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Conserved domains on  [gi|1952683640|ref|XP_038291808|]
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interferon regulatory factor 5 isoform X3 [Canis lupus familiaris]

Protein Classification

interferon regulatory factor( domain architecture ID 10457095)

interferon regulatory factor (IRF) is a transcriptional regulator that is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 267-451 3.75e-92

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 278.76  E-value: 3.75e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640 267 LTDLEIKFQYRGRPPRALTISNPQGCRLFYsqlEPTQDQVELFGPVSLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLI 346
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSY---GPPDPQVALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640 347 LQLQGQDLYAIRLCQCKVFWSGPCASaHGSHPNPIQREVKTKLFSLEHFLNELILFQKGQTnTPPPFEIFFCFGEEWPDR 426
Cdd:pfam10401  78 LWVAGQGLYAKRLCQSRVFWSGPEAP-GGDKPNKLERDATVKLFDLAKFLRELILFQEGRG-RSPDYTITLCFGEEWPDD 155

                         170       180
                  ....*....|....*....|....*
gi 1952683640 427 KPREKKLITVQVVPVAARLLLEMFS 451
Cdd:pfam10401 156 KPREKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 16-121 3.59e-61

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 195.86  E-value: 3.59e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  16 RLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGPSQEGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALN 95
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 1952683640  96 KSRDFRLIYDGPRDMPPQPYKIYEVC 121
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 171-328 1.51e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  171 PSLSITEAVQPGPPMAPYSLPKEDVKWPPTLQPPVvlgPPAPDPSLLGPTPGNPAGfgELLPEVLPSLQPGPLAASLPPT 250
Cdd:PHA03247  2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP---PPPPQPQPPPPPPPRPQP--PLAPTTDPAGAGEPSGAVPQPW 2963

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  251 GEQLLPDLLISPHML---PLTDLEIKfqyrGRPPRALTISNPQGCRLFYSQLEPTQDQVElfGPVSLEQVRFPSPEDIPS 327
Cdd:PHA03247  2964 LGALVPGRVAVPRFRvpqPAPSREAP----ASSTPPLTGHSLSRVSSWASSLALHEETDP--PPVSLKQTLWPPDDTEDS 3037


                   .
gi 1952683640  328 D 328
Cdd:PHA03247  3038 D 3038
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 267-451 3.75e-92

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 278.76  E-value: 3.75e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640 267 LTDLEIKFQYRGRPPRALTISNPQGCRLFYsqlEPTQDQVELFGPVSLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLI 346
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSY---GPPDPQVALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640 347 LQLQGQDLYAIRLCQCKVFWSGPCASaHGSHPNPIQREVKTKLFSLEHFLNELILFQKGQTnTPPPFEIFFCFGEEWPDR 426
Cdd:pfam10401  78 LWVAGQGLYAKRLCQSRVFWSGPEAP-GGDKPNKLERDATVKLFDLAKFLRELILFQEGRG-RSPDYTITLCFGEEWPDD 155

                         170       180
                  ....*....|....*....|....*
gi 1952683640 427 KPREKKLITVQVVPVAARLLLEMFS 451
Cdd:pfam10401 156 KPREKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 16-121 3.59e-61

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 195.86  E-value: 3.59e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  16 RLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGPSQEGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALN 95
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 1952683640  96 KSRDFRLIYDGPRDMPPQPYKIYEVC 121
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 16-122 2.82e-52

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 172.90  E-value: 2.82e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640   16 RLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGPSQEGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALN 95
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*..
gi 1952683640   96 KSRDFRLIYDGPRDmPPQPYKIYEVCS 122
Cdd:smart00348  81 KSRDFEEIKDASTD-PPDPYRVYRLLP 106
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 15-122 9.52e-45

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 152.83  E-value: 9.52e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  15 VRLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGpSQEGDNTIFKAWAKETGKYTEGVDEaDPAKWKANLRCAL 94
Cdd:cd00103     2 MRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPGGTP-DPAEWKARLLCAL 79

                          90       100
                  ....*....|....*....|....*...
gi 1952683640  95 NKSRDFRLIYDGPRDMPPQPYKIYEVCS 122
Cdd:cd00103    80 RSSRGFEEVKDKSKDTPGDPHRVYRLLP 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 171-328 1.51e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  171 PSLSITEAVQPGPPMAPYSLPKEDVKWPPTLQPPVvlgPPAPDPSLLGPTPGNPAGfgELLPEVLPSLQPGPLAASLPPT 250
Cdd:PHA03247  2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP---PPPPQPQPPPPPPPRPQP--PLAPTTDPAGAGEPSGAVPQPW 2963

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  251 GEQLLPDLLISPHML---PLTDLEIKfqyrGRPPRALTISNPQGCRLFYSQLEPTQDQVElfGPVSLEQVRFPSPEDIPS 327
Cdd:PHA03247  2964 LGALVPGRVAVPRFRvpqPAPSREAP----ASSTPPLTGHSLSRVSSWASSLALHEETDP--PPVSLKQTLWPPDDTEDS 3037


                   .
gi 1952683640  328 D 328
Cdd:PHA03247  3038 D 3038
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 121-326 5.07e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.75  E-value: 5.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640 121 CSNGSAPAESQPSEDYTFGAGEEEEEEEEDVSSGPFLAASACTDVLQRMLPSLSIteaVQPGPPMAPYSLPKEdvkwppt 200
Cdd:pfam03154 176 AQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTL---IQQTPTLHPQRLPSP------- 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640 201 lQPPVVLGPPAPDPSLLGPTPGNPAGFGELLPEVLPSLQPGP--LAASLPPTGEQLLPDLLISP-HMLPLTDLEIKFQYR 277
Cdd:pfam03154 246 -HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPshMQHPVPPQPFPLTPQSSQSQvPPGPSPAAPGQSQQR 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1952683640 278 GRPPRALTISNPQgcrlfysqlEPTQDQVELFGPVSLEQVRFPSPEDIP 326
Cdd:pfam03154 325 IHTPPSQSQLQSQ---------QPPREQPLPPAPLSMPHIKPPPTTPIP 364
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 267-451 3.75e-92

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 278.76  E-value: 3.75e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640 267 LTDLEIKFQYRGRPPRALTISNPQGCRLFYsqlEPTQDQVELFGPVSLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLI 346
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSY---GPPDPQVALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640 347 LQLQGQDLYAIRLCQCKVFWSGPCASaHGSHPNPIQREVKTKLFSLEHFLNELILFQKGQTnTPPPFEIFFCFGEEWPDR 426
Cdd:pfam10401  78 LWVAGQGLYAKRLCQSRVFWSGPEAP-GGDKPNKLERDATVKLFDLAKFLRELILFQEGRG-RSPDYTITLCFGEEWPDD 155

                         170       180
                  ....*....|....*....|....*
gi 1952683640 427 KPREKKLITVQVVPVAARLLLEMFS 451
Cdd:pfam10401 156 KPREKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 16-121 3.59e-61

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 195.86  E-value: 3.59e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  16 RLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGPSQEGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALN 95
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 1952683640  96 KSRDFRLIYDGPRDMPPQPYKIYEVC 121
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 16-122 2.82e-52

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 172.90  E-value: 2.82e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640   16 RLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGPSQEGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALN 95
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*..
gi 1952683640   96 KSRDFRLIYDGPRDmPPQPYKIYEVCS 122
Cdd:smart00348  81 KSRDFEEIKDASTD-PPDPYRVYRLLP 106
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 15-122 9.52e-45

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 152.83  E-value: 9.52e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  15 VRLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGpSQEGDNTIFKAWAKETGKYTEGVDEaDPAKWKANLRCAL 94
Cdd:cd00103     2 MRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPGGTP-DPAEWKARLLCAL 79

                          90       100
                  ....*....|....*....|....*...
gi 1952683640  95 NKSRDFRLIYDGPRDMPPQPYKIYEVCS 122
Cdd:cd00103    80 RSSRGFEEVKDKSKDTPGDPHRVYRLLP 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 171-328 1.51e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  171 PSLSITEAVQPGPPMAPYSLPKEDVKWPPTLQPPVvlgPPAPDPSLLGPTPGNPAGfgELLPEVLPSLQPGPLAASLPPT 250
Cdd:PHA03247  2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP---PPPPQPQPPPPPPPRPQP--PLAPTTDPAGAGEPSGAVPQPW 2963

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640  251 GEQLLPDLLISPHML---PLTDLEIKfqyrGRPPRALTISNPQGCRLFYSQLEPTQDQVElfGPVSLEQVRFPSPEDIPS 327
Cdd:PHA03247  2964 LGALVPGRVAVPRFRvpqPAPSREAP----ASSTPPLTGHSLSRVSSWASSLALHEETDP--PPVSLKQTLWPPDDTEDS 3037


                   .
gi 1952683640  328 D 328
Cdd:PHA03247  3038 D 3038
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 121-326 5.07e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.75  E-value: 5.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640 121 CSNGSAPAESQPSEDYTFGAGEEEEEEEEDVSSGPFLAASACTDVLQRMLPSLSIteaVQPGPPMAPYSLPKEdvkwppt 200
Cdd:pfam03154 176 AQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTL---IQQTPTLHPQRLPSP------- 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952683640 201 lQPPVVLGPPAPDPSLLGPTPGNPAGFGELLPEVLPSLQPGP--LAASLPPTGEQLLPDLLISP-HMLPLTDLEIKFQYR 277
Cdd:pfam03154 246 -HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPshMQHPVPPQPFPLTPQSSQSQvPPGPSPAAPGQSQQR 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1952683640 278 GRPPRALTISNPQgcrlfysqlEPTQDQVELFGPVSLEQVRFPSPEDIP 326
Cdd:pfam03154 325 IHTPPSQSQLQSQ---------QPPREQPLPPAPLSMPHIKPPPTTPIP 364
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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