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Conserved domains on  [gi|1953003308|ref|XP_038386336|]
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protocadherin gamma-C3 isoform X9 [Canis lupus familiaris]

Protein Classification

protocadherin( domain architecture ID 13228202)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
249-348 1.84e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 1.84e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 249 YRASVLEDAPPGTVVVQVHATDLDEGPNGEIIYSFGNHNrasVRDLFSLDPVTGMLTIKGLLDFEDTKLHEIYIQAKDKG 328
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78
                          90       100
                  ....*....|....*....|
gi 1953003308 329 ATPEGAHCKVLVEVVDVNDN 348
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
33-113 7.17e-32

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 400525  Cd Length: 83  Bit Score: 118.78  E-value: 7.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  33 VRYEILEEREKGFAVGNVVTDLGLDLGSLSTRRLQVLPGASRRFFEVNRKTGEMFVNDRLDREELCGTLPSCTITLELVV 112
Cdd:pfam08266   2 IRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLL 81

                  .
gi 1953003308 113 E 113
Cdd:pfam08266  82 E 82
Cadherin_tail super family cl24520
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
813-907 4.67e-30

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


The actual alignment was detected with superfamily member pfam15974:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 115.50  E-value: 4.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 813 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 888
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80
                          90       100
                  ....*....|....*....|
gi 1953003308 889 HVPD-YRQNVYIPGSNATLT 907
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
461-563 9.85e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 9.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 461 SYDVYVEENNIPGVPILNLSVWDPDAPQNAHLSFFLLEQGTENglvgrYFTINRDNGIVSSLVSLDYEDRREFEITVYVT 540
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75
                          90       100
                  ....*....|....*....|...
gi 1953003308 541 DGGTPVLTTNISVNIFVTDRNDN 563
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
361-453 1.70e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 361 VPEDAPLGTVIALLSVIDLDAGENGLVTCEV---PPGLPFSLTSslkNYFTLKTSVALDRETVPEYNLSITARDAGTPSL 437
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82
                          90
                  ....*....|....*.
gi 1953003308 438 SALTVVRVQVSDINDN 453
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
139-240 1.32e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 139 EMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS---LNEYFALrvqtredSTKYAELVLERGLDWEREPSLQLVLT 215
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVT 73
                          90       100
                  ....*....|....*....|....*
gi 1953003308 216 ALDGGTPARSATLPIRITVLDANDN 240
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
580-667 4.24e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 4.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 580 LPRSTAAGHVVTRVVGWDPDAGHNAWLCYSLLGASNQSLFAVGLHTGQVSTSRPVQDTDVPRQTLMVLIKDNGEPSLSTT 659
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85

                  ....*...
gi 1953003308 660 ATLTVSVT 667
Cdd:cd11304    86 ATVTITVL 93
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
689-770 3.57e-07

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 435374  Cd Length: 84  Bit Score: 48.68  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 689 NLTFYLLLSLILVSVGFAVTVLGVIIFKVYKWKQSKHLYRApvSSLYRTPvSSLHADAVRSGLMPPHLYHQVYLTTDSRH 768
Cdd:pfam16492   1 NLTFYLVIALASVSFLFLLSVIVLIALRLRRWRSSALLGSS--GSLCSVP-APHFPGNDGTGTLPQSYSYEVCLTSDSGK 77

                  ..
gi 1953003308 769 SD 770
Cdd:pfam16492  78 SE 79
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
249-348 1.84e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 1.84e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 249 YRASVLEDAPPGTVVVQVHATDLDEGPNGEIIYSFGNHNrasVRDLFSLDPVTGMLTIKGLLDFEDTKLHEIYIQAKDKG 328
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78
                          90       100
                  ....*....|....*....|
gi 1953003308 329 ATPEGAHCKVLVEVVDVNDN 348
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
33-113 7.17e-32

