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Conserved domains on  [gi|1958802423|ref|XP_038939516|]
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major facilitator superfamily domain-containing protein 9 isoform X3 [Rattus norvegicus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-336 2.22e-103

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17390:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 350  Bit Score: 307.62  E-value: 2.22e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   1 MSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSV 80
Cdd:cd17390    80 FSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  81 FLLNAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaattpearrsgrnlrppwvevmstlkdmknlifSAL 160
Cdd:cd17390   160 FILNAGLVWFLL-----------------------------------------------------------------SKL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 161 WDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLLL 240
Cdd:cd17390   175 WDLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSL 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 241 LLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSLG 320
Cdd:cd17390   255 LGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLG 334

                         330
                  ....*....|....*.
gi 1958802423 321 AALALVAILIMTLYRP 336
Cdd:cd17390   335 AVLALAAILLMLARQR 350
 
Name Accession Description Interval E-value
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 1-336 2.22e-103

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 307.62  E-value: 2.22e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   1 MSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSV 80
Cdd:cd17390    80 FSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  81 FLLNAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaattpearrsgrnlrppwvevmstlkdmknlifSAL 160
Cdd:cd17390   160 FILNAGLVWFLL-----------------------------------------------------------------SKL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 161 WDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLLL 240
Cdd:cd17390   175 WDLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSL 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 241 LLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSLG 320
Cdd:cd17390   255 LGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLG 334

                         330
                  ....*....|....*.
gi 1958802423 321 AALALVAILIMTLYRP 336
Cdd:cd17390   335 AVLALAAILLMLARQR 350
MFS_1 pfam07690
Major Facilitator Superfamily;
1-302 2.81e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 57.81  E-value: 2.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   1 MSTNVFLFTLARVPVGVFK-HTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGgfYVTAFMCCS 79
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAgALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--WRAAFLILA 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  80 VFLLNAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaaTTPEARRSGRNLRPPWVEVMSTLKDmknlIFSA 159
Cdd:pfam07690 159 ILSLLAAVLLLLP----------------------------------RPPPESKRPKPAEEARLSLIVAWKA----LLRD 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 160 LWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLL 239
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958802423 240 L-LLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAP 302
Cdd:pfam07690 281 GlLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-301 3.87e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.21  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   1 MSTNVFLFTLARVPVGVFKHTL-SISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG---GFYVTAFM 76
Cdd:COG2814    94 LAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGwrwVFLVNAVL 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  77 CCSVFLLnagLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaATTPEARRSGRNlrppwvEVMSTLKDmknli 156
Cdd:COG2814   174 ALLALLL---LLRLLP---------------------------------ESRPAARARLRG------SLRELLRR----- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 157 fSALWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRlyKHNSHMVLLHSSALT 236
Cdd:COG2814   207 -PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLL 283

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958802423 237 CLLLLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILA 301
Cdd:COG2814   284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
 
Name Accession Description Interval E-value
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 1-336 2.22e-103

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 307.62  E-value: 2.22e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   1 MSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSV 80
Cdd:cd17390    80 FSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAI 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  81 FLLNAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaattpearrsgrnlrppwvevmstlkdmknlifSAL 160
Cdd:cd17390   160 FILNAGLVWFLL-----------------------------------------------------------------SKL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 161 WDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLLL 240
Cdd:cd17390   175 WDLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSL 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 241 LLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSLG 320
Cdd:cd17390   255 LGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLG 334

                         330
                  ....*....|....*.
gi 1958802423 321 AALALVAILIMTLYRP 336
Cdd:cd17390   335 AVLALAAILLMLARQR 350
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 1-331 2.82e-28

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 112.67  E-value: 2.82e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   1 MSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGgFYVTAFMCCSV 80
Cdd:cd17330    83 LSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG-YALPFLVAAAL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  81 FLLNAGLVWLLPWRetslnipdsgwsldqkhatvtiksestlqgaattpearrsgrnlrppwvevmstlkdmknlifsaL 160
Cdd:cd17330   162 ALLNLVLVLFFLPP-----------------------------------------------------------------L 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 161 WDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRlYKHNSHMVLLHSSALTCLLL 240
Cdd:cd17330   177 RRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLA-KRLGERKLLRLGLLLAIIGL 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 241 LLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSG-LAQEISPCGPPSL 319
Cdd:cd17330   256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGpLYSFLGPGVPFLL 335

                         330
                  ....*....|..
gi 1958802423 320 GAALALVAILIM 331
Cdd:cd17330   336 AAGLLLIALFLL 347
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 1-333 4.48e-27

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 110.00  E-value: 4.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   1 MSTNVFLFTLARVPvGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELdGGFYVTAFMCCSV 80
Cdd:cd17331    84 FASSVPMLFLSRLP-SVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKK-FGEQAAALVAAVG 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  81 FLLNAGLVWLLpwretslnIPDSgwsldqkhatvtiksestlqgaATTPEARRSGRNLRPPWVEVMSTLKDMknLIFSAL 160
Cdd:cd17331   162 SLLSIVLVILL--------IPSN----------------------TKSKREKEAKESASPPSVFNLKEILRL--LRLPGV 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 161 WDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLA-GFAVGPILRLYKHNShMVLLHSSALTCLL 239
Cdd:cd17331   210 AFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVqGLLVGPLTKRFGERS-LLKLSVALLAIGY 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 240 LLLYSTTNSMAMVVLsSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSG-LAQEISPCGPPS 318
Cdd:cd17331   289 LLLAFVTTVWQLLVL-LLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGaLLQAYGFPSFGL 367

                         330
                  ....*....|....*
gi 1958802423 319 LGAALALVAILIMTL 333
Cdd:cd17331   368 LGAAINGLLTVYLLL 382
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 27-335 6.65e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 68.76  E-value: 6.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  27 ALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELdGGFYVTAFMCCSVFLLNAGLVWLLPWRetslnipdsgws 106
Cdd:cd17325   107 ALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA-LGYRAPFLVCAALALLALVLALLLLPE------------ 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 107 ldqkhatvtiksestlqgaatTPEARRSGRNLRPPWVEVMSTLKDMKNLIFsalwdVFLVRLLMGVAVMLYYSNFVLALE 186
Cdd:cd17325   174 ---------------------PRPPPNKRAVSAARLRSGLRLLLRDRRLLA-----LFLAIFVLAFAFGALEPFLPLYAA 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 187 ERFGVRPKTTGYLISYTSALGTLAGFAVGPILrlYKHNSHMVLLHSSALTCLLLLLYSTTNSMAMVVLSSTLLSFSTTIG 266
Cdd:cd17325   228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLS--DRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 267 RTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSG-LAQEISPCGPPSLGAALALVAILIMTLYR 335
Cdd:cd17325   306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGfLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
1-302 2.81e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 57.81  E-value: 2.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   1 MSTNVFLFTLARVPVGVFK-HTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGgfYVTAFMCCS 79
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAgALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--WRAAFLILA 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  80 VFLLNAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaaTTPEARRSGRNLRPPWVEVMSTLKDmknlIFSA 159
Cdd:pfam07690 159 ILSLLAAVLLLLP----------------------------------RPPPESKRPKPAEEARLSLIVAWKA----LLRD 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 160 LWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLL 239
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958802423 240 L-LLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAP 302
Cdd:pfam07690 281 GlLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 1-333 2.52e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 54.88  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   1 MSTNVFLFTLARVPVGV-FKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDggfYVTAFMCCS 79
Cdd:cd17474    83 LSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS---WRYPFFLLA 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  80 VFLLNAGLVWLLPwretslnipdsgwsLDQKHATVTIKSESTLqgaattpeaRRSGRNLRPPWVEVMSTLKDMKNLIFSA 159
Cdd:cd17474   160 ALIPVAFLAILFL--------------LPEPKEKAKSSSATKL---------RDLKKALRGRGLLTFLVSAFLYFFLYFA 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 160 LwdvflvrllmgvavmLYYSNFVLalEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLyKHNSHMVLLHSSALTCLL 239
Cdd:cd17474   217 F---------------LTYLPFLL--ELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKK-RFGARRILVIGLLLYALS 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 240 LLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSL 319
Cdd:cd17474   279 LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL 358

                         330
                  ....*....|....
gi 1958802423 320 GAALALVAILIMTL 333
Cdd:cd17474   359 VGAAIALAAAVLLA 372
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-301 3.87e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.21  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   1 MSTNVFLFTLARVPVGVFKHTL-SISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG---GFYVTAFM 76
Cdd:COG2814    94 LAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGwrwVFLVNAVL 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  77 CCSVFLLnagLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaATTPEARRSGRNlrppwvEVMSTLKDmknli 156
Cdd:COG2814   174 ALLALLL---LLRLLP---------------------------------ESRPAARARLRG------SLRELLRR----- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 157 fSALWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRlyKHNSHMVLLHSSALT 236
Cdd:COG2814   207 -PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLL 283

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958802423 237 CLLLLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILA 301
Cdd:COG2814   284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 2-83 2.83e-06

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 48.81  E-value: 2.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   2 STNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSVF 81
Cdd:cd17389   114 SRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMPALF 193


                  ..
gi 1958802423  82 LL 83
Cdd:cd17389   194 AL 195
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 27-334 6.48e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.42  E-value: 6.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  27 ALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSVFLLNAGLVWLLPWRETSlnipdsgws 106
Cdd:cd06174   107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPP--------- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 107 ldqkhatvtiksestlqgaattpeARRSGRNLRPPWVEVMSTLKDMKNliFSALWDVFLVRLLMGVAVMLYYSNFVLALE 186
Cdd:cd06174   178 ------------------------ESARAKNEEASSKSVLKLLKRVLK--NPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 187 ERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLLLLLYSTTNSMAMVVLSStLLSFSTTIG 266
Cdd:cd06174   232 DLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL-LLGFGLGGL 310

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958802423 267 RTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSLGAALALVAILIMTLY 334
Cdd:cd06174   311 LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 25-91 7.52e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.19  E-value: 7.52e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958802423  25 SRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFyvTAFMCCSVFLLNAGLVWLL 91
Cdd:cd17325   309 TLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA--TPFLAAAALLLLAAVLFLL 373
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 22-65 9.08e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 43.71  E-value: 9.08e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958802423  22 LSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTE 65
Cdd:cd17502   101 MSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD 144
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 2-217 1.15e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 43.78  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   2 STNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELD--GGFYVTAFMCCS 79
Cdd:cd17388    88 APTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISprAPFLVAAGLNGL 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  80 VFLLnaGLVWLlpwretslnipdsgwsldqkhatvtiksestlqgaattPEARRSGRNLRPPWVEV-----MSTLKDMKN 154
Cdd:cd17388   168 NFLL--GLFVL--------------------------------------PESLPPERRRAFRWRRAnpfgsLRWLTGFPG 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958802423 155 LifSALWDVFLVRLLMGVAVMlyySNFVLALEERFGVRPKTTGYLISYTSALGTLA-GFAVGPI 217
Cdd:cd17388   208 L--LGLLAVFFLIQLIGQVPA---TTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFqAFVTGPI 266
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
159-337 1.45e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.32  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 159 ALWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCL 238
Cdd:COG2271   181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 239 LLLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPP- 317
Cdd:COG2271   261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAf 340

                         170       180
                  ....*....|....*....|
gi 1958802423 318 SLGAALALVAILIMTLYRPP 337
Cdd:COG2271   341 LLLAALALLAALLALLLLRE 360
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 3-83 2.35e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 42.64  E-value: 2.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423   3 TNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG---GFYVTAFMCCS 79
Cdd:cd17391    87 TNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGirnVFFITGGLLFL 166


                  ....
gi 1958802423  80 VFLL 83
Cdd:cd17391   167 AFLL 170
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 22-83 2.71e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 42.56  E-value: 2.71e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958802423  22 LSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG---GFYVTAFMCCSVFLL 83
Cdd:cd17323   105 LAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGwrwIFWFLAIISGFCLIL 169
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 2-74 5.87e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 41.45  E-value: 5.87e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958802423   2 STNVFLFTLARVPVGVFKHTLS-ISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGG----FYVTA 74
Cdd:cd17328    84 APNFWQLLLFRALVGIGEASYSpIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGwrwaFRVTG 161
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 21-335 1.08e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  21 TLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELD--GGFYVTAFMccsvfLLNAGLVWLLPWREtsl 98
Cdd:cd17473   105 IMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGwrAPFLVYLLA-----LPVLILVLLFLPEP--- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  99 nipdsgwsldqkhatvtiksestlQGAATTPEARRSGRNLRPPWVevmstlkdmknlifsalwDVFLVRLLMGVAVMLYY 178
Cdd:cd17473   177 ------------------------ARKSKSAASPGAATAAALPWK------------------RVLPIYFLAFLAMLLFY 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 179 S---NFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLlhSSALTCLLLLLYSTTNSMAMVVLS 255
Cdd:cd17473   215 VipiQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI--GFALMALGFLLLALASGLWVVLLG 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423 256 STLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEI--SPCGPPSLGAALALVAILIMTL 333
Cdd:cd17473   293 AILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLtgGLSGAFLILGVLALVLAIVLLL 372


                  ..
gi 1958802423 334 YR 335
Cdd:cd17473   373 LR 374
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 21-90 1.13e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.60  E-value: 1.13e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958802423  21 TLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLteLDGGFYVTAFMCCSVFLLNAGLVWL 90
Cdd:cd17370   304 QESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL--WDLISPSAAFLFSAVLALIALLLLL 371
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-68 3.33e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 38.64  E-value: 3.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958802423   1 MSTNVFLFTLARVPVGVFKHTLS-ISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG 68
Cdd:COG0477    98 LAPSPELLIAARALQGIGAGGLMpGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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