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Conserved domains on  [gi|1953309014|ref|XP_038279988|]
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alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X5 [Canis lupus familiaris]

Protein Classification

2OG-Fe(II) oxygenase family protein( domain architecture ID 229412)

2OG-Fe(II) oxygenase family protein belongs to the large and diverse Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenase superfamily and may share a common reaction mechanism, using Fe(II) and the cosubstrate 2-OG in the active site to activate oxygen, resulting in the two-electron oxidation of a target substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
90-227 7.01e-49

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


:

Pssm-ID: 442379  Cd Length: 200  Bit Score: 159.94  E-value: 7.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953309014  90 LCLYPGFIDLKEADWVLEQLCEVVPWKQRTGiregPIFSFldvTYKQPRLTAWYG--ELPYTYSRITMEPNPhWPAVLRT 167
Cdd:COG3145    18 AVYLPGFLSPEEADALLAALRAEAPWRQPVI----PIFGK---TMSVPRLNAWYGwvGAGYRYSGTDPEPPP-WPPALLA 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953309014 168 LKDQIEENTGHTFNSLLCNLYRDEKDSVDWHSDDEPSLGRCPVIASLSFGATRAFEMRRK 227
Cdd:COG3145    90 LKRRVEAAAGFPFNSCLLNLYRDGQDRMGWHQDDEEELGFNPPIASVSLGATRRFRFGHK 149
 
Name Accession Description Interval E-value
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
90-227 7.01e-49

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 159.94  E-value: 7.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953309014  90 LCLYPGFIDLKEADWVLEQLCEVVPWKQRTGiregPIFSFldvTYKQPRLTAWYG--ELPYTYSRITMEPNPhWPAVLRT 167
Cdd:COG3145    18 AVYLPGFLSPEEADALLAALRAEAPWRQPVI----PIFGK---TMSVPRLNAWYGwvGAGYRYSGTDPEPPP-WPPALLA 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953309014 168 LKDQIEENTGHTFNSLLCNLYRDEKDSVDWHSDDEPSLGRCPVIASLSFGATRAFEMRRK 227
Cdd:COG3145    90 LKRRVEAAAGFPFNSCLLNLYRDGQDRMGWHQDDEEELGFNPPIASVSLGATRRFRFGHK 149
2OG-FeII_Oxy_2 pfam13532
2OG-Fe(II) oxygenase superfamily;
90-225 7.66e-18

2OG-Fe(II) oxygenase superfamily;


Pssm-ID: 433285  Cd Length: 191  Bit Score: 78.90  E-value: 7.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953309014  90 LCLYPGFIDLKEADWVLEQLCEVVPWKQrTGIREGPIFSFLDVTYKQprlTAWYGELP-YTYSR---ITMEPNPHWPAVL 165
Cdd:pfam13532   2 LVLLPGFLSPEEAAELLRELLEEGPFRQ-PTTQGGRPMSVRMTNCGQ---LGWVTDGPgYRYSGvdpVTGEPWPPFPEAL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953309014 166 RTLKDQIEENT---GHTFNSLLCNLYRDeKDSVDWHSD-DEPSLGrcPVIASLSFGATRAFEMR 225
Cdd:pfam13532  78 LQLAERLAAEAgypGWSPNACLVNFYRD-GARMGLHQDrDESGPG--APIVSLSLGASATFRFG 138
 
Name Accession Description Interval E-value
AlkB COG3145
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];
90-227 7.01e-49

Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair];


Pssm-ID: 442379  Cd Length: 200  Bit Score: 159.94  E-value: 7.01e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953309014  90 LCLYPGFIDLKEADWVLEQLCEVVPWKQRTGiregPIFSFldvTYKQPRLTAWYG--ELPYTYSRITMEPNPhWPAVLRT 167
Cdd:COG3145    18 AVYLPGFLSPEEADALLAALRAEAPWRQPVI----PIFGK---TMSVPRLNAWYGwvGAGYRYSGTDPEPPP-WPPALLA 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953309014 168 LKDQIEENTGHTFNSLLCNLYRDEKDSVDWHSDDEPSLGRCPVIASLSFGATRAFEMRRK 227
Cdd:COG3145    90 LKRRVEAAAGFPFNSCLLNLYRDGQDRMGWHQDDEEELGFNPPIASVSLGATRRFRFGHK 149
2OG-FeII_Oxy_2 pfam13532
2OG-Fe(II) oxygenase superfamily;
90-225 7.66e-18

2OG-Fe(II) oxygenase superfamily;


Pssm-ID: 433285  Cd Length: 191  Bit Score: 78.90  E-value: 7.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953309014  90 LCLYPGFIDLKEADWVLEQLCEVVPWKQrTGIREGPIFSFLDVTYKQprlTAWYGELP-YTYSR---ITMEPNPHWPAVL 165
Cdd:pfam13532   2 LVLLPGFLSPEEAAELLRELLEEGPFRQ-PTTQGGRPMSVRMTNCGQ---LGWVTDGPgYRYSGvdpVTGEPWPPFPEAL 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1953309014 166 RTLKDQIEENT---GHTFNSLLCNLYRDeKDSVDWHSD-DEPSLGrcPVIASLSFGATRAFEMR 225
Cdd:pfam13532  78 LQLAERLAAEAgypGWSPNACLVNFYRD-GARMGLHQDrDESGPG--APIVSLSLGASATFRFG 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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