434
Cdd:pfam08016  395 PLLFLTFVFLVIFILLNLFLAII 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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