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 400525  Cd Length: 83  Bit Score: 118.78  E-value: 7.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  33 VRYEILEEREKGFAVGNVVTDLGLDLGSLSTRRLQVLPGASRRFFEVNRKTGEMFVNDRLDREELCGTLPSCTITLELVV 112
Cdd:pfam08266   2 IRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLL 81

                  .
gi 1953003308 113 E 113
Cdd:pfam08266  82 E 82
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
813-907 4.67e-30

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 115.50  E-value: 4.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 813 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 888
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80
                          90       100
                  ....*....|....*....|
gi 1953003308 889 HVPD-YRQNVYIPGSNATLT 907
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
461-563 9.85e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 9.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 461 SYDVYVEENNIPGVPILNLSVWDPDAPQNAHLSFFLLEQGTENglvgrYFTINRDNGIVSSLVSLDYEDRREFEITVYVT 540
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75
                          90       100
                  ....*....|....*....|...
gi 1953003308 541 DGGTPVLTTNISVNIFVTDRNDN 563
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
361-453 1.70e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 361 VPEDAPLGTVIALLSVIDLDAGENGLVTCEV---PPGLPFSLTSslkNYFTLKTSVALDRETVPEYNLSITARDAGTPSL 437
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82
                          90
                  ....*....|....*.
gi 1953003308 438 SALTVVRVQVSDINDN 453
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
267-350 3.45e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 3.45e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  267 HATDLDEGPNGEIIYSFgnhNRASVRDLFSLDPVTGMLTIKGLLDFEDTKLHEIYIQAKDKGATPEGAHCKVLVEVVDVN 346
Cdd:smart00112   1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77

                   ....
gi 1953003308  347 DNAP 350
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
480-565 4.15e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 4.15e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  480 SVWDPDAPQNAHLSFFLLEQGtenglVGRYFTINRDNGIVSSLVSLDYEDRREFEITVYVTDGGTPVLTTNISVNIFVTD 559
Cdd:smart00112   1 SATDADSGENGKVTYSILSGN-----DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75

                   ....*.
gi 1953003308  560 RNDNAP 565
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
139-240 1.32e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 139 EMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS---LNEYFALrvqtredSTKYAELVLERGLDWEREPSLQLVLT 215
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVT 73
                          90       100
                  ....*....|....*....|....*
gi 1953003308 216 ALDGGTPARSATLPIRITVLDANDN 240
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
249-342 8.43e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 8.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 249 YRASVLEDAPPGTVVVQVHATDLDEGPNGEIIYSFGNHNrasVRDLFSLDPVTGMLTIKGLLDFEDTKLHEIYIQAKDKG 328
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG---PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77
                          90
                  ....*....|....
gi 1953003308 329 ATPEGAHCKVLVEV 342
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
375-455 1.18e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  375 SVIDLDAGENGLVTCEV---PPGLPFSLTSslkNYFTLKTSVALDRETVPEYNLSITARDAGTPSLSALTVVRVQVSDIN 451
Cdd:smart00112   1 SATDADSGENGKVTYSIlsgNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77

                   ....
gi 1953003308  452 DNPP 455
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
462-558 2.17e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 462 YDVYVEENNIPGVPILNLSVWDPDAPQNAHLSFFLLEQGtenglVGRYFTINRDNGIVSSLVSLDYEDRREFEITVYVTD 541
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG-----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75
                          90
                  ....*....|....*..
gi 1953003308 542 GGTPVLTTNISVNIFVT 558
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
580-667 4.24e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 4.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 580 LPRSTAAGHVVTRVVGWDPDAGHNAWLCYSLLGASNQSLFAVGLHTGQVSTSRPVQDTDVPRQTLMVLIKDNGEPSLSTT 659
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85

                  ....*...
gi 1953003308 660 ATLTVSVT 667
Cdd:cd11304    86 ATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
158-242 2.31e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  158 SAHDPDVGSNSLQTYELS---LNEYFALrvqtrEDSTKyaELVLERGLDWEREPSLQLVLTALDGGTPARSATLPIRITV 234
Cdd:smart00112   1 SATDADSGENGKVTYSILsgnDDGLFSI-----DPETG--EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73

