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Conserved domains on  [gi|1958799394|ref|XP_038938473|]
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inhibitor of Bruton tyrosine kinase isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 763-875 5.21e-65

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 215.31  E-value: 5.21e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  763 KCSFLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVD 842
Cdd:cd18302      1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958799394  843 FVCSVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18302     81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 546-651 8.68e-45

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 157.06  E-value: 8.68e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  546 FFEEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyRKDEDAAGCHLFVVEKVHP 625
Cdd:cd18301      1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                           90       100
                   ....*....|....*....|....*.
gi 1958799394  626 DLFEYLLQFMYTDTCDFLTHGFKPRM 651
Cdd:cd18301     72 EIFEQLLQFIYTDTCDLLTDGYKPKL 97
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 871-930 6.95e-30

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


:

Pssm-ID: 350575  Cd Length: 60  Bit Score: 112.99  E-value: 6.95e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  871 LTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKM 930
Cdd:cd18500      1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 super family cl34932
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 1.76e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


The actual alignment was detected with superfamily member COG5184:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 91.58  E-value: 1.76e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184    118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  223 VEGLSGHScsQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184    195 VGGLSGVV--AVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  302 EAVYTLGLNG-GQLGhlldpNGEKC-VTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184    268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 7.34e-14

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.83  E-value: 7.34e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799394   47 VKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666    148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 763-875 5.21e-65

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 215.31  E-value: 5.21e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  763 KCSFLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVD 842
Cdd:cd18302      1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958799394  843 FVCSVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18302     81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 546-651 8.68e-45

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 157.06  E-value: 8.68e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  546 FFEEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyRKDEDAAGCHLFVVEKVHP 625
Cdd:cd18301      1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                           90       100
                   ....*....|....*....|....*.
gi 1958799394  626 DLFEYLLQFMYTDTCDFLTHGFKPRM 651
Cdd:cd18301     72 EIFEQLLQFIYTDTCDLLTDGYKPKL 97
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 871-930 6.95e-30

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 112.99  E-value: 6.95e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  871 LTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKM 930
Cdd:cd18500      1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 1.76e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 91.58  E-value: 1.76e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184    118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  223 VEGLSGHScsQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184    195 VGGLSGVV--AVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  302 EAVYTLGLNG-GQLGhlldpNGEKC-VTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184    268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 761-871 6.35e-17

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 77.68  E-value: 6.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  761 QKKCSFLYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavvIKESQN 840
Cdd:pfam00651    4 LREQGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK---LISEEN 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958799394  841 VDfvcSVLVVADQLLITRLKEMCEVALAENL 871
Cdd:pfam00651   80 VD---DLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 561-639 2.55e-15

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 73.06  E-value: 2.55e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799394  561 DSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 639
Cdd:pfam00651    8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-------------VSPEDFEALLEFMYTGK 73
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 769-871 1.00e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 71.18  E-value: 1.00e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavVIKESQNVDfvcSVL 848
Cdd:smart00225    1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGK--LDLPEENVE---ELL 74

                            90       100
                    ....*....|....*....|...
gi 1958799394   849 VVADQLLITRLKEMCEVALAENL 871
Cdd:smart00225   75 ELADYLQIPGLVELCEEFLLKLL 97
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 565-639 1.75e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 70.41  E-value: 1.75e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394   565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 639
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGK 62
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 7.34e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.83  E-value: 7.34e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799394   47 VKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666    148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-116 1.38e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 1.38e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   27 KGSERQIKIFLSSYCynAATVKDAFGRNALHLVSSCGKKAVLDWLIEKGVdllVKDKESGWTALHRSIFYGHINCVWSLL 106
Cdd:pfam12796    7 NGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKLLL 81

                           90
                   ....*....|
gi 1958799394  107 KHGVSLYMQD 116
Cdd:pfam12796   82 EKGADINVKD 91
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
247-299 1.58e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.22  E-value: 1.58e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  247 DGCVYTFGLNTFHQLGiIPPPSSCNVPRQIQAkyLKGRTIIGVAAGRFHTVLW 299
Cdd:pfam00415    1 DGRVYTWGRNDYGQLG-LGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 17-123 3.31e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 3.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   17 HALDVLSVITKGSERQIKIFLSsycYNA-ATVKDAFGRNALHLVSSCG--KKAVLDWLIEKGVDLLVKDK---------- 83
Cdd:PHA03100   108 TPLLYAISKKSNSYSIVEYLLD---NGAnVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDINAKNRvnyllsygvp 184

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958799394   84 -----ESGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PHA03100   185 inikdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
PHA03098 PHA03098
kelch-like protein; Provisional
 783-923 7.16e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.52  E-value: 7.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  783 HKCVLCARLEYFHSMLSRSWIEAsscaALEMPIQAEILKVILDYLYTDeaVVIKESQNVDfvcSVLVVADQLLITRLKEM 862
Cdd:PHA03098    26 HKIILSSSSEYFKKMFKNNFKEN----EINLNIDYDSFNEVIKYIYTG--KINITSNNVK---DILSIANYLIIDFLINL 96

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958799394  863 CEVALAENLTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDL 923
Cdd:PHA03098    97 CINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI 157
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 763-875 5.21e-65

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 215.31  E-value: 5.21e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  763 KCSFLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVD 842
Cdd:cd18302      1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958799394  843 FVCSVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18302     81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 546-651 8.68e-45

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 157.06  E-value: 8.68e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  546 FFEEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyRKDEDAAGCHLFVVEKVHP 625
Cdd:cd18301      1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                           90       100
                   ....*....|....*....|....*.
gi 1958799394  626 DLFEYLLQFMYTDTCDFLTHGFKPRM 651
Cdd:cd18301     72 EIFEQLLQFIYTDTCDLLTDGYKPKL 97
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 871-930 6.95e-30

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 112.99  E-value: 6.95e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  871 LTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKM 930
Cdd:cd18500      1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-854 1.19e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 84.53  E-value: 1.19e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  767 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEAVVikesqNVDFVC 845
Cdd:cd18186      1 LCDVTLV-VGGREFPAHRAVLAARSPYFRAMFSSGMKESSS-SEIELDdVSPEAFEALLDYIYTGELEL-----SEENVE 73


                   ....*....
gi 1958799394  846 SVLVVADQL 854
Cdd:cd18186     74 ELLAAADKL 82
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 1.76e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 91.58  E-value: 1.76e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184    118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  223 VEGLSGHScsQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184    195 VGGLSGVV--AVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  302 EAVYTLGLNG-GQLGhlldpNGEKC-VTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184    268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-362 4.65e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 90.42  E-value: 4.65e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  144 VYTWGDNTNFTLGHGSQNSKHHPELLDLFSRsrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRLV 223
Cdd:COG5184     19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN----VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKV 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  224 EGLSGhsCSQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGiIPPPSSCNVPRQIQAkylKGRTIIGVAAGRFHTVLWTRE- 302
Cdd:COG5184     95 PGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG-DGTTTNRLTPVQVDA---GLSGVVAIAAGGYHTCALKSDg 168

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958799394  303 AVYTLGLNG-GQLGHLLDPNgekcVTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184    169 TVWCWGANSyGQLGDGTTTD----RPTPVQVGGLSG----VVAVAAGGDHSCALKSDGTVW 221
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-642 6.28e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 76.82  E-value: 6.28e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyrkdeDAAGCHLFVVEKVHPDLFEYLLQFMYTDTCDF 642
Cdd:cd18186      1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGM-------------KESSSSEIELDDVSPEAFEALLDYIYTGELEL 67
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 761-871 6.35e-17

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 77.68  E-value: 6.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  761 QKKCSFLYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavvIKESQN 840
Cdd:pfam00651    4 LREQGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK---LISEEN 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958799394  841 VDfvcSVLVVADQLLITRLKEMCEVALAENL 871
Cdd:pfam00651   80 VD---DLLAAADKLQIPSLVDKCEEFLIKSL 107
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 1.09e-15

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 80.02  E-value: 1.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRsrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184     68 TVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG----VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQ 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  223 V-EGLSGhsCSQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSScNVPRQIQAKylkgRTIIGVAAGRFHT-VLWT 300
Cdd:COG5184    144 VdAGLSG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDR-PTPVQVGGL----SGVVAVAAGGDHScALKS 216

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  301 REAVYTLGLNG-GQLGHLLDPNgekcVTTPRQVSALHhkdiAVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184    217 DGTVWCWGSNSsGQLGDGTTTD----RATPVQVAGLT----GVVAIAAGGSHTCALKSDGTVW 271
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 766-871 1.65e-15

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 74.25  E-value: 1.65e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  766 FLYDVTMKsVDGKEFPCHKCVLCARLEYFHSML----SRSWIEASSCAALEMP-IQAEILKVILDYLYTDEAVVikesqN 840
Cdd:cd18296     16 SFPDVCFQ-VEGHRFPCHKAFFCGRSDYFKALLrdhfAESEENNGSIPVVTLHdVSPEVFAIVLYYIYTDDTDL-----P 89

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958799394  841 VDFVCSVLVVADQLLITRLKEMCEVALAENL 871
Cdd:cd18296     90 PENAYDVLYVADMYLLPGLKRLCGTVLAQSL 120
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 561-639 2.55e-15

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 73.06  E-value: 2.55e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799394  561 DSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 639
Cdd:pfam00651    8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-------------VSPEDFEALLEFMYTGK 73
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 769-871 1.00e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 71.18  E-value: 1.00e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavVIKESQNVDfvcSVL 848
Cdd:smart00225    1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGK--LDLPEENVE---ELL 74

                            90       100
                    ....*....|....*....|...
gi 1958799394   849 VVADQLLITRLKEMCEVALAENL 871
Cdd:smart00225   75 ELADYLQIPGLVELCEEFLLKLL 97
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 757-861 1.25e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 71.52  E-value: 1.25e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  757 LKLSQKkcSFLYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCaalEMPIQA---EILKVILDYLYTDeAV 833
Cdd:cd18286      9 LQLFLN--GEDSDITIK-VDGKTFKAHRCILCARSSYFAAMLSGSWAESNSS---EITLTGvshAAVSFVLLFIYGG-VL 81

                           90       100
                   ....*....|....*....|....*...
gi 1958799394  834 VIKESQNvdfVCSVLVVADQLLITRLKE 861
Cdd:cd18286     82 DLPDDVN---LGELLSLADMYGLDGLKD 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 565-639 1.75e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 70.41  E-value: 1.75e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394   565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 639
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGK 62
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-875 3.91e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 70.05  E-value: 3.91e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  755 NKLKLSQKKCsflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQAEILKVILDYLYTDEAV 833
Cdd:cd18240      9 NELRLEGKLC----DVVIR-VNGVEFPAHRNILCACSPYFRALFTNGWNE-TEKKVYKIPgVSPEMMELIIEYAYTRTVP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958799394  834 VikesqNVDFVCSVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18240     83 I-----TAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 7.34e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.83  E-value: 7.34e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799394   47 VKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666    148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 1.87e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 1.87e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799394   47 VKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666    115 ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-641 1.39e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 65.78  E-value: 1.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  547 FEEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsDGTLLEltdvyrKDEDAAGCHLFVVEKVHPD 626
Cdd:cd18296      1 RVDLDELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALL--RDHFAE------SEENNGSIPVVTLHDVSPE 72

                           90
                   ....*....|....*
gi 1958799394  627 LFEYLLQFMYTDTCD 641
Cdd:cd18296     73 VFAIVLYYIYTDDTD 87
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 9.45e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 63.64  E-value: 9.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYtDEAVVIKEsqnvDFVCSVL 848
Cdd:cd18265     25 DVVLL-VDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMY-GGGLRIQE----DNVESVL 98

                           90       100
                   ....*....|....*....|....*..
gi 1958799394  849 VVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18265     99 EASDLLQVSKLREACVRFLEGQLHPCN 125
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-875 1.10e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 63.65  E-value: 1.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  765 SFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVikesqNVDFV 844
Cdd:cd18268     21 RILTDVIL-CTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILI-----TRDNV 94

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958799394  845 CSVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18268     95 LPLMEAASMLQYPKLFEACSLYLQDQLTPEN 125
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-116 1.38e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 1.38e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   27 KGSERQIKIFLSSYCynAATVKDAFGRNALHLVSSCGKKAVLDWLIEKGVdllVKDKESGWTALHRSIFYGHINCVWSLL 106
Cdd:pfam12796    7 NGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKLLL 81

                           90
                   ....*....|
gi 1958799394  107 KHGVSLYMQD 116
Cdd:pfam12796   82 EKGADINVKD 91
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
247-299 1.58e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.22  E-value: 1.58e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  247 DGCVYTFGLNTFHQLGiIPPPSSCNVPRQIQAkyLKGRTIIGVAAGRFHTVLW 299
Cdd:pfam00415    1 DGRVYTWGRNDYGQLG-LGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-876 3.06e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 61.79  E-value: 3.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAvvikesQNVDFVC-SV 847
Cdd:cd18345     20 DVTL-CVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKA------PNLDKMAdDL 92

                           90       100
                   ....*....|....*....|....*....
gi 1958799394  848 LVVADQLLITRLKEMCEVALAENLTLKNA 876
Cdd:cd18345     93 LAAADKYALERLKVMCEEALCSNLSVENV 121
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 769-864 6.88e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 60.33  E-value: 6.88e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEavvIKESQNVDFVCsV 847
Cdd:cd18300     11 DVTFI-VEDGTIPAHKALLVARCDVMAAMFGGNFRESSA-KEVELPgVSKETFLALLEYLYTDQ---APILEDGDCVG-L 84

                           90
                   ....*....|....*..
gi 1958799394  848 LVVADQLLITRLKEMCE 864
Cdd:cd18300     85 IVLANRLCLPRLVALCE 101
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 550-639 8.64e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 60.81  E-value: 8.64e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  550 FGKLLretDEMDSFhDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLsdGTLLEltdvyRKDEDAagchlfVVEKVHPDLFE 629
Cdd:cd18280      5 FGALL---ESEEGA-DVTFNVDGEKFRAHKLVLAARSPVFRSMLF--GPMRE-----ENEGEI------VIEDVEPPVFK 67

                           90
                   ....*....|
gi 1958799394  630 YLLQFMYTDT 639
Cdd:cd18280     68 ALLHFIYKDE 77
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-863 1.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 59.66  E-value: 1.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  775 VDGKEFPCHKCVLCARLEYFHSMLSRSW-IEASSCAALE-MPIQAEILKVILDYLYTDEavvIKESQnvDFVCSVLVVAD 852
Cdd:cd18245     21 VGGEEIPVQKNVLAAASPYFRAKLNYNPpKDDGSTYKIElEGISVEVMEEILDYIYTGQ---IKLSE--DNIQDIVQAAD 95

                           90
                   ....*....|.
gi 1958799394  853 QLLITRLKEMC 863
Cdd:cd18245     96 LLLMTDLKDLC 106
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 232-354 1.69e-10

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 64.23  E-value: 1.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  232 SQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHTVLWTRE-AVYTLGLN 310
Cdd:COG5184      1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPG----LSNVVAVAAGGDHTCALKADgTVWCWGNN 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958799394  311 G-GQLGhlldpNGEK-CVTTPRQVSALHH-KDIAV----SLVAASDGATVC 354
Cdd:COG5184     76 SyGQLG-----DGTTtDRTTPVKVPGLTGvVAVAAgyyhSCALKSDGTVWC 121
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-876 1.78e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 59.78  E-value: 1.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  761 QKKCSFLyDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqN 840
Cdd:cd18250     16 RAERKFF-DVTL-CAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQD--N 91

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958799394  841 VDfvcSVLVVADQLLITRLKEMCEVALAENLTLKNA 876
Cdd:cd18250     92 VE---ALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 546-645 2.02e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 59.18  E-value: 2.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  546 FFEEFGKLLretdEMDSFHDVTFQVGNRLFP--AHKYVLAVRSDFFQKLFLsdgtllelTDVYRKDEDAAgchlFVVEKV 623
Cdd:cd18294      1 FAADMKSLI----NNPEFSDVKFLVGPERQEifAHKCILAARCEVFRAMFL--------TGPQKESTQSP----LVLSDI 64

                           90       100
                   ....*....|....*....|..
gi 1958799394  624 HPDLFEYLLQFMYTDTCDFLTH 645
Cdd:cd18294     65 EPEVFRAVLEFIYTNCVTLSNH 86
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 536-637 2.49e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 59.17  E-value: 2.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  536 YEIPVVSSSSffEEFGKLLRETDemdsFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLsdGTLLE--LTDVYRKDEDAA 613
Cdd:cd18287      1 GEIDHVHFLS--EDIGALFLNEE----YSDVTFVVEEKRFPAHRVILAARSEYFRALLY--GGMREsqQSEIELKDTNAE 72

                           90       100
                   ....*....|....*....|....
gi 1958799394  614 GchlfvvekvhpdlFEYLLQFMYT 637
Cdd:cd18287     73 A-------------FKALLKYIYT 83
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-263 5.22e-10

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 62.69  E-value: 5.22e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRsrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184    219 TVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVK 294

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1958799394  223 VEGLSGhsCSQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGI 263
Cdd:COG5184    295 VPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGD 333
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 749-875 5.34e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 58.48  E-value: 5.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  749 IAKKTGNKLKLSQ-KKCSFLydvtmksVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYL 827
Cdd:cd18343      8 LAEDLGNLWENSRfTDCSLF-------VGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFI 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1958799394  828 YTDEAvvikesQNVDFVC-SVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18343     81 YTGKA------PNLDKMAdNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 543-637 5.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 58.07  E-value: 5.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  543 SSSFFEEFGKLLRETDemdsFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDEDAAGChlfvvek 622
Cdd:cd18292      1 SREFLQDIAQLYNNEE----LSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECA------- 69

                           90
                   ....*....|....*
gi 1958799394  623 vhpDLFEYLLQFMYT 637
Cdd:cd18292     70 ---AVFEKFLRYLYT 81
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 562-637 6.31e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 57.35  E-value: 6.31e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958799394  562 SFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVyrkdedaagchlfVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18314      5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEV-------------TLEDVEPEIFETVLKYMYT 67
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-638 6.59e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 58.03  E-value: 6.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  547 FEEFgklLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyrKDEDAAGchlFVVEKVHPD 626
Cdd:cd18295      6 YDEF---LRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKW----------KDKREIN---LKHPLVNPD 69

                           90
                   ....*....|..
gi 1958799394  627 LFEYLLQFMYTD 638
Cdd:cd18295     70 AFRALLQYLYTG 81
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 7.47e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 58.27  E-value: 7.47e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  767 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVikESQNVDfvcS 846
Cdd:cd18237     21 LCDVIL-IVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISV--NSNNVQ---S 94

                           90       100
                   ....*....|....*....|....*....
gi 1958799394  847 VLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18237     95 LLDAANQYQIEPVKKMCVDFLKEQLDASN 123
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 562-673 7.87e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 58.18  E-value: 7.87e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  562 SFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlSDGTLLELTDVYRkdedaagchlfvVEKVHPDLFEYLLQFMYTDTCD 641
Cdd:cd18256     19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALF-AGGMSESSKDVVQ------------IHGVEPDIFHILLDFIYTGVVE 85

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958799394  642 FLTHGFKPRMI---MNKKSEDSKGSPE---SRLHAVNC 673
Cdd:cd18256     86 VTVSNVQELLVaadMLQLTEVVEICCEflkGQLHPSNC 123
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 1.01e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 57.91  E-value: 1.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEaVVIKESQnvdfVCSVL 848
Cdd:cd18252     23 DITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQ-ICITERN----VQSLL 97

                           90       100
                   ....*....|....*....|....*..
gi 1958799394  849 VVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18252     98 EAADLLQFISVKKACEQFLVRHLDIDN 124
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-871 1.28e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 57.15  E-value: 1.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqNVDFvcsVL 848
Cdd:cd18253     20 DVII-CVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTE--NVQY---LF 93

                           90       100
                   ....*....|....*....|...
gi 1958799394  849 VVADQLLITRLKEMCEVALAENL 871
Cdd:cd18253     94 ETSSLFQISPLRDACAKFLEEQL 116
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 1.34e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 57.55  E-value: 1.34e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  767 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKesQNVDfvcS 846
Cdd:cd18236     24 LTDVIL-CVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITK--QNVQ---R 97

                           90       100
                   ....*....|....*....|....*....
gi 1958799394  847 VLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18236     98 VLEAASLFQFLRMVDACASFLTEALHPEN 126
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 1.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 56.77  E-value: 1.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqnvdFVCSVL 848
Cdd:cd18279     20 DCCL-CVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDK-----MADDLL 93

                           90       100
                   ....*....|....*....|....*..
gi 1958799394  849 VVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18279     94 AAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 3.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 56.38  E-value: 3.03e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtllelTDVYRKdedaagchlFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18224     28 DVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTE-----LDVART---------YVVDFITPANFEKVLSFIYT 86
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-875 4.25e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 56.40  E-value: 4.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  761 QKKCSFLYDVTM--KSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-------IQAEILKVILDYLYTDE 831
Cdd:cd18241     17 QRKQGLFCDITLafGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRS-GRVEMRkwssepgPDPDTVEAVIQYMYTGR 95

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958799394  832 AVVIKESqnvdfVCSVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18241     96 IRVSTGN-----VHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-876 5.62e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 55.73  E-value: 5.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  775 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIkesQNVDFVCSVLVVADQL 854
Cdd:cd18344     30 VAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAPHL---HSHSMACDVLAAADKY 106

                           90       100
                   ....*....|....*....|..
gi 1958799394  855 LITRLKEMCEVALAENLTLKNA 876
Cdd:cd18344    107 GLEGLKVLCEDALCRNLSVENA 128
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 752-863 7.87e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 55.14  E-value: 7.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  752 KTGNKLKLSQKKCsflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDE 831
Cdd:cd18242     10 NTMNSLRKSNTLC----DVTLR-VEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTET 84

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958799394  832 AVVikesqNVDFVCSVLVVADQLLITRLKEMC 863
Cdd:cd18242     85 VHV-----TVENVQELLPAACLLQLKGVKQAC 111
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-637 9.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 54.96  E-value: 9.56e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdgtlleltdvyrkDEDAAGCHLFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18306     18 FCDVILQVGGHEIPAHRAVLACASPYLFELFSS-------------DSDGESILTVKLDGLDPDAVEVLVNYAYT 79
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-853 9.85e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 54.55  E-value: 9.85e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQAEILKVILDYLYTDEAVVIKESQnvDFVCSV 847
Cdd:cd18287     24 DVTF-VVEEKRFPAHRVILAARSEYFRALLYGGMRE-SQQSEIELKdTNAEAFKALLKYIYTGRLTLTDLKE--DVLLDV 99


                   ....*.
gi 1958799394  848 LVVADQ 853
Cdd:cd18287    100 LGLAHQ 105
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-870 1.49e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 54.21  E-value: 1.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMKSVdGKEFPCHKCVLCaRLEYFHSMLSRSWIEA-SSCAALEMP---IQAEILKVILDYLYTDEaVVIKESQnvdfV 844
Cdd:cd18305     17 DITICAL-GREWKLHKIYLC-QSGYFASMFSGSWKESkETVINLEIPddnITVEALNVVFGSLYRDE-IEIKPSR----V 89

                           90       100
                   ....*....|....*....|....*.
gi 1958799394  845 CSVLVVADQLLITRLKEMCEVALAEN 870
Cdd:cd18305     90 VSILAAATLLQLDGLIQQCSEVMKET 115
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 767-875 1.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 54.02  E-value: 1.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  767 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEAVVIKesqnvDFVC 845
Cdd:cd18352     13 LSDVTF-LVEGRRFYAHRIALLASSDAFRAMFDGGYREKEA-RDIEIPnIRWEVFELMMRFIYTGSVDITN-----DIAK 85

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958799394  846 SVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18352     86 DLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 2.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 53.82  E-value: 2.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEAVVIKESQNVDFvcSV 847
Cdd:cd18297     14 DVTFL-VEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQT-PVIEIPdIRYDIFQLMMQYLYTGGVESLDVAQDDAL--EL 89

                           90       100
                   ....*....|....*....|....*...
gi 1958799394  848 LVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18297     90 LRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-864 2.20e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 53.40  E-value: 2.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  776 DGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALE-MPIQAEILKVILDYLYTDEAvvikeSQNVDFVCSVLVVADQL 854
Cdd:cd18294     24 ERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVlSDIEPEVFRAVLEFIYTNCV-----TLSNHTVIEVLAAAVEY 98

                           90
                   ....*....|
gi 1958799394  855 LITRLKEMCE 864
Cdd:cd18294     99 GLDELRKLCE 108
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-867 2.46e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 53.49  E-value: 2.46e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASS-CAALEmPIQAEILKVILDYLYTDE-------AVVIKESQN 840
Cdd:cd18280     16 DVTF-NVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEgEIVIE-DVEPPVFKALLHFIYKDElpddvepAGSDSSSLD 93

                           90       100
                   ....*....|....*....|....*..
gi 1958799394  841 VDFVCSVLVVADQLLITRLKEMCEVAL 867
Cdd:cd18280     94 TTMAQHLLAAADRYALERLRLLCESRL 120
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-138 3.29e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.50  E-value: 3.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   47 VKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDLL 126
Cdd:COG0666    181 ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDND-GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259

                           90
                   ....*....|..
gi 1958799394  127 MKDRPAHVVFKN 138
Cdd:COG0666    260 AAAGAALIVKLL 271
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 764-880 8.25e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 52.90  E-value: 8.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  764 CSFLYDVTMKSV-------DGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavVIK 836
Cdd:cd18273     23 ARLLTDVTIEVNgpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGR--VTL 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958799394  837 ESQNVDfvcSVLVVADQLLITRLKEMCEVALAENLTLKNAAMLL 880
Cdd:cd18273    101 SEANVQ---RLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-642 8.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 51.94  E-value: 8.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDvyrkdedaagchlfvvekVHPDLFEYLLQFMYTDTCDF 642
Cdd:cd18303     18 YSDITIKLADKSIPAHKFVLAARSEKWSNENLASTNELDLSD------------------ISYEVVLALLRWLYTDELDL 79
Ank_2 pfam12796
Ankyrin repeats (3 copies);
56-123 8.68e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.27  E-value: 8.68e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799394   56 LHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHgVSLYMQDkEGLSPL 123
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTAL 65
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-876 1.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 52.03  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  775 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAvvikesQNVDFVCS-VLVVADQ 853
Cdd:cd18342     29 VAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMADdLLAAADK 102

                           90       100
                   ....*....|....*....|...
gi 1958799394  854 LLITRLKEMCEVALAENLTLKNA 876
Cdd:cd18342    103 YALERLKVMCEDALCSNLSVENA 125
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 765-863 1.19e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 51.48  E-value: 1.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  765 SFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQAEILKVILDYLYTDEAvvikESQnVDF 843
Cdd:cd18295     17 GSYSDVTF-NVHGESFPAHRCILSARSPYFAEMFETKWKD-KREINLKHPlVNPDAFRALLQYLYTGRL----EIH-VDD 89

                           90       100
                   ....*....|....*....|....
gi 1958799394  844 VCSVLVVADQ----LLITRLKEMC 863
Cdd:cd18295     90 VEDCKRLAKQcrleELIEELEAKC 113
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-864 1.34e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 51.13  E-value: 1.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKV---ILDYLYTDEAVVikesqNVDFVC 845
Cdd:cd18292     19 DIVLR-VGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVfekFLRYLYTGQISV-----NLETAL 92

                           90
                   ....*....|....*....
gi 1958799394  846 SVLVVADQLLITRLKEMCE 864
Cdd:cd18292     93 PLLMLADKYNVTDLKQLCV 111
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 757-871 1.56e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 51.91  E-value: 1.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  757 LKLSQKKCSFLyDVTMKSvDGKEFPCHKCVLCARLEYFHSMLSRSWIEA-SSCAALEMPIQAEILKVILDYLYTDEAVVI 835
Cdd:cd18267     31 LNLLRQQRLFT-DVLLHA-GNRSFPCHRAVLAACSRYFEAMFSGGLKESqDSEVNFHDSIHPEVLELLLDYAYSSRVIIN 108

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958799394  836 KESQNvdfvcSVLVVADQLLITRLKEMCEVALAENL 871
Cdd:cd18267    109 EENAE-----SLLEAGDMLEFQDIRDACAEFLEKNL 139
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 759-876 1.56e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 51.53  E-value: 1.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  759 LSQKKCSF----LYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEaVV 834
Cdd:cd18274     10 LQQLKAMYdegqLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSR-VT 88

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958799394  835 IKESQnvdfVCSVLVVADQLLITRLKEMCEVALAENLTLKNA 876
Cdd:cd18274     89 LTEAN----VQALFTAASIFQIPSLQDQCAQFMISRLDPQNS 126
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-875 2.90e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 50.78  E-value: 2.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  755 NKLKLSQKKCSFLyDVTMKSVDgKEFPCHKCVLCARLEYFHSMLSRSWIEA-SSCAALEMPIQAEILKVILDYLYTDEAV 833
Cdd:cd18254     11 THLNTLRKQCMFT-DVTLWAGN-RSFPCHRAVLAACSRYFEAMFSNGLRESlDSTVNFHDSLHPEVLELLLDFAYSSRII 88

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958799394  834 VIKESQNvdfvcSVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18254     89 INEENAE-----SLLEAGDMLQFHDVRDAAAEFLEKNLYPSN 125
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-863 2.94e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 50.48  E-value: 2.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  755 NKLKLSQKKCsflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVV 834
Cdd:cd18256     12 NKLRGQHEFC----DVQLQ-VGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEV 86

                           90       100
                   ....*....|....*....|....*....
gi 1958799394  835 ikesqNVDFVCSVLVVADQLLITRLKEMC 863
Cdd:cd18256     87 -----TVSNVQELLVAADMLQLTEVVEIC 110
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 3.44e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 50.98  E-value: 3.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  767 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEM-PIQAEILKVILDYLYTDEAVVIKEsqNVDfvc 845
Cdd:cd18259     32 LSDVTL-LVGGREFPCHRSVLALCSHYFNAMFTGDFVESIS-ARVEIkDVDPAVMESLIDFAYTGKLTINQG--NVE--- 104

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958799394  846 SVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18259    105 ALIRTSNRLQFPTVRKVCSRYLQQQIDATN 134
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-876 3.82e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 50.34  E-value: 3.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  755 NKLKLSQKKCsflyDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVV 834
Cdd:cd18306     10 NALRKNRQFC----DVIL-QVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEV 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958799394  835 ikesqNVDFVCSVLVVADQLLITRLKEMCEVALAENLTLKNA 876
Cdd:cd18306     85 -----PADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNC 121
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-660 4.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 50.40  E-value: 4.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlSDGtLLELTDvyrkdeDAAGCHlfvvEKVHPDLFEYLLQFMYTDtcdf 642
Cdd:cd18254     22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAMF-SNG-LRESLD------STVNFH----DSLHPEVLELLLDFAYSS---- 85

                           90
                   ....*....|....*...
gi 1958799394  643 lthgfkpRMIMNKKSEDS 660
Cdd:cd18254     86 -------RIIINEENAES 96
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-863 4.41e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 50.12  E-value: 4.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  762 KKCSFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqNV 841
Cdd:cd18235     16 RKQNLLCDVIL-VADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEE--NV 92

                           90       100
                   ....*....|....*....|..
gi 1958799394  842 DfvcSVLVVADQLLITRLKEMC 863
Cdd:cd18235     93 Q---VLLPAANLLQLTDVRDAC 111
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-875 4.83e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 50.09  E-value: 4.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  767 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVikesqNVDFVCS 846
Cdd:cd18255     18 LLDVTL-IADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTL-----DLDCIQD 91

                           90       100
                   ....*....|....*....|....*....
gi 1958799394  847 VLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18255     92 VLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-863 5.07e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 49.59  E-value: 5.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  767 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTdeAVVIKESQNVDfvcS 846
Cdd:cd18247     19 LCDVTLK-VGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYS--GRIAIDTSNVQ---S 92

                           90
                   ....*....|....*..
gi 1958799394  847 VLVVADQLLITRLKEMC 863
Cdd:cd18247     93 LLVGASFLQLQSVKDAC 109
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 767-871 5.15e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 49.46  E-value: 5.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  767 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVdfvcS 846
Cdd:cd18360     10 LADVVFK-IQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPASILQAM----A 84

                           90       100
                   ....*....|....*....|....*
gi 1958799394  847 VLVVADQLLITRLKEMCEVALAENL 871
Cdd:cd18360     85 LLICAEMYQVSRLQHICELYIITQL 109
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-864 1.00e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 48.79  E-value: 1.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  768 YDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScaaLEMPIQA---EILKVILDYLYTDEaVVIKESQNVDfv 844
Cdd:cd18298     13 SDLKFR-VDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDK---NVIEIDQysyPVYYAFLRYLYTDQ-VDLPPEDAIG-- 85

                           90       100
                   ....*....|....*....|
gi 1958799394  845 csVLVVADQLLITRLKEMCE 864
Cdd:cd18298     86 --LLDLANSYCEERLKKLCE 103
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-641 1.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 48.55  E-value: 1.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  565 DVTFQVGN----RLFPAHKYVLAVRSDFFQKLFLsdGTLLEltdvyRKDEdaagchlFVVEKVHPDLFEYLLQFMYTDTC 640
Cdd:cd18282      9 DVHFIVGPpggtQRIPAHKYVLATGSSVFYAMFY--GGLAE-----NKNE-------IEIPDVEPAAFLNLLRYLYCDEI 74


                   .
gi 1958799394  641 D 641
Cdd:cd18282     75 D 75
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 549-637 1.82e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 48.05  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  549 EFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGT-----LLELTDVyrkDEDAagchlfvvekv 623
Cdd:cd18238      1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAeskqdSITIKDI---DEEA----------- 66

                           90
                   ....*....|....
gi 1958799394  624 hpdlFEYLLQFMYT 637
Cdd:cd18238     67 ----VELLVDFAYT 76
Ank_4 pfam13637
Ankyrin repeats (many copies);
52-102 1.84e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 1.84e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958799394   52 GRNALHLVSSCGKKAVLDWLIEKGVDLLVKDkESGWTALHRSIFYGHINCV 102
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVEVL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
143-192 1.87e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.97  E-value: 1.87e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958799394  143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSRvyVKQVVLCKFHSVFL 192
Cdd:pfam00415    3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNK--VVQVACGGDHTVAL 50
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 871-923 2.15e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 47.61  E-value: 2.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  871 LTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDL 923
Cdd:cd14822      1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKEL 53
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-875 4.05e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 47.87  E-value: 4.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  766 FLYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLsRSWIEASSCAALEMP-IQAEILKVILDYLYTDEAvvikeSQNVDFV 844
Cdd:cd18264     27 FLCDVVLE-AEGNEFPAHRSLLACSSDYFRALF-KDYTQESKARVIHLPvVSAAGLQRVLDFIYTSWL-----SLSLDTL 99

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958799394  845 CSVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18264    100 EDTLEAASYLQVTEAIGLCSQYLINNLAPEN 130
Ank_5 pfam13857
Ankyrin repeats (many copies);
71-125 5.81e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.64  E-value: 5.81e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394   71 LIEKGVDLLVKDKESGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-660 5.83e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 47.68  E-value: 5.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsDGTLLELTDVYRKDEDAagchlfvvekVHPDLFEYLLQFMYTDtcdf 642
Cdd:cd18267     40 FTDVLLHAGNRSFPCHRAVLAACSRYFEAMF--SGGLKESQDSEVNFHDS----------IHPEVLELLLDYAYSS---- 103

                           90
                   ....*....|....*...
gi 1958799394  643 lthgfkpRMIMNKKSEDS 660
Cdd:cd18267    104 -------RVIINEENAES 114
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 6.03e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 46.21  E-value: 6.03e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtLLELTdvyrKDEdaagchlFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18234      3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTND--VREAT----EEE-------IKLKDVDPDALWTLVQYCYT 62
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-637 6.34e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 46.75  E-value: 6.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  548 EEFGKLLretdEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLF-----LSDGTLLELTDvyrkdedaagchlfvvek 622
Cdd:cd18279      7 EDLGNLW----ENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFehemeESKKNRVEIND------------------ 64

                           90
                   ....*....|....*
gi 1958799394  623 VHPDLFEYLLQFMYT 637
Cdd:cd18279     65 VDPEVFKEMMRFIYT 79
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 548-637 7.62e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 46.05  E-value: 7.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  548 EEFGKLLREtdemDSFHDVTFQVGNRL-FPAHKYVLAVRSDFFQKLFlsdGTLLELTdvyrKDEDaagchlfvvekVHPD 626
Cdd:cd18299      1 EDLRNLLHS----PSCADVVFILQGGVrIFAHRIVLAAASSVFADLF---LMMTVVT----LDSD-----------ITPE 58

                           90
                   ....*....|.
gi 1958799394  627 LFEYLLQFMYT 637
Cdd:cd18299     59 AFRRVLEFLYT 69
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-863 8.34e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 46.32  E-value: 8.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  761 QKKCSFLYDVTMKSvDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMP-IQAEILKVILDYLYTDEAVVIKESQ 839
Cdd:cd18293      9 QQNSGVFCDVLLQA-EGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLELQgLKAHTLLKLVDFLYTSELEVSSEEA 87

                           90       100
                   ....*....|....*....|....
gi 1958799394  840 NvdfvcSVLVVADQLLITRLKEMC 863
Cdd:cd18293     88 Q-----DVLAAARRLQISELESLC 106
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 562-641 8.75e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 46.11  E-value: 8.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  562 SFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLS-----DGTLLELTDV-YrkdedaagchlfvvekvhpDLFEYLLQFM 635
Cdd:cd18297     11 EMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSgsteaQTPVIEIPDIrY-------------------DIFQLMMQYL 71


                   ....*.
gi 1958799394  636 YTDTCD 641
Cdd:cd18297     72 YTGGVE 77
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-831 9.16e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 46.34  E-value: 9.16e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394  767 LYDVTMKSvDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDE 831
Cdd:cd18276     21 LTDVVLVA-EGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSD 84
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
233-260 1.09e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.18  E-value: 1.09e-05
                           10        20
                   ....*....|....*....|....*...
gi 1958799394  233 QVAAAKDHTVVLTEDGCVYTFGLNTFHQ 260
Cdd:pfam13540    3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.10e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 45.94  E-value: 1.10e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsdgtlleltdvyrKDEDAAGCHLFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18212     25 DITLIVENVQFRAHKALLAASSEYFSMMF--------------ADEGEVGQSIYMLEGMVAETFGALLEFIYT 83
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 1.16e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 45.90  E-value: 1.16e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdgtllELTDVYRKDEDAAGchlfvvekVHPDLFEYLLQFMYTDT 639
Cdd:cd18242     23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTS-----EMSEKGKSEVELQG--------LTASTMEILLDFVYTET 84
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 769-864 1.38e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 45.65  E-value: 1.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMKSVDGKEFPCHKCVLCARLEYFHSMlsrSWIEASSCAALEMP--IQAEILKVILDYLYTDEAVVIKESqnvdfVCS 846
Cdd:cd18311     16 DLTLQFRDNEQLKVHRLVLSACTDYFNVL---EQTCEIVDDTLIMPneLQADAVVPVINFMYTGQLEFEEKS-----YGK 87

                           90
                   ....*....|....*...
gi 1958799394  847 VLVVADQLLITRLKEMCE 864
Cdd:cd18311     88 LLRTAKELNMTVLLKLLE 105
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-864 1.42e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 46.11  E-value: 1.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEM-PIQAEILKVILDYLYTDEAVVIKESqnvdfVCSV 847
Cdd:cd18207     29 DVLLR-VGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMhTISSKVFGDILDFAYTSRIVVRLES-----FPEL 102

                           90
                   ....*....|....*..
gi 1958799394  848 LVVADQLLITRLKEMCE 864
Cdd:cd18207    103 MTAAKFLLMRSVIDICQ 119
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.50e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 45.83  E-value: 1.50e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799394  565 DVTFQVGNR----LFPAHKYVLAVRSDFFQKLFLSDgtLLEltdvyrkdedaagCHLFVV--EKVHPDLFEYLLQFMYT 637
Cdd:cd18248     23 DVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSG--LRE-------------CGMEVVpiEGVHPCVMSRLIEFAYT 86
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-637 1.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 45.38  E-value: 1.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  554 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsdgtlleltdvyrkdEDAAGCHLFVVEKVHPDLFEYLLQ 633
Cdd:cd18221      9 LNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF----------------QDFTQEPLVEIEGVSNMAFRHLIE 72


                   ....
gi 1958799394  634 FMYT 637
Cdd:cd18221     73 FTYT 76
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-864 1.53e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 45.74  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  767 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVikesqNVDFVCS 846
Cdd:cd18238     15 LCDVTLK-VGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTL-----TVDNVQS 88

                           90
                   ....*....|....*...
gi 1958799394  847 VLVVADQLLITRLKEMCE 864
Cdd:cd18238     89 LLYAASLLQVEEVAKACC 106
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 761-863 1.60e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 45.03  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  761 QKKCSflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEaVVIKESQN 840
Cdd:cd18314      3 DSEFS---DVVLC-VGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQ-VTLSEENV 77

                           90       100
                   ....*....|....*....|...
gi 1958799394  841 VDfvcsVLVVADQLLITRLKEMC 863
Cdd:cd18314     78 LD----LLMLASKYQVPDLEKLC 96
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 548-650 1.95e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 46.21  E-value: 1.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  548 EEFGKLLretdEMDSFHDVTFQVG--NRLFPAHKYVLAVRSDFF------------QKLFLSDGTLLELTDVyRKDEDAA 613
Cdd:cd18308     12 DDFGRLL----ESRQFCDVEFIVGeeEERIPAHIAFVAARSKWLrnkilqarerqkQKAEQEVEDEGSEADS-SSASKND 86

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958799394  614 GCHLFV-VEKVHPDLFEYLLQFMYTDTCDFLTHGFKPR 650
Cdd:cd18308     87 SPMLEVrLPEADPEAFELILSFIYTDKIDPTRKGQDPG 124
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-875 2.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 45.60  E-value: 2.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  775 VDGKEFPCHKCVLCARLEYFHSMLsRSWIEASSCAALEMP-IQAEILKVILDYLYTDEAVVikESQNVDfvcSVLVVADQ 853
Cdd:cd18340     34 IKEKEFPCHRLVLAACSPYFRAMF-LSDLEESKKREIVLEdVDPDVMGKILHYIYTSEIEI--TEQNVQ---DIFAAANM 107

                           90       100
                   ....*....|....*....|..
gi 1958799394  854 LLITRLKEMCEVALAENLTLKN 875
Cdd:cd18340    108 FQIPSIFTVCVSFLQKRLCLSN 129
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 2.62e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 45.01  E-value: 2.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMKsVDGKEFPCHKCVLCARleyfhsmlSRSWIEASSCAALEMP---IQAEILKVILDYLYTDEavvIKESQNVDFVC 845
Cdd:cd18303     20 DITIK-LADKSIPAHKFVLAAR--------SEKWSNENLASTNELDlsdISYEVVLALLRWLYTDE---LDLTLDDEFLL 87

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958799394  846 SVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18303     88 ELMKAAKRFQLTDLVERCERALMSSVNVDN 117
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 553-637 2.65e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 45.14  E-value: 2.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  553 LLRETDEM---DSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsDGTLLEltdvYRKDEdaagchlFVVEKVHPDLFE 629
Cdd:cd18250      8 LLRGLSELraeRKFFDVTLCAGGREFPCHRTVLAAASSYFRAMF--AGELRE----SRADR-------VVLHGVSAEILG 74


                   ....*...
gi 1958799394  630 YLLQFMYT 637
Cdd:cd18250     75 LLLDFSYT 82
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 767-843 2.86e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 43.69  E-value: 2.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  767 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLsrswIEASSC--AALEMP-IQAEILKVILDYLYTDEaVVIKESQNVDF 843
Cdd:cd18315      1 LVDVTL-ACEGGSLKAHKLVLAAASPYFAALL----KETPPDehPVIILPdVPYSELKALLDFIYTGE-VNVSQEQLESL 74
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-642 3.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 44.84  E-value: 3.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  554 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVyrkdedaagchlfVVEKVHPDLFEYLLQ 633
Cdd:cd18341     18 LKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEV-------------VLDNVDPNIMDMILK 84


                   ....*....
gi 1958799394  634 FMYTDTCDF 642
Cdd:cd18341     85 YLYSAEIDL 93
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-593 3.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 44.45  E-value: 3.96e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1958799394  548 EEFGKLLretdEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLF 593
Cdd:cd18345      7 DDLGLLF----ERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMF 48
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 4.49e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 43.82  E-value: 4.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  565 DVTFQVG----NRLFPAHKYVLAVRSDFFQKLFLSDGTlleltdvyrkdEDAAGCHlfvVEKVHPDLFEYLLQFMYTDTC 640
Cdd:cd18349     10 DVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLA-----------EVKSEIH---IPDVEPAAFLILLKYMYSDEI 75


                   ..
gi 1958799394  641 DF 642
Cdd:cd18349     76 DL 77
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 750-863 5.04e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 44.29  E-value: 5.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  750 AKKTGNKLKlSQkkcSFLYDVTMKSVDgKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYT 829
Cdd:cd18338      8 AFKVMNELR-SQ---NLLCDVTIVAED-VEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYT 82

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1958799394  830 DEAVVIKESQNVdfvcsVLVVADQLLITRLKEMC 863
Cdd:cd18338     83 AEIQVTEENVQV-----LLPAAGLLQLQDVKKTC 111
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-875 5.08e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 44.19  E-value: 5.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  775 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMP---IQAEILKVILDYLYTDEAVVikESQNVDfvcSVLVVA 851
Cdd:cd18258     24 VEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLELTmsnINADVLELLLEFVYTGSLII--DSANAK---TLLEAA 98

                           90       100
                   ....*....|....*....|....
gi 1958799394  852 DQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18258     99 NKFQFHTFCKVCVSFLEKQLTASN 122
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 565-637 6.02e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 42.92  E-value: 6.02e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLsDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18315      3 DVTLACEGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIILPD-------------VPYSELKALLDFIYT 61
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 9.63e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 43.73  E-value: 9.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVV-IKESQNvdfvcsV 847
Cdd:cd18272     34 DVTI-SVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLrVEELQE------T 106

                           90       100
                   ....*....|....*....|....*...
gi 1958799394  848 LVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18272    107 YEVADMYQLTALFEECSRFLARTVQVRN 134
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-637 9.83e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 43.55  E-value: 9.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  554 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtllelTDVYRKDEdaagchlFVVEKVHPDLFEYLLQ 633
Cdd:cd18269     18 LKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSD------LEESKKKE-------VVLEDVDPDVMGMILK 84


                   ....
gi 1958799394  634 FMYT 637
Cdd:cd18269     85 YLYT 88
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 777-831 9.99e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 42.32  E-value: 9.99e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958799394  777 GKEFPCHKCVLCARLEYFHSMLSRSW-IEASSCAALEM-PIQAEILKVILDYLYTDE 831
Cdd:cd18283     11 GTCFPVHRAILSARCPFFRDLLSSSPgYGAEIPVDLPTaGIDVPMFSALLRYLYTGE 67
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.27e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 43.06  E-value: 1.27e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFL---SDGTLLELTDvyrkdedaagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18193     23 DCTVAIGDVYFKAHKSVLASFSNYFKMLFVhqtSECVRLKPTD------------------IQPDIFSYLLHLMYT 80
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 872-923 1.35e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 41.11  E-value: 1.35e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958799394  872 TLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDL 923
Cdd:cd14733      1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLEL 52
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 542-637 1.36e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 42.65  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  542 SSSSF--FEEF---GKLLretdemdsfhDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtLLEltdvYRKDEdaagch 616
Cdd:cd18247      3 PSSGFpvMEEIrrqGKLC----------DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHD--MVE----SKQDE------ 60

                           90       100
                   ....*....|....*....|.
gi 1958799394  617 lFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18247     61 -ITMQGIEPSALEALINFAYS 80
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-637 1.54e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 42.53  E-value: 1.54e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQ-KLFLSDGTLLELTDVyrkdedaagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18200     18 FCDLSVHVQGRVFRAHKAVLAASSPYFHdKLLLNDTNCLVLPSV-----------------IEAAAFENLLQLIYS 76
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-879 1.55e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 42.90  E-value: 1.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  775 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqNVDFvcsVLVVADQL 854
Cdd:cd18271     31 VKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDD--NVEM---FFQMSSFL 105

                           90       100
                   ....*....|....*....|....*
gi 1958799394  855 LITRLKEMCEVALAENLTLKNAAML 879
Cdd:cd18271    106 QVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-637 1.55e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 43.03  E-value: 1.55e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyrkdEDAAGCHLFVVEKVHPDLFEYLLQFMYT 637
Cdd:cd18207     27 FCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQE------------GDGGTPRELEMHTISSKVFGDILDFAYT 89
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-871 1.59e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 42.75  E-value: 1.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  755 NKLKLSQKKCSFLYDVTMKSVDgKEFPCHKCVLCARLEYFHSMLSRSWIEassCAALEMPIQA---EILKVILDYLYTDE 831
Cdd:cd18248     13 NELRLSQQLCDVTLKVKYQDPK-EEFMAHKVVLASSSPYFKAMFTSGLRE---CGMEVVPIEGvhpCVMSRLIEFAYTAS 88

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958799394  832 AVVIKESqnvdfVCSVLVVADQLLITRLKEMCEVALAENL 871
Cdd:cd18248     89 ISVGEKC-----VLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 779-831 1.65e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 43.10  E-value: 1.65e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958799394  779 EFPCHKCVLCARLEYFHSMLSRSWIEASSCAAL--------EMPIQAEILKVILDYLYTDE 831
Cdd:cd18284     29 ELRCHKAILSARSPFFRNLLQRRIRTGEDRTLStptrivldESIIPRRYARVLLHAMYTDS 89
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-640 1.74e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 42.96  E-value: 1.74e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFL---SDGTLLELTDvyrkdedaagchlfvvekVHPDLFEYLLQFMYTDTC 640
Cdd:cd18213     23 DCTVAIGDVYFKAHRAVLAAFSNYFKMIFIhqsSECIKIQPTD------------------IQPDIFSYLLHIMYTGKG 83
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-639 2.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 42.17  E-value: 2.29e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLsdgtlleltdvyRKDEDAAGchLFVVEKVHPDLFEYLLQFMYTDT 639
Cdd:cd18209     18 LCDVLLIVGDQKFRAHKNVLAASSEYFQSLFT------------EKENESQS--VFQLDFCEPDAFENVLNYIYSSS 80
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 2.50e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 42.23  E-value: 2.50e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdGTLLELTDVYRKDedaagchlFVVekvhPDLFEYLLQFMYTDT 639
Cdd:cd18326     27 DVVILVEGREFPTHRSVLAACSQYFKKLFTS-GAVVDQQNVYEID--------FVS----AEALTALLDFAYTAT 88
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-639 2.57e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 42.16  E-value: 2.57e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlSDGTLLELTDVyrkdeDAAGCHLFVVEKVHPDLFEYLLQFMYTDT 639
Cdd:cd18228     19 FCDVTIRVQDKIFRAHKVVLAACSDFFRSKL-VGQASPRLVLV-----SPAGKCVLDLHHVTVTGFAPLLEYAYTST 89
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-637 3.21e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 42.12  E-value: 3.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSD-----GTLLELTDvyrkdedaagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18259     32 LSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDfvesiSARVEIKD------------------VDPAVMESLIDFAYT 93
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 17-123 3.31e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 3.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   17 HALDVLSVITKGSERQIKIFLSsycYNA-ATVKDAFGRNALHLVSSCG--KKAVLDWLIEKGVDLLVKDK---------- 83
Cdd:PHA03100   108 TPLLYAISKKSNSYSIVEYLLD---NGAnVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDINAKNRvnyllsygvp 184

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958799394   84 -----ESGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PHA03100   185 inikdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-642 3.57e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 42.25  E-value: 3.57e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDEDAAGchlfvvekvhpdlFEYLLQFMYTDTCDF 642
Cdd:cd18244     32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATG-------------FSHVLQFMYYGTIEL 96
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 3.82e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 41.95  E-value: 3.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEmpiqaeiLKVILDYLYTDEAVVikesqNVDFVCSVL 848
Cdd:cd18243     34 DVTL-TAQGQQFHCHKAVLASCSQYFRSLFSINNLVLQGCSSIG-------LRLVLEYLYTANVTL-----SLDTVEEVL 100

                           90       100
                   ....*....|....*....|....*..
gi 1958799394  849 VVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18243    101 SVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-880 3.89e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 41.91  E-value: 3.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  766 FLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVikesqNVDFVC 845
Cdd:cd18270     25 LLTDIVL-IVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAI-----NDSTVE 98

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958799394  846 SVLVVADQLLITRLKEMCEVALAENLTLKNAAMLL 880
Cdd:cd18270     99 QLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-637 3.91e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 41.53  E-value: 3.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  548 EEFGKLLretdEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtlLELTDVYRKDedaagchlfvVEKVHPDL 627
Cdd:cd18343     10 EDLGNLW----ENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHE---MEESKKNRVE----------INDVDPEV 72

                           90
                   ....*....|
gi 1958799394  628 FEYLLQFMYT 637
Cdd:cd18343     73 FKEMMRFIYT 82
BACK_RCBTB1_2 cd18498
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, ...
 871-923 3.93e-04

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors.


Pssm-ID: 350573  Cd Length: 64  Bit Score: 39.95  E-value: 3.93e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  871 LTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDL 923
Cdd:cd18498      1 ITVENAAFLYAAAIKYNAKELEEFCFKFAVNHLTAVVQTEAFSKLDESTLKDF 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-157 4.08e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.63  E-value: 4.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   47 VKDAFGRNALHL-VSSCGKKAVLDWLIEKGVDLLVKDKeSGWTALHR--SIFYGHINCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PHA03095    78 APERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDK-VGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPL 156

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958799394  124 DLLMKDRPAHV------VFKNTDPTEVytwgDNTNFTLGH 157
Cdd:PHA03095   157 AVLLKSRNANVellrllIDAGADVYAV----DDRFRSLLH 192
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 752-841 4.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 41.56  E-value: 4.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  752 KTGNKLKLSQKKCsflyDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMpIQAEILKVILDYLYTDE 831
Cdd:cd18204      7 KTLNEQRLEGEFC----DIAI-VVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDF-LRSDIFEEVLNYMYTAK 80

                           90
                   ....*....|
gi 1958799394  832 AVVIKESQNV 841
Cdd:cd18204     81 ISVKKEDVNL 90
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-864 4.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 41.47  E-value: 4.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  774 SVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESqnvdfVCSVLVVADQ 853
Cdd:cd18353     26 RVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDSVDLPPED-----AIGLLDLATS 100

                           90
                   ....*....|.
gi 1958799394  854 LLITRLKEMCE 864
Cdd:cd18353    101 YCENRLKKLCQ 111
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 4.57e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 41.70  E-value: 4.57e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18237     23 DVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKD-------------AEPDIIELLVEFAYT 82
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-637 4.58e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 41.74  E-value: 4.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  554 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtlLELTdvyRKDEdaagchlFVVEKVHPDLFEYLLQ 633
Cdd:cd18340     18 LKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSD---LEES---KKRE-------IVLEDVDPDVMGKILH 84


                   ....
gi 1958799394  634 FMYT 637
Cdd:cd18340     85 YIYT 88
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 745-875 5.12e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 41.50  E-value: 5.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  745 KINVIAKKTGNKLK---LSQKKCSflyDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMpIQAEILK 821
Cdd:cd18351      2 KLTEIKRKQTSRLDphfLNNKEMS---DVTF-LVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISY-VKYHIFQ 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958799394  822 VILDYLYT--DEAVVIKESQnvdfVCSVLVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18351     77 LVMQYLYCggTESLLIKNNE----IMELLSAAKFFQLEALQRHCEIICAKSINTEN 128
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 767-830 5.47e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 40.73  E-value: 5.47e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799394  767 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEM----PIQAEILKVILDYLYTD 830
Cdd:cd18301     18 IHDVVFQ-VGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCDVvhieKVPPEIFEQLLQFIYTD 84
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 553-637 6.81e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 41.52  E-value: 6.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  553 LLRETDemDSFHDVTFQV-GNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDEDAAGchlfvVEKVHPDLFEYL 631
Cdd:cd18310     10 LLDSPD--LFYSDAEIIVeGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIP-----GGIVGYDAFMLV 82


                   ....*.
gi 1958799394  632 LQFMYT 637
Cdd:cd18310     83 LSYLYS 88
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 6.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 40.72  E-value: 6.86e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVyrkdedaagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18334     23 DVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDM-----------------VNPTVFRQILDFIYT 78
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 7.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 40.62  E-value: 7.29e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdGTLLELTDVYRKDedaagchlFvvekVHPDLFEYLLQFMYTDT 639
Cdd:cd18198     27 DVVILVQGREYRTHRSVLAACSQYFKKLFTS-GAVVDQQNVYEID--------F----VSPEALTALLEFAYTAT 88
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 563-640 7.41e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 40.30  E-value: 7.41e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtlleltdvYRkdEDAAGchLFVVEKVHPDLFEYLLQFMYTDTC 640
Cdd:cd18300      9 FSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGN---------FR--ESSAK--EVELPGVSKETFLALLEYLYTDQA 73
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-123 7.60e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.02  E-value: 7.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   43 NAATVKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSP 122
Cdd:COG0666     45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG-GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123


                   .
gi 1958799394  123 L 123
Cdd:COG0666    124 L 124
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 774-863 1.03e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 39.79  E-value: 1.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  774 SVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQ---AEILKVILDYLYTDEaVVIKEsQNVDfvcSVLVV 850
Cdd:cd18307      7 SVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDylsPETVEQLLDYFYTGK-IVISE-KNVE---DLLKG 81

                           90
                   ....*....|...
gi 1958799394  851 ADQLLITRLKEMC 863
Cdd:cd18307     82 AKYFNIPRLKDHC 94
BACK_AtBPM-like cd14736
BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The ...
 869-918 1.07e-03

BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins. BPM protein, also termed protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350516  Cd Length: 62  Bit Score: 38.48  E-value: 1.07e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958799394  869 ENLTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSED 918
Cdd:cd14736      2 EGVDVNTVATTLALAEQHHASQLKAVCLKFVARNLAAVMQTDGFEYLKES 51
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-638 1.11e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 40.50  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  565 DVTFQVGN----RLFPAHKYVLAVRSDFFQKLF---LSDGTL-LELTDVyrkdEDAAgchlfvvekvhpdlFEYLLQFMY 636
Cdd:cd18281     24 DVHFIVGKgdneQRIPAHKFVLSIGSAVFDAMFnggMATTSAeIELPDV----EPAA--------------FLALLRFLY 85


                   ..
gi 1958799394  637 TD 638
Cdd:cd18281     86 SD 87
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 752-869 1.14e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 40.33  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  752 KTGNKLKLSQKKCSFlYDVTMKSVDGKeFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDE 831
Cdd:cd18358      6 RKANRIKECLSKGTF-SDVTFKLDDGT-INAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQ 83

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958799394  832 avvIKESQNVDFVcSVLVVADQLLITRLkemceVALAE 869
Cdd:cd18358     84 ---LSPTADLDPL-ELIALANRFCLPHL-----VALTE 112
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-829 1.15e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 40.24  E-value: 1.15e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  767 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYT 829
Cdd:cd18215     19 LTDVVL-VVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYT 80
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-637 1.26e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 39.74  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  554 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKlflsdgtlleltdVYRKDEDAagchlfVV----EKVHPDLFE 629
Cdd:cd18217      9 LNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGA-------------QYKDTEDN------IVfldqSQVSADGFQ 69


                   ....*...
gi 1958799394  630 YLLQFMYT 637
Cdd:cd18217     70 KLLEFIYT 77
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-863 1.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 39.92  E-value: 1.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  761 QKKCSFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSML-SRSWIEASSCAALEMpIQAEILKVILDYLYTDEAVVIKESq 839
Cdd:cd18326     19 QRTQGLLCDVVI-LVEGREFPTHRSVLAACSQYFKKLFtSGAVVDQQNVYEIDF-VSAEALTALLDFAYTATLTVSTSN- 95

                           90       100
                   ....*....|....*....|....
gi 1958799394  840 nvdfVCSVLVVADQLLITRLKEMC 863
Cdd:cd18326     96 ----VGDILSAARLLEIPAVSHVC 115
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 59-123 1.32e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.32  E-value: 1.32e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394   59 VSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PLN03192   532 VASTGNAALLEELLKAKLDPDIGDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL 595
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 551-637 1.46e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 39.88  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  551 GKLLRETDEM---DSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDEDAAGCHLFVVEKVHPDL 627
Cdd:cd18195      3 GALLLQLNEQrlrGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQSPERVLELPGVKAGV 82

                           90
                   ....*....|
gi 1958799394  628 FEYLLQFMYT 637
Cdd:cd18195     83 FSDVLNFIYS 92
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-642 1.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 40.19  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  554 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQkLFlsdgtlleltdvYRKDEDAAGCHLFVVEKVHPDLFEYLLQ 633
Cdd:cd18194     14 LREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LF------------YRDRLDKRDLVRLNSDIVTAPAFGLLLD 80


                   ....*....
gi 1958799394  634 FMYTDTCDF 642
Cdd:cd18194     81 FMYEGRLAL 89
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 775-832 1.53e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 38.80  E-value: 1.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799394  775 VDGKEFPCHKCVLCARLEYFhSMLSRSWIEASSCAALEMP-IQAEILKVILDYLYTDEA 832
Cdd:cd01165      5 VEGEKFHVNKELLAQSSEYF-RALFRGGFRESGQAEINLRdISPEDFRALLEFLYGGKR 62
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-841 1.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 39.77  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  761 QKKCSFLYDVTMKSVDGKeFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEaVVIKESQ 839
Cdd:cd18223     12 QRIQGILCDVTIVVEDTK-FKAHKNVLAASSLYFKNAFSSQEIWISS-HVLELPdLKAEVFAEILNFIYSSK-VVVKRQE 88


                   ..
gi 1958799394  840 NV 841
Cdd:cd18223     89 TV 90
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 552-637 1.71e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 39.25  E-value: 1.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  552 KLLREtdEMdsFHDVTFQVGNRLFPAHKYVLAVRS-DFFQKlflsdgtLLELTDVYRKDEdaagchLFVVEKVHPDLFEY 630
Cdd:cd18285      8 RLLRE--EL--HTDVTFYVGSTLFKAHKAILLARVpEFFSH-------IIGKLSSLEDQE------PINIENLEASEFKT 70


                   ....*..
gi 1958799394  631 LLQFMYT 637
Cdd:cd18285     71 FLRQVYT 77
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-875 1.75e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 40.08  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLsRSWIEASSCAALEMP-IQAEILKVILDYLYTDEavVIKESQNVDfvcSV 847
Cdd:cd18269     29 DCVLK-IGDKEFPCHRLVLAACSPYFRAMF-LSDLEESKKKEVVLEdVDPDVMGMILKYLYTSE--IDLNDQNVQ---DI 101

                           90       100
                   ....*....|....*....|....*...
gi 1958799394  848 LVVADQLLITRLKEMCEVALAENLTLKN 875
Cdd:cd18269    102 FALASRFQIPSIFTVCVSYLQKRLSLSN 129
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 561-640 1.78e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 39.65  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  561 DSFHDVTFQ-VGNRLFPAHKYVLAVRSDFFQKLFLSDGTlleltdvyrkdEDAAGCHLFVveKVHPDLFEYLLQFMYTDT 639
Cdd:cd18302      3 SDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWI-----------EASSCSALTM--PIPSDILEIILDYLYTDE 69


                   .
gi 1958799394  640 C 640
Cdd:cd18302     70 A 70
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 1.90e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 40.16  E-value: 1.90e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdgtlleltdvYRKDEDAAGCHLFVVEKVHpdlFEYLLQFMYT 637
Cdd:cd18264     30 DVVLEAEGNEFPAHRSLLACSSDYFRALFKD----------YTQESKARVIHLPVVSAAG---LQRVLDFIYT 89
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-836 2.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 39.04  E-value: 2.12e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799394  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSrswiEASSCAALEMpIQAEILKVILDYLYTDEAVVIK 836
Cdd:cd18219     23 DVTV-IVEDRKFRAHKNILSASSTYFHQLFS----VAGQVVELNF-IRADIFAEILNYIYSSKIVRVR 84
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 565-646 2.96e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 38.47  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdgtlleltdvyrkdEDAAGCHLFV---VEKVHPDLFEYLLQFMYTDtcD 641
Cdd:cd18283      4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSS--------------SPGYGAEIPVdlpTAGIDVPMFSALLRYLYTG--E 67


                   ....*
gi 1958799394  642 FLTHG 646
Cdd:cd18283     68 FGSED 72
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 563-595 3.14e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 39.29  E-value: 3.14e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958799394  563 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLS 595
Cdd:cd18309     20 FCDITLLLDGHPIPAHKAILAARCSYFEAMFRS 52
PHA03095 PHA03095
ankyrin-like protein; Provisional
 46-132 3.28e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.55  E-value: 3.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   46 TVKDAFGRNALH--LVSSCGKKAVLDWLIEKGVDLLVKDKeSGWTALHrsIFYGHINC----VWSLLKHGVSLYMQDKEG 119
Cdd:PHA03095   111 NAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDL-YGMTPLA--VLLKSRNAnvelLRLLIDAGADVYAVDDRF 187

                           90
                   ....*....|....*.
gi 1958799394  120 LSPLDLLM---KDRPA 132
Cdd:PHA03095   188 RSLLHHHLqsfKPRAR 203
BACK_SPOP_like cd14821
BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar ...
 871-902 3.34e-03

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill, and similar proteins. Both SPOP and SPOPL serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.


Pssm-ID: 350517  Cd Length: 59  Bit Score: 36.99  E-value: 3.34e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958799394  871 LTLKNAAMLLEFASMYNAEQLKLSCLQFIGLN 902
Cdd:cd14821      1 LSVENAAEVLVLADLHSAEQLKTHAIDFINSH 32
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 552-639 3.58e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 38.47  E-value: 3.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  552 KLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsdgtlleltdVYRKDEDAAGCHLFVVEKVHPDLFEYL 631
Cdd:cd18245      3 RALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKL-----------NYNPPKDDGSTYKIELEGISVEVMEEI 71


                   ....*...
gi 1958799394  632 LQFMYTDT 639
Cdd:cd18245     72 LDYIYTGQ 79
Ank_5 pfam13857
Ankyrin repeats (many copies);
48-91 3.68e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 3.68e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958799394   48 KDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALH 91
Cdd:pfam13857   12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEE-GLTALD 54
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-864 3.99e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 38.37  E-value: 3.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  761 QKKCSFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRsWIEAS---SCAALEMpIQAEILKVILDYLYTDEAVVIKE 837
Cdd:cd18330     12 QRKRDFFCDCSI-IVEGRIFKAHRNILFANSGYFRALLIH-YIQDSgrhSTASLDI-VTSEAFSIILDFLYSGKLDLCSE 88

                           90       100
                   ....*....|....*....|....*..
gi 1958799394  838 SqnvdfVCSVLVVADQLLITRLKEMCE 864
Cdd:cd18330     89 N-----VIEVMSAASYLQMTDVVNFCK 110
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 4.11e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 38.62  E-value: 4.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTL-----LELTDvyrkdedaagchlfvvekVHPDLFEYLLQFMYTDT 639
Cdd:cd18223     20 DVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWisshvLELPD------------------LKAEVFAEILNFIYSSK 81
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-649 4.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 38.30  E-value: 4.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  554 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyrkdeDAAGCHLFVVEKVHPDLFEYLLQ 633
Cdd:cd18332     10 LNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRV-------------GEGVSVLTLPSGLEARGFQLLLD 76

                           90
                   ....*....|....*.
gi 1958799394  634 FMYTdTCDFLTHGFKP 649
Cdd:cd18332     77 FMYT-SRLPLTPRTVP 91
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-831 4.36e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 38.66  E-value: 4.36e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958799394  755 NKLKLSQKKCsflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMpIQAEILKVILDYLYTDE 831
Cdd:cd18224     18 NKCRLSETMC----DVTIV-VGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDF-ITPANFEKVLSFIYTSE 88
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 4.42e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 38.87  E-value: 4.42e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtLLEltdvyRKDEDAAgchlfvVEKVHPDLFEYLLQFMYT 637
Cdd:cd18336     21 DVLLIAGNLKIPAHRLVLSAVSDYFAAMFTND--VRE-----AKQEEIK------MEGVDPDALKALVHYAYT 80
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 538-639 4.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 38.67  E-value: 4.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  538 IPVVSSSSffeEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVyrkdedAAGCHL 617
Cdd:cd18327      3 IPFPEHSS---ELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGA------GGGQDV 73

                           90       100
                   ....*....|....*....|..
gi 1958799394  618 FVVEKVHPDLFEYLLQFMYTDT 639
Cdd:cd18327     74 CELDFVGPEALGALLEFAYTAT 95
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-872 5.19e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 38.79  E-value: 5.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  761 QKKCSFLYDVTMKSVDGKeFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEaVVIKESQN 840
Cdd:cd18261     22 QRNDGILCDITLVAEEQK-FHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQ-ILLEPGVI 99

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958799394  841 VDfvcsVLVVADQLLITRLKEMCEVALAENLT 872
Cdd:cd18261    100 QD----VLAAGSHLQLLELLSLCSHYLIQELN 127
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-637 5.43e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 38.28  E-value: 5.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  548 EEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtlleltdvYRKDEDAagchLFVVEKVHPDL 627
Cdd:cd18253      3 ESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCND---------HRESREM----LVEINGILAEA 69

                           90
                   ....*....|
gi 1958799394  628 FEYLLQFMYT 637
Cdd:cd18253     70 MDCFLQYVYT 79
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 550-637 5.56e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 38.09  E-value: 5.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  550 FGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsdgtlleltdvyrKDEDAAGCHLFVVEKVHPDLFE 629
Cdd:cd18204      5 FLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLF--------------KKLEVDSSSVIEIDFLRSDIFE 70


                   ....*...
gi 1958799394  630 YLLQFMYT 637
Cdd:cd18204     71 EVLNYMYT 78
Ank_4 pfam13637
Ankyrin repeats (many copies);
86-124 5.73e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 5.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958799394   86 GWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLD 124
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALH 39
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 752-869 5.82e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 37.91  E-value: 5.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  752 KTGNKLKLSQKKCsflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLsrsWIEASSCAALEMPIQAEILKVILDYLYTDE 831
Cdd:cd18200      7 ETLNKHRLEGKFC----DLSVH-VQGRVFRAHKAVLAASSPYFHDKL---LLNDTNCLVLPSVIEAAAFENLLQLIYSGR 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958799394  832 AVVIKESqnvdfVCSVLVVADQLLITRLKEMCEVALAE 869
Cdd:cd18200     79 LTLCMDA-----LPSHLLVASGLQMWQVVDRCSELLKE 111
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-864 5.85e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 37.82  E-value: 5.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  769 DVTMkSVDGKEFPCHKCVLCARLEYFHSM----LSRSWIEASSCAalempiqaEILKVILDYLYTDEAVVIKESqnvdfV 844
Cdd:cd18232     20 DATL-DVGGRVFKAHWSVLACCSHFFQSLygdgTSGSVVLPESFA--------EVFGLLLDFFYTGELALTREN-----R 85

                           90       100
                   ....*....|....*....|
gi 1958799394  845 CSVLVVADQLLITRLKEMCE 864
Cdd:cd18232     86 DRVLLAAKELRVPEAVELCQ 105
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-639 5.85e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 38.32  E-value: 5.85e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdGTLLELTDVYRkdedaagchlfvVEKVHPDLFEYLLQFMYTDT 639
Cdd:cd18328     27 DVVLIVQDQEYRTHRSVLAACSKYFKKLFTA-GTLADQPYVYE------------IDFVTPEALSAILEFAYTST 88
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 551-637 6.41e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 37.89  E-value: 6.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  551 GKLLRETDEMDS---FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTdvyrkdedaagchlfvveKVHPDL 627
Cdd:cd18219      6 GSLLKSLNEQRGhglFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQVVELN------------------FIRADI 67

                           90
                   ....*....|
gi 1958799394  628 FEYLLQFMYT 637
Cdd:cd18219     68 FAEILNYIYS 77
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-637 6.63e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 37.90  E-value: 6.63e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgTLLELtdvyrkDEDAagchlfvvekVHPDLFEYLLQFMYT 637
Cdd:cd18216     22 DVIIVVENSLFRAHKNVLAASSGYFKSLVLHD-NLIHL------DQDM----------VSPTVFQQILDFIYT 77
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-123 6.80e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.72  E-value: 6.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394   25 ITKGSERQIKIFLSsycYNA-ATVKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKeSGWTALHRSIFYGHINCVW 103
Cdd:PHA02874   132 IKKGDLESIKMLFE---YGAdVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN-NGESPLHNAAEYGDYACIK 207

                           90       100
                   ....*....|....*....|
gi 1958799394  104 SLLKHGVSLYMQDKEGLSPL 123
Cdd:PHA02874   208 LLIDHGNHIMNKCKNGFTPL 227
PHA03098 PHA03098
kelch-like protein; Provisional
 783-923 7.16e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.52  E-value: 7.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  783 HKCVLCARLEYFHSMLSRSWIEAsscaALEMPIQAEILKVILDYLYTDeaVVIKESQNVDfvcSVLVVADQLLITRLKEM 862
Cdd:PHA03098    26 HKIILSSSSEYFKKMFKNNFKEN----EINLNIDYDSFNEVIKYIYTG--KINITSNNVK---DILSIANYLIIDFLINL 96

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958799394  863 CEVALAENLTLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDL 923
Cdd:PHA03098    97 CINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI 157
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-636 7.94e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 38.29  E-value: 7.94e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdgtlleltdvyRKDEDAAGCHLFVVEKVHPDLFEYLLQFMY 636
Cdd:cd18350     26 DVTFLVEGKLFYAHKVLLVTASNRFKSLLTN-----------KSEQESQGSKTIEISDIKYHIFQMLMQYLY 86
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 766-869 8.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 38.44  E-value: 8.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  766 FLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAA-LEMP-------IQAEILKVILDYLYT-------D 830
Cdd:cd18310     17 FYSDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPkLELRelipggiVGYDAFMLVLSYLYSgrlrlvpK 96

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1958799394  831 EAVVIKESQ--------NVDFVCSVLVVADQLLITRLKEMCEVALAE 869
Cdd:cd18310     97 EGSACVDSDcwhvacrpAVDFALEVLYAASVFQIPELVSLFQRRLLD 143
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 759-864 8.48e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 37.19  E-value: 8.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  759 LSQKKCSflyDVTMKSVDGKEFPCHKCVLCARLEYFHSMLS-RSWIEASSCaalempIQAEILKVILDYLYTDEAvvike 837
Cdd:cd18299      7 LHSPSCA---DVVFILQGGVRIFAHRIVLAAASSVFADLFLmMTVVTLDSD------ITPEAFRRVLEFLYTGVL----- 72

                           90       100
                   ....*....|....*....|....*..
gi 1958799394  838 SQNVDFVCSVLVVADQLLITRLKEMCE 864
Cdd:cd18299     73 DENEDDLKELKDAAELLELFDLVMMCT 99
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-863 9.04e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 37.88  E-value: 9.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799394  765 SFLYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVikesqNVDFV 844
Cdd:cd18251     21 GILFDVVLV-VEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELEL-----SLDNV 94

                           90
                   ....*....|....*....
gi 1958799394  845 CSVLVVADQLLITRLKEMC 863
Cdd:cd18251     95 QETLTAACQLQIPEVIGFC 113
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-834 9.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 37.47  E-value: 9.18e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958799394  761 QKKCSFLyDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSwiEASSCAALEMpIQAEILKVILDYLYTDEAVV 834
Cdd:cd18226     17 QKQSSFC-DLVI-TVEGKEFSAHKVVVAVGSSYFHACLSKN--PNTDAVTLDH-VSYSVFQHLLEFLYTSEFFV 85
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-595 9.28e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 37.76  E-value: 9.28e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958799394  565 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLS 595
Cdd:cd18255     20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTG 50
BACK_RHOBTB cd18499
BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing proteins ...
 872-910 9.85e-03

BACK (BTB and C-terminal Kelch) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline rich region, a tandem of 2 BTB domains, and a C-terminal BACK domain. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi.


Pssm-ID: 350574  Cd Length: 76  Bit Score: 36.45  E-value: 9.85e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958799394  872 TLKNAAMLLEFASMYNAEQLKLSCLQFIGLNMAALLEAR 910
Cdd:cd18499      1 IDEDVIDLLELAQLHNADQLAAWCLHFISTNYNAFCKHR 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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