NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958799724|ref|XP_038938564|]
View 

microtubule-associated protein 4 isoform X21 [Rattus norvegicus]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1930-1959 3.24e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 3.24e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958799724 1930 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1959
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1961-1991 6.67e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.80  E-value: 6.67e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958799724 1961 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1991
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1907-1928 3.95e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 47.79  E-value: 3.95e-07
                           10        20
                   ....*....|....*....|..
gi 1958799724 1907 DLKSVRSKVGSTENMKHQPGGG 1928
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1686-1894 9.86e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 9.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799724 1686 RPTKSRGPTPHQPKSAsqeRERAKLLKASGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPIT------------ 1753
Cdd:PHA03247  2713 HALVSATPLPPGPAAA---RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAgpprrltrpava 2789

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799724 1754 -ETKVAEKRTSPSKPSSAPALRPGPktTPTISKATSPSTLVSTGSSSRSPSTTLPKRP--TTTKTEGKPAdvkrmtaksA 1830
Cdd:PHA03247  2790 sLSESRESLPSPWDPADPPAAVLAP--AAALPPAASPAGPLPPPTSAQPTAPPPPPGPppPSLPLGGSVA---------P 2858

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799724 1831 TADLSRskttsassvkRNTTPTGATPPAGMASTRVKPMSAPCRS----SVALSVDKKPTSTKPSSSAP 1894
Cdd:PHA03247  2859 GGDVRR----------RPPSRSPAAKPAAPARPPVRRLARPAVSrsteSFALPPDQPERPPQPQAPPP 2916
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1930-1959 3.24e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 3.24e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958799724 1930 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1959
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1961-1991 6.67e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.80  E-value: 6.67e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958799724 1961 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1991
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1907-1928 3.95e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 47.79  E-value: 3.95e-07
                           10        20
                   ....*....|....*....|..
gi 1958799724 1907 DLKSVRSKVGSTENMKHQPGGG 1928
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1686-1894 9.86e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 9.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799724 1686 RPTKSRGPTPHQPKSAsqeRERAKLLKASGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPIT------------ 1753
Cdd:PHA03247  2713 HALVSATPLPPGPAAA---RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAgpprrltrpava 2789

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799724 1754 -ETKVAEKRTSPSKPSSAPALRPGPktTPTISKATSPSTLVSTGSSSRSPSTTLPKRP--TTTKTEGKPAdvkrmtaksA 1830
Cdd:PHA03247  2790 sLSESRESLPSPWDPADPPAAVLAP--AAALPPAASPAGPLPPPTSAQPTAPPPPPGPppPSLPLGGSVA---------P 2858

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799724 1831 TADLSRskttsassvkRNTTPTGATPPAGMASTRVKPMSAPCRS----SVALSVDKKPTSTKPSSSAP 1894
Cdd:PHA03247  2859 GGDVRR----------RPPSRSPAAKPAAPARPPVRRLARPAVSrsteSFALPPDQPERPPQPQAPPP 2916
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1930-1959 3.24e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 65.12  E-value: 3.24e-13
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958799724 1930 VQIQNKKVDISKVSSKCGSKANIKHKPGGG 1959
Cdd:pfam00418    1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1961-1991 6.67e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 52.80  E-value: 6.67e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958799724 1961 VKIESQKLNFKeKAQAKVGSLDNVGHLPAGG 1991
Cdd:pfam00418    1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 1907-1928 3.95e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 47.79  E-value: 3.95e-07
                           10        20
                   ....*....|....*....|..
gi 1958799724 1907 DLKSVRSKVGSTENMKHQPGGG 1928
Cdd:pfam00418    9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1686-1894 9.86e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 9.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799724 1686 RPTKSRGPTPHQPKSAsqeRERAKLLKASGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPIT------------ 1753
Cdd:PHA03247  2713 HALVSATPLPPGPAAA---RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAgpprrltrpava 2789

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958799724 1754 -ETKVAEKRTSPSKPSSAPALRPGPktTPTISKATSPSTLVSTGSSSRSPSTTLPKRP--TTTKTEGKPAdvkrmtaksA 1830
Cdd:PHA03247  2790 sLSESRESLPSPWDPADPPAAVLAP--AAALPPAASPAGPLPPPTSAQPTAPPPPPGPppPSLPLGGSVA---------P 2858

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958799724 1831 TADLSRskttsassvkRNTTPTGATPPAGMASTRVKPMSAPCRS----SVALSVDKKPTSTKPSSSAP 1894
Cdd:PHA03247  2859 GGDVRR----------RPPSRSPAAKPAAPARPPVRRLARPAVSrsteSFALPPDQPERPPQPQAPPP 2916
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH