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Conserved domains on  [gi|1958660828|ref|XP_038942730|]
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protocadherin Fat 2 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3328-3424 6.86e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 127.04  E-value: 6.86e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3328 YTVRVLENAVVGDVILTVSASDDDGPVNSAITYSLVGGNQLGHFTINPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPP 3407
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958660828 3408 LHEDTEVAVEVVDVNDN 3424
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1141-1238 4.10e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 4.10e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1141 VFYPSVLEDAPLGTSVLQLEAWDPDSSSQGKLTFNLTSGNHLGHFIVHPFTGLLTTAKQLDRENKDEYVLEVTVQDNGDP 1220
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958660828 1221 SLRSTSRVVVCILDVNDN 1238
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2276-2375 9.44e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 9.44e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2276 VYTTSVSEGSPAQTPVIQLLASDQDSGQNQDVSYQIVEDGSDvsKFFRINGSTGEIFTIQELDYETHQHFRVKVRAMDKG 2355
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958660828 2356 DPPLTGETLVVVNVSDINDN 2375
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1036-1133 1.39e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 1.39e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1036 VYQGQVQENSPAGTPVMVVTAQDDDSGLDGELQYFLRAGTGLETFSINQDTGMLETLAPLDREFTPYYWLTVLAVDRGSV 1115
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958660828 1116 PLSAVTEVYIEVTDINDN 1133
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3018-3111 1.82e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 1.82e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3018 YTGKVREDVTPGHFILKVSAIDVDMDTNAQITYSLHGPGAQE-FKLDPHTGELTTLTVLDRERKDVYNLVAKATDGGG-- 3094
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1958660828 3095 QSCQAEVTLHIEDVNDN 3111
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2803-2904 2.64e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 2.64e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2803 PYKAFLTENMPGGTTVIQVTANDQDTGSDGQVSYRLSvepGSNIHELFAVDSESGWITTLQELDCETQQTYSFYVVAFDH 2882
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|..
gi 1958660828 2883 GqTIQLSSQALVEVSITDENDN 2904
Cdd:cd11304     78 G-GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 719-816 3.08e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.08e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  719 PQSIDILEQVPINTPLARLAATDPDTGFHGKLVYVISDGNEEGCFDIELETGLLMVAAALDYETTSFYVLNVTVYDLGTP 798
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958660828  799 PKSSWKLLTVTVKDWNDN 816
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 462-560 4.45e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 4.45e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  462 SYEGTLDENIPPGTSVLTVTATDQDHGDNGHITYSI-AGPKAVPFSIDPLLGVISTTKPMDYELMKRiYTFRVRASDWGS 540
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 1958660828  541 PfRQEKEVSVSLRLKNLNDN 560
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3802-3923 1.34e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 104.81  E-value: 1.34e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3802 LKTLQPWALLMFTN--ETASISLKLANGFSHLEYHCPGGFYGNLSSRYPVNDGQWHSMLLEERDTSVHLLVDITDNASLV 3879
Cdd:pfam02210    1 FRTRQPNGLLLYAGggGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958660828 3880 IPEECQGLRTERQLLLGGLVPSNPSSNVSL--GFEGCLDAVVVNGE 3923
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLLLPALPVraGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 825-921 4.73e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 4.73e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  825 YQLTISEDTEVGTTIAELKTEDADSEDNRRVRYTLL--TPTEKFSLHPFTGELVVTGHLDRESESQYILKAEARDQPtkG 902
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG--G 79

                           90
                   ....*....|....*....
gi 1958660828  903 HQLFSVTDLIVTLEDINDN 921
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2074-2163 8.97e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 8.97e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2074 PYYTVIQDGTEPGDVLFQVSATDKDLGANGSVTYGFAEDYA--YFRIDPYVGDISLKKPFDYQALNKYHLRVIARDSGIP 2151
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|..
gi 1958660828 2152 PLQTEVEVHVTV 2163
Cdd:cd11304     81 PLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1560-1650 1.43e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.43e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1560 YEANVPDTTAPGTELLQVRAVDADRGANAEIHYSFLKGNSDGFFNIDSLLGIITVAQRLYHVHLTRHALTVKAEDQGSPR 1639
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1958660828 1640 RHDLALVVIHV 1650
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 931-1026 2.85e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 2.85e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  931 RLKVPEDMPLGTVLTFLDASDPDLGPAGEVKYILVE-DAHGTFQVHPMTGALSLEKELDFERRAGYNLSFWASDSGKPlS 1009
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-P 81

                           90
                   ....*....|....*..
gi 1958660828 1010 RRTLCHVEVLVMDVNEN 1026
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2485-2581 6.53e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 6.53e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2485 VYEAELAENAKVGTKVIELLAIDKDSGPYGTVDYTIINKLAGERFFINPR-GQITTLQKLDREnsTERVIAIKVMARDGG 2563
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDRE--EQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958660828 2564 G--KVAFCTVKIILTDENDN 2581
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1766-1867 6.53e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 6.53e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1766 HISEAAPLHSLILgednsplVVRASDSDREANSLLVYKILEPEALKFFKIDPSMGTLTTTSELDFEDTPLFQFNIYVHDQ 1845
Cdd:cd11304      5 SVPENAPPGTVVL-------TVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|..
gi 1958660828 1846 GTPILFAprSAKVIIHVRDVND 1867
Cdd:cd11304     78 GGPPLSS--TATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2913-3009 1.10e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 1.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2913 YRGSVVENNEPGELVATLKTLDADvSDQNRQVTCYITEGDPLGQFSISQvgDEWRISSRKTLDREHIAKYLLRVTASDG- 2991
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDP--STGEITTAKPLDREEQSSYTLTVTATDGg 78

                           90       100
                   ....*....|....*....|
gi 1958660828 2992 --KFQASVPVEVFVVDINDN 3009
Cdd:cd11304     79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3122-3211 1.73e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.73e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3122 VAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLT-DSADGQFSIDATSGVIRLEKPLQVRASSAVELTVRASDLGTPiPL 3200
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PL 82

                           90
                   ....*....|.
gi 1958660828 3201 STLGTVTVSVV 3211
Cdd:cd11304     83 SSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2176-2268 5.60e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 5.60e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2176 YKVKVPENITLYTPILHTQAR---SPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTALGS 2252
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958660828 2253 FS-EATVEVLVEDINDN 2268
Cdd:cd11304     82 LSsTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1664-1754 5.77e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 5.77e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1664 EYFIEIPESVPIGSPILLLSA-----GSSSEVTYELREGNKDSVFSMNSYSGLISTQKRLDHEKVPSYRLRIRGSNMAG- 1737
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1958660828 1738 -VFTEVVALVYIIDENDN 1754
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2383-2475 9.22e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 9.22e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2383 QYEANVSELATCGHLVLKVQALDPDIGDTSRLEYLILSGNQDRHFSINSTSGIISMfnlcKKQLD----SSYNLRVGASD 2458
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT----AKPLDreeqSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|
gi 1958660828 2459 G---VFRATVPVYINTTNAN 2475
Cdd:cd11304     77 GggpPLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
3433-3524 1.87e-19

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 1.87e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3433 YSTSVQENSPIGIKVLQLILDDPDSPQNGPPyFFRITEGNTGSVFRVTPD-GWLVTAASLSKKAREWYQLHIEVSDSGLP 3511
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1958660828 3512 PLSSSTLVRVQVT 3524
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1247-1335 1.84e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1247 FNVRLSERLSPlsPEPVYRLVASDPDEGLNGSVTYSIEESDEES-FRIDPVTGVVSSSSTF---AAGEYNiLTIKATDSG 1322
Cdd:cd11304      2 YEVSVPENAPP--GTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLdreEQSSYT-LTVTATDGG 78

                           90
                   ....*....|...
gi 1958660828 1323 QPALSTSVRLHIE 1335
Cdd:cd11304     79 GPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-249 1.88e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.88e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  152 SYRVTISEDRPLKSPICKVTATDADLGQNAEFYYAF--NARSEVFAIHPTSGVVTVAGKLNVTRRGKYELQVLAVDrmrk 229
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD---- 76

                           90       100
                   ....*....|....*....|
gi 1958660828  230 iSEGNGFGNLASLVIRVEPV 249
Cdd:cd11304     77 -GGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2697-2795 2.47e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 2.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2697 YTFSAPEDLPEGSEIGSVKAV----AAQDPIIYSLVQGttpesNSDDVFSLDQDTGVLKVRKAMDHESTKWYQIDLMAHC 2772
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1958660828 2773 PHEDtDLVSLVSVSIQVEDVNDN 2795
Cdd:cd11304     77 GGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1452-1551 4.38e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 4.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1452 HYEIRVPQDTLPGVELLRVQATDQDHGKG--LIYTILSSQDPGsanLFQLDPSSGVLVTVGTL--ELHsgpSQHILTVMV 1527
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDG---LFSIDPSTGEITTAKPLdrEEQ---SSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 1958660828 1528 RDQEMPIKRNFVWVTIHVEDGNLH 1551
Cdd:cd11304     75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3226-3319 1.96e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.44  E-value: 1.96e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3226 STQVPEDAPIDMEVLHLaTLTRPGSEKTG---YHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSS 3302
Cdd:cd11304      3 EVSVPENAPPGTVVLTV-SATDPDSGENGevtYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958660828 3303 LSDVTTIVINVTDVNEH 3319
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2590-2683 4.54e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 4.54e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2590 YTVSIPSNVSRDSPIIQVLAYDADEGRNADVTYSVDSTEDlaEEIIEVNPTTGVVKVKESLVGLENRAVDFNIKAQDGGP 2669
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1958660828 2670 PHWDSLVPVRLQVV 2683
Cdd:cd11304     80 PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1972-2066 3.54e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 3.54e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1972 VYRARVTENTPHRKALVILGVH--GNHLNDTLSYFLLNGTD--LFHMIESAGVLQTRGgTFDREQQDTHEVAVEVRDNRV 2047
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1958660828 2048 PQRVAQALVRVSVEDVNDN 2066
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-661 6.35e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 6.35e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  570 TVSLRQDVPVGKSIMAVSAIDMDELQN--LKYEIVSGNEQDYFHLNHFSGVISLKRSfmnLTAVRPTIYSLKITASDGKN 647
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKP---LDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*
gi 1958660828  648 YASPTTLKVTV-VKD 661
Cdd:cd11304     80 PPLSSTATVTItVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 366-454 7.00e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 7.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  366 VYRVKLSEFSPPGSRVALVKVT----TALPNLRYSLKPSSRNTAFKLNARTGLITTTKLVDFHEQNQYQLHVK-TSLGQ- 439
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTaTDGGGp 80

                           90
                   ....*....|....*...
gi 1958660828  440 ---ATTTVIIDIVDCNNH 454
Cdd:cd11304     81 plsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1354-1444 1.12e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 1.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1354 YSFTVMETDPVNHMVGVISV----EGRPGLFWFHISDGDKDMDFDIEKTTGSIVIARPLDTRRKSSYNLTVEVTDG---- 1425
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpp 81

                           90
                   ....*....|....*....
gi 1958660828 1426 FHTIATqVHIFmIANINHH 1444
Cdd:cd11304     82 LSSTAT-VTIT-VLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 38-143 8.79e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 8.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   38 YNATIYENSAPKTYVespvkmGMYLA-----EPHWVVKYRIISGDAAGVFKTEEHVvGNfcflrIRTKSSntalLNREVR 112
Cdd:cd11304      2 YEVSVPENAPPGTVV------LTVSAtdpdsGENGEVTYSIVSGNEDGLFSIDPST-GE-----ITTAKP----LDREEQ 65

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958660828  113 DSYTLIVQASDK-SLEFEALTQVVVHILDQND 143
Cdd:cd11304     66 SSYTLTVTATDGgGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3535-3621 4.48e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 4.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3535 PLEISITkgEEEFQGGMIGKIHATDRD--PQDTLTYSLEqEGGLDRYFTVGASDGKIIASQGLPH---GRYSFNVTVSDG 3609
Cdd:cd11304      1 SYEVSVP--ENAPPGTVVLTVSATDPDsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDReeqSSYTLTVTATDG 77

                           90
                   ....*....|....*
gi 1958660828 3610 ---TFTTTTGVHVHV 3621
Cdd:cd11304     78 ggpPLSSTATVTITV 92
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3992-4022 8.40e-09

