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Conserved domains on  [gi|1952723149|ref|XP_038314950|]
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corrinoid adenosyltransferase isoform X2 [Canis lupus familiaris]

Protein Classification

ATP:cob(I)alamin adenosyltransferase( domain architecture ID 10487543)

ATP:cob(I)alamin adenosyltransferase catalyzes the final step in the conversion of cyanocobalamin (vitamin B12) to adenosylcobalamin, catalyzing the transfer of the adenosyl moiety from ATP to cobalamin

EC:  2.5.1.17
Gene Ontology:  GO:0008817|GO:0031419|GO:0009235|GO:0005524
PubMed:  11160088
SCOP:  4003724

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cob_adeno_trans pfam01923
Cobalamin adenosyltransferase; Cobalamin adenosyltransferase This family contains the gene ...
 53-167 1.51e-44

Cobalamin adenosyltransferase; Cobalamin adenosyltransferase This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation.The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12.


:

Pssm-ID: 460384  Cd Length: 163  Bit Score: 146.10  E-value: 1.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723149  53 YTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALEFITEkgHPFAEELQKIQCSLQDVGSALATPHSSArea 132
Cdd:pfam01923   1 YTRTGDKGTTSLGGGERVPKDDPRVEAYGTVDELNSAIGLARALLPD--EDLRELLERIQNDLFDLGADLATPGPKE--- 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952723149 133 hlRHATFEAGPILELEQWIDKYSNQLPPLTAFILP 167
Cdd:pfam01923  76 --PKLRITEEDVERLEKEIDEYNAELPPLKSFILP 108
 
Name Accession Description Interval E-value
Cob_adeno_trans pfam01923
Cobalamin adenosyltransferase; Cobalamin adenosyltransferase This family contains the gene ...
 53-167 1.51e-44

Cobalamin adenosyltransferase; Cobalamin adenosyltransferase This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation.The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12.


Pssm-ID: 460384  Cd Length: 163  Bit Score: 146.10  E-value: 1.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723149  53 YTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALEFITEkgHPFAEELQKIQCSLQDVGSALATPHSSArea 132
Cdd:pfam01923   1 YTRTGDKGTTSLGGGERVPKDDPRVEAYGTVDELNSAIGLARALLPD--EDLRELLERIQNDLFDLGADLATPGPKE--- 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952723149 133 hlRHATFEAGPILELEQWIDKYSNQLPPLTAFILP 167
Cdd:pfam01923  76 --PKLRITEEDVERLEKEIDEYNAELPPLKSFILP 108
PduO COG2096
Cob(II)alamin adenosyltransferase [Coenzyme transport and metabolism]; Cob(II)alamin ...
 51-183 2.82e-39

Cob(II)alamin adenosyltransferase [Coenzyme transport and metabolism]; Cob(II)alamin adenosyltransferase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441699  Cd Length: 180  Bit Score: 132.94  E-value: 2.82e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723149  51 KIYTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALEFITEkgHPFAEELQKIQCSLQDVGSALATPHSSar 130
Cdd:COG2096     2 KIYTRTGDKGTTGLGGGSRVSKDDPRVEAYGTVDELNSAIGLARALLLD--EDLRELLERIQNDLFDLGADLATPGEK-- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1952723149 131 EAHLRhatFEAGPILELEQWIDKYSNQLPPLTAFILPpiptfysQGARAAVHC 183
Cdd:COG2096    78 RPPLR---ITEEDVERLEEEIDELNAELPPLKSFILP-------GGSPAAAAL 120
PduO_Nterm TIGR00636
ATP:cob(I)alamin adenosyltransferase; This model represents as ATP:cob(I)alamin ...
 53-167 8.75e-26