                   ....*...
gi 1953003308  235 LDANDNAP 242
Cdd:smart00112  74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
361-447 4.93e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 4.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 361 VPEDAPLGTVIALLSVIDLDAGENGLVT---CEVPPGLPFSLTSSLKnyfTLKTSVALDRETVPEYNLSITARDAGTPSL 437
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFysiLGGGPGGNFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPPL 81
                          90
                  ....*....|
gi 1953003308 438 SALTVVRVQV 447
Cdd:pfam00028  82 SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
597-669 4.93e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 4.93e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1953003308  597 DPDAGHNAWLCYSLLGASNQSLFAVGLHTGQVSTSRPVQDTDVPRQTLMVLIKDNGEPSLSTTATLTVSVTEE 669
Cdd:smart00112   4 DADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
34-131 3.44e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.63  E-value: 3.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  34 RYEILEEREKGFAVGNV-VTDLglDLGSLSTRRLQVLPGASRRFFEVNRKTGEMFVNDRLDREElcgtLPSCTITLElVV 112
Cdd:cd11304     3 EVSVPENAPPGTVVLTVsATDP--DSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVT-AT 75
                          90       100
                  ....*....|....*....|...
gi 1953003308 113 ETPLELFSA----EVVVQDINDN 131
Cdd:cd11304    76 DGGGPPLSStatvTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
580-667 8.50e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 8.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 580 LPRSTAAGHVVTRVVGWDPDAGHNAWLCYSLLGASNQSLFAVGLHTGQVSTSRPVqDTDVPRQ-TLMVLIKDNGEPSLST 658
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL-DRESIGEyELTVEATDSGGPPLSS 83

                  ....*....
gi 1953003308 659 TATLTVSVT 667
Cdd:pfam00028  84 TATVTITVL 92
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
689-770 3.57e-07

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 435374  Cd Length: 84  Bit Score: 48.68  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 689 NLTFYLLLSLILVSVGFAVTVLGVIIFKVYKWKQSKHLYRApvSSLYRTPvSSLHADAVRSGLMPPHLYHQVYLTTDSRH 768
Cdd:pfam16492   1 NLTFYLVIALASVSFLFLLSVIVLIALRLRRWRSSALLGSS--GSLCSVP-APHFPGNDGTGTLPQSYSYEVCLTSDSGK 77

                  ..
gi 1953003308 769 SD 770
Cdd:pfam16492  78 SE 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
50-133 6.97e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.73  E-value: 6.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308   50 VVTDLglDLGSLSTRRLQVLPGASRRFFEVNRKTGEMFVNDRLDREElcgtLPSCTITLELVVETPLELFS---AEVVVQ 126
Cdd:smart00112   1 SATDA--DSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGPPLSStatVTITVL 74

                   ....*..
gi 1953003308  127 DINDNNP 133
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
143-235 7.13e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 7.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 143 EISEAVAPGTRFPLESAHDPDVGSNSLQTYELSLNEY---FALRVQTREdstkyaeLVLERGLDWEREPSLQLVLTALDG 219
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDS 76
                          90
                  ....*....|....*.
gi 1953003308 220 GTPARSATLPIRITVL 235
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
249-348 1.84e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 1.84e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 249 YRASVLEDAPPGTVVVQVHATDLDEGPNGEIIYSFGNHNrasVRDLFSLDPVTGMLTIKGLLDFEDTKLHEIYIQAKDKG 328
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGN---EDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78
                          90       100
                  ....*....|....*....|
gi 1953003308 329 ATPEGAHCKVLVEVVDVNDN 348
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
33-113 7.17e-32

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 400525  Cd Length: 83  Bit Score: 118.78  E-value: 7.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  33 VRYEILEEREKGFAVGNVVTDLGLDLGSLSTRRLQVLPGASRRFFEVNRKTGEMFVNDRLDREELCGTLPSCTITLELVV 112
Cdd:pfam08266   2 IRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVLL 81

                  .
gi 1953003308 113 E 113
Cdd:pfam08266  82 E 82
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
813-907 4.67e-30

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 115.50  E-value: 4.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 813 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 888
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80
                          90       100
                  ....*....|....*....|
gi 1953003308 889 HVPD-YRQNVYIPGSNATLT 907
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
461-563 9.85e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 9.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 461 SYDVYVEENNIPGVPILNLSVWDPDAPQNAHLSFFLLEQGTENglvgrYFTINRDNGIVSSLVSLDYEDRREFEITVYVT 540
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75
                          90       100
                  ....*....|....*....|...
gi 1953003308 541 DGGTPVLTTNISVNIFVTDRNDN 563
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
361-453 1.70e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 1.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 361 VPEDAPLGTVIALLSVIDLDAGENGLVTCEV---PPGLPFSLTSslkNYFTLKTSVALDRETVPEYNLSITARDAGTPSL 437
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82
                          90
                  ....*....|....*.
gi 1953003308 438 SALTVVRVQVSDINDN 453
Cdd:cd11304    83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
267-350 3.45e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 3.45e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  267 HATDLDEGPNGEIIYSFgnhNRASVRDLFSLDPVTGMLTIKGLLDFEDTKLHEIYIQAKDKGATPEGAHCKVLVEVVDVN 346
Cdd:smart00112   1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77

                   ....
gi 1953003308  347 DNAP 350
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
480-565 4.15e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 4.15e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  480 SVWDPDAPQNAHLSFFLLEQGtenglVGRYFTINRDNGIVSSLVSLDYEDRREFEITVYVTDGGTPVLTTNISVNIFVTD 559
Cdd:smart00112   1 SATDADSGENGKVTYSILSGN-----DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75

                   ....*.
gi 1953003308  560 RNDNAP 565
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
139-240 1.32e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 139 EMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS---LNEYFALrvqtredSTKYAELVLERGLDWEREPSLQLVLT 215
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSI-------DPSTGEITTAKPLDREEQSSYTLTVT 73
                          90       100
                  ....*....|....*....|....*
gi 1953003308 216 ALDGGTPARSATLPIRITVLDANDN 240
Cdd:cd11304    74 ATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
249-342 8.43e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 8.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 249 YRASVLEDAPPGTVVVQVHATDLDEGPNGEIIYSFGNHNrasVRDLFSLDPVTGMLTIKGLLDFEDTKLHEIYIQAKDKG 328
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG---PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77
                          90
                  ....*....|....
gi 1953003308 329 ATPEGAHCKVLVEV 342
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
375-455 1.18e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  375 SVIDLDAGENGLVTCEV---PPGLPFSLTSslkNYFTLKTSVALDRETVPEYNLSITARDAGTPSLSALTVVRVQVSDIN 451
Cdd:smart00112   1 SATDADSGENGKVTYSIlsgNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77

                   ....
gi 1953003308  452 DNPP 455
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
462-558 2.17e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.50  E-value: 2.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 462 YDVYVEENNIPGVPILNLSVWDPDAPQNAHLSFFLLEQGtenglVGRYFTINRDNGIVSSLVSLDYEDRREFEITVYVTD 541
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG-----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75
                          90
                  ....*....|....*..
gi 1953003308 542 GGTPVLTTNISVNIFVT 558
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
580-667 4.24e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.05  E-value: 4.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 580 LPRSTAAGHVVTRVVGWDPDAGHNAWLCYSLLGASNQSLFAVGLHTGQVSTSRPVQDTDVPRQTLMVLIKDNGEPSLSTT 659
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85

                  ....*...
gi 1953003308 660 ATLTVSVT 667
Cdd:cd11304    86 ATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
158-242 2.31e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 2.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  158 SAHDPDVGSNSLQTYELS---LNEYFALrvqtrEDSTKyaELVLERGLDWEREPSLQLVLTALDGGTPARSATLPIRITV 234
Cdd:smart00112   1 SATDADSGENGKVTYSILsgnDDGLFSI-----DPETG--EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73

                   ....*...
gi 1953003308  235 LDANDNAP 242
Cdd:smart00112  74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
361-447 4.93e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 4.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 361 VPEDAPLGTVIALLSVIDLDAGENGLVT---CEVPPGLPFSLTSSLKnyfTLKTSVALDRETVPEYNLSITARDAGTPSL 437
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFysiLGGGPGGNFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPPL 81
                          90
                  ....*....|
gi 1953003308 438 SALTVVRVQV 447
Cdd:pfam00028  82 SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
597-669 4.93e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 4.93e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1953003308  597 DPDAGHNAWLCYSLLGASNQSLFAVGLHTGQVSTSRPVQDTDVPRQTLMVLIKDNGEPSLSTTATLTVSVTEE 669
Cdd:smart00112   4 DADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
34-131 3.44e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.63  E-value: 3.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  34 RYEILEEREKGFAVGNV-VTDLglDLGSLSTRRLQVLPGASRRFFEVNRKTGEMFVNDRLDREElcgtLPSCTITLElVV 112
Cdd:cd11304     3 EVSVPENAPPGTVVLTVsATDP--DSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVT-AT 75
                          90       100
                  ....*....|....*....|...
gi 1953003308 113 ETPLELFSA----EVVVQDINDN 131
Cdd:cd11304    76 DGGGPPLSStatvTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
580-667 8.50e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 8.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 580 LPRSTAAGHVVTRVVGWDPDAGHNAWLCYSLLGASNQSLFAVGLHTGQVSTSRPVqDTDVPRQ-TLMVLIKDNGEPSLST 658
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL-DRESIGEyELTVEATDSGGPPLSS 83

                  ....*....
gi 1953003308 659 TATLTVSVT 667
Cdd:pfam00028  84 TATVTITVL 92
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
689-770 3.57e-07

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 435374  Cd Length: 84  Bit Score: 48.68  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 689 NLTFYLLLSLILVSVGFAVTVLGVIIFKVYKWKQSKHLYRApvSSLYRTPvSSLHADAVRSGLMPPHLYHQVYLTTDSRH 768
Cdd:pfam16492   1 NLTFYLVIALASVSFLFLLSVIVLIALRLRRWRSSALLGSS--GSLCSVP-APHFPGNDGTGTLPQSYSYEVCLTSDSGK 77

                  ..
gi 1953003308 769 SD 770
Cdd:pfam16492  78 SE 79
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
50-133 6.97e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.73  E-value: 6.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308   50 VVTDLglDLGSLSTRRLQVLPGASRRFFEVNRKTGEMFVNDRLDREElcgtLPSCTITLELVVETPLELFS---AEVVVQ 126
Cdd:smart00112   1 SATDA--DSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGPPLSStatVTITVL 74

                   ....*..
gi 1953003308  127 DINDNNP 133
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
143-235 7.13e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 7.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308 143 EISEAVAPGTRFPLESAHDPDVGSNSLQTYELSLNEY---FALRVQTREdstkyaeLVLERGLDWEREPSLQLVLTALDG 219
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDS 76
                          90
                  ....*....|....*.
gi 1953003308 220 GTPARSATLPIRITVL 235
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
35-131 4.84e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.41  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953003308  35 YEILEEREKGFAVGNVVTDLGldlgSLSTRRLQVLPGASRR---FFEVNRKTGEMFVNDRLDREELCGTLPSCTI--TLE 109
Cdd:cd00031     4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEAlpsWLHWEPHSGILEGLEKLDREDKGVHYISVSAasLGA 79
                          90       100
                  ....*....|....*....|..
gi 1953003308 110 LVVETPLELfsaEVVVQDINDN 131
Cdd:cd00031    80 NVPQTSSVF---SIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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