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Conserved domains on  [gi|1953316760|ref|XP_038514625|]
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protocadherin gamma-B2 isoform X6 [Canis lupus familiaris]

Protein Classification

protocadherin( domain architecture ID 11175791)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 32-112 4.82e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 130.73  E-value: 4.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  32 QIRYSIPEELAKNSVVGNLAKDLGLSVRDLPARKLRV--SAEKEYFTVNPESGDLLVSDRIDREQICGKKSLCILDFDTV 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVvsKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 1953316760 110 AEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 687-769 2.97e-32

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 119.94  E-value: 2.97e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 687 ELQFYLVVALALISVLFLLAVILAVALRLRRSSSSTTWGCFQtNVCSKTESGVISSYSEGTLP--YSYNLCAASHSSKTD 764
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSG-NLCSVPAPHFPGNDGTGTLPqsYSYEVCLTSDSGKSE 79


                  ....*
gi 1953316760 765 FKFLN 769
Cdd:pfam16492  80 FKFLK 84
Cadherin_tail super family cl24520
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 810-904 1.19e-29

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


The actual alignment was detected with superfamily member pfam15974:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 114.73  E-value: 1.19e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 810 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 885
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 1953316760 886 HVPD-YRQNVYIPGSNATLT 904
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 2.65e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 2.65e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 456 SYVVHVAENNPPAASIAQVSASDPDLGPNGRVSYSIVASDLEpralaSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQAR 535
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1953316760 536 DQGSPALSANVSLRVLVGDRNDN 558
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-342 2.79e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 2.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 246 IYKVSLQEGVPRGFSVLRVTATDQDEGVNAEITYSFHNVDElvEQFFNLDKTTGEITTKDYFDFETANSYTLSVEAKDPG 325
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90
                  ....*....|....*....
gi 1953316760 326 D--LAAHCSIQVEILDEND 342
Cdd:cd11304    79 GppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 351-448 1.44e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 351 SIFTPLPEDSPPGTVVALIKTRDRDSGENGEVYCSILGKAD---FILNSYSknyYKLVTDGPLDREEIPEYNISVMATDR 427
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPST---GEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1953316760 428 GKPPLSSSISITLHIADVNDN 448
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 144-238 2.85e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 144 ESTKPGKTFPLDPALDSDAGPNSLQRYHL---NDNEHFDLSEKqtpNGhkypELILKHFLDREKQSFHQLVLTAVDGGDP 220
Cdd:cd11304     8 ENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDPS---TG----EITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1953316760 221 PQSGTTQIQIQVTDANDN 238
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 577-662 2.88e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 577 TVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLS 655
Cdd:cd11304     5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-DREEQSSyTLTVTATDGGGPPLS 83


                  ....*..
gi 1953316760 656 ATATLLL 662
Cdd:cd11304    84 STATVTI 90
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 32-112 4.82e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 130.73  E-value: 4.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  32 QIRYSIPEELAKNSVVGNLAKDLGLSVRDLPARKLRV--SAEKEYFTVNPESGDLLVSDRIDREQICGKKSLCILDFDTV 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVvsKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 1953316760 110 AEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 687-769 2.97e-32

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 119.94  E-value: 2.97e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 687 ELQFYLVVALALISVLFLLAVILAVALRLRRSSSSTTWGCFQtNVCSKTESGVISSYSEGTLP--YSYNLCAASHSSKTD 764
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSG-NLCSVPAPHFPGNDGTGTLPqsYSYEVCLTSDSGKSE 79


                  ....*
gi 1953316760 765 FKFLN 769
Cdd:pfam16492  80 FKFLK 84
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 810-904 1.19e-29

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 114.73  E-value: 1.19e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 810 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 885
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 1953316760 886 HVPD-YRQNVYIPGSNATLT 904
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 2.65e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 2.65e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 456 SYVVHVAENNPPAASIAQVSASDPDLGPNGRVSYSIVASDLEpralaSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQAR 535
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1953316760 536 DQGSPALSANVSLRVLVGDRNDN 558
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-342 2.79e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 2.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 246 IYKVSLQEGVPRGFSVLRVTATDQDEGVNAEITYSFHNVDElvEQFFNLDKTTGEITTKDYFDFETANSYTLSVEAKDPG 325
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90
                  ....*....|....*....
gi 1953316760 326 D--LAAHCSIQVEILDEND 342
Cdd:cd11304    79 GppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 351-448 1.44e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 351 SIFTPLPEDSPPGTVVALIKTRDRDSGENGEVYCSILGKAD---FILNSYSknyYKLVTDGPLDREEIPEYNISVMATDR 427
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPST---GEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1953316760 428 GKPPLSSSISITLHIADVNDN 448
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 144-238 2.85e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 144 ESTKPGKTFPLDPALDSDAGPNSLQRYHL---NDNEHFDLSEKqtpNGhkypELILKHFLDREKQSFHQLVLTAVDGGDP 220
Cdd:cd11304     8 ENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDPS---TG----EITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1953316760 221 PQSGTTQIQIQVTDANDN 238
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 577-662 2.88e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 577 TVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLS 655
Cdd:cd11304     5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-DREEQSSyTLTVTATDGGGPPLS 83


                  ....*..
gi 1953316760 656 ATATLLL 662
Cdd:cd11304    84 STATVTI 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 372-450 1.20e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 1.20e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  372 RDRDSGENGEVYCSILGKAD---FILNSYSKnyyKLVTDGPLDREEIPEYNISVMATDRGKPPLSSSISITLHIADVNDN 448
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDdglFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1953316760  449 AP 450
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 2.29e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 2.29e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  475 SASDPDLGPNGRVSYSIVASDLEpralaSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGD 554
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1953316760  555 RNDNAP 560
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 1.68e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 1.68e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  265 TATDQDEGVNAEITYSFhnVDELVEQFFNLDKTTGEITTKDYFDFETANSYTLSVEAKDPG--DLAAHCSIQVEILDEND 342
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpPLSSTATVTITVLDVND 78


                   ...
gi 1953316760  343 CAP 345
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 1.98e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  157 ALDSDAGPNSLQRYHL---NDNEHFDLSEKqtpNGhkypELILKHFLDREKQSFHQLVLTAVDGGDPPQSGTTQIQIQVT 233
Cdd:smart00112   2 ATDADSGENGKVTYSIlsgNDDGLFSIDPE---TG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1953316760  234 DANDNPP 240
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
457-552 7.70e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 7.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 457 YVVHVAENNPPAASIAQVSASDPDLGPNGRVSYSIVASDLEPRalasyVSVSAQSGVVFAQRAFDHEQLRAFELTLQARD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*.
gi 1953316760 537 QGSPALSANVSLRVLV 552
Cdd:pfam00028  76 SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
356-442 1.49e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 356 LPEDSPPGTVVALIKTRDRDSGENGEVYCSILG---KADFILNSYSKNyykLVTDGPLDREEIPEYNISVMATDRGKPPL 432
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGggpGGNFRIDPDTGD---ISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 1953316760 433 SSSISITLHI 442
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
247-336 3.47e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 3.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 247 YKVSLQEGVPRGFSVLRVTATDQDEGVNAEITYSFHNVDElvEQFFNLDKTTGEITTKDYFDFETANSYTLSVEAKDPGD 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 1953316760 327 LA----AHCSIQVE 336
Cdd:pfam00028  79 PPlsstATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-660 5.82e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 5.82e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  592 VAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDA-ARQRLLVAVRDGGQPPLSATATL 660
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL-DREEqPEYTLTVEATDGGGPPLSSTATV 69
Cadherin pfam00028
Cadherin domain;
577-660 3.58e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 3.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 577 TVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLS 655
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL-DRESIGEyELTVEATDSGGPPLS 82


                  ....*
gi 1953316760 656 ATATL 660
Cdd:pfam00028  83 STATV 87
Cadherin pfam00028
Cadherin domain;
142-233 1.24e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 142 IGESTKPGKTFPLDPALDSDAGPNSLQRYHL---NDNEHFDLSEKqtpNGhkypELILKHFLDREKQSFHQLVLTAVDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPD---TG----DISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 1953316760 219 DPPQSGTTQIQIQVT 233
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 2.89e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  32 QIRYSIPEELAKNSVVGNL-AKDlglsvRDLPAR-----KLRVSAEKEYFTVNPESGDLLVSDRIDREQICgKKSLCILD 105
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVsATD-----PDSGENgevtySIVSGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTA 74

                          90       100
                  ....*....|....*....|....
gi 1953316760 106 FDTVAENPLNIFHVAVLVQDINDN 129
Cdd:cd11304    75 TDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 71-131 1.14e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.14e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953316760   71 EKEYFTVNPESGDLLVSDRIDREQIcGKKSLCILDFDTVAENPLNIFHVAVLVQDINDNTP 131
Cdd:smart00112  22 DDGLFSIDPETGEITTTKPLDREEQ-PEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 32-112 4.82e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 130.73  E-value: 4.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  32 QIRYSIPEELAKNSVVGNLAKDLGLSVRDLPARKLRV--SAEKEYFTVNPESGDLLVSDRIDREQICGKKSLCILDFDTV 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVvsKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 1953316760 110 AEN 112
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 687-769 2.97e-32

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 119.94  E-value: 2.97e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 687 ELQFYLVVALALISVLFLLAVILAVALRLRRSSSSTTWGCFQtNVCSKTESGVISSYSEGTLP--YSYNLCAASHSSKTD 764
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSG-NLCSVPAPHFPGNDGTGTLPqsYSYEVCLTSDSGKSE 79


                  ....*
gi 1953316760 765 FKFLN 769
Cdd:pfam16492  80 FKFLK 84
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 810-904 1.19e-29

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 114.73  E-value: 1.19e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 810 PPNTDWRFSQAQRPGTSGS-QNGDETGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 885
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 1953316760 886 HVPD-YRQNVYIPGSNATLT 904
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 2.65e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 2.65e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 456 SYVVHVAENNPPAASIAQVSASDPDLGPNGRVSYSIVASDLEpralaSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQAR 535
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|...
gi 1953316760 536 DQGSPALSANVSLRVLVGDRNDN 558
Cdd:cd11304    76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-342 2.79e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.02  E-value: 2.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 246 IYKVSLQEGVPRGFSVLRVTATDQDEGVNAEITYSFHNVDElvEQFFNLDKTTGEITTKDYFDFETANSYTLSVEAKDPG 325
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90
                  ....*....|....*....
gi 1953316760 326 D--LAAHCSIQVEILDEND 342
Cdd:cd11304    79 GppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 351-448 1.44e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 351 SIFTPLPEDSPPGTVVALIKTRDRDSGENGEVYCSILGKAD---FILNSYSknyYKLVTDGPLDREEIPEYNISVMATDR 427
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPST---GEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1953316760 428 GKPPLSSSISITLHIADVNDN 448
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 144-238 2.85e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 144 ESTKPGKTFPLDPALDSDAGPNSLQRYHL---NDNEHFDLSEKqtpNGhkypELILKHFLDREKQSFHQLVLTAVDGGDP 220
Cdd:cd11304     8 ENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDPS---TG----EITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1953316760 221 PQSGTTQIQIQVTDANDN 238
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 577-662 2.88e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.88e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 577 TVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLS 655
Cdd:cd11304     5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-DREEQSSyTLTVTATDGGGPPLS 83


                  ....*..
gi 1953316760 656 ATATLLL 662
Cdd:cd11304    84 STATVTI 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 372-450 1.20e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 1.20e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  372 RDRDSGENGEVYCSILGKAD---FILNSYSKnyyKLVTDGPLDREEIPEYNISVMATDRGKPPLSSSISITLHIADVNDN 448
Cdd:smart00112   3 TDADSGENGKVTYSILSGNDdglFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1953316760  449 AP 450
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 2.29e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 2.29e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  475 SASDPDLGPNGRVSYSIVASDLEpralaSYVSVSAQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGD 554
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1953316760  555 RNDNAP 560
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 1.68e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 1.68e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  265 TATDQDEGVNAEITYSFhnVDELVEQFFNLDKTTGEITTKDYFDFETANSYTLSVEAKDPG--DLAAHCSIQVEILDEND 342
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpPLSSTATVTITVLDVND 78


                   ...
gi 1953316760  343 CAP 345
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 1.98e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  157 ALDSDAGPNSLQRYHL---NDNEHFDLSEKqtpNGhkypELILKHFLDREKQSFHQLVLTAVDGGDPPQSGTTQIQIQVT 233
Cdd:smart00112   2 ATDADSGENGKVTYSIlsgNDDGLFSIDPE---TG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1953316760  234 DANDNPP 240
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
457-552 7.70e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 7.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 457 YVVHVAENNPPAASIAQVSASDPDLGPNGRVSYSIVASDLEPRalasyVSVSAQSGVVFAQRAFDHEQLRAFELTLQARD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*.
gi 1953316760 537 QGSPALSANVSLRVLV 552
Cdd:pfam00028  76 SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
356-442 1.49e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 1.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 356 LPEDSPPGTVVALIKTRDRDSGENGEVYCSILG---KADFILNSYSKNyykLVTDGPLDREEIPEYNISVMATDRGKPPL 432
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGggpGGNFRIDPDTGD---ISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 1953316760 433 SSSISITLHI 442
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
247-336 3.47e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 3.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 247 YKVSLQEGVPRGFSVLRVTATDQDEGVNAEITYSFHNVDElvEQFFNLDKTTGEITTKDYFDFETANSYTLSVEAKDPGD 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGP--GGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 1953316760 327 LA----AHCSIQVE 336
Cdd:pfam00028  79 PPlsstATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-660 5.82e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 5.82e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  592 VAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDA-ARQRLLVAVRDGGQPPLSATATL 660
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL-DREEqPEYTLTVEATDGGGPPLSSTATV 69
Cadherin pfam00028
Cadherin domain;
577-660 3.58e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 3.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 577 TVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLS 655
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL-DRESIGEyELTVEATDSGGPPLS 82


                  ....*
gi 1953316760 656 ATATL 660
Cdd:pfam00028  83 STATV 87
Cadherin pfam00028
Cadherin domain;
142-233 1.24e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.77  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 142 IGESTKPGKTFPLDPALDSDAGPNSLQRYHL---NDNEHFDLSEKqtpNGhkypELILKHFLDREKQSFHQLVLTAVDGG 218
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPD---TG----DISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 1953316760 219 DPPQSGTTQIQIQVT 233
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 2.89e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 2.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  32 QIRYSIPEELAKNSVVGNL-AKDlglsvRDLPAR-----KLRVSAEKEYFTVNPESGDLLVSDRIDREQICgKKSLCILD 105
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVsATD-----PDSGENgevtySIVSGNEDGLFSIDPSTGEITTAKPLDREEQS-SYTLTVTA 74

                          90       100
                  ....*....|....*....|....
gi 1953316760 106 FDTVAENPLNIFHVAVLVQDINDN 129
Cdd:cd11304    75 TDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 71-131 1.14e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.26  E-value: 1.14e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1953316760   71 EKEYFTVNPESGDLLVSDRIDREQIcGKKSLCILDFDTVAENPLNIFHVAVLVQDINDNTP 131
Cdd:smart00112  22 DDGLFSIDPETGEITTTKPLDREEQ-PEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 3.99e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.49  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760  33 IRYSIPEELAKNSVVGNLAKDLGLSVRDLpARKLRVSAEK--EYFTVNPESGDLLVSDRIDREQICgKKSLCILDFDTVA 110
Cdd:cd00031     2 PDGSAVEGRSRGSFRVSIPTDLIASSGEI-IKISAAGKEAlpSWLHWEPHSGILEGLEKLDREDKG-VHYISVSAASLGA 79

                          90
                  ....*....|....*....
gi 1953316760 111 ENPLNIFHVAVLVQDINDN 129
Cdd:cd00031    80 NVPQTSSVFSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 353-448 3.53e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 37.71  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1953316760 353 FTPLPEDSPPGTVVALIKTRDRDSGEngevYCSILGKAD------FILNSYSKNyykLVTDGPLDREEIPEYNISVMATD 426
Cdd:cd00031     4 GSAVEGRSRGSFRVSIPTDLIASSGE----IIKISAAGKealpswLHWEPHSGI---LEGLEKLDREDKGVHYISVSAAS 76

                          90       100
                  ....*....|....*....|..
gi 1953316760 427 RGKPPLSSSISITLHIADVNDN 448
Cdd:cd00031    77 LGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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