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Conserved domains on  [gi|1907171862|ref|XP_036021867|]
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epsilon-sarcoglycan isoform X8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sarcoglycan_2 super family cl23856
Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are ...
33-378 7.90e-146

Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localization of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.


The actual alignment was detected with superfamily member pfam05510:

Pssm-ID: 461668  Cd Length: 410  Bit Score: 420.92  E-value: 7.90e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862  33 FLLTGEVSNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARhnLIINIMSA 112
Cdd:pfam05510  41 FNWTHEVISEQFTYRPSLEGYPDLPSWMRYMYSTEYHAGFLYGTPPAENAGKPLIIEIIALNRQNYETRR--LIINMMVA 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 113 EEFPLPYQAEFFIKNMNVEEML---ASEVLGDFLGavKNVWQPER--LNAINITSALDRGGRVPLPINDmKEGVYVMVGA 187
Cdd:pfam05510 119 HKFPTPNVIQMKIDNLNWVHMMdpgRVENLRNIFR--KDLWPPSRedLSIIFMESAVNMGGRLPLRPQQ-REGVIVHVGS 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 188 DVAFSSCLREVEnpqnqlrcsQEMEP---VITCDKKfRTH---------FHIDWCKISLVD------------KTKQVST 243
Cdd:pfam05510 196 DAQFSSRLRELQ---------EEVRPlykLPSCTYK-RTSvqkifenvgFKLDWCAFRLVGsespteilyhsgKQKQVQT 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 244 YQEVVRGEGILPDGGEYK---PPSDSLKSRDYYTDFLVTLAVPSAVALVLFLILAYIMCCRREG---------------- 304
Cdd:pfam05510 266 PQEVIRGHGILPDGGEERwmgPPREDVPERNYIDEFAIAFAIPGMIFAILFGILSAILCFQHEKfydphseyffanifhi 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 305 -----------VEKRDMQTPDIQLVHHSSIQ-KSTKELRDMSKnreiawplstlpvfhpvtgeviPPTHTDNYDSTNMPL 372
Cdd:pfam05510 346 ceescamsessVEKRNMQTSTVQMVHCSDIQaQSTTTLKSLKD----------------------PPFLLDNYDSTNMSM 403

                  ....*.
gi 1907171862 373 MQAQQN 378
Cdd:pfam05510 404 RSQSPN 409
 
Name Accession Description Interval E-value
Sarcoglycan_2 pfam05510
Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are ...
33-378 7.90e-146

Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localization of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.


Pssm-ID: 461668  Cd Length: 410  Bit Score: 420.92  E-value: 7.90e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862  33 FLLTGEVSNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARhnLIINIMSA 112
Cdd:pfam05510  41 FNWTHEVISEQFTYRPSLEGYPDLPSWMRYMYSTEYHAGFLYGTPPAENAGKPLIIEIIALNRQNYETRR--LIINMMVA 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 113 EEFPLPYQAEFFIKNMNVEEML---ASEVLGDFLGavKNVWQPER--LNAINITSALDRGGRVPLPINDmKEGVYVMVGA 187
Cdd:pfam05510 119 HKFPTPNVIQMKIDNLNWVHMMdpgRVENLRNIFR--KDLWPPSRedLSIIFMESAVNMGGRLPLRPQQ-REGVIVHVGS 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 188 DVAFSSCLREVEnpqnqlrcsQEMEP---VITCDKKfRTH---------FHIDWCKISLVD------------KTKQVST 243
Cdd:pfam05510 196 DAQFSSRLRELQ---------EEVRPlykLPSCTYK-RTSvqkifenvgFKLDWCAFRLVGsespteilyhsgKQKQVQT 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 244 YQEVVRGEGILPDGGEYK---PPSDSLKSRDYYTDFLVTLAVPSAVALVLFLILAYIMCCRREG---------------- 304
Cdd:pfam05510 266 PQEVIRGHGILPDGGEERwmgPPREDVPERNYIDEFAIAFAIPGMIFAILFGILSAILCFQHEKfydphseyffanifhi 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 305 -----------VEKRDMQTPDIQLVHHSSIQ-KSTKELRDMSKnreiawplstlpvfhpvtgeviPPTHTDNYDSTNMPL 372
Cdd:pfam05510 346 ceescamsessVEKRNMQTSTVQMVHCSDIQaQSTTTLKSLKD----------------------PPFLLDNYDSTNMSM 403

                  ....*.
gi 1907171862 373 MQAQQN 378
Cdd:pfam05510 404 RSQSPN 409
CADG smart00736
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ...
39-114 2.09e-12

Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions.


Pssm-ID: 214795 [Multi-domain]  Cd Length: 97  Bit Score: 62.74  E-value: 2.09e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907171862   39 VSNDPITFNTNLMGYPDRPGWLRYIQRTpysdGVLYGSPTAENVGKpTIIEITAYNRRTfETARHNLIINIMSAEE 114
Cdd:smart00736  27 ADGDTLTYSATLSDGSALPSWLSFDSDT----GTLSGTPTNSDVGS-LSLKVTATDSSG-ASASDTFTITVVNTND 96
 
Name Accession Description Interval E-value
Sarcoglycan_2 pfam05510
Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are ...
33-378 7.90e-146

Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localization of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.


Pssm-ID: 461668  Cd Length: 410  Bit Score: 420.92  E-value: 7.90e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862  33 FLLTGEVSNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARhnLIINIMSA 112
Cdd:pfam05510  41 FNWTHEVISEQFTYRPSLEGYPDLPSWMRYMYSTEYHAGFLYGTPPAENAGKPLIIEIIALNRQNYETRR--LIINMMVA 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 113 EEFPLPYQAEFFIKNMNVEEML---ASEVLGDFLGavKNVWQPER--LNAINITSALDRGGRVPLPINDmKEGVYVMVGA 187
Cdd:pfam05510 119 HKFPTPNVIQMKIDNLNWVHMMdpgRVENLRNIFR--KDLWPPSRedLSIIFMESAVNMGGRLPLRPQQ-REGVIVHVGS 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 188 DVAFSSCLREVEnpqnqlrcsQEMEP---VITCDKKfRTH---------FHIDWCKISLVD------------KTKQVST 243
Cdd:pfam05510 196 DAQFSSRLRELQ---------EEVRPlykLPSCTYK-RTSvqkifenvgFKLDWCAFRLVGsespteilyhsgKQKQVQT 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 244 YQEVVRGEGILPDGGEYK---PPSDSLKSRDYYTDFLVTLAVPSAVALVLFLILAYIMCCRREG---------------- 304
Cdd:pfam05510 266 PQEVIRGHGILPDGGEERwmgPPREDVPERNYIDEFAIAFAIPGMIFAILFGILSAILCFQHEKfydphseyffanifhi 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907171862 305 -----------VEKRDMQTPDIQLVHHSSIQ-KSTKELRDMSKnreiawplstlpvfhpvtgeviPPTHTDNYDSTNMPL 372
Cdd:pfam05510 346 ceescamsessVEKRNMQTSTVQMVHCSDIQaQSTTTLKSLKD----------------------PPFLLDNYDSTNMSM 403

                  ....*.
gi 1907171862 373 MQAQQN 378
Cdd:pfam05510 404 RSQSPN 409
CADG smart00736
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ...
39-114 2.09e-12

Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions.


Pssm-ID: 214795 [Multi-domain]  Cd Length: 97  Bit Score: 62.74  E-value: 2.09e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907171862   39 VSNDPITFNTNLMGYPDRPGWLRYIQRTpysdGVLYGSPTAENVGKpTIIEITAYNRRTfETARHNLIINIMSAEE 114
Cdd:smart00736  27 ADGDTLTYSATLSDGSALPSWLSFDSDT----GTLSGTPTNSDVGS-LSLKVTATDSSG-ASASDTFTITVVNTND 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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