ATP:cob(I)alamin adenosyltransferase; This model represents as ATP:cob(I)alamin adenosyltransferase family corresponding to the N-terminal half of Salmonella PduO, a 1,2-propanediol utilization protein that probably is bifunctional. PduO represents one of at least three families of ATP:corrinoid adenosyltransferase: others are CobA (which partially complements PduO) and EutT. It was not clear originally whether ATP:cob(I)alamin adenosyltransferase activity resides in the N-terminal region of PduO, modeled here, but this has now become clear from the characterization of MeaD from Methylobacterium extorquens. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213544  Cd Length: 171  Bit Score: 98.18  E-value: 8.75e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723149  53 YTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALEFITEKghPFAEELQKIQCSLQDVGSALATPhssarea 132
Cdd:TIGR00636   1 YTKTGDKGQTKLAGGDRVGKDSPRVEAYGTLDELNSFIGVALSLLKWE--DLKEDLERIQNDLFDIGGDLATP------- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1952723149 133 hlrhatFEAGPILE-----LEQWIDKYSNQLPPLTAFILP 167
Cdd:TIGR00636  72 ------GDTKKITEedvkwLEERIDQYRKELPPLKLFVLP 105
 
Name Accession Description Interval E-value
Cob_adeno_trans pfam01923
Cobalamin adenosyltransferase; Cobalamin adenosyltransferase This family contains the gene ...
 53-167 1.51e-44

Cobalamin adenosyltransferase; Cobalamin adenosyltransferase This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation.The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12.


Pssm-ID: 460384  Cd Length: 163  Bit Score: 146.10  E-value: 1.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723149  53 YTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALEFITEkgHPFAEELQKIQCSLQDVGSALATPHSSArea 132
Cdd:pfam01923   1 YTRTGDKGTTSLGGGERVPKDDPRVEAYGTVDELNSAIGLARALLPD--EDLRELLERIQNDLFDLGADLATPGPKE--- 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1952723149 133 hlRHATFEAGPILELEQWIDKYSNQLPPLTAFILP 167
Cdd:pfam01923  76 --PKLRITEEDVERLEKEIDEYNAELPPLKSFILP 108
PduO COG2096
Cob(II)alamin adenosyltransferase [Coenzyme transport and metabolism]; Cob(II)alamin ...
 51-183 2.82e-39

Cob(II)alamin adenosyltransferase [Coenzyme transport and metabolism]; Cob(II)alamin adenosyltransferase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441699  Cd Length: 180  Bit Score: 132.94  E-value: 2.82e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723149  51 KIYTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALEFITEkgHPFAEELQKIQCSLQDVGSALATPHSSar 130
Cdd:COG2096     2 KIYTRTGDKGTTGLGGGSRVSKDDPRVEAYGTVDELNSAIGLARALLLD--EDLRELLERIQNDLFDLGADLATPGEK-- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1952723149 131 EAHLRhatFEAGPILELEQWIDKYSNQLPPLTAFILPpiptfysQGARAAVHC 183
Cdd:COG2096    78 RPPLR---ITEEDVERLEEEIDELNAELPPLKSFILP-------GGSPAAAAL 120
PduO_Nterm TIGR00636
ATP:cob(I)alamin adenosyltransferase; This model represents as ATP:cob(I)alamin ...
 53-167 8.75e-26

ATP:cob(I)alamin adenosyltransferase; This model represents as ATP:cob(I)alamin adenosyltransferase family corresponding to the N-terminal half of Salmonella PduO, a 1,2-propanediol utilization protein that probably is bifunctional. PduO represents one of at least three families of ATP:corrinoid adenosyltransferase: others are CobA (which partially complements PduO) and EutT. It was not clear originally whether ATP:cob(I)alamin adenosyltransferase activity resides in the N-terminal region of PduO, modeled here, but this has now become clear from the characterization of MeaD from Methylobacterium extorquens. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213544  Cd Length: 171  Bit Score: 98.18  E-value: 8.75e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952723149  53 YTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALEFITEKghPFAEELQKIQCSLQDVGSALATPhssarea 132
Cdd:TIGR00636   1 YTKTGDKGQTKLAGGDRVGKDSPRVEAYGTLDELNSFIGVALSLLKWE--DLKEDLERIQNDLFDIGGDLATP------- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1952723149 133 hlrhatFEAGPILE-----LEQWIDKYSNQLPPLTAFILP 167
Cdd:TIGR00636  72 ------GDTKKITEedvkwLEERIDQYRKELPPLKLFVLP 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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