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Conserved domains on  [gi|1958660031|ref|XP_038942418|]
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rRNA methyltransferase 1, mitochondrial isoform X1 [Rattus norvegicus]

Protein Classification

RNA methyltransferase( domain architecture ID 13031090)

SpoU family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner; similar to mitochondrial rRNA methyltransferase 1 (MRM1) that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008173
PubMed:  17338813|30457841

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 68-225 1.26e-76

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


:

Pssm-ID: 349978  Cd Length: 158  Bit Score: 228.56  E-value: 1.26e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  68 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTV 147
Cdd:cd18105     1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKENGWKVVGTS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660031 148 GCPGPEiSQSSKVPVTSCLEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTILPGRHLP-PGLESLNVSVATGILLHSI 225
Cdd:cd18105    81 APPSAS-SDKKTIPANELSELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGRSAEnPGVDSLNVSVAAGILLHSL 158
 
Name Accession Description Interval E-value
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 68-225 1.26e-76

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 228.56  E-value: 1.26e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  68 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTV 147
Cdd:cd18105     1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKENGWKVVGTS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660031 148 GCPGPEiSQSSKVPVTSCLEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTILPGRHLP-PGLESLNVSVATGILLHSI 225
Cdd:cd18105    81 APPSAS-SDKKTIPANELSELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGRSAEnPGVDSLNVSVAAGILLHSL 158
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 33-231 7.41e-53

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 171.53  E-value: 7.41e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  33 CSRPVHQGVCMEVSRLRPRPCDEAADTSSGDDpqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSK 112
Cdd:COG0566    84 SGTETHQGVLAVVRPPEYADLEDLLAEAGEPP---LLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNPKVVR 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 113 ASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTVGcpgpeisqSSKVPVTsclEFIWDRPTLLVLGNEGSGLSQGVFAT 192
Cdd:COG0566   161 ASAGALFHVPVARVTNLADALEELKEAGFWVVGTDL--------DGEASLY---EVDLPGPVALVLGNEGKGLSRLVLEA 229

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958660031 193 CQLLLTIlPgrhLPPGLESLNVSVATGILLHSICSQKKG 231
Cdd:COG0566   230 CDELVRI-P---MAGGVESLNVAVAAAILLYEAARQRRA 264
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 37-229 6.51e-39

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 135.16  E-value: 6.51e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  37 VHQGVCMEVSRLRPRPCDEAADTS-SGDDPqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASA 115
Cdd:TIGR00186  61 NHQGIAAKVKPILYKDLNDLYKTAkSKKQP--FLLILDEITDPHNLGAILRTAEAFGVDGVILPKRRSAPLNSTVVKTSS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 116 GAMEVMDVFASPDLASFLQAKAQQGWLVVGTVGCPGPEISQSSKvpvtsclefiwDRPTLLVLGNEGSGLSQGVFATCQL 195
Cdd:TIGR00186 139 GAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDAQDTLYQVKL-----------TKPLALVVGNEGEGVSRLIKENCDF 207

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958660031 196 LLTIlPGRhlpPGLESLNVSVATGILLHSICSQK 229
Cdd:TIGR00186 208 LIKI-PMA---GKVDSLNVSVAAGILLFEIKRQR 237
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 70-223 4.94e-38

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 129.57  E-value: 4.94e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  70 LVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSC-PLTPVVSKASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTvg 148
Cdd:pfam00588   4 VVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSAdPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVAT-- 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958660031 149 cpgpeiSQSSKvpvtSCLEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlPGRhlpPGLESLNVSVATGILLH 223
Cdd:pfam00588  82 ------SLGGK----SLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRI-PMS---GDVESLNVAVAAAIALY 142
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
37-229 1.24e-26

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 103.12  E-value: 1.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  37 VHQGVcmeVSRLRP-RPCDEA---ADTSSGDDPqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSK 112
Cdd:PRK11181   66 VHQGI---IARVKPgRQLQENdlpDLLASLEQP--FLLILDGVTDPHNLGACLRSADAAGVHAVIVPKDRSAQLNATAKK 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 113 ASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTVGCPGPEISQSSkvpVTSclefiwdrPTLLVLGNEGSGLSQGVFAT 192
Cdd:PRK11181  141 VACGAAETVPLIRVTNLARTMRMLQEKNIWIVGTAGEADHTLYQSK---LTG--------PLALVMGAEGEGMRRLTREH 209

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958660031 193 CQLLLTI-LPGrhlppGLESLNVSVATGILLHSICSQK 229
Cdd:PRK11181  210 CDELISIpMAG-----SVSSLNVSVATGICLFEAVRQR 242
 
Name Accession Description Interval E-value
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 68-225 1.26e-76

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 228.56  E-value: 1.26e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  68 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTV 147
Cdd:cd18105     1 LWLLLDEITDPQNLGAILRSAYFLGVDGVVVSSKNSAPLSPVVSKASAGALELMPIYSVDNLASFLKSSKENGWKVVGTS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660031 148 GCPGPEiSQSSKVPVTSCLEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTILPGRHLP-PGLESLNVSVATGILLHSI 225
Cdd:cd18105    81 APPSAS-SDKKTIPANELSELLLEKPTILVLGNEGRGLRTNIKNLCDYLVSIPGGRSAEnPGVDSLNVSVAAGILLHSL 158
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 33-231 7.41e-53

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 171.53  E-value: 7.41e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  33 CSRPVHQGVCMEVSRLRPRPCDEAADTSSGDDpqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSK 112
Cdd:COG0566    84 SGTETHQGVLAVVRPPEYADLEDLLAEAGEPP---LLLVLDGVQDPGNLGAILRSAAAFGVDGVILPKRRADPYNPKVVR 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 113 ASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTVGcpgpeisqSSKVPVTsclEFIWDRPTLLVLGNEGSGLSQGVFAT 192
Cdd:COG0566   161 ASAGALFHVPVARVTNLADALEELKEAGFWVVGTDL--------DGEASLY---EVDLPGPVALVLGNEGKGLSRLVLEA 229

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1958660031 193 CQLLLTIlPgrhLPPGLESLNVSVATGILLHSICSQKKG 231
Cdd:COG0566   230 CDELVRI-P---MAGGVESLNVAVAAAILLYEAARQRRA 264
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 68-225 7.35e-46

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 149.84  E-value: 7.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  68 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTv 147
Cdd:cd18103     1 LLLILDGITDPHNLGAIIRSAEAFGVDGVIIPKRRSAPLTPTVAKASAGALEHLPIARVTNLARALEELKEAGFWIYGA- 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958660031 148 gcpgpeiSQSSKVPVTsclEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlPgrhLPPGLESLNVSVATGILLHSI 225
Cdd:cd18103    80 -------DGEAEKSLY---DVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKI-P---MAGKVDSLNVSVAAGIILYEI 143
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 68-225 4.01e-45

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 147.96  E-value: 4.01e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  68 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTV 147
Cdd:cd18095     1 LVLVLDGVQDPGNLGTIIRTAAAFGVDGVILSKGTVDPYNPKVVRASMGALFRLPIIRVDDLEELLEELKEAGYKVVAAD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958660031 148 GCPGpeisqsskvpvTSCLEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlPGrhlPPGLESLNVSVATGILLHSI 225
Cdd:cd18095    81 LDGG-----------SSLYDLDLPKPVALVLGNEGNGLSDELLELCDKRVTI-PM---SGGVESLNVAVAAAILLYEL 143
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 37-229 6.51e-39

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 135.16  E-value: 6.51e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  37 VHQGVCMEVSRLRPRPCDEAADTS-SGDDPqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASA 115
Cdd:TIGR00186  61 NHQGIAAKVKPILYKDLNDLYKTAkSKKQP--FLLILDEITDPHNLGAILRTAEAFGVDGVILPKRRSAPLNSTVVKTSS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 116 GAMEVMDVFASPDLASFLQAKAQQGWLVVGTVGCPGPEISQSSKvpvtsclefiwDRPTLLVLGNEGSGLSQGVFATCQL 195
Cdd:TIGR00186 139 GAVEYVPLARVTNLSRTITKLKESGFWTVGTDLDAQDTLYQVKL-----------TKPLALVVGNEGEGVSRLIKENCDF 207

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958660031 196 LLTIlPGRhlpPGLESLNVSVATGILLHSICSQK 229
Cdd:TIGR00186 208 LIKI-PMA---GKVDSLNVSVAAGILLFEIKRQR 237
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 70-223 4.94e-38

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 129.57  E-value: 4.94e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  70 LVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSC-PLTPVVSKASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTvg 148
Cdd:pfam00588   4 VVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSAdPYNPKAIRASAGALFHLPLVVVDNLEEALKDLKEAGYAVVAT-- 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958660031 149 cpgpeiSQSSKvpvtSCLEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlPGRhlpPGLESLNVSVATGILLH 223
Cdd:pfam00588  82 ------SLGGK----SLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRI-PMS---GDVESLNVAVAAAIALY 142
PRK11181 PRK11181
23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;
37-229 1.24e-26

23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB;


Pssm-ID: 183021 [Multi-domain]  Cd Length: 244  Bit Score: 103.12  E-value: 1.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  37 VHQGVcmeVSRLRP-RPCDEA---ADTSSGDDPqqLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSK 112
Cdd:PRK11181   66 VHQGI---IARVKPgRQLQENdlpDLLASLEQP--FLLILDGVTDPHNLGACLRSADAAGVHAVIVPKDRSAQLNATAKK 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 113 ASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTVGCPGPEISQSSkvpVTSclefiwdrPTLLVLGNEGSGLSQGVFAT 192
Cdd:PRK11181  141 VACGAAETVPLIRVTNLARTMRMLQEKNIWIVGTAGEADHTLYQSK---LTG--------PLALVMGAEGEGMRRLTREH 209

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958660031 193 CQLLLTI-LPGrhlppGLESLNVSVATGILLHSICSQK 229
Cdd:PRK11181  210 CDELISIpMAG-----SVSSLNVSVATGICLFEAVRQR 242
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 70-228 1.37e-23

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 92.92  E-value: 1.37e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  70 LVLEGIQDPRNLGAVMRSAYFLGVDRV-ITSRRNScplTPVVSKASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTvg 148
Cdd:cd18092    19 VVLENVHDPHNASAVLRTCDAFGVQDVhVIEPKNK---FKKNRGVAMGADKWLDVHRHDSTEECLAALKEQGYRIVAT-- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 149 CPGPEisqssKVPVTsclEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlpgrhlpP--GL-ESLNVSVATGILLHSI 225
Cdd:cd18092    94 SLSPD-----AVPLD---ELDYTRPTALVFGNEKDGVSEEALAAADERVYI-------PmyGFvESLNVSVAAAIILYEL 158


                  ...
gi 1958660031 226 CSQ 228
Cdd:cd18092   159 QRQ 161
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 70-225 5.68e-22

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 88.05  E-value: 5.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  70 LVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTvgc 149
Cdd:cd18082     2 LVLDNIRSPGNIGSIFRTADAFGVEKIYLVGPTADIFDPKAKRTSRGTHFSVPYERVDNFEEYLKSLKEEGYPLIGL--- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660031 150 pgpEISQSSKvPVTSClEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlPGRhlpPGLESLNVSVATGILLHSI 225
Cdd:cd18082    79 ---ELTDGSI-PLSEF-KFKKPKKIALIFGNERSGLSPELLALCDYTVHI-PMS---GKNSSLNVSVATGIALYEF 145
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 70-222 2.76e-20

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 83.74  E-value: 2.76e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  70 LVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASpDLASFLQAkAQQGWLVVGTVgC 149
Cdd:cd18109     3 LALDGIQDPGNLGTIIRTADWFGIRQIICSPDTVDPYNPKVVQASMGSIFRVQIHYT-DLPALLAE-LKKAFPVYGAD-L 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958660031 150 PGPEISqsskvpvtsclEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlPGRhlPPGLESLNVSVATGILL 222
Cdd:cd18109    80 DGENLY-----------EFTLPEKGILVMGNEGHGISPEVLKLLTHRLTI-PRY--GKGAESLNVAVATAILL 138
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 68-222 2.02e-19

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 81.46  E-value: 2.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  68 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVFASPDLASFLQAKAQQGWLVVGTv 147
Cdd:cd18097     1 LVVVLDNLRSAHNVGSIFRTADAAGVEKIYLCGYTPTPPHPKVAKTALGAEESVPWEHFEDTLEAVRALKARGYTIIAL- 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660031 148 gcpgpEISQSSkVPVTsclEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTI-LPGRHlppglESLNVSVATGILL 222
Cdd:cd18097    80 -----ETTENS-VPLH---EARLPRPLALVLGNEVRGVSPEVLALCDAVVEIpMFGRK-----NSLNVAVAAAVAL 141
PRK10864 PRK10864
putative methyltransferase; Provisional
 38-222 3.10e-17

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 79.44  E-value: 3.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  38 HQGVCMEVSRlrpRPCDEAADTSSGDDPQQLWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGA 117
Cdd:PRK10864  172 HGGVCFLIKK---RNGTDVQQWLAQAGAQDCVLALEDVGNPHNLGGIMRSCAHFGVKGVVVQDAALLESGAAIRTAEGGA 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 118 MEVMDVFASpDLASFLQAKAQQGWLVVGTVGCPGPEISQsSKVPvtsclefiwdRPTLLVLGNEGSGLSQGVFATCQLLL 197
Cdd:PRK10864  249 EHVQPITGD-SFVDVLDDFRQAGYTIVTTSSHKGTPLFK-ASLP----------AKMVLVLGQEYDGLSDAARQQGDLSV 316

                         170       180
                  ....*....|....*....|....*
gi 1958660031 198 TIlPGRHLppgLESLNVSVATGILL 222
Cdd:PRK10864  317 SI-DGTGN---VESLNVSVATGVLL 337
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 68-224 1.07e-12

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 63.39  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  68 LWLVLEGIQDPRNLGAVMRSAYFLGVDRV-ITSRRnscPLTPVVSKASAGAMEVMDVFASPDLASFLqakAQQGWLVVGT 146
Cdd:cd18096     1 LYLVLHNVAKRHNIGTIVRSANAFGVKEVhLVGRR---KFNPFGAMGTDRHVKFRHFDTLAEAKEYL---KERGIRLVGV 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958660031 147 vgcpgpEISQSSKvPVTSCLefiWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlpgRHLPPGLESLNVSVATGILLHS 224
Cdd:cd18096    75 ------EIVPGAE-PIETHP---FPGDTAFVLGNEGTGLSDEQLAICDGFVYI---PQYGSGTASLNVSVAASIVLHH 139
SpoU-like_RNA-MTase cd18104
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 68-222 1.67e-12

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349977  Cd Length: 146  Bit Score: 62.98  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  68 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGAMEVMDVF--ASPDLASFLQakaQQGWLVVG 145
Cdd:cd18104     1 LILVLEGLEKPGNLGAILRSADAAGADAVILCDPKTDLFNPNVIRASLGAVFTLPVAeaSSEETLAWLK---ENKIRILA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 146 TvgCPGPEISqsskvpvtsclefIWD----RPTLLVLGNEGSGLSQGVFATCQLLLTIlP--GRhlppgLESLNVSVATG 219
Cdd:cd18104    78 T--TPKAEKL-------------YYEadlrGPIAIVVGSESEGLSEFWLKAADERVRI-PmaGQ-----ADSLNVSVAAA 136


                  ...
gi 1958660031 220 ILL 222
Cdd:cd18104   137 ILL 139
SpoU-like_AviRb cd18107
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ...
 68-225 3.65e-12

SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349980  Cd Length: 148  Bit Score: 62.02  E-value: 3.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  68 LWLVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAG---AMEVMDVFASPDLASFLQA--KAQQGWL 142
Cdd:cd18107     1 LVVLFDRPTSPGNLGTIIRSADALGAHGLVVTGHAADVYDPKTIRASTGslfSLPIVRVPSNRELEDWVEArkARGTPLQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 143 VVGTvgcpgpeiSQSSKVPVTsclEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlpgrHLPPGLESLNVSVATGILL 222
Cdd:cd18107    81 LVGT--------DEHGDHQIA---DHDFTRPTLLLIGNETAGLSAAWRELCDETVSI----PMAGSASSLNAACAASIFL 145


                  ...
gi 1958660031 223 HSI 225
Cdd:cd18107   146 YEA 148
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 75-223 7.31e-10

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 55.61  E-value: 7.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  75 IQDPRNLGAVMRSAYFLGVDRVITSRRNSC--PLTPVVSKASAGAMEVMDVfASPDLASFLQAKAQQGWLVVGtvgcpgp 152
Cdd:cd18091     8 IDKPPNLGGLCRTCEIFGVSKLVLPNLAVVedKQFKALSVSAEKWLPIEEV-KPEDLLPYLKEKKQEGYTIVG------- 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958660031 153 eISQSSK-VPVTsclEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlpgrhlpPGL---ESLNVSVATGILLH 223
Cdd:cd18091    80 -LEQTANsVSLH---DFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEI-------PQLgviRSLNVHVSGAIAIY 143
SpoU-like_TrmJ cd18093
SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl ...
 68-225 3.46e-07

SAM-dependent tRNA methylase related to TrmJ; tRNA methyltransferase TrmJ catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 32 in both tRNASer1 and tRNAGln2. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349966  Cd Length: 153  Bit Score: 48.26  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  68 LWLVLEGIQDPRNLGAVMRSAYFLGVD--RVITSRRNscPLTPVVSKASAGAMEVMD---VFasPDLASFLqAKAQqgwL 142
Cdd:cd18093     1 IRVVLVEPQHPGNIGAVARAMKNFGLSdlRLVNPRCD--DPEEAARALASGAEDVLEnakVY--DTLEEAL-ADCD---L 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 143 VVGTVGcpgpEISQSSKVPVTS------CLEFIWDRPTLLVLGNEGSGLSQGVFATCQLLLTIlpgrhlP--PGLESLNV 214
Cdd:cd18093    73 VVATTA----RPRGLRRPLLTPrelaelLKEHAAGGKVALVFGREDSGLTNEELALCDLLVTI------PtnPEYPSLNL 142

                         170
                  ....*....|.
gi 1958660031 215 SVATGILLHSI 225
Cdd:cd18093   143 AQAVAIVLYEL 153
SpoU-like_RNMTL1 cd18106
SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) ...
 70-222 5.48e-07

SAM-dependent rRNA methylase related to RNMTL1; RNMTL1 (also known as HC90, MRM3 and RMTL1) catalyzes the methylation of 2'-O-ribose residues G1370 to GmG residue of the mitochondrial 16S rRNA. RNMTL1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349979  Cd Length: 148  Bit Score: 47.63  E-value: 5.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  70 LVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNSCPLTPVVSKASAGA---MEVMDVFASPDLASFLQAKAQqgwLVVGt 146
Cdd:cd18106     3 VICDNIRDPGNLGSILRSAAAAGCSKVLLTKGCVDPWEPKVLRAGAGAhfrLPIYGNLSWDDIPNYLPDDSK---VFLA- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 147 vgcpgpeisqSSKVPVTSCLEFIWDR-PTLLVLGNEGSGLSQgvfATCQLL-------LTIlPgrhLPPGLESLNVSVAT 218
Cdd:cd18106    79 ----------DNNLPVQPYDSIDYCSgPIVLVIGGETHGVSP---EAYKLAhstggsrVHI-P---LANGVDSLNSAVAA 141


                  ....
gi 1958660031 219 GILL 222
Cdd:cd18106   142 SILL 145
SpoU-like_NHR cd18108
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) ...
 70-223 4.98e-05

Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) confers resistance to the thiazole antibiotic nosiheptide via catalyzing 2'O-methylation of 23S rRNA at the nucleotide A1067. NHR is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349981  Cd Length: 144  Bit Score: 42.08  E-value: 4.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  70 LVLEGIQDPRNLGAVMRSAYFLGVDRVITSRRNscpLTPV----VSKASAGAMEVMDVFASP--DLASFLQAKAQQgwLV 143
Cdd:cd18108     3 VVLDGVRIVGNIGAIVRTSLALGAAGIVLVDSD---LATVadrrLLRASRGYVFSLPVVLADreEAVAFLRDNDIP--LM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 144 VGTVGCPGPeISQSSKVPvtsclefiwdRPTLLVLGNEGSGLSQGVFATCQLLLTIlpgrHLPPGLESLNVSVATGILLH 223
Cdd:cd18108    78 TLDADGDVP-VKELGDRP----------DRLALVFGSEKGGPSGLFEEAAAGTVSI----PMSSSTESLNVSVSAGIALH 142
TrmJ COG0565
tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ...
 67-223 2.91e-03

tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase [Translation, ribosomal structure and biogenesis]; tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440331 [Multi-domain]  Cd Length: 237  Bit Score: 37.79  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031  67 QLWLVLEGIQDPRNLGAVMRSAYFLGVDR-VITSRRnsCPLTPVVSKASAGAMEVMD---VFASpdLASFLqAKAQqgwL 142
Cdd:COG0565     3 NIRVVLVEPQHPGNIGAAARAMKNFGLSDlRLVNPR--GWPDEEARAMASGADDVLEnarVVDT--LEEAL-ADCD---L 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660031 143 VVGTVGcpgpeISQSSKVPVTS---CLEFIWDR----PTLLVLGNEGSGLSQGVFATCQLLLTIlpgrhlP--PGLESLN 213
Cdd:COG0565    75 VVGTTA-----RPRELRKPVLTpreAAEELLARaaggKVALVFGRERSGLTNEELALCDALVTI------PtnPEYPSLN 143

                         170
                  ....*....|
gi 1958660031 214 VSVATGILLH 223
Cdd:COG0565   144 LAQAVQVVAY 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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