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Conserved domains on  [gi|1953097365|ref|XP_038404037|]
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fibronectin type III domain-containing protein 8 [Canis lupus familiaris]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10440908)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
187-267 6.19e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 6.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953097365 187 VSDSTAVISWTYAL-GKQQVSFYQVLLQEVaktNDNEPPKAKNRPWifNKilgTTVKLMELKPNTSYCLTVRAANTAGVG 265
Cdd:pfam00041  11 VTSTSLTVSWTPPPdGNGPITGYEVEYRPK---NSGEPWNEITVPG--TT---TSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                  ..
gi 1953097365 266 KW 267
Cdd:pfam00041  83 PP 84
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
187-267 6.19e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 6.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953097365 187 VSDSTAVISWTYAL-GKQQVSFYQVLLQEVaktNDNEPPKAKNRPWifNKilgTTVKLMELKPNTSYCLTVRAANTAGVG 265
Cdd:pfam00041  11 VTSTSLTVSWTPPPdGNGPITGYEVEYRPK---NSGEPWNEITVPG--TT---TSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                  ..
gi 1953097365 266 KW 267
Cdd:pfam00041  83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 185-275 1.33e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953097365 185 HTVSDSTAVISWTYALGKQ-QVSFYQVllqEVAKTNDNEPPKAKNRPwifnkILGTTVKLMELKPNTSYCLTVRAANTAG 263
Cdd:cd00063    10 TDVTSTSVTLSWTPPEDDGgPITGYVV---EYREKGSGDWKEVEVTP-----GSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 1953097365 264 VGKWCKPYKFAT 275
Cdd:cd00063    82 ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 185-265 9.43e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 9.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953097365  185 HTVSDSTAVISWTYALGKQQVSF---YQVLLQEVAKTNDNEPPKAKNrpwifnkilgTTVKLMELKPNTSYCLTVRAANT 261
Cdd:smart00060  10 TDVTSTSVTLSWEPPPDDGITGYivgYRVEYREEGSEWKEVNVTPSS----------TSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
gi 1953097365  262 AGVG 265
Cdd:smart00060  80 AGEG 83
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
187-267 6.19e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 6.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953097365 187 VSDSTAVISWTYAL-GKQQVSFYQVLLQEVaktNDNEPPKAKNRPWifNKilgTTVKLMELKPNTSYCLTVRAANTAGVG 265
Cdd:pfam00041  11 VTSTSLTVSWTPPPdGNGPITGYEVEYRPK---NSGEPWNEITVPG--TT---TSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                  ..
gi 1953097365 266 KW 267
Cdd:pfam00041  83 PP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 185-275 1.33e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953097365 185 HTVSDSTAVISWTYALGKQ-QVSFYQVllqEVAKTNDNEPPKAKNRPwifnkILGTTVKLMELKPNTSYCLTVRAANTAG 263
Cdd:cd00063    10 TDVTSTSVTLSWTPPEDDGgPITGYVV---EYREKGSGDWKEVEVTP-----GSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 1953097365 264 VGKWCKPYKFAT 275
Cdd:cd00063    82 ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 185-265 9.43e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 9.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953097365  185 HTVSDSTAVISWTYALGKQQVSF---YQVLLQEVAKTNDNEPPKAKNrpwifnkilgTTVKLMELKPNTSYCLTVRAANT 261
Cdd:smart00060  10 TDVTSTSVTLSWEPPPDDGITGYivgYRVEYREEGSEWKEVNVTPSS----------TSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
gi 1953097365  262 AGVG 265
Cdd:smart00060  80 AGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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