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Conserved domains on  [gi|1953370019|ref|XP_038301052|]
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cystatin-A [Canis lupus familiaris]

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-92 3.69e-23

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 84.69  E-value: 3.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953370019  4 GGLTEAKPATPEVQEIANEVKPQLEEKT-NETYQEFEAVEYKTQVVAGINYYIKVRVGDNSYI-HLKIFKGLPGQ-NPTL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLdEKWL 80

                         90
                 ....*....|..
gi 1953370019 81 TLTGYQTDKSKD 92
Cdd:pfam00031 81 GLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-92 3.69e-23

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 84.69  E-value: 3.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953370019  4 GGLTEAKPATPEVQEIANEVKPQLEEKT-NETYQEFEAVEYKTQVVAGINYYIKVRVGDNSYI-HLKIFKGLPGQ-NPTL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLdEKWL 80

                         90
                 ....*....|..
gi 1953370019 81 TLTGYQTDKSKD 92
Cdd:pfam00031 81 GLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-61 9.67e-19

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 74.00  E-value: 9.67e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1953370019    1 MMPGGLTEAKPATPEVQEIANEVKPQLEEKTNETY--QEFEAVEYKTQVVAGINYYIKVRVGD 61
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGE 63
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-61 1.80e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 60.57  E-value: 1.80e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1953370019   4 GGLTEAKPATPEVQEIANEVKPQLEEKTNETYQEF-EAVEYKTQVVAGINYYIKVRVGD 61
Cdd:cd00042     1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFfKVLSAKSQVVAGTNYYITVEAGD 59
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-92 3.69e-23

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 84.69  E-value: 3.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953370019  4 GGLTEAKPATPEVQEIANEVKPQLEEKT-NETYQEFEAVEYKTQVVAGINYYIKVRVGDNSYI-HLKIFKGLPGQ-NPTL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLdEKWL 80

                         90
                 ....*....|..
gi 1953370019 81 TLTGYQTDKSKD 92
Cdd:pfam00031 81 GLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-61 9.67e-19

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 74.00  E-value: 9.67e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1953370019    1 MMPGGLTEAKPATPEVQEIANEVKPQLEEKTNETY--QEFEAVEYKTQVVAGINYYIKVRVGD 61
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGE 63
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-61 1.80e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 60.57  E-value: 1.80e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1953370019   4 GGLTEAKPATPEVQEIANEVKPQLEEKTNETYQEF-EAVEYKTQVVAGINYYIKVRVGD 61
Cdd:cd00042     1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFfKVLSAKSQVVAGTNYYITVEAGD 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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