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 53.54  E-value: 8.40e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958660828 3992 CTSAPCQEGGTCVSSPEGTSCNCPHPYTGDR 4022
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3953-3986 7.45e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 7.45e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958660828 3953 C-SQSPCLNGGSCSPALGSgYLCRCPPPFSGRNCE 3986
Cdd:cd00054      5 CaSGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 4084-4268 1.60e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.31  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 4084 EDPDLLARSIGVDTQASPAIELDPLNTSSCNNlnQPEPSKTSVPNE-LVTFGPSSKQRPMVCSVPPRLPpaavSSHPGHE 4162
Cdd:pfam03154  177 QSGAASPPSPPPPGTTQAATAGPTPSAPSVPP--QGSPATSQPPNQtQSTAAPHTLIQQTPTLHPQRLP----SPHPPLQ 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 4163 PIIKrtwsgeelvypsgaavwPPTYSRKKHWEYPHPeTMQGTLPPSPRR-HVGPAVMPDPtGLYGGFPFPLELENKRAPL 4241
Cdd:pfam03154  251 PMTQ-----------------PPPPSQVSPQPLPQP-SLHGQMPPMPHSlQTGPSHMQHP-VPPQPFPLTPQSSQSQVPP 311

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1958660828 4242 PPRYSNQNLEDLMPPRPPS---------PREHLLAP 4268
Cdd:pfam03154  312 GPSPAAPGQSQQRIHTPPSqsqlqsqqpPREQPLPP 347
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1877-1959 2.19e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1877 YEVAVVEPIHPGMGLLTVQAEDND----SRVTYSIKTSNADEAVTIHPTTGQISVVNP---ATLRLFQkFSIRASDGLYH 1949
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgpnGRIFYSILGGGPGGNFRIDPDTGDISTTKPldrESIGEYE-LTVEATDSGGP 79

                           90
                   ....*....|...
gi 1958660828 1950 ---DTAVVKISLT 1959
Cdd:pfam00028   80 plsSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3328-3424 6.86e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 127.04  E-value: 6.86e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3328 YTVRVLENAVVGDVILTVSASDDDGPVNSAITYSLVGGNQLGHFTINPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPP 3407
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958660828 3408 LHEDTEVAVEVVDVNDN 3424
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1141-1238 4.10e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 4.10e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1141 VFYPSVLEDAPLGTSVLQLEAWDPDSSSQGKLTFNLTSGNHLGHFIVHPFTGLLTTAKQLDRENKDEYVLEVTVQDNGDP 1220
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958660828 1221 SLRSTSRVVVCILDVNDN 1238
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2276-2375 9.44e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 9.44e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2276 VYTTSVSEGSPAQTPVIQLLASDQDSGQNQDVSYQIVEDGSDvsKFFRINGSTGEIFTIQELDYETHQHFRVKVRAMDKG 2355
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958660828 2356 DPPLTGETLVVVNVSDINDN 2375
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1036-1133 1.39e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 1.39e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1036 VYQGQVQENSPAGTPVMVVTAQDDDSGLDGELQYFLRAGTGLETFSINQDTGMLETLAPLDREFTPYYWLTVLAVDRGSV 1115
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958660828 1116 PLSAVTEVYIEVTDINDN 1133
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3018-3111 1.82e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 1.82e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3018 YTGKVREDVTPGHFILKVSAIDVDMDTNAQITYSLHGPGAQE-FKLDPHTGELTTLTVLDRERKDVYNLVAKATDGGG-- 3094
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1958660828 3095 QSCQAEVTLHIEDVNDN 3111
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2803-2904 2.64e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 2.64e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2803 PYKAFLTENMPGGTTVIQVTANDQDTGSDGQVSYRLSvepGSNIHELFAVDSESGWITTLQELDCETQQTYSFYVVAFDH 2882
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|..
gi 1958660828 2883 GqTIQLSSQALVEVSITDENDN 2904
Cdd:cd11304     78 G-GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 719-816 3.08e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.08e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  719 PQSIDILEQVPINTPLARLAATDPDTGFHGKLVYVISDGNEEGCFDIELETGLLMVAAALDYETTSFYVLNVTVYDLGTP 798
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958660828  799 PKSSWKLLTVTVKDWNDN 816
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 462-560 4.45e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 4.45e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  462 SYEGTLDENIPPGTSVLTVTATDQDHGDNGHITYSI-AGPKAVPFSIDPLLGVISTTKPMDYELMKRiYTFRVRASDWGS 540
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 1958660828  541 PfRQEKEVSVSLRLKNLNDN 560
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3346-3426 9.02e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 103.58  E-value: 9.02e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  3346 SASDDDGPVNSAITYSLVGGNQLGHFTINPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPPLHEDTEVAVEVVDVNDNP 3425
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958660828  3426 P 3426
Cdd:smart00112   81 P 81
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3802-3923 1.34e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 104.81  E-value: 1.34e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3802 LKTLQPWALLMFTN--ETASISLKLANGFSHLEYHCPGGFYGNLSSRYPVNDGQWHSMLLEERDTSVHLLVDITDNASLV 3879
Cdd:pfam02210    1 FRTRQPNGLLLYAGggGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958660828 3880 IPEECQGLRTERQLLLGGLVPSNPSSNVSL--GFEGCLDAVVVNGE 3923
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLLLPALPVraGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 825-921 4.73e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 4.73e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  825 YQLTISEDTEVGTTIAELKTEDADSEDNRRVRYTLL--TPTEKFSLHPFTGELVVTGHLDRESESQYILKAEARDQPtkG 902
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG--G 79

                           90
                   ....*....|....*....
gi 1958660828  903 HQLFSVTDLIVTLEDINDN 921
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2074-2163 8.97e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 8.97e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2074 PYYTVIQDGTEPGDVLFQVSATDKDLGANGSVTYGFAEDYA--YFRIDPYVGDISLKKPFDYQALNKYHLRVIARDSGIP 2151
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|..
gi 1958660828 2152 PLQTEVEVHVTV 2163
Cdd:cd11304     81 PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2296-2377 1.13e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.12  E-value: 1.13e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2296 ASDQDSGQNQDVSYQIVedGSDVSKFFRINGSTGEIFTIQELDYETHQHFRVKVRAMDKGDPPLTGETLVVVNVSDINDN 2375
Cdd:smart00112    2 ATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1958660828  2376 PP 2377
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1560-1650 1.43e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.43e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1560 YEANVPDTTAPGTELLQVRAVDADRGANAEIHYSFLKGNSDGFFNIDSLLGIITVAQRLYHVHLTRHALTVKAEDQGSPR 1639
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1958660828 1640 RHDLALVVIHV 1650
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 931-1026 2.85e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 2.85e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  931 RLKVPEDMPLGTVLTFLDASDPDLGPAGEVKYILVE-DAHGTFQVHPMTGALSLEKELDFERRAGYNLSFWASDSGKPlS 1009
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-P 81

                           90
                   ....*....|....*..
gi 1958660828 1010 RRTLCHVEVLVMDVNEN 1026
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
3797-3923 2.88e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 100.88  E-value: 2.88e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  3797 QIHFYLKTLQPWALLMFT---NETASISLKLANGFSHLEYHCPGGFYGNLSSRYPVNDGQWHSMLLEERDTSVHLLVDIT 3873
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgskGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1958660828  3874 DNASLVIPEECQGLRTERQLLLGGLVPS--NPSSNVSLGFEGCLDAVVVNGE 3923
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDlkLPPLPVTPGFRGCIRNLKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1161-1240 4.46e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.58  E-value: 4.46e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  1161 AWDPDSSSQGKLTFNLTSGNHLGHFIVHPFTGLLTTAKQLDRENKDEYVLEVTVQDNGDPSLRSTSRVVVCILDVNDNPP 1240
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2277-2369 1.07e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 1.07e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2277 YTTSVSEGSPAQTPVIQLLASDQDSGQNQDVSYQIVEDGSDvsKFFRINGSTGEIFTIQELDYETHQHFRVKVRAMDKGD 2356
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG--GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1958660828 2357 PPLTGETLVVVNV 2369
Cdd:pfam00028   79 PPLSSTATVTITV 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3777-3921 1.25e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 99.80  E-value: 1.25e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3777 TLRFSGQSYVRYRPLEA--QNWQIHFYLKTLQPWALLMFT---NETASISLKLANGFSHLEYHCpGGFYGNLSSRYPVND 3851
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAprTRLSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGRLVLRYDL-GSGSLVLSSKTPLND 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958660828 3852 GQWHSMLLEERDTSVHLLVDITDNASLVIPEECQGLRTERQLLLGGLVPS--NPSSNVSLGFEGCLDAVVVN 3921
Cdd:cd00110     80 GQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDlkSPGLPVSPGFVGCIRDLKVN 151
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1055-1135 5.12e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.49  E-value: 5.12e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  1055 TAQDDDSGLDGELQYFLRAGTGLETFSINQDTGMLETLAPLDREFTPYYWLTVLAVDRGSVPLSAVTEVYIEVTDINDNI 1134
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958660828  1135 P 1135
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2485-2581 6.53e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 6.53e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2485 VYEAELAENAKVGTKVIELLAIDKDSGPYGTVDYTIINKLAGERFFINPR-GQITTLQKLDREnsTERVIAIKVMARDGG 2563
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDRE--EQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958660828 2564 G--KVAFCTVKIILTDENDN 2581
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1766-1867 6.53e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 6.53e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1766 HISEAAPLHSLILgednsplVVRASDSDREANSLLVYKILEPEALKFFKIDPSMGTLTTTSELDFEDTPLFQFNIYVHDQ 1845
Cdd:cd11304      5 SVPENAPPGTVVL-------TVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|..
gi 1958660828 1846 GTPILFAprSAKVIIHVRDVND 1867
Cdd:cd11304     78 GGPPLSS--TATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 739-818 7.13e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 7.13e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   739 ATDPDTGFHGKLVYVISDGNEEGCFDIELETGLLMVAAALDYETTSFYVLNVTVYDLGTPPKSSWKLLTVTVKDWNDNPP 818
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
3328-3418 2.32e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.90  E-value: 2.32e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3328 YTVRVLENAVVGDVILTVSASDDDGPVNSAITYSLVGGNQLGHFTINPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPP 3407
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1958660828 3408 LHEDTEVAVEV 3418
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3036-3113 3.04e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 3.04e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  3036 SAIDVDMDTNAQITYSLHGPGAQE-FKLDPHTGELTTLTVLDRERKDVYNLVAKATDGGGQ--SCQAEVTLHIEDVNDNA 3112
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNA 80


                    .
gi 1958660828  3113 P 3113
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2822-2906 3.62e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 3.62e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2822 TANDQDTGSDGQVSYRLSvepGSNIHELFAVDSESGWITTLQELDCETQQTYSFYVVAFDHGQTiQLSSQALVEVSITDE 2901
Cdd:smart00112    1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDV 76


                    ....*
gi 1958660828  2902 NDNPP 2906
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
1037-1128 4.62e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.13  E-value: 4.62e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1037 YQGQVQENSPAGTPVMVVTAQDDDSGLDGELQYFLRAGTGLETFSINQDTGMLETLAPLDREFTPYYWLTVLAVDRGSVP 1116
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1958660828 1117 LSAVTEVYIEVT 1128
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2913-3009 1.10e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 1.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2913 YRGSVVENNEPGELVATLKTLDADvSDQNRQVTCYITEGDPLGQFSISQvgDEWRISSRKTLDREHIAKYLLRVTASDG- 2991
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDP--STGEITTAKPLDREEQSSYTLTVTATDGg 78

                           90       100
                   ....*....|....*....|
gi 1958660828 2992 --KFQASVPVEVFVVDINDN 3009
Cdd:cd11304     79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3122-3211 1.73e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.73e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3122 VAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLT-DSADGQFSIDATSGVIRLEKPLQVRASSAVELTVRASDLGTPiPL 3200
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PL 82

                           90
                   ....*....|.
gi 1958660828 3201 STLGTVTVSVV 3211
Cdd:cd11304     83 SSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2176-2268 5.60e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 5.60e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2176 YKVKVPENITLYTPILHTQAR---SPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTALGS 2252
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958660828 2253 FS-EATVEVLVEDINDN 2268
Cdd:cd11304     82 LSsTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1664-1754 5.77e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 5.77e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1664 EYFIEIPESVPIGSPILLLSA-----GSSSEVTYELREGNKDSVFSMNSYSGLISTQKRLDHEKVPSYRLRIRGSNMAG- 1737
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1958660828 1738 -VFTEVVALVYIIDENDN 1754
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1145-1233 9.25e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 9.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1145 SVLEDAPLGTSVLQLEAWDPDSSSQGKLTFNLTSGNHLGHFIVHPFTGLLTTAKQLDRENKDEYVLEVTVQDNGDPSLRS 1224
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1958660828 1225 TSRVVVCIL 1233
Cdd:pfam00028   84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
720-810 3.06e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 3.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  720 QSIDILEQVPINTPLARLAATDPDTGFHGKLVYVISDGNEEGCFDIELETGLLMVAAALDYETTSFYVLNVTVYDLGTPP 799
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1958660828  800 KSSWKLLTVTV 810
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2075-2163 7.13e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 7.13e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2075 YYTVIQDGTEPGDVLFQVSATDKDLGANGSVTYGFAEDYAY--FRIDPYVGDISLKKPFDYQALNKYHLRVIARDSGIPP 2152
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1958660828 2153 LQTEVEVHVTV 2163
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2383-2475 9.22e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 9.22e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2383 QYEANVSELATCGHLVLKVQALDPDIGDTSRLEYLILSGNQDRHFSINSTSGIISMfnlcKKQLD----SSYNLRVGASD 2458
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT----AKPLDreeqSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|
gi 1958660828 2459 G---VFRATVPVYINTTNAN 2475
Cdd:cd11304     77 GggpPLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
3433-3524 1.87e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 1.87e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3433 YSTSVQENSPIGIKVLQLILDDPDSPQNGPPyFFRITEGNTGSVFRVTPD-GWLVTAASLSKKAREWYQLHIEVSDSGLP 3511
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1958660828 3512 PLSSSTLVRVQVT 3524
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3018-3106 1.89e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 1.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3018 YTGKVREDVTPGHFILKVSAIDVDMDTNAQITYSL--HGPGAQeFKLDPHTGELTTLTVLDRERKDVYNLVAKATDGGGQ 3095
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGN-FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|.
gi 1958660828 3096 SCQAEVTLHIE 3106
Cdd:pfam00028   80 PLSSTATVTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3433-3524 3.81e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 3.81e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3433 YSTSVQENSPIGIKVLQLILDDPDSPQNGPpYFFRITEGNTGSVFRVTPD-GWLVTAASLSKKAREWYQLHIEVSDSGLP 3511
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1958660828 3512 PLSSSTLVRVQVT 3524
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
463-552 1.61e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.61e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  463 YEGTLDENIPPGTSVLTVTATDQDHGDNGHITYSIA-GPKAVPFSIDPLLGVISTTKPMDYELMkRIYTFRVRASDWGSP 541
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESI-GEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1958660828  542 FR-QEKEVSVSL 552
Cdd:pfam00028   80 PLsSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1247-1335 1.84e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1247 FNVRLSERLSPlsPEPVYRLVASDPDEGLNGSVTYSIEESDEES-FRIDPVTGVVSSSSTF---AAGEYNiLTIKATDSG 1322
Cdd:cd11304      2 YEVSVPENAPP--GTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLdreEQSSYT-LTVTATDGG 78

                           90
                   ....*....|...
gi 1958660828 1323 QPALSTSVRLHIE 1335
Cdd:cd11304     79 GPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-249 1.88e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.88e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  152 SYRVTISEDRPLKSPICKVTATDADLGQNAEFYYAF--NARSEVFAIHPTSGVVTVAGKLNVTRRGKYELQVLAVDrmrk 229
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD---- 76

                           90       100
                   ....*....|....*....|
gi 1958660828  230 iSEGNGFGNLASLVIRVEPV 249
Cdd:cd11304     77 -GGGPPLSSTATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
1560-1651 2.39e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 2.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1560 YEANVPDTTAPGTELLQVRAVDADRGANAEIHYSFLKGNSDGFFNIDSLLGIITVAQRLYHVHLTRHALTVKAEDQGSPR 1639
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1958660828 1640 RHDLALVVIHVH 1651
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2697-2795 2.47e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 2.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2697 YTFSAPEDLPEGSEIGSVKAV----AAQDPIIYSLVQGttpesNSDDVFSLDQDTGVLKVRKAMDHESTKWYQIDLMAHC 2772
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1958660828 2773 PHEDtDLVSLVSVSIQVEDVNDN 2795
Cdd:cd11304     77 GGGP-PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1788-1870 2.62e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 2.62e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  1788 RASDSDREANSLLVYKILEPEALKFFKIDPSMGTLTTTSELDFEDTPLFQFNIYVHDQGTPILFAPrsAKVIIHVRDVND 1867
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSST--ATVTITVLDVND 78


                    ...
gi 1958660828  1868 SPP 1870
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 846-923 2.80e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 2.80e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   846 DADSEDNRRVRYTLL--TPTEKFSLHPFTGELVVTGHLDRESESQYILKAEARDQPtkGHQLFSVTDLIVTLEDINDNPP 923
Cdd:smart00112    4 DADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1452-1551 4.38e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 4.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1452 HYEIRVPQDTLPGVELLRVQATDQDHGKG--LIYTILSSQDPGsanLFQLDPSSGVLVTVGTL--ELHsgpSQHILTVMV 1527
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDG---LFSIDPSTGEITTAKPLdrEEQ---SSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 1958660828 1528 RDQEMPIKRNFVWVTIHVEDGNLH 1551
Cdd:cd11304     75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2804-2899 1.19e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.19e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2804 YKAFLTENMPGGTTVIQVTANDQDTGSDGQVSYRLSvepGSNIHELFAVDSESGWITTLQELDCETQQTYSFYVVAFDHG 2883
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL---GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*.
gi 1958660828 2884 QTiQLSSQALVEVSIT 2899
Cdd:pfam00028   78 GP-PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3226-3319 1.96e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.44  E-value: 1.96e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3226 STQVPEDAPIDMEVLHLaTLTRPGSEKTG---YHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSS 3302
Cdd:cd11304      3 EVSVPENAPPGTVVLTV-SATDPDSGENGevtYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958660828 3303 LSDVTTIVINVTDVNEH 3319
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3127-3210 2.40e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 2.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3127 NTTVKTPVAVVFARDPDQGANAQVVYSLT-DSADGQFSIDATSGVIRLEKPLQVRASSAVELTVRASDLGTPiPLSTLGT 3205
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTAT 86


                   ....*
gi 1958660828 3206 VTVSV 3210
Cdd:pfam00028   87 VTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2093-2163 5.91e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 5.91e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958660828  2093 SATDKDLGANGSVTYGFAEDYA--YFRIDPYVGDISLKKPFDYQALNKYHLRVIARDSGIPPLQTEVEVHVTV 2163
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 481-562 1.03e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.03e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   481 TATDQDHGDNGHITYSIA-GPKAVPFSIDPLLGVISTTKPMDYELMKRiYTFRVRASDWGSPfRQEKEVSVSLRLKNLND 559
Cdd:smart00112    1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1958660828   560 NQP 562
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2590-2683 4.54e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 4.54e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2590 YTVSIPSNVSRDSPIIQVLAYDADEGRNADVTYSVDSTEDlaEEIIEVNPTTGVVKVKESLVGLENRAVDFNIKAQDGGP 2669
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1958660828 2670 PHWDSLVPVRLQVV 2683
Cdd:cd11304     80 PPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2505-2583 8.21e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 8.21e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2505 AIDKDSGPYGTVDYTIINKLAGERFFINPR-GQITTLQKLDREnsTERVIAIKVMARDGGG--KVAFCTVKIILTDENDN 2581
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDRE--EQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                    ..
gi 1958660828  2582 AP 2583
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2193-2270 9.98e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.69  E-value: 9.98e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660828  2193 TQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTALGSFS-EATVEVLVEDINDNPP 2270
Cdd:smart00112    3 TDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSsTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
825-916 2.00e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 2.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  825 YQLTISEDTEVGTTIAELKTEDADSEDNRRVRYTLLTPTEK--FSLHPFTGELVVTGHLDRESESQYILKAEARDQPTKG 902
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....
gi 1958660828  903 hqLFSVTDLIVTLE 916
Cdd:pfam00028   81 --LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1972-2066 3.54e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 3.54e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1972 VYRARVTENTPHRKALVILGVH--GNHLNDTLSYFLLNGTD--LFHMIESAGVLQTRGgTFDREQQDTHEVAVEVRDNRV 2047
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1958660828 2048 PQRVAQALVRVSVEDVNDN 2066
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3139-3211 3.79e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 3.79e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958660828  3139 ARDPDQGANAQVVYSLTD-SADGQFSIDATSGVIRLEKPLQVRASSAVELTVRASDLGTPiPLSTLGTVTVSVV 3211
Cdd:smart00112    2 ATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVL 74
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-661 6.35e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 6.35e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  570 TVSLRQDVPVGKSIMAVSAIDMDELQN--LKYEIVSGNEQDYFHLNHFSGVISLKRSfmnLTAVRPTIYSLKITASDGKN 647
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKP---LDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*
gi 1958660828  648 YASPTTLKVTV-VKD 661
Cdd:cd11304     80 PPLSSTATVTItVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 366-454 7.00e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 7.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  366 VYRVKLSEFSPPGSRVALVKVT----TALPNLRYSLKPSSRNTAFKLNARTGLITTTKLVDFHEQNQYQLHVK-TSLGQ- 439
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTaTDGGGp 80

                           90
                   ....*....|....*...
gi 1958660828  440 ---ATTTVIIDIVDCNNH 454
Cdd:cd11304     81 plsSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1578-1658 1.09e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.09e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  1578 RAVDADRGANAEIHYSFLKGNSDGFFNIDSLLGIITVAQRLYHVHLTRHALTVKAEDQGSPRRHDLALVVIHVHPSDSSA 1657
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958660828  1658 P 1658
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1354-1444 1.12e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 1.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1354 YSFTVMETDPVNHMVGVISV----EGRPGLFWFHISDGDKDMDFDIEKTTGSIVIARPLDTRRKSSYNLTVEVTDG---- 1425
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpp 81

                           90
                   ....*....|....*....
gi 1958660828 1426 FHTIATqVHIFmIANINHH 1444
Cdd:cd11304     82 LSSTAT-VTIT-VLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2934-3011 1.36e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 1.36e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2934 DADvSDQNRQVTCYITEGDPLGQFSISQVGDEwrISSRKTLDREHIAKYLLRVTASDG---KFQASVPVEVFVVDINDNS 3010
Cdd:smart00112    4 DAD-SGENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 1958660828  3011 P 3011
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3255-3321 1.46e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 1.46e-14
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958660828  3255 YHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSSLSDVTTIVINVTDVNEHHP 3321
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1684-1756 2.26e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 2.26e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958660828  1684 AGSSSEVTYELREGNKDSVFSMNSYSGLISTQKRLDHEKVPSYRLRIRGSNMAGV--FTEVVALVYIIDENDNPP 1756
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1763-1862 4.42e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 4.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1763 FLGHISEAAPLHSLILgednsplVVRASDSDREANSLLVYKILEPEALKFFKIDPSMGTLTTTSELDFEDTPLFQFNIYV 1842
Cdd:pfam00028    1 YSASVPENAPVGTEVL-------TVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90       100
                   ....*....|....*....|
gi 1958660828 1843 HDQGTPILFAPrsAKVIIHV 1862
Cdd:pfam00028   74 TDSGGPPLSST--ATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 949-1026 7.27e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 7.27e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660828   949 ASDPDLGPAGEVKYILV-EDAHGTFQVHPMTGALSLEKELDFERRAGYNLSFWASDSGKPlSRRTLCHVEVLVMDVNEN 1026
Cdd:smart00112    2 ATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79
Cadherin pfam00028
Cadherin domain;
2486-2576 1.08e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2486 YEAELAENAKVGTKVIELLAIDKDSGPYGTVDYTIINKLAGERFFINPR-GQITTLQKLDRENSTERVIAIKVMARDGGG 2564
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1958660828 2565 KVAFCTVKIILT 2576
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2384-2470 4.76e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 4.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2384 YEANVSELATCGHLVLKVQALDPDIGDTSRLEYLILSGNQDRHFSINSTSGIISMfnlcKKQLD----SSYNLRVGASDG 2459
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDIST----TKPLDresiGEYELTVEATDS 76

                           90
                   ....*....|....
gi 1958660828 2460 VFRA---TVPVYIN 2470
Cdd:pfam00028   77 GGPPlssTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1267-1335 5.42e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 5.42e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958660828  1267 VASDPDEGLNGSVTYSIEESDEES-FRIDPVTGVVSSSSTF---AAGEYNiLTIKATDSGQPALSTSVRLHIE 1335
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
934-1019 1.36e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 1.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  934 VPEDMPLGTVLTFLDASDPDLGPAGEVKY-ILVEDAHGTFQVHPMTGALSLEKELDFERRAGYNLSFWASDSG-KPLSRR 1011
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgPPLSST 84


                   ....*...
gi 1958660828 1012 TLCHVEVL 1019
Cdd:pfam00028   85 ATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1247-1335 2.09e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 2.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1247 FNVRLSERlSPLSPEpVYRLVASDPDEGLNGSVTYSIEESDEE-SFRIDPVTGVVSSSSTF---AAGEYNiLTIKATDSG 1322
Cdd:pfam00028    1 YSASVPEN-APVGTE-VLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLdreSIGEYE-LTVEATDSG 77

                           90
                   ....*....|...
gi 1958660828 1323 QPALSTSVRLHIE 1335
Cdd:pfam00028   78 GPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
153-226 5.23e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660828  153 YRVTISEDRPLKSPICKVTATDADLGQNAEFYYAF--NARSEVFAIHPTSGVVTVAGKLNVTRRGKYELQVLAVDR 226
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 38-143 8.79e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 8.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   38 YNATIYENSAPKTYVespvkmGMYLA-----EPHWVVKYRIISGDAAGVFKTEEHVvGNfcflrIRTKSSntalLNREVR 112
Cdd:cd11304      2 YEVSVPENAPPGTVV------LTVSAtdpdsGENGEVTYSIVSGNEDGLFSIDPST-GE-----ITTAKP----LDREEQ 65

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958660828  113 DSYTLIVQASDK-SLEFEALTQVVVHILDQND 143
Cdd:cd11304     66 SSYTLTVTATDGgGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2723-2797 2.43e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.37  E-value: 2.43e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2723 IIYSLVQGttpesNSDDVFSLDQDTGVLKVRKAMDHESTKWYQIDLMAhcphedTD-----LVSLVSVSIQVEDVNDNRP 2797
Cdd:smart00112   13 VTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA------TDgggppLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1998-2068 3.53e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 3.53e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958660828  1998 NDTLSYFLLNGTD--LFHMIESAGVLQTRGgTFDREQQDTHEVAVEVRDNRVPQRVAQALVRVSVEDVNDNIP 2068
Cdd:smart00112   10 NGKVTYSILSGNDdgLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3454-3531 3.60e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 3.60e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660828  3454 DPDSPQNGPpYFFRITEGNTGSVFRVTPD-GWLVTAASLSKKAREWYQLHIEVSDSGLPPLSSSTLVRVQVTEQSRYPP 3531
Cdd:smart00112    4 DADSGENGK-VTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2176-2263 5.16e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 5.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2176 YKVKVPENITLYTPILHTQARSP-EGL--RLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTAL-G 2251
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPdLGPngRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpP 80

                           90
                   ....*....|..
gi 1958660828 2252 SFSEATVEVLVE 2263
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1665-1748 5.32e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 5.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1665 YFIEIPESVPIGSPILLLSA-----GSSSEVTYELREGNKDSVFSMNSYSGLISTQKRLDHEKVPSYRLRIRGSNMAGVF 1739
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTAtdpdlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                   ....*....
gi 1958660828 1740 TEVVALVYI 1748
Cdd:pfam00028   81 LSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
3226-3314 7.05e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 7.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3226 STQVPEDAPIDMEVLHLATLTR--PGSEKTGYHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSSL 3303
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPdlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1958660828 3304 SDVTTIVINVT 3314
Cdd:pfam00028   82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1471-1553 8.33e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 8.33e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  1471 QATDQDHGKG--LIYTILSSQDPGsanLFQLDPSSGVLVTVGTLELHSGPsQHILTVMVRDQEMPIKRNFVWVTIHVEDG 1548
Cdd:smart00112    1 SATDADSGENgkVTYSILSGNDDG---LFSIDPETGEITTTKPLDREEQP-EYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 1958660828  1549 NLHSP 1553
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
2697-2790 2.61e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.62  E-value: 2.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2697 YTFSAPEDLPEGSEIGSVKAVAAQDP----IIYSLVQGttpesNSDDVFSLDQDTGVLKVRKAMDHESTKWYQIDLMAhc 2772
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngrIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA-- 73

                           90       100
                   ....*....|....*....|.
gi 1958660828 2773 phEDTDLVSLVS---VSIQVE 2790
Cdd:pfam00028   74 --TDSGGPPLSStatVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2402-2475 3.40e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 3.40e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2402 QALDPDIGDTSRLEYLILSGNQDRHFSINSTSGIISmfnlCKKQLD----SSYNLRVGASDG---VFRATVPVYINTTNA 2474
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEIT----TTKPLDreeqPEYTLTVEATDGggpPLSSTATVTITVLDV 76


                    .
gi 1958660828  2475 N 2475
Cdd:smart00112   77 N 77
Cadherin pfam00028
Cadherin domain;
2590-2682 3.77e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 3.77e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2590 YTVSIPSNVSRDSPIIQVLAYDADEGRNADVTYSVdsTEDLAEEIIEVNPTTGVVKVKESLVGLENRAVDFNIKAQDGGP 2669
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1958660828 2670 PHWDSLVPVRLQV 2682
Cdd:pfam00028   79 PPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 392-456 4.17e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 4.17e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   392 NLRYSLKPSSRNTAFKLNARTGLITTTKLVDFHEQNQYQLHVKTSLG-----QATTTVIIDIVDCNNHAP 456
Cdd:smart00112   12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2913-2991 8.48e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 8.48e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660828 2913 YRGSVVENNEPGELVATLKTLDADvSDQNRQVTCYITEGDPLGQFSISQVGDEwrISSRKTLDREHIAKYLLRVTASDG 2991
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGD--ISTTKPLDRESIGEYELTVEATDS 76
Cadherin pfam00028
Cadherin domain;
1453-1546 2.63e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 2.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1453 YEIRVPQDTLPGVELLRVQATDQDHG--KGLIYTILSsqdPGSANLFQLDPSSGVLVTVGTLELHSgPSQHILTVMVRDQ 1530
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRES-IGEYELTVEATDS 76

                           90
                   ....*....|....*.
gi 1958660828 1531 EMPIKRNFVWVTIHVE 1546
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3535-3621 4.48e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 4.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3535 PLEISITkgEEEFQGGMIGKIHATDRD--PQDTLTYSLEqEGGLDRYFTVGASDGKIIASQGLPH---GRYSFNVTVSDG 3609
Cdd:cd11304      1 SYEVSVP--ENAPPGTVVLTVSATDPDsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDReeqSSYTLTVTATDG 77

                           90
                   ....*....|....*
gi 1958660828 3610 ---TFTTTTGVHVHV 3621
Cdd:cd11304     78 ggpPLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1374-1446 5.18e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 5.18e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660828  1374 EGRPGLFWFHISDGDKDMDFDIEKTTGSIVIARPLDTRRKSSYNLTVEVTDG---FHTIATQVHIFmIANINHHRP 1446
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTIT-VLDVNDNAP 81
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3992-4022 8.40e-09

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 53.54  E-value: 8.40e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958660828 3992 CTSAPCQEGGTCVSSPEGTSCNCPHPYTGDR 4022
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 171-254 2.29e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 2.29e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   171 TATDADLGQNAEFYYAFNARSE--VFAIHPTSGVVTVAGKLNVTRRGKYELQVLAVDrmrkiSEGNGFGNLASLVIRVEP 248
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-----GGGPPLSSTATVTITVLD 75


                    ....*.
gi 1958660828   249 VHRKPP 254
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
570-658 5.35e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 5.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  570 TVSLRQDVPVGKSIMAVSAIDMDELQN--LKYEIVSGNEQDYFHLNHFSGVISLKRsfmNLTAVRPTIYSLKITASDGKN 647
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTK---PLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1958660828  648 YA--SPTTLKVTV 658
Cdd:pfam00028   79 PPlsSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-146 7.32e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.35  E-value: 7.32e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828    65 PHWVVKYRIISGDAAGVFkteehvvgnfcflRIRTKS---SNTALLNREVRDSYTLIVQASDK-SLEFEALTQVVVHILD 140
Cdd:smart00112    9 ENGKVTYSILSGNDDGLF-------------SIDPETgeiTTTKPLDREEQPEYTLTVEATDGgGPPLSSTATVTITVLD 75


                    ....*.
gi 1958660828   141 QNDLKP 146
Cdd:smart00112   76 VNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3953-3986 7.45e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 7.45e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958660828 3953 C-SQSPCLNGGSCSPALGSgYLCRCPPPFSGRNCE 3986
Cdd:cd00054      5 CaSGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3992-4024 1.28e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 1.28e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958660828 3992 CTSA-PCQEGGTCVSSPEGTSCNCPHPYTGDRCE 4024
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
367-448 1.88e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  367 YRVKLSEFSPPGSRVALVKVT----TALPNLRYSLKPSSRNTAFKLNARTGLITTTKLVDFHEQNQYQLHVK-TSLGQ-- 439
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEaTDSGGpp 80

                           90
                   ....*....|.
gi 1958660828  440 --ATTTVIIDI 448
Cdd:pfam00028   81 lsSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1354-1425 1.90e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.90e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660828 1354 YSFTVMETDPVNHMVGVISV----EGRPGLFWFHISDGDKDMDFDIEKTTGSIVIARPLDTRRKSSYNLTVEVTDG 1425
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2609-2683 2.93e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 2.93e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660828  2609 AYDADEGRNADVTYSVDSTEDlaEEIIEVNPTTGVVKVKESLVgLENRAV-DFNIKAQDGGPPHWDSLVPVRLQVV 2683
Cdd:smart00112    2 ATDADSGENGKVTYSILSGND--DGLFSIDPETGEITTTKPLD-REEQPEyTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 587-661 3.64e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 3.64e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958660828   587 SAIDMDELQN--LKYEIVSGNEQDYFHLNHFSGVISLKRSfmnLTAVRPTIYSLKITASDGKNYASPTTLKVTV-VKD 661
Cdd:smart00112    1 SATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTKP---LDREEQPEYTLTVEATDGGGPPLSSTATVTItVLD 75
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3953-3984 7.42e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 48.15  E-value: 7.42e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958660828 3953 CSQSPCLNGGSCSPaLGSGYLCRCPPPFSGRN 3984
Cdd:pfam00008    1 CAPNPCSNGGTCVD-TPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
3953-3986 1.32e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 1.32e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958660828  3953 C-SQSPCLNGGSCSPALGSgYLCRCPPPFS-GRNCE 3986
Cdd:smart00179    5 CaSGNPCQNGGTCVNTVGS-YRCECPPGYTdGRNCE 39
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 4084-4268 1.60e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.31  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 4084 EDPDLLARSIGVDTQASPAIELDPLNTSSCNNlnQPEPSKTSVPNE-LVTFGPSSKQRPMVCSVPPRLPpaavSSHPGHE 4162
Cdd:pfam03154  177 QSGAASPPSPPPPGTTQAATAGPTPSAPSVPP--QGSPATSQPPNQtQSTAAPHTLIQQTPTLHPQRLP----SPHPPLQ 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 4163 PIIKrtwsgeelvypsgaavwPPTYSRKKHWEYPHPeTMQGTLPPSPRR-HVGPAVMPDPtGLYGGFPFPLELENKRAPL 4241
Cdd:pfam03154  251 PMTQ-----------------PPPPSQVSPQPLPQP-SLHGQMPPMPHSlQTGPSHMQHP-VPPQPFPLTPQSSQSQVPP 311

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1958660828 4242 PPRYSNQNLEDLMPPRPPS---------PREHLLAP 4268
Cdd:pfam03154  312 GPSPAAPGQSQQRIHTPPSqsqlqsqqpPREQPLPP 347
Cadherin pfam00028
Cadherin domain;
38-139 6.98e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.21  E-value: 6.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   38 YNATIYENSAPKTyveSPVKMGMYLA--EPHWVVKYRIISGDAAGVFkteehvvgnfcflRIRTKS---SNTALLNREVR 112
Cdd:pfam00028    1 YSASVPENAPVGT---EVLTVTATDPdlGPNGRIFYSILGGGPGGNF-------------RIDPDTgdiSTTKPLDRESI 64

                           