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Conserved domains on  [gi|1907171842|ref|XP_036021864|]
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amiloride-sensitive sodium channel subunit alpha isoform X2 [Mus musculus]

Protein Classification

amiloride-sensitive sodium channel family protein( domain architecture ID 235)

amiloride-sensitive sodium channel family protein such as vertebrate acid-sensing ion channels which are cation channels with high affinity for sodium; may be partial

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ASC super family cl02990
Amiloride-sensitive sodium channel;
1-349 0e+00

Amiloride-sensitive sodium channel;


The actual alignment was detected with superfamily member TIGR00859:

Pssm-ID: 445980 [Multi-domain]  Cd Length: 595  Bit Score: 578.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842   1 MYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMR 80
Cdd:TIGR00859 248 MYGNCYTFNSGENSNLLTSSMPGAENGLKLVLDIEQDEYLPLLSTEAGARVMVHSQDEPPFIDDLGFGVRPGTETSISMQ 327
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842  81 KEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYYKL 160
Cdd:TIGR00859 328 EDELQRLGGPYGDCTENGSDVPVENLYNSSYSIQACLRSCFQRYMVENCGCAYYHYPLPGGAEYCNYEQHPDWAYCYYKL 407
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842 161 QAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESP 240
Cdd:TIGR00859 408 YAEFDQEELGCFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNEYNITLIRNGIAKLNIFFEELNYRTIEESP 487
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842 241 SVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRsRYWSPGRGARGAREVASTPASSFPSRFCPH 320
Cdd:TIGR00859 488 AYNVVTLLSNLGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRFR-KWWQRRRGPPYAEPPEPVSADTPPSLQLDD 566
                         330       340
                  ....*....|....*....|....*....
gi 1907171842 321 PTSPPPSLPQQGTTPPLALTAPPPAYATL 349
Cdd:TIGR00859 567 PPTFPSALPLPHASGLSLPGTPPPNYNTL 595
 
Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
1-349 0e+00

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 578.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842   1 MYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMR 80
Cdd:TIGR00859 248 MYGNCYTFNSGENSNLLTSSMPGAENGLKLVLDIEQDEYLPLLSTEAGARVMVHSQDEPPFIDDLGFGVRPGTETSISMQ 327
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842  81 KEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYYKL 160
Cdd:TIGR00859 328 EDELQRLGGPYGDCTENGSDVPVENLYNSSYSIQACLRSCFQRYMVENCGCAYYHYPLPGGAEYCNYEQHPDWAYCYYKL 407
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842 161 QAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESP 240
Cdd:TIGR00859 408 YAEFDQEELGCFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNEYNITLIRNGIAKLNIFFEELNYRTIEESP 487
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842 241 SVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRsRYWSPGRGARGAREVASTPASSFPSRFCPH 320
Cdd:TIGR00859 488 AYNVVTLLSNLGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRFR-KWWQRRRGPPYAEPPEPVSADTPPSLQLDD 566
                         330       340
                  ....*....|....*....|....*....
gi 1907171842 321 PTSPPPSLPQQGTTPPLALTAPPPAYATL 349
Cdd:TIGR00859 567 PPTFPSALPLPHASGLSLPGTPPPNYNTL 595
ASC pfam00858
Amiloride-sensitive sodium channel;
1-272 4.60e-87

Amiloride-sensitive sodium channel;


Pssm-ID: 425912  Cd Length: 444  Bit Score: 270.18  E-value: 4.60e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842   1 MYGNCYTFNNKNNSNLWMSSM---PGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSI 77
Cdd:pfam00858 173 EYGNCYTFNSGDNESPLYPRRlkgAGSGNGLSLILNIQQEEYSPLDSEEAGFKVMIHSPDEPPFVDSLGFSVPPGTETSV 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842  78 SMRKEALDSLGGNYGDCTENGSDvpvKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGV------EFC--DYLK 149
Cdd:pfam00858 253 GIQPQETTTLRRPYGNCYFDDER---VLLYFKSYSQSNCLLECRQNYILKLCGCVPFFMPLPPGTkctgadYPCllNYQD 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842 150 QSSWGYCYYKLqaaFSLDSLGCfsKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEmlsLQNNYTINNKRNGVAKLNIFFK 229
Cdd:pfam00858 330 KLLWVHCLYES---DSTDSLSC--DCLPPCNETEYETEISYSRWPSESSAKYLLV---LKNNSSESYIRENLAKLNIYFK 401
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1907171842 230 ELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAEL 272
Cdd:pfam00858 402 ELNYETYKRSPAYTWTDLLSNIGGQLGLFLGASVLSLVEILYF 444
 
Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
1-349 0e+00

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 578.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842   1 MYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMR 80
Cdd:TIGR00859 248 MYGNCYTFNSGENSNLLTSSMPGAENGLKLVLDIEQDEYLPLLSTEAGARVMVHSQDEPPFIDDLGFGVRPGTETSISMQ 327
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842  81 KEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYYKL 160
Cdd:TIGR00859 328 EDELQRLGGPYGDCTENGSDVPVENLYNSSYSIQACLRSCFQRYMVENCGCAYYHYPLPGGAEYCNYEQHPDWAYCYYKL 407
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842 161 QAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESP 240
Cdd:TIGR00859 408 YAEFDQEELGCFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNEYNITLIRNGIAKLNIFFEELNYRTIEESP 487
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842 241 SVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRsRYWSPGRGARGAREVASTPASSFPSRFCPH 320
Cdd:TIGR00859 488 AYNVVTLLSNLGGQMGLWMGASVLCVLELLELIIDLIFITLLRLLWRFR-KWWQRRRGPPYAEPPEPVSADTPPSLQLDD 566
                         330       340
                  ....*....|....*....|....*....
gi 1907171842 321 PTSPPPSLPQQGTTPPLALTAPPPAYATL 349
Cdd:TIGR00859 567 PPTFPSALPLPHASGLSLPGTPPPNYNTL 595
ASC pfam00858
Amiloride-sensitive sodium channel;
1-272 4.60e-87

Amiloride-sensitive sodium channel;


Pssm-ID: 425912  Cd Length: 444  Bit Score: 270.18  E-value: 4.60e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842   1 MYGNCYTFNNKNNSNLWMSSM---PGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSI 77
Cdd:pfam00858 173 EYGNCYTFNSGDNESPLYPRRlkgAGSGNGLSLILNIQQEEYSPLDSEEAGFKVMIHSPDEPPFVDSLGFSVPPGTETSV 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842  78 SMRKEALDSLGGNYGDCTENGSDvpvKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGV------EFC--DYLK 149
Cdd:pfam00858 253 GIQPQETTTLRRPYGNCYFDDER---VLLYFKSYSQSNCLLECRQNYILKLCGCVPFFMPLPPGTkctgadYPCllNYQD 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842 150 QSSWGYCYYKLqaaFSLDSLGCfsKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEmlsLQNNYTINNKRNGVAKLNIFFK 229
Cdd:pfam00858 330 KLLWVHCLYES---DSTDSLSC--DCLPPCNETEYETEISYSRWPSESSAKYLLV---LKNNSSESYIRENLAKLNIYFK 401
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1907171842 230 ELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAEL 272
Cdd:pfam00858 402 ELNYETYKRSPAYTWTDLLSNIGGQLGLFLGASVLSLVEILYF 444
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
2-272 1.10e-44

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 162.32  E-value: 1.10e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842   2 YGNCYTFNNKNNSNLwMSSMPGVNNGLSLTLRTEQNDFIPLlSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRK 81
Cdd:TIGR00867 333 FGNCYTFNYNRSVNL-SSSRAGPMYGLRLLLFVNQSDYLPT-TEAAGVRLTIHDKDEFPFPDTFGYSAPTGYISSFGVRL 410
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842  82 EALDSLGGNYGDCTENGSDVP-VKNLYpsKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDylkqsswgycyykl 160
Cdd:TIGR00867 411 KQMSRLPAPYGNCVDTGKDSSyIYKGY--IYSPEGCHRSCFQRLIIAKCGCADPRFPVPEGTRHCQ-------------- 474
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171842 161 qaAFSLDSLGCFSK----------------CRKPCSVTNYKLSAGYSRWPSVKSQ----DWIFEMLSLQNNYTinnkRNG 220
Cdd:TIGR00867 475 --AFNKTDRECLETltgdlgelhhsifkcrCQQPCQESIYTTTYSAAKWPSGSLKitlgSCDSNTASECNEYY----REN 548
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907171842 221 VAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAEL 272
Cdd:TIGR00867 549 AAMIEVFYEQLNYELLTESEAYTLVNLIADFGGQLGLWLGASVITVCEFVFL 600
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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