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Conserved domains on  [gi|1958799396|ref|XP_038938474|]
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inhibitor of Bruton tyrosine kinase isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 764-870 3.88e-61

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 202.59  E-value: 3.88e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 764 KCSFLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVD 843
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100
                  ....*....|....*....|....*..
gi 1958799396 844 FVCSVLVVADQLLITRLKEMCEVALAE 870
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVE 107
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-652 1.43e-43

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 152.83  E-value: 1.43e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 547 FFEEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyRKDEDAAGCHLFVVEKVHP 626
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                          90       100
                  ....*....|....*....|....*.
gi 1958799396 627 DLFEYLLQFMYTDTCDFLTHGFKPRM 652
Cdd:cd18301    72 EIFEQLLQFIYTDTCDLLTDGYKPKL 97
ATS1 super family cl34932
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 1.25e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


The actual alignment was detected with superfamily member COG5184:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 91.19  E-value: 1.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 223 VEGLSGHScsQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184   195 VGGLSGVV--AVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 302 EAVYTLGLNG-GQLGhlldpNGEKC-VTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 4.54e-14

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.83  E-value: 4.54e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799396  47 VKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 764-870 3.88e-61

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 202.59  E-value: 3.88e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 764 KCSFLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVD 843
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100
                  ....*....|....*....|....*..
gi 1958799396 844 FVCSVLVVADQLLITRLKEMCEVALAE 870
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVE 107
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-652 1.43e-43

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 152.83  E-value: 1.43e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 547 FFEEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyRKDEDAAGCHLFVVEKVHP 626
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                          90       100
                  ....*....|....*....|....*.
gi 1958799396 627 DLFEYLLQFMYTDTCDFLTHGFKPRM 652
Cdd:cd18301    72 EIFEQLLQFIYTDTCDLLTDGYKPKL 97
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 1.25e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 91.19  E-value: 1.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 223 VEGLSGHScsQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184   195 VGGLSGVV--AVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 302 EAVYTLGLNG-GQLGhlldpNGEKC-VTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 762-871 6.57e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 74.22  E-value: 6.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 762 QKKCSFLYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavvIKESQN 841
Cdd:pfam00651   4 LREQGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK---LISEEN 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958799396 842 VDfvcSVLVVADQLLITRLKEMCEVALAEN 871
Cdd:pfam00651  80 VD---DLLAAADKLQIPSLVDKCEEFLIKS 106
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 562-640 8.31e-15

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 71.13  E-value: 8.31e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799396 562 DSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 640
Cdd:pfam00651   8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-------------VSPEDFEALLEFMYTGK 73
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 4.54e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.83  E-value: 4.54e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799396  47 VKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 566-640 8.61e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 67.72  E-value: 8.61e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396  566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 640
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGK 62
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 770-872 1.06e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 67.72  E-value: 1.06e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  770 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavVIKESQNVDfvcSVL 849
Cdd:smart00225   1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGK--LDLPEENVE---ELL 74

                           90       100
                   ....*....|....*....|...
gi 1958799396  850 VVADQLLITRLKEMCEVALAENH 872
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKLL 97
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
247-299 2.03e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.45  E-value: 2.03e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 247 DGCVYTFGLNTFHQLGiIPPPSSCNVPRQIQAkyLKGRTIIGVAAGRFHTVLW 299
Cdd:pfam00415   1 DGRVYTWGRNDYGQLG-LGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-116 2.09e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 2.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  27 KGSERQIKIFLSSYCynAATVKDAFGRNALHLVSSCGKKAVLDWLIEKGVdllVKDKESGWTALHRSIFYGHINCVWSLL 106
Cdd:pfam12796   7 NGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKLLL 81

                          90
                  ....*....|
gi 1958799396 107 KHGVSLYMQD 116
Cdd:pfam12796  82 EKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 17-123 4.58e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.50  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  17 HALDVLSVITKGSERQIKIFLSsycYNA-ATVKDAFGRNALHLVSSCG--KKAVLDWLIEKGVDLLVKDK---------- 83
Cdd:PHA03100  108 TPLLYAISKKSNSYSIVEYLLD---NGAnVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDINAKNRvnyllsygvp 184

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958799396  84 -----ESGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PHA03100  185 inikdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 764-870 3.88e-61

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 202.59  E-value: 3.88e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 764 KCSFLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVD 843
Cdd:cd18302     1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                          90       100
                  ....*....|....*....|....*..
gi 1958799396 844 FVCSVLVVADQLLITRLKEMCEVALAE 870
Cdd:cd18302    81 FLCNVLVIADQLLITRLKEICEVALVE 107
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-652 1.43e-43

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 152.83  E-value: 1.43e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 547 FFEEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyRKDEDAAGCHLFVVEKVHP 626
Cdd:cd18301     1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                          90       100
                  ....*....|....*....|....*.
gi 1958799396 627 DLFEYLLQFMYTDTCDFLTHGFKPRM 652
Cdd:cd18301    72 EIFEQLLQFIYTDTCDLLTDGYKPKL 97
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 1.25e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 91.19  E-value: 1.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   118 TVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG---VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 223 VEGLSGHScsQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHT-VLWTR 301
Cdd:COG5184   195 VGGLSGVV--AVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDR-ATPVQVAG----LTGVVAIAAGGSHTcALKSD 267

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 302 EAVYTLGLNG-GQLGhlldpNGEKC-VTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   268 GTVWCWGDNSyGQLG-----DGTTTdRSTPVKVPGLSG----VVAVAAGSSHTCALLTDGTVW 321
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-362 3.28e-19

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 90.04  E-value: 3.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 144 VYTWGDNTNFTLGHGSQNSKHHPELLDLFSRsrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRLV 223
Cdd:COG5184    19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN----VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 224 EGLSGhsCSQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGiIPPPSSCNVPRQIQAkylKGRTIIGVAAGRFHTVLWTRE- 302
Cdd:COG5184    95 PGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG-DGTTTNRLTPVQVDA---GLSGVVAIAAGGYHTCALKSDg 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958799396 303 AVYTLGLNG-GQLGHLLDPNgekcVTTPRQVSALHHkdiaVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   169 TVWCWGANSyGQLGDGTTTD----RPTPVQVGGLSG----VVAVAAGGDHSCALKSDGTVW 221
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-855 6.61e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 81.83  E-value: 6.61e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEAVVikesqNVDFVC 846
Cdd:cd18186     1 LCDVTLV-VGGREFPAHRAVLAARSPYFRAMFSSGMKESSS-SEIELDdVSPEAFEALLDYIYTGELEL-----SEENVE 73


                  ....*....
gi 1958799396 847 SVLVVADQL 855
Cdd:cd18186    74 ELLAAADKL 82
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-643 2.51e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 74.51  E-value: 2.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyrkdeDAAGCHLFVVEKVHPDLFEYLLQFMYTDTCDF 643
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGM-------------KESSSSEIELDDVSPEAFEALLDYIYTGELEL 67
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 762-871 6.57e-16

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 74.22  E-value: 6.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 762 QKKCSFLYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavvIKESQN 841
Cdd:pfam00651   4 LREQGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK---LISEEN 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958799396 842 VDfvcSVLVVADQLLITRLKEMCEVALAEN 871
Cdd:pfam00651  80 VD---DLLAAADKLQIPSLVDKCEEFLIKS 106
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-362 7.52e-16

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 80.02  E-value: 7.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRsrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184    68 TVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG----VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQ 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 223 V-EGLSGhsCSQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSScNVPRQIQAKylkgRTIIGVAAGRFHT-VLWT 300
Cdd:COG5184   144 VdAGLSG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDR-PTPVQVGGL----SGVVAVAAGGDHScALKS 216

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 301 REAVYTLGLNG-GQLGHLLDPNgekcVTTPRQVSALHhkdiAVSLVAASDGATVCVTTRGDIY 362
Cdd:COG5184   217 DGTVWCWGSNSsGQLGDGTTTD----RATPVQVAGLT----GVVAIAAGGSHTCALKSDGTVW 271
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 562-640 8.31e-15

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 71.13  E-value: 8.31e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799396 562 DSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 640
Cdd:pfam00651   8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-------------VSPEDFEALLEFMYTGK 73
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 767-871 1.68e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 70.79  E-value: 1.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 767 FLYDVTMKsVDGKEFPCHKCVLCARLEYFHSML----SRSWIEASSCAALEMP-IQAEILKVILDYLYTDEAVVikesqN 841
Cdd:cd18296    16 SFPDVCFQ-VEGHRFPCHKAFFCGRSDYFKALLrdhfAESEENNGSIPVVTLHdVSPEVFAIVLYYIYTDDTDL-----P 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958799396 842 VDFVCSVLVVADQLLITRLKEMCEVALAEN 871
Cdd:cd18296    90 PENAYDVLYVADMYLLPGLKRLCGTVLAQS 119
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 4.54e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.83  E-value: 4.54e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799396  47 VKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 758-862 7.52e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 68.82  E-value: 7.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 758 LKLSQKkcSFLYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCaalEMPIQA---EILKVILDYLYTDeAV 834
Cdd:cd18286     9 LQLFLN--GEDSDITIK-VDGKTFKAHRCILCARSSYFAAMLSGSWAESNSS---EITLTGvshAAVSFVLLFIYGG-VL 81

                          90       100
                  ....*....|....*....|....*...
gi 1958799396 835 VIKESQNvdfVCSVLVVADQLLITRLKE 862
Cdd:cd18286    82 DLPDDVN---LGELLSLADMYGLDGLKD 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 566-640 8.61e-14

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 67.72  E-value: 8.61e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396  566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYTDT 640
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGK 62
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 770-872 1.06e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 67.72  E-value: 1.06e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  770 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavVIKESQNVDfvcSVL 849
Cdd:smart00225   1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGK--LDLPEENVE---ELL 74

                           90       100
                   ....*....|....*....|...
gi 1958799396  850 VVADQLLITRLKEMCEVALAENH 872
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKLL 97
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-125 1.16e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 1.16e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799396  47 VKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:COG0666   115 ARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDND-GNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 548-642 3.01e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 64.24  E-value: 3.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 548 FEEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsDGTLLEltdvyrKDEDAAGCHLFVVEKVHPD 627
Cdd:cd18296     1 RVDLDELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALL--RDHFAE------SEENNGSIPVVTLHDVSPE 72

                          90
                  ....*....|....*
gi 1958799396 628 LFEYLLQFMYTDTCD 642
Cdd:cd18296    73 VFAIVLYYIYTDDTD 87
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 756-864 9.57e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 62.73  E-value: 9.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 756 NKLKLSQKKCsflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQAEILKVILDYLYTDEAV 834
Cdd:cd18240     9 NELRLEGKLC----DVVIR-VNGVEFPAHRNILCACSPYFRALFTNGWNE-TEKKVYKIPgVSPEMMELIIEYAYTRTVP 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958799396 835 VikesqNVDFVCSVLVVADQLLITRLKEMC 864
Cdd:cd18240    83 I-----TAENVEELLPAADQFNIMGIVKAC 107
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
247-299 2.03e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.45  E-value: 2.03e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 247 DGCVYTFGLNTFHQLGiIPPPSSCNVPRQIQAkyLKGRTIIGVAAGRFHTVLW 299
Cdd:pfam00415   1 DGRVYTWGRNDYGQLG-LGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-116 2.09e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 2.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  27 KGSERQIKIFLSSYCynAATVKDAFGRNALHLVSSCGKKAVLDWLIEKGVdllVKDKESGWTALHRSIFYGHINCVWSLL 106
Cdd:pfam12796   7 NGNLELVKLLLENGA--DANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD---VNLKDNGRTALHYAARSGHLEIVKLLL 81

                          90
                  ....*....|
gi 1958799396 107 KHGVSLYMQD 116
Cdd:pfam12796  82 EKGADINVKD 91
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-871 3.18e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 61.71  E-value: 3.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 776 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYtDEAVVIKEsqnvDFVCSVLVVADQL 855
Cdd:cd18265    30 VDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMY-GGGLRIQE----DNVESVLEASDLL 104

                          90
                  ....*....|....*.
gi 1958799396 856 LITRLKEMCeVALAEN 871
Cdd:cd18265   105 QVSKLREAC-VRFLEG 119
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 232-354 1.04e-10

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 64.23  E-value: 1.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 232 SQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGIIPPPSScNVPRQIQAkylkGRTIIGVAAGRFHTVLWTRE-AVYTLGLN 310
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPG----LSNVVAVAAGGDHTCALKADgTVWCWGNN 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958799396 311 G-GQLGhlldpNGEK-CVTTPRQVSALHH-KDIAV----SLVAASDGATVC 354
Cdd:COG5184    76 SyGQLG-----DGTTtDRTTPVKVPGLTGvVAVAAgyyhSCALKSDGTVWC 121
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 551-640 1.07e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 60.04  E-value: 1.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 551 FGKLLretDEMDSFhDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLsdGTLLEltdvyRKDEDAagchlfVVEKVHPDLFE 630
Cdd:cd18280     5 FGALL---ESEEGA-DVTFNVDGEKFRAHKLVLAARSPVFRSMLF--GPMRE-----ENEGEI------VIEDVEPPVFK 67

                          90
                  ....*....|
gi 1958799396 631 YLLQFMYTDT 640
Cdd:cd18280    68 ALLHFIYKDE 77
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-864 1.56e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 58.89  E-value: 1.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 776 VDGKEFPCHKCVLCARLEYFHSMLSRSW-IEASSCAALE-MPIQAEILKVILDYLYTDEavvIKESQnvDFVCSVLVVAD 853
Cdd:cd18245    21 VGGEEIPVQKNVLAAASPYFRAKLNYNPpKDDGSTYKIElEGISVEVMEEILDYIYTGQ---IKLSE--DNIQDIVQAAD 95

                          90
                  ....*....|.
gi 1958799396 854 QLLITRLKEMC 864
Cdd:cd18245    96 LLLMTDLKDLC 106
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 770-865 1.72e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 58.79  E-value: 1.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEavvIKESQNVDFVCsV 848
Cdd:cd18300    11 DVTFI-VEDGTIPAHKALLVARCDVMAAMFGGNFRESSA-KEVELPgVSKETFLALLEYLYTDQ---APILEDGDCVG-L 84

                          90
                  ....*....|....*..
gi 1958799396 849 LVVADQLLITRLKEMCE 865
Cdd:cd18300    85 IVLANRLCLPRLVALCE 101
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 547-646 3.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 58.41  E-value: 3.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 547 FFEEFGKLLretdEMDSFHDVTFQVGNRLFP--AHKYVLAVRSDFFQKLFLsdgtllelTDVYRKDEDAAgchlFVVEKV 624
Cdd:cd18294     1 FAADMKSLI----NNPEFSDVKFLVGPERQEifAHKCILAARCEVFRAMFL--------TGPQKESTQSP----LVLSDI 64

                          90       100
                  ....*....|....*....|..
gi 1958799396 625 HPDLFEYLLQFMYTDTCDFLTH 646
Cdd:cd18294    65 EPEVFRAVLEFIYTNCVTLSNH 86
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-263 3.67e-10

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 62.69  E-value: 3.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRsrvyVKQVVLCKFHSVFLSQQGQVYTCGHGRGGRLGHGDEQTCLVPRL 222
Cdd:COG5184   219 TVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVK 294

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1958799396 223 VEGLSGhsCSQVAAAKDHTVVLTEDGCVYTFGLNTFHQLGI 263
Cdd:COG5184   295 VPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGD 333
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 537-638 4.96e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 58.02  E-value: 4.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 537 YEIPVVSSSSffEEFGKLLRETDemdsFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLsdGTLLE--LTDVYRKDEDAA 614
Cdd:cd18287     1 GEIDHVHFLS--EDIGALFLNEE----YSDVTFVVEEKRFPAHRVILAARSEYFRALLY--GGMREsqQSEIELKDTNAE 72

                          90       100
                  ....*....|....*....|....
gi 1958799396 615 GchlfvvekvhpdlFEYLLQFMYT 638
Cdd:cd18287    73 A-------------FKALLKYIYT 83
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-871 6.07e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 57.87  E-value: 6.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 766 SFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVikesqNVDFV 845
Cdd:cd18268    21 RILTDVIL-CTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILI-----TRDNV 94

                          90       100
                  ....*....|....*....|....*.
gi 1958799396 846 CSVLVVADQLLITRLKEMCEVALAEN 871
Cdd:cd18268    95 LPLMEAASMLQYPKLFEACSLYLQDQ 120
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 563-638 9.40e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 56.20  E-value: 9.40e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958799396 563 SFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVyrkdedaagchlfVVEKVHPDLFEYLLQFMYT 638
Cdd:cd18314     5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEV-------------TLEDVEPEIFETVLKYMYT 67
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 544-638 1.28e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 56.53  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 544 SSSFFEEFGKLLRETDemdsFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDEDAAGChlfvvek 623
Cdd:cd18292     1 SREFLQDIAQLYNNEE----LSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECA------- 69

                          90
                  ....*....|....*
gi 1958799396 624 vhpDLFEYLLQFMYT 638
Cdd:cd18292    70 ---AVFEKFLRYLYT 81
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-674 2.02e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 56.26  E-value: 2.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 563 SFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlSDGTLLELTDVYRkdedaagchlfvVEKVHPDLFEYLLQFMYTDTCD 642
Cdd:cd18256    19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALF-AGGMSESSKDVVQ------------IHGVEPDIFHILLDFIYTGVVE 85

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958799396 643 FLTHGFKPRMI---MNKKSEDSKGSPE---SRLHAVNC 674
Cdd:cd18256    86 VTVSNVQELLVaadMLQLTEVVEICCEflkGQLHPSNC 123
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 548-639 2.37e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 56.10  E-value: 2.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 548 FEEFgklLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyrKDEDAAGchlFVVEKVHPD 627
Cdd:cd18295     6 YDEF---LRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKW----------KDKREIN---LKHPLVNPD 69

                          90
                  ....*....|..
gi 1958799396 628 LFEYLLQFMYTD 639
Cdd:cd18295    70 AFRALLQYLYTG 81
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 4.54e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 55.22  E-value: 4.54e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtllelTDVYRKdedaagchlFVVEKVHPDLFEYLLQFMYT 638
Cdd:cd18224    28 DVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTE-----LDVART---------YVVDFITPANFEKVLSFIYT 86
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-870 4.91e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 55.19  E-value: 4.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVikESQNVDfvcS 847
Cdd:cd18237    21 LCDVIL-IVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISV--NSNNVQ---S 94

                          90       100
                  ....*....|....*....|...
gi 1958799396 848 VLVVADQLLITRLKEMCEVALAE 870
Cdd:cd18237    95 LLDAANQYQIEPVKKMCVDFLKE 117
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-870 6.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 54.77  E-value: 6.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 762 QKKCSFLyDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqN 841
Cdd:cd18250    16 RAERKFF-DVTL-CAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQD--N 91

                          90       100
                  ....*....|....*....|....*....
gi 1958799396 842 VDfvcSVLVVADQLLITRLKEMCEVALAE 870
Cdd:cd18250    92 VE---ALLRAADLFQFPSVKEACCAYLQQ 117
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-870 7.73e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 54.46  E-value: 7.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 775 SVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqNVDFvcsVLVVADQ 854
Cdd:cd18253    24 CVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTE--NVQY---LFETSSL 98

                          90
                  ....*....|....*.
gi 1958799396 855 LLITRLKEMCEVALAE 870
Cdd:cd18253    99 FQISPLRDACAKFLEE 114
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-871 8.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 54.47  E-value: 8.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAvvikesQNVDFVC-SV 848
Cdd:cd18345    20 DVTL-CVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKA------PNLDKMAdDL 92

                          90       100
                  ....*....|....*....|...
gi 1958799396 849 LVVADQLLITRLKEMCEVALAEN 871
Cdd:cd18345    93 LAAADKYALERLKVMCEEALCSN 115
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 753-864 9.07e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 54.37  E-value: 9.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 753 KTGNKLKLSQKKCsflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDE 832
Cdd:cd18242    10 NTMNSLRKSNTLC----DVTLR-VEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTET 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958799396 833 AVVikesqNVDFVCSVLVVADQLLITRLKEMC 864
Cdd:cd18242    85 VHV-----TVENVQELLPAACLLQLKGVKQAC 111
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-870 1.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 54.47  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKesQNVDfvcS 847
Cdd:cd18236    24 LTDVIL-CVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITK--QNVQ---R 97

                          90       100
                  ....*....|....*....|...
gi 1958799396 848 VLVVADQLLITRLKEMCEVALAE 870
Cdd:cd18236    98 VLEAASLFQFLRMVDACASFLTE 120
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-871 1.51e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 53.44  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMKSVdGKEFPCHKCVLCaRLEYFHSMLSRSWIEA-SSCAALEMP---IQAEILKVILDYLYTDEaVVIKESQnvdfV 845
Cdd:cd18305    17 DITICAL-GREWKLHKIYLC-QSGYFASMFSGSWKESkETVINLEIPddnITVEALNVVFGSLYRDE-IEIKPSR----V 89

                          90       100
                  ....*....|....*....|....*.
gi 1958799396 846 CSVLVVADQLLITRLKEMCEVALAEN 871
Cdd:cd18305    90 VSILAAATLLQLDGLIQQCSEVMKET 115
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-638 1.56e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 53.80  E-value: 1.56e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdgtlleltdvyrkDEDAAGCHLFVVEKVHPDLFEYLLQFMYT 638
Cdd:cd18306    18 FCDVILQVGGHEIPAHRAVLACASPYLFELFSS-------------DSDGESILTVKLDGLDPDAVEVLVNYAYT 79
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-854 1.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 53.39  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQAEILKVILDYLYTDEAVVIKESQnvDFVCSV 848
Cdd:cd18287    24 DVTF-VVEEKRFPAHRVILAARSEYFRALLYGGMRE-SQQSEIELKdTNAEAFKALLKYIYTGRLTLTDLKE--DVLLDV 99


                  ....*.
gi 1958799396 849 LVVADQ 854
Cdd:cd18287   100 LGLAHQ 105
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-138 2.06e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.50  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  47 VKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDLL 126
Cdd:COG0666   181 ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDND-GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259

                          90
                  ....*....|..
gi 1958799396 127 MKDRPAHVVFKN 138
Cdd:COG0666   260 AAAGAALIVKLL 271
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-868 2.58e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 53.10  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDE-------AVVIKESQNV 842
Cdd:cd18280    16 DVTF-NVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDElpddvepAGSDSSSLDT 94

                          90       100
                  ....*....|....*....|....*.
gi 1958799396 843 DFVCSVLVVADQLLITRLKEMCEVAL 868
Cdd:cd18280    95 TMAQHLLAAADRYALERLRLLCESRL 120
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 777-865 2.68e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 52.63  E-value: 2.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 777 DGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALE-MPIQAEILKVILDYLYTDEAvvikeSQNVDFVCSVLVVADQL 855
Cdd:cd18294    24 ERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVlSDIEPEVFRAVLEFIYTNCV-----TLSNHTVIEVLAAAVEY 98

                          90
                  ....*....|
gi 1958799396 856 LITRLKEMCE 865
Cdd:cd18294    99 GLDELRKLCE 108
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-869 3.12e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 52.91  E-value: 3.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESqnvdfVCSVL 849
Cdd:cd18252    23 DITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERN-----VQSLL 97

                          90       100
                  ....*....|....*....|
gi 1958799396 850 VVADQLLITRLKEMCEVALA 869
Cdd:cd18252    98 EAADLLQFISVKKACEQFLV 117
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 750-871 4.63e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 52.31  E-value: 4.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 750 IAKKTGNKLKLSQ-KKCSFLydvtmksVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYL 828
Cdd:cd18343     8 LAEDLGNLWENSRfTDCSLF-------VGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958799396 829 YTDEAvvikesQNVDFVC-SVLVVADQLLITRLKEMCEVALAEN 871
Cdd:cd18343    81 YTGKA------PNLDKMAdNLLAAADKYALERLKVMCEEALCNN 118
Ank_2 pfam12796
Ankyrin repeats (3 copies);
56-123 1.28e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 1.28e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799396  56 LHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHgVSLYMQDkEGLSPL 123
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKN-GRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTAL 65
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 760-864 1.41e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 51.14  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 760 LSQKKCSF----LYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEaVV 835
Cdd:cd18274    10 LQQLKAMYdegqLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSR-VT 88

                          90       100
                  ....*....|....*....|....*....
gi 1958799396 836 IKESQnvdfVCSVLVVADQLLITRLKEMC 864
Cdd:cd18274    89 LTEAN----VQALFTAASIFQIPSLQDQC 113
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-643 1.53e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 50.78  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDvyrkdedaagchlfvvekVHPDLFEYLLQFMYTDTCDF 643
Cdd:cd18303    18 YSDITIKLADKSIPAHKFVLAARSEKWSNENLASTNELDLSD------------------ISYEVVLALLRWLYTDELDL 79
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-864 2.33e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 50.63  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 762 QKKCSFLYDVTM--KSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-------IQAEILKVILDYLYTDE 832
Cdd:cd18241    17 QRKQGLFCDITLafGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRS-GRVEMRkwssepgPDPDTVEAVIQYMYTGR 95

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958799396 833 AVVIKESqnvdfVCSVLVVADQLLITRLKEMC 864
Cdd:cd18241    96 IRVSTGN-----VHEVLELADRFLLIRLKEFC 122
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-871 2.35e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 50.22  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqnvdFVCSVL 849
Cdd:cd18279    20 DCCL-CVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDK-----MADDLL 93

                          90       100
                  ....*....|....*....|..
gi 1958799396 850 VVADQLLITRLKEMCEVALAEN 871
Cdd:cd18279    94 AAADKYALERLKVMCEDALCSN 115
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-865 2.85e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 49.98  E-value: 2.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKV---ILDYLYTDEAVVikesqNVDF 844
Cdd:cd18292    17 LSDIVLR-VGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELVEDPECAAVfekFLRYLYTGQISV-----NLET 90

                          90       100
                  ....*....|....*....|.
gi 1958799396 845 VCSVLVVADQLLITRLKEMCE 865
Cdd:cd18292    91 ALPLLMLADKYNVTDLKQLCV 111
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-661 3.21e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 50.01  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlSDGtLLELTDvyrkdeDAAGCHlfvvEKVHPDLFEYLLQFMYTDtcdf 643
Cdd:cd18254    22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAMF-SNG-LRESLD------STVNFH----DSLHPEVLELLLDFAYSS---- 85

                          90
                  ....*....|....*...
gi 1958799396 644 lthgfkpRMIMNKKSEDS 661
Cdd:cd18254    86 -------RIIINEENAES 96
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 758-871 4.33e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 50.37  E-value: 4.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 758 LKLSQKKCSFLyDVTMKSvDGKEFPCHKCVLCARLEYFHSMLSRSWIEA-SSCAALEMPIQAEILKVILDYLYTDEAVVI 836
Cdd:cd18267    31 LNLLRQQRLFT-DVLLHA-GNRSFPCHRAVLAACSRYFEAMFSGGLKESqDSEVNFHDSIHPEVLELLLDYAYSSRVIIN 108

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958799396 837 KESQNvdfvcSVLVVADQLLITRLKEMCEVALAEN 871
Cdd:cd18267   109 EENAE-----SLLEAGDMLEFQDIRDACAEFLEKN 138
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 766-864 4.66e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 49.56  E-value: 4.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 766 SFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEaSSCAALEMP-IQAEILKVILDYLYTDEAvvikESQnVDF 844
Cdd:cd18295    17 GSYSDVTF-NVHGESFPAHRCILSARSPYFAEMFETKWKD-KREINLKHPlVNPDAFRALLQYLYTGRL----EIH-VDD 89

                          90       100
                  ....*....|....*....|....
gi 1958799396 845 VCSVLVVADQ----LLITRLKEMC 864
Cdd:cd18295    90 VEDCKRLAKQcrleELIEELEAKC 113
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 763-864 5.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 49.35  E-value: 5.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 763 KKCSFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESqnv 842
Cdd:cd18235    16 RKQNLLCDVIL-VADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEEN--- 91

                          90       100
                  ....*....|....*....|..
gi 1958799396 843 dfVCSVLVVADQLLITRLKEMC 864
Cdd:cd18235    92 --VQVLLPAANLLQLTDVRDAC 111
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 756-864 5.54e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 49.32  E-value: 5.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 756 NKLKLSQKKCsflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVV 835
Cdd:cd18256    12 NKLRGQHEFC----DVQLQ-VGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEV 86

                          90       100
                  ....*....|....*....|....*....
gi 1958799396 836 ikesqNVDFVCSVLVVADQLLITRLKEMC 864
Cdd:cd18256    87 -----TVSNVQELLVAADMLQLTEVVEIC 110
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-864 6.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 49.44  E-value: 6.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqNVDfvcS 847
Cdd:cd18259    32 LSDVTL-LVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGKLTINQG--NVE---A 105

                          90
                  ....*....|....*..
gi 1958799396 848 VLVVADQLLITRLKEMC 864
Cdd:cd18259   106 LIRTSNRLQFPTVRKVC 122
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-864 6.46e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 48.82  E-value: 6.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTdeAVVIKESQNVDfvcS 847
Cdd:cd18247    19 LCDVTLK-VGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYS--GRIAIDTSNVQ---S 92

                          90
                  ....*....|....*..
gi 1958799396 848 VLVVADQLLITRLKEMC 864
Cdd:cd18247    93 LLVGASFLQLQSVKDAC 109
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-642 7.57e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 48.55  E-value: 7.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 566 DVTFQVGN----RLFPAHKYVLAVRSDFFQKLFLsdGTLLEltdvyRKDEdaagchlFVVEKVHPDLFEYLLQFMYTDTC 641
Cdd:cd18282     9 DVHFIVGPpggtQRIPAHKYVLATGSSVFYAMFY--GGLAE-----NKNE-------IEIPDVEPAAFLNLLRYLYCDEI 74


                  .
gi 1958799396 642 D 642
Cdd:cd18282    75 D 75
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 756-839 9.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 48.85  E-value: 9.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 756 NKLKLSQKKCSFLyDVTMKSVDgKEFPCHKCVLCARLEYFHSMLSRSWIEA-SSCAALEMPIQAEILKVILDYLYTDEAV 834
Cdd:cd18254    11 THLNTLRKQCMFT-DVTLWAGN-RSFPCHRAVLAACSRYFEAMFSNGLRESlDSTVNFHDSLHPEVLELLLDFAYSSRII 88


                  ....*
gi 1958799396 835 VIKES 839
Cdd:cd18254    89 INEEN 93
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 768-866 9.70e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 48.31  E-value: 9.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESQNVdfvcS 847
Cdd:cd18360    10 LADVVFK-IQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPASILQAM----A 84

                          90
                  ....*....|....*....
gi 1958799396 848 VLVVADQLLITRLKEMCEV 866
Cdd:cd18360    85 LLICAEMYQVSRLQHICEL 103
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-871 1.46e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 48.04  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEAVVIKESQNVDFvcSV 848
Cdd:cd18297    14 DVTFL-VEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQT-PVIEIPdIRYDIFQLMMQYLYTGGVESLDVAQDDAL--EL 89

                          90       100
                  ....*....|....*....|...
gi 1958799396 849 LVVADQLLITRLKEMCEVALAEN 871
Cdd:cd18297    90 LRAASFFQLDGLKRHCEILLSQQ 112
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
143-192 1.99e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.59  E-value: 1.99e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958799396 143 EVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSRvyVKQVVLCKFHSVFL 192
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNK--VVQVACGGDHTVAL 50
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 768-871 2.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 47.09  E-value: 2.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEAVVIKesqnvDFVC 846
Cdd:cd18352    13 LSDVTF-LVEGRRFYAHRIALLASSDAFRAMFDGGYREKEA-RDIEIPnIRWEVFELMMRFIYTGSVDITN-----DIAK 85

                          90       100
                  ....*....|....*....|....*
gi 1958799396 847 SVLVVADQLLITRLKEMCEVALAEN 871
Cdd:cd18352    86 DLLRAADQYLLEGLKRLCEYTIAQD 110
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 769-865 2.93e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 46.86  E-value: 2.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 769 YDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASScaaLEMPIQA---EILKVILDYLYTDEAvvikeSQNVDFV 845
Cdd:cd18298    13 SDLKFR-VDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDK---NVIEIDQysyPVYYAFLRYLYTDQV-----DLPPEDA 83

                          90       100
                  ....*....|....*....|
gi 1958799396 846 CSVLVVADQLLITRLKEMCE 865
Cdd:cd18298    84 IGLLDLANSYCEERLKKLCE 103
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-871 3.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 47.26  E-value: 3.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 776 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIkesQNVDFVCSVLVVADQL 855
Cdd:cd18344    30 VAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAPHL---HSHSMACDVLAAADKY 106

                          90
                  ....*....|....*.
gi 1958799396 856 LITRLKEMCEVALAEN 871
Cdd:cd18344   107 GLEGLKVLCEDALCRN 122
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-661 3.81e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 47.68  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsDGTLLELTDVYRKDEDAagchlfvvekVHPDLFEYLLQFMYTDtcdf 643
Cdd:cd18267    40 FTDVLLHAGNRSFPCHRAVLAACSRYFEAMF--SGGLKESQDSEVNFHDS----------IHPEVLELLLDYAYSS---- 103

                          90
                  ....*....|....*...
gi 1958799396 644 lthgfkpRMIMNKKSEDS 661
Cdd:cd18267   104 -------RVIINEENAES 114
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 550-638 4.69e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 46.51  E-value: 4.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 550 EFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGT-----LLELTDVyrkDEDAagchlfvvekv 624
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAeskqdSITIKDI---DEEA----------- 66

                          90
                  ....*....|....
gi 1958799396 625 hpdlFEYLLQFMYT 638
Cdd:cd18238    67 ----VELLVDFAYT 76
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 549-638 5.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 46.37  E-value: 5.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 549 EEFGKLLretdEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLF-----LSDGTLLELTDvyrkdedaagchlfvvek 623
Cdd:cd18279     7 EDLGNLW----ENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFehemeESKKNRVEIND------------------ 64

                          90
                  ....*....|....*
gi 1958799396 624 VHPDLFEYLLQFMYT 638
Cdd:cd18279    65 VDPEVFKEMMRFIYT 79
Ank_4 pfam13637
Ankyrin repeats (many copies);
52-102 5.28e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 5.28e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958799396  52 GRNALHLVSSCGKKAVLDWLIEKGVDLLVKDkESGWTALHRSIFYGHINCV 102
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVD-GNGETALHFAASNGNVEVL 50
Ank_5 pfam13857
Ankyrin repeats (many copies);
71-125 5.77e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.26  E-value: 5.77e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396  71 LIEKGVDLLVKDKESGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPLDL 125
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-864 6.04e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 46.32  E-value: 6.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 762 QKKCSFLYDVTMKSvDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMP-IQAEILKVILDYLYTDEAVVIKESQ 840
Cdd:cd18293     9 QQNSGVFCDVLLQA-EGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLELQgLKAHTLLKLVDFLYTSELEVSSEEA 87

                          90       100
                  ....*....|....*....|....
gi 1958799396 841 NvdfvcSVLVVADQLLITRLKEMC 864
Cdd:cd18293    88 Q-----DVLAAARRLQISELESLC 106
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 8.03e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 45.43  E-value: 8.03e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtLLELTdvyrKDEdaagchlFVVEKVHPDLFEYLLQFMYT 638
Cdd:cd18234     3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTND--VREAT----EEE-------IKLKDVDPDALWTLVQYCYT 62
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-638 9.99e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 45.38  E-value: 9.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 555 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsdgtlleltdvyrkdEDAAGCHLFVVEKVHPDLFEYLLQ 634
Cdd:cd18221     9 LNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF----------------QDFTQEPLVEIEGVSNMAFRHLIE 72


                  ....
gi 1958799396 635 FMYT 638
Cdd:cd18221    73 FTYT 76
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 777-832 1.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 45.57  E-value: 1.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958799396 777 DGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDE 832
Cdd:cd18276    29 EGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSD 84
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 563-642 1.18e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 45.34  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 563 SFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLS-----DGTLLELTDV-YrkdedaagchlfvvekvhpDLFEYLLQFM 636
Cdd:cd18297    11 EMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSgsteaQTPVIEIPDIrY-------------------DIFQLMMQYL 71


                  ....*.
gi 1958799396 637 YTDTCD 642
Cdd:cd18297    72 YTGGVE 77
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-640 1.22e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 45.51  E-value: 1.22e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdgtllELTDVYRKDEDAAGchlfvvekVHPDLFEYLLQFMYTDT 640
Cdd:cd18242    23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTS-----EMSEKGKSEVELQG--------LTASTMEILLDFVYTET 84
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
233-260 1.32e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.41  E-value: 1.32e-05
                          10        20
                  ....*....|....*....|....*...
gi 1958799396 233 QVAAAKDHTVVLTEDGCVYTFGLNTFHQ 260
Cdd:pfam13540   3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-869 1.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 45.97  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 765 CSFLYDVTMKSV-------DGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEavVIK 837
Cdd:cd18273    23 ARLLTDVTIEVNgpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGR--VTL 100

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958799396 838 ESQNVDfvcSVLVVADQLLITRLKEMCEVALA 869
Cdd:cd18273   101 SEANVQ---RLYAAANMLQLEYVREACASFLA 129
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-871 1.40e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 45.48  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 776 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAvvikesQNVDFVC-SVLVVADQ 854
Cdd:cd18342    29 VAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKA------PNLDKMAdDLLAAADK 102

                          90
                  ....*....|....*..
gi 1958799396 855 LLITRLKEMCEVALAEN 871
Cdd:cd18342   103 YALERLKVMCEDALCSN 119
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-865 1.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 45.34  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEM-PIQAEILKVILDYLYTDEAVVIKESqnvdfVCSV 848
Cdd:cd18207    29 DVLLR-VGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMhTISSKVFGDILDFAYTSRIVVRLES-----FPEL 102

                          90
                  ....*....|....*..
gi 1958799396 849 LVVADQLLITRLKEMCE 865
Cdd:cd18207   103 MTAAKFLLMRSVIDICQ 119
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 549-651 1.76e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 45.83  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 549 EEFGKLLretdEMDSFHDVTFQVG--NRLFPAHKYVLAVRSDFF------------QKLFLSDGTLLELTDVyRKDEDAA 614
Cdd:cd18308    12 DDFGRLL----ESRQFCDVEFIVGeeEERIPAHIAFVAARSKWLrnkilqarerqkQKAEQEVEDEGSEADS-SSASKND 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958799396 615 GCHLFV-VEKVHPDLFEYLLQFMYTDTCDFLTHGFKPR 651
Cdd:cd18308    87 SPMLEVrLPEADPEAFELILSFIYTDKIDPTRKGQDPG 124
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 1.95e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 44.79  E-value: 1.95e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsdgtlleltdvyrKDEDAAGCHLFVVEKVHPDLFEYLLQFMYT 638
Cdd:cd18212    25 DITLIVENVQFRAHKALLAASSEYFSMMF--------------ADEGEVGQSIYMLEGMVAETFGALLEFIYT 83
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-865 1.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 44.69  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVikesqNVDFVCS 847
Cdd:cd18255    18 LLDVTL-IADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTL-----DLDCIQD 91

                          90
                  ....*....|....*...
gi 1958799396 848 VLVVADQLLITRLKEMCE 865
Cdd:cd18255    92 VLGAAVHLQMLPVVELCE 109
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 762-864 2.33e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 43.87  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 762 QKKCSflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEaVVIKESQN 841
Cdd:cd18314     3 DSEFS---DVVLC-VGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQ-VTLSEENV 77

                          90       100
                  ....*....|....*....|...
gi 1958799396 842 VDfvcsVLVVADQLLITRLKEMC 864
Cdd:cd18314    78 LD----LLMLASKYQVPDLEKLC 96
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 770-865 2.34e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 44.11  E-value: 2.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMKSVDGKEFPCHKCVLCARLEYFHSMlsrSWIEASSCAALEMP--IQAEILKVILDYLYTDEAVVIKESqnvdfVCS 847
Cdd:cd18311    16 DLTLQFRDNEQLKVHRLVLSACTDYFNVL---EQTCEIVDDTLIMPneLQADAVVPVINFMYTGQLEFEEKS-----YGK 87

                          90
                  ....*....|....*...
gi 1958799396 848 VLVVADQLLITRLKEMCE 865
Cdd:cd18311    88 LLRTAKELNMTVLLKLLE 105
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 549-643 2.44e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 44.12  E-value: 2.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 549 EEFGKLLREtdemDSFHDVTFQVGNRL-FPAHKYVLAVRSDFFQKLFlsdGTLLELTdvyrKDEDaagchlfvvekVHPD 627
Cdd:cd18299     1 EDLRNLLHS----PSCADVVFILQGGVrIFAHRIVLAAASSVFADLF---LMMTVVT----LDSD-----------ITPE 58

                          90
                  ....*....|....*.
gi 1958799396 628 LFEYLLQFMYTDTCDF 643
Cdd:cd18299    59 AFRRVLEFLYTGVLDE 74
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 756-871 2.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 44.56  E-value: 2.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 756 NKLKLSQKKCsflyDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVV 835
Cdd:cd18306    10 NALRKNRQFC----DVIL-QVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEV 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958799396 836 ikesqNVDFVCSVLVVADQLLITRLKEMCEVALAEN 871
Cdd:cd18306    85 -----PADLVKSVYSAAKKLKMDRVKKACGDFLLEK 115
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 2.79e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 44.29  E-value: 2.79e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799396 566 DVTFQVGNR----LFPAHKYVLAVRSDFFQKLFLSDgtLLEltdvyrkdedaagCHLFVV--EKVHPDLFEYLLQFMYT 638
Cdd:cd18248    23 DVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSG--LRE-------------CGMEVVpiEGVHPCVMSRLIEFAYT 86
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-643 2.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 43.82  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 566 DVTFQVG----NRLFPAHKYVLAVRSDFFQKLFLSDGTlleltdvyrkdEDAAGCHlfvVEKVHPDLFEYLLQFMYTDTC 641
Cdd:cd18349    10 DVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLA-----------EVKSEIH---IPDVEPAAFLILLKYMYSDEI 75


                  ..
gi 1958799396 642 DF 643
Cdd:cd18349    76 DL 77
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-865 3.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 44.20  E-value: 3.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVikesqNVDFVCS 847
Cdd:cd18238    15 LCDVTLK-VGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTL-----TVDNVQS 88

                          90
                  ....*....|....*...
gi 1958799396 848 VLVVADQLLITRLKEMCE 865
Cdd:cd18238    89 LLYAASLLQVEEVAKACC 106
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-643 3.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 44.45  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 555 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdgtlleltdvyrkDEDAAGCHLFVVEKVHPDLFEYLLQ 634
Cdd:cd18341    18 LKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLS-------------EESEEKKKEVVLDNVDPNIMDMILK 84


                  ....*....
gi 1958799396 635 FMYTDTCDF 643
Cdd:cd18341    85 YLYSAEIDL 93
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 751-864 3.32e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 44.29  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 751 AKKTGNKLKlSQkkcSFLYDVTMKSVDgKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYT 830
Cdd:cd18338     8 AFKVMNELR-SQ---NLLCDVTIVAED-VEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYT 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1958799396 831 DEAVVIKESQNVdfvcsVLVVADQLLITRLKEMC 864
Cdd:cd18338    83 AEIQVTEENVQV-----LLPAAGLLQLQDVKKTC 111
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-638 3.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 44.37  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 554 LLRETDEM---DSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsDGTLLEltdvYRKDEdaagchlFVVEKVHPDLFE 630
Cdd:cd18250     8 LLRGLSELraeRKFFDVTLCAGGREFPCHRTVLAAASSYFRAMF--AGELRE----SRADR-------VVLHGVSAEILG 74


                  ....*...
gi 1958799396 631 YLLQFMYT 638
Cdd:cd18250    75 LLLDFSYT 82
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 549-594 3.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 44.07  E-value: 3.76e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958799396 549 EEFGKLLretdEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLF 594
Cdd:cd18345     7 DDLGLLF----ERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMF 48
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 768-844 4.68e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 42.54  E-value: 4.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 768 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLsrswIEASSC--AALEMP-IQAEILKVILDYLYTDEaVVIKESQNVDF 844
Cdd:cd18315     1 LVDVTL-ACEGGSLKAHKLVLAAASPYFAALL----KETPPDehPVIILPdVPYSELKALLDFIYTGE-VNVSQEQLESL 74
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 753-872 6.74e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 43.41  E-value: 6.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 753 KTGNKLKLSQKKCSFlYDVTMKSVDGKeFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDE 832
Cdd:cd18358     6 RKANRIKECLSKGTF-SDVTFKLDDGT-INAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQ 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958799396 833 avvIKESQNVDFVcSVLVVADQLLITRLkemceVALAENH 872
Cdd:cd18358    84 ---LSPTADLDPL-ELIALANRFCLPHL-----VALTEQH 114
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 778-832 7.68e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 42.32  E-value: 7.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958799396 778 GKEFPCHKCVLCARLEYFHSMLSRSW-IEASSCAALEM-PIQAEILKVILDYLYTDE 832
Cdd:cd18283    11 GTCFPVHRAILSARCPFFRDLLSSSPgYGAEIPVDLPTaGIDVPMFSALLRYLYTGE 67
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 566-638 8.84e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 41.77  E-value: 8.84e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLsDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYT 638
Cdd:cd18315     3 DVTLACEGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIILPD-------------VPYSELKALLDFIYT 61
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-638 1.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 43.16  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 555 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtllelTDVYRKDEdaagchlFVVEKVHPDLFEYLLQ 634
Cdd:cd18269    18 LKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSD------LEESKKKE-------VVLEDVDPDVMGMILK 84


                  ....
gi 1958799396 635 FMYT 638
Cdd:cd18269    85 YLYT 88
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 780-832 1.27e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 43.10  E-value: 1.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958799396 780 EFPCHKCVLCARLEYFHSMLSRSWIEASSCAAL--------EMPIQAEILKVILDYLYTDE 832
Cdd:cd18284    29 ELRCHKAILSARSPFFRNLLQRRIRTGEDRTLStptrivldESIIPRRYARVLLHAMYTDS 89
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 1.41e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 42.29  E-value: 1.41e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFL---SDGTLLELTDvyrkdedaagchlfvvekVHPDLFEYLLQFMYT 638
Cdd:cd18193    23 DCTVAIGDVYFKAHKSVLASFSNYFKMLFVhqtSECVRLKPTD------------------IQPDIFSYLLHLMYT 80
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-835 1.45e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 42.27  E-value: 1.45e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 776 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMP---IQAEILKVILDYLYTDEAVV 835
Cdd:cd18258    24 VEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLELTmsnINADVLELLLEFVYTGSLII 86
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-638 1.48e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 42.64  E-value: 1.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyrkdEDAAGCHLFVVEKVHPDLFEYLLQFMYT 638
Cdd:cd18207    27 FCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQE------------GDGGTPRELEMHTISSKVFGDILDFAYT 89
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-638 1.53e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 42.15  E-value: 1.53e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQ-KLFLSDGTLLELTDVyrkdedaagchlfvvekVHPDLFEYLLQFMYT 638
Cdd:cd18200    18 FCDLSVHVQGRVFRAHKAVLAASSPYFHdKLLLNDTNCLVLPSV-----------------IEAAAFENLLQLIYS 76
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-830 1.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 42.48  E-value: 1.75e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396 767 FLYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLsRSWIEASSCAALEMP-IQAEILKVILDYLYT 830
Cdd:cd18264    27 FLCDVVLE-AEGNEFPAHRSLLACSSDYFRALF-KDYTQESKARVIHLPvVSAAGLQRVLDFIYT 89
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-640 1.83e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 41.78  E-value: 1.83e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLsdgtlleltdvyRKDEDAAGchLFVVEKVHPDLFEYLLQFMYTDT 640
Cdd:cd18209    18 LCDVLLIVGDQKFRAHKNVLAASSEYFQSLFT------------EKENESQS--VFQLDFCEPDAFENVLNYIYSSS 80
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 543-638 1.96e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 41.88  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 543 SSSSF--FEEF---GKLLretdemdsfhDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtLLEltdvYRKDEdaagch 617
Cdd:cd18247     3 PSSGFpvMEEIrrqGKLC----------DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHD--MVE----SKQDE------ 60

                          90       100
                  ....*....|....*....|.
gi 1958799396 618 lFVVEKVHPDLFEYLLQFMYT 638
Cdd:cd18247    61 -ITMQGIEPSALEALINFAYS 80
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-641 1.96e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 42.19  E-value: 1.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFL---SDGTLLELTDvyrkdedaagchlfvvekVHPDLFEYLLQFMYTDTC 641
Cdd:cd18213    23 DCTVAIGDVYFKAHRAVLAAFSNYFKMIFIhqsSECIKIQPTD------------------IQPDIFSYLLHIMYTGKG 83
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-640 2.15e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 41.84  E-value: 2.15e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdGTLLELTDVYRKDedaagchlFVVekvhPDLFEYLLQFMYTDT 640
Cdd:cd18326    27 DVVILVEGREFPTHRSVLAACSQYFKKLFTS-GAVVDQQNVYEID--------FVS----AEALTALLDFAYTAT 88
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 549-638 2.57e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 41.53  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 549 EEFGKLLretdEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtlLELTDVYRKDedaagchlfvVEKVHPDL 628
Cdd:cd18343    10 EDLGNLW----ENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHE---MEESKKNRVE----------INDVDPEV 72

                          90
                  ....*....|
gi 1958799396 629 FEYLLQFMYT 638
Cdd:cd18343    73 FKEMMRFIYT 82
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-640 3.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 41.38  E-value: 3.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlSDGTLLELTDVyrkdeDAAGCHLFVVEKVHPDLFEYLLQFMYTDT 640
Cdd:cd18228    19 FCDVTIRVQDKIFRAHKVVLAACSDFFRSKL-VGQASPRLVLV-----SPAGKCVLDLHHVTVTGFAPLLEYAYTST 89
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-868 3.35e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 41.15  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMKsVDGKEFPCHKCVLCARleyfhsmlSRSWIEASSCAALEMP---IQAEILKVILDYLYTDEavvIKESQNVDFVC 846
Cdd:cd18303    20 DITIK-LADKSIPAHKFVLAAR--------SEKWSNENLASTNELDlsdISYEVVLALLRWLYTDE---LDLTLDDEFLL 87

                          90       100
                  ....*....|....*....|..
gi 1958799396 847 SVLVVADQLLITRLKEMCEVAL 868
Cdd:cd18303    88 ELMKAAKRFQLTDLVERCERAL 109
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 756-864 3.43e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 41.21  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 756 NKLKLSQKKCSFLYDVTMKSVDgKEFPCHKCVLCARLEYFHSMLSRSWIEassCAALEMPIQA---EILKVILDYLYTDE 832
Cdd:cd18248    13 NELRLSQQLCDVTLKVKYQDPK-EEFMAHKVVLASSSPYFKAMFTSGLRE---CGMEVVPIEGvhpCVMSRLIEFAYTAS 88

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958799396 833 AVVIKESqnvdfVCSVLVVADQLLITRLKEMC 864
Cdd:cd18248    89 ISVGEKC-----VLHVLPGAVMYQMDSVVKAC 115
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 564-638 3.43e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 41.74  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSD-----GTLLELTDvyrkdedaagchlfvvekVHPDLFEYLLQFMYT 638
Cdd:cd18259    32 LSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDfvesiSARVEIKD------------------VDPAVMESLIDFAYT 93
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 3.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 41.32  E-value: 3.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDedaagchlfvvekVHPDLFEYLLQFMYT 638
Cdd:cd18237    23 DVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKD-------------AEPDIIELLVEFAYT 82
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-842 4.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 41.36  E-value: 4.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799396 776 VDGKEFPCHKCVLCARLEYFHSMLsRSWIEASSCAALEMP-IQAEILKVILDYLYTDEAVVikESQNV 842
Cdd:cd18340    34 IKEKEFPCHRLVLAACSPYFRAMF-LSDLEESKKREIVLEdVDPDVMGKILHYIYTSEIEI--TEQNV 98
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 4.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 40.72  E-value: 4.52e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVyrkdedaagchlfvvekVHPDLFEYLLQFMYT 638
Cdd:cd18334    23 DVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDM-----------------VNPTVFRQILDFIYT 78
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 17-123 4.58e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.50  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  17 HALDVLSVITKGSERQIKIFLSsycYNA-ATVKDAFGRNALHLVSSCG--KKAVLDWLIEKGVDLLVKDK---------- 83
Cdd:PHA03100  108 TPLLYAISKKSNSYSIVEYLLD---NGAnVNIKNSDGENLLHLYLESNkiDLKILKLLIDKGVDINAKNRvnyllsygvp 184

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958799396  84 -----ESGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PHA03100  185 inikdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-123 4.84e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.02  E-value: 4.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  43 NAATVKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSP 122
Cdd:COG0666    45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG-GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETP 123


                  .
gi 1958799396 123 L 123
Cdd:COG0666   124 L 124
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-638 4.89e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 40.97  E-value: 4.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 555 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtlLELTdvyRKDEdaagchlFVVEKVHPDLFEYLLQ 634
Cdd:cd18340    18 LKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSD---LEES---KKRE-------IVLEDVDPDVMGKILH 84


                  ....
gi 1958799396 635 FMYT 638
Cdd:cd18340    85 YIYT 88
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-830 5.13e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 41.14  E-value: 5.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958799396 767 FLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYT 830
Cdd:cd18270    25 LLTDIVL-IVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 87
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-865 5.18e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 40.70  E-value: 5.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 775 SVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKESqnvdfVCSVLVVADQ 854
Cdd:cd18353    26 RVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDSVDLPPED-----AIGLLDLATS 100

                          90
                  ....*....|.
gi 1958799396 855 LLITRLKEMCE 865
Cdd:cd18353   101 YCENRLKKLCQ 111
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-157 5.47e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.47  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  47 VKDAFGRNALHL-VSSCGKKAVLDWLIEKGVDLLVKDKeSGWTALHR--SIFYGHINCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PHA03095   78 APERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDK-VGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPL 156

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1958799396 124 DLLMKDRPAHV------VFKNTDPTEVytwgDNTNFTLGH 157
Cdd:PHA03095  157 AVLLKSRNANVellrllIDAGADVYAV----DDRFRSLLH 192
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-639 5.93e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 40.88  E-value: 5.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 566 DVTFQVGN----RLFPAHKYVLAVRSDFFQKLF---LSDGTL-LELTDVyrkdEDAAgchlfvvekvhpdlFEYLLQFMY 637
Cdd:cd18281    24 DVHFIVGKgdneQRIPAHKFVLSIGSAVFDAMFnggMATTSAeIELPDV----EPAA--------------FLALLRFLY 85


                  ..
gi 1958799396 638 TD 639
Cdd:cd18281    86 SD 87
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 552-638 6.36e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 40.65  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 552 GKLLRETDEM---DSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDEDAAGCHLFVVEKVHPDL 628
Cdd:cd18195     3 GALLLQLNEQrlrGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQSPERVLELPGVKAGV 82

                          90
                  ....*....|
gi 1958799396 629 FEYLLQFMYT 638
Cdd:cd18195    83 FSDVLNFIYS 92
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-643 6.51e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 40.71  E-value: 6.51e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDEDAAGchlfvvekvhpdlFEYLLQFMYTDTCDF 643
Cdd:cd18244    32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATG-------------FSHVLQFMYYGTIEL 96
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 554-638 6.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 40.75  E-value: 6.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 554 LLRETDemDSFHDVTFQV-GNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVYRKDEDAAGchlfvVEKVHPDLFEYL 632
Cdd:cd18310    10 LLDSPD--LFYSDAEIIVeGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIP-----GGIVGYDAFMLV 82


                  ....*.
gi 1958799396 633 LQFMYT 638
Cdd:cd18310    83 LSYLYS 88
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-640 6.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 40.23  E-value: 6.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdGTLleltdvyrkdedAAGCHLFVVEKVHPDLFEYLLQFMYTDT 640
Cdd:cd18198    27 DVVILVQGREYRTHRSVLAACSQYFKKLFTS-GAV------------VDQQNVYEIDFVSPEALTALLEFAYTAT 88
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 753-842 8.26e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 40.02  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 753 KTGNKLKLSQKKCsflyDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMpIQAEILKVILDYLYTDE 832
Cdd:cd18204     7 KTLNEQRLEGEFC----DIAI-VVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDF-LRSDIFEEVLNYMYTAK 80

                          90
                  ....*....|
gi 1958799396 833 AVVIKESQNV 842
Cdd:cd18204    81 ISVKKEDVNL 90
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 59-123 9.09e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.93  E-value: 9.09e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396  59 VSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALHRSIFYGHINCVWSLLKHGVSLYMQDKEGLSPL 123
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSK-GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL 595
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 768-831 9.88e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 39.19  E-value: 9.88e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799396 768 LYDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEM----PIQAEILKVILDYLYTD 831
Cdd:cd18301    18 IHDVVFQ-VGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCDVvhieKVPPEIFEQLLQFIYTD 84
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-830 1.04e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 39.86  E-value: 1.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 768 LYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYT 830
Cdd:cd18215    19 LTDVVL-VVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYT 80
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-843 1.05e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 40.20  E-value: 1.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799396 776 VDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVVIKEsqNVD 843
Cdd:cd18271    31 VKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDD--NVE 96
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-864 1.13e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 39.92  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 762 QKKCSFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSML-SRSWIEASSCAALEMpIQAEILKVILDYLYTDEAVVIKESq 840
Cdd:cd18326    19 QRTQGLLCDVVI-LVEGREFPTHRSVLAACSQYFKKLFtSGAVVDQQNVYEIDF-VSAEALTALLDFAYTATLTVSTSN- 95

                          90       100
                  ....*....|....*....|....
gi 1958799396 841 nvdfVCSVLVVADQLLITRLKEMC 864
Cdd:cd18326    96 ----VGDILSAARLLEIPAVSHVC 115
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 564-641 1.18e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 39.14  E-value: 1.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtlleltdvYRkdEDAAGchLFVVEKVHPDLFEYLLQFMYTDTC 641
Cdd:cd18300     9 FSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGN---------FR--ESSAK--EVELPGVSKETFLALLEYLYTDQA 73
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 553-638 1.21e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 39.25  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 553 KLLREtdEMdsFHDVTFQVGNRLFPAHKYVLAVRS-DFFQKlflsdgtLLELTDVYRKDEdaagchLFVVEKVHPDLFEY 631
Cdd:cd18285     8 RLLRE--EL--HTDVTFYVGSTLFKAHKAILLARVpEFFSH-------IIGKLSSLEDQE------PINIENLEASEFKT 70


                  ....*..
gi 1958799396 632 LLQFMYT 638
Cdd:cd18285    71 FLRQVYT 77
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-864 1.44e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 39.02  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 775 SVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQ---AEILKVILDYLYTDEaVVIKEsQNVDfvcSVLVV 851
Cdd:cd18307     7 SVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDylsPETVEQLLDYFYTGK-IVISE-KNVE---DLLKG 81

                          90
                  ....*....|...
gi 1958799396 852 ADQLLITRLKEMC 864
Cdd:cd18307    82 AKYFNIPRLKDHC 94
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-643 1.96e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 39.42  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 555 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQkLFlsdgtlleltdvYRKDEDAAGCHLFVVEKVHPDLFEYLLQ 634
Cdd:cd18194    14 LREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LF------------YRDRLDKRDLVRLNSDIVTAPAFGLLLD 80


                  ....*....
gi 1958799396 635 FMYTDTCDF 643
Cdd:cd18194    81 FMYEGRLAL 89
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 564-596 2.06e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 39.29  E-value: 2.06e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958799396 564 FHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLS 596
Cdd:cd18309    20 FCDITLLLDGHPIPAHKAILAARCSYFEAMFRS 52
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-842 2.09e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 39.00  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 762 QKKCSFLYDVTMKSVDGKeFPCHKCVLCARLEYFHSMLSRSWIEASScAALEMP-IQAEILKVILDYLYTDEaVVIKESQ 840
Cdd:cd18223    12 QRIQGILCDVTIVVEDTK-FKAHKNVLAASSLYFKNAFSSQEIWISS-HVLELPdLKAEVFAEILNFIYSSK-VVVKRQE 88


                  ..
gi 1958799396 841 NV 842
Cdd:cd18223    89 TV 90
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-869 2.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 39.49  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQAEILKVILDYLYTDEAVV-IKESQNvdfvcsV 848
Cdd:cd18272    34 DVTI-SVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLrVEELQE------T 106

                          90       100
                  ....*....|....*....|.
gi 1958799396 849 LVVADQLLITRLKEMCEVALA 869
Cdd:cd18272   107 YEVADMYQLTALFEECSRFLA 127
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 566-647 2.39e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 38.08  E-value: 2.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdgtlleltdvyrkdEDAAGCHLFV---VEKVHPDLFEYLLQFMYTDtcD 642
Cdd:cd18283     4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSS--------------SPGYGAEIPVdlpTAGIDVPMFSALLRYLYTG--E 67


                  ....*
gi 1958799396 643 FLTHG 647
Cdd:cd18283    68 FGSED 72
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-638 2.42e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 38.58  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 555 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDvyrkdedaagchlfvVEKVHPDLFEYLLQ 634
Cdd:cd18217     9 LNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLD---------------QSQVSADGFQKLLE 73


                  ....
gi 1958799396 635 FMYT 638
Cdd:cd18217    74 FIYT 77
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 2.43e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 39.01  E-value: 2.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdgtlleltdvYRKDEDAAGCHLFVVEKVHpdlFEYLLQFMYT 638
Cdd:cd18264    30 DVVLEAEGNEFPAHRSLLACSSDYFRALFKD----------YTQESKARVIHLPVVSAAG---LQRVLDFIYT 89
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 776-833 2.47e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 37.65  E-value: 2.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958799396 776 VDGKEFPCHKCVLCARLEYFhSMLSRSWIEASSCAALEMP-IQAEILKVILDYLYTDEA 833
Cdd:cd01165     5 VEGEKFHVNKELLAQSSEYF-RALFRGGFRESGQAEINLRdISPEDFRALLEFLYGGKR 62
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 562-641 2.47e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 38.50  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 562 DSFHDVTFQ-VGNRLFPAHKYVLAVRSDFFQKLFLSDGTlleltdvyrkdEDAAGCHLFVveKVHPDLFEYLLQFMYTDT 640
Cdd:cd18302     3 SDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWI-----------EASSCSALTM--PIPSDILEIILDYLYTDE 69


                  .
gi 1958799396 641 C 641
Cdd:cd18302    70 A 70
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 553-640 3.10e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 38.09  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 553 KLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsdgtlleltdVYRKDEDAAGCHLFVVEKVHPDLFEYL 632
Cdd:cd18245     3 RALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKL-----------NYNPPKDDGSTYKIELEGISVEVMEEI 71


                  ....*...
gi 1958799396 633 LQFMYTDT 640
Cdd:cd18245    72 LDYIYTGQ 79
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-837 3.33e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 37.89  E-value: 3.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799396 770 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSrswiEASSCAALEMpIQAEILKVILDYLYTDEAVVIK 837
Cdd:cd18219    23 DVTV-IVEDRKFRAHKNILSASSTYFHQLFS----VAGQVVELNF-IRADIFAEILNYIYSSKIVRVR 84
Ank_5 pfam13857
Ankyrin repeats (many copies);
48-91 3.69e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 3.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958799396  48 KDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKEsGWTALH 91
Cdd:pfam13857  12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEE-GLTALD 54
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-650 4.07e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 37.91  E-value: 4.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 555 LRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGtlleltdvyrkdeDAAGCHLFVVEKVHPDLFEYLLQ 634
Cdd:cd18332    10 LNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRV-------------GEGVSVLTLPSGLEARGFQLLLD 76

                          90
                  ....*....|....*.
gi 1958799396 635 FMYTdTCDFLTHGFKP 650
Cdd:cd18332    77 FMYT-SRLPLTPRTVP 91
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 539-640 4.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 38.29  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 539 IPVVSSSSffeEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTLLELTDVyrkdedAAGCHL 618
Cdd:cd18327     3 IPFPEHSS---ELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGA------GGGQDV 73

                          90       100
                  ....*....|....*....|..
gi 1958799396 619 FVVEKVHPDLFEYLLQFMYTDT 640
Cdd:cd18327    74 CELDFVGPEALGALLEFAYTAT 95
PHA03095 PHA03095
ankyrin-like protein; Provisional
 46-132 4.21e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.78  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  46 TVKDAFGRNALH--LVSSCGKKAVLDWLIEKGVDLLVKDKeSGWTALHrsIFYGHINC----VWSLLKHGVSLYMQDKEG 119
Cdd:PHA03095  111 NAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDL-YGMTPLA--VLLKSRNAnvelLRLLIDAGADVYAVDDRF 187

                          90
                  ....*....|....*.
gi 1958799396 120 LSPLDLLM---KDRPA 132
Cdd:PHA03095  188 RSLLHHHLqsfKPRAR 203
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-123 4.32e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.72  E-value: 4.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396  25 ITKGSERQIKIFLSsycYNA-ATVKDAFGRNALHLVSSCGKKAVLDWLIEKGVDLLVKDKeSGWTALHRSIFYGHINCVW 103
Cdd:PHA02874  132 IKKGDLESIKMLFE---YGAdVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDN-NGESPLHNAAEYGDYACIK 207

                          90       100
                  ....*....|....*....|
gi 1958799396 104 SLLKHGVSLYMQDKEGLSPL 123
Cdd:PHA02874  208 LLIDHGNHIMNKCKNGFTPL 227
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 746-871 4.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 38.42  E-value: 4.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 746 KINVIAKKTGNKLK---LSQKKCSflyDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMpIQAEILK 822
Cdd:cd18351     2 KLTEIKRKQTSRLDphfLNNKEMS---DVTF-LVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISY-VKYHIFQ 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958799396 823 VILDYLYT--DEAVVIKESQnvdfVCSVLVVADQLLITRLKEMCEVALAEN 871
Cdd:cd18351    77 LVMQYLYCggTESLLIKNNE----IMELLSAAKFFQLEALQRHCEIICAKS 123
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-865 4.44e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 37.98  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 762 QKKCSFLYDVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRsWIEAS---SCAALEMpIQAEILKVILDYLYTDEAVVIKE 838
Cdd:cd18330    12 QRKRDFFCDCSI-IVEGRIFKAHRNILFANSGYFRALLIH-YIQDSgrhSTASLDI-VTSEAFSIILDFLYSGKLDLCSE 88

                          90       100
                  ....*....|....*....|....*..
gi 1958799396 839 SqnvdfVCSVLVVADQLLITRLKEMCE 865
Cdd:cd18330    89 N-----VIEVMSAASYLQMTDVVNFCK 110
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-637 4.87e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 38.29  E-value: 4.87e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLflsdgtlleLTDvyRKDEDAAGCHLFVVEKVHPDLFEYLLQFMY 637
Cdd:cd18350    26 DVTFLVEGKLFYAHKVLLVTASNRFKSL---------LTN--KSEQESQGSKTIEISDIKYHIFQMLMQYLY 86
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 767-872 5.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 38.44  E-value: 5.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 767 FLYDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAA-LEMP-------IQAEILKVILDYLYT-------D 831
Cdd:cd18310    17 FYSDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPkLELRelipggiVGYDAFMLVLSYLYSgrlrlvpK 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1958799396 832 EAVVIKESQ--------NVDFVCSVLVVADQLLITRLkemceVALAENH 872
Cdd:cd18310    97 EGSACVDSDcwhvacrpAVDFALEVLYAASVFQIPEL-----VSLFQRR 140
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 756-832 5.21e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 37.89  E-value: 5.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958799396 756 NKLKLSQKKCsflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEMpIQAEILKVILDYLYTDE 832
Cdd:cd18224    18 NKCRLSETMC----DVTIV-VGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDF-ITPANFEKVLSFIYTSE 88
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-640 5.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 37.85  E-value: 5.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDGTL-----LELTDvyrkdedaagchlfvvekVHPDLFEYLLQFMYTDT 640
Cdd:cd18223    20 DVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWisshvLELPD------------------LKAEVFAEILNFIYSSK 81
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-640 5.40e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 37.94  E-value: 5.40e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSdGTLLELTDVYRkdedaagchlfvVEKVHPDLFEYLLQFMYTDT 640
Cdd:cd18328    27 DVVLIVQDQEYRTHRSVLAACSKYFKKLFTA-GTLADQPYVYE------------IDFVTPEALSAILEFAYTST 88
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 5.53e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 38.10  E-value: 5.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtLLEltdvyRKDEDAAgchlfvVEKVHPDLFEYLLQFMYT 638
Cdd:cd18336    21 DVLLIAGNLKIPAHRLVLSAVSDYFAAMFTND--VRE-----AKQEEIK------MEGVDPDALKALVHYAYT 80
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-864 5.73e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 38.10  E-value: 5.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSWIEASSCAALEmpiqaeiLKVILDYLYTDEAVVikesqNVDFVCSVL 849
Cdd:cd18243    34 DVTL-TAQGQQFHCHKAVLASCSQYFRSLFSINNLVLQGCSSIG-------LRLVLEYLYTANVTL-----SLDTVEEVL 100

                          90
                  ....*....|....*
gi 1958799396 850 VVADQLLITRLKEMC 864
Cdd:cd18243   101 SVSKILHIPQVTKLC 115
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 753-870 5.83e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 37.53  E-value: 5.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 753 KTGNKLKLSQKKCsflyDVTMKsVDGKEFPCHKCVLCARLEYFHSMLsrsWIEASSCAALEMPIQAEILKVILDYLYTDE 832
Cdd:cd18200     7 ETLNKHRLEGKFC----DLSVH-VQGRVFRAHKAVLAASSPYFHDKL---LLNDTNCLVLPSVIEAAAFENLLQLIYSGR 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958799396 833 AVVIKESqnvdfVCSVLVVADQLLITRLKEMCEVALAE 870
Cdd:cd18200    79 LTLCMDA-----LPSHLLVASGLQMWQVVDRCSELLKE 111
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 549-638 7.80e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 37.51  E-value: 7.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 549 EEFGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgtlleltdvYRKDEDAagchLFVVEKVHPDL 628
Cdd:cd18253     3 ESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCND---------HRESREM----LVEINGILAEA 69

                          90
                  ....*....|
gi 1958799396 629 FEYLLQFMYT 638
Cdd:cd18253    70 MDCFLQYVYT 79
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 551-638 9.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 36.94  E-value: 9.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 551 FGKLLRETDEMDSFHDVTFQVGNRLFPAHKYVLAVRSDFFQKLFlsdgtlleltdvyrKDEDAAGCHLFVVEKVHPDLFE 630
Cdd:cd18204     5 FLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLF--------------KKLEVDSSSVIEIDFLRSDIFE 70


                  ....*...
gi 1958799396 631 YLLQFMYT 638
Cdd:cd18204    71 EVLNYMYT 78
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 9.26e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 37.13  E-value: 9.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958799396 566 DVTFQVGNRLFPAHKYVLAVRSDFFQKLFLSDgTLLELtdvyrkDEDAagchlfvvekVHPDLFEYLLQFMYT 638
Cdd:cd18216    22 DVIIVVENSLFRAHKNVLAASSGYFKSLVLHD-NLIHL------DQDM----------VSPTVFQQILDFIYT 77
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 770-865 9.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 36.66  E-value: 9.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799396 770 DVTMkSVDGKEFPCHKCVLCARLEYFHSMLSRSwieasSCAALEMPIQ-AEILKVILDYLYTDEAVVIKESqnvdfVCSV 848
Cdd:cd18232    20 DATL-DVGGRVFKAHWSVLACCSHFFQSLYGDG-----TSGSVVLPESfAEVFGLLLDFFYTGELALTREN-----RDRV 88

                          90
                  ....*....|....*..
gi 1958799396 849 LVVADQLLITRLKEMCE 865
Cdd:cd18232    89 LLAAKELRVPEAVELCQ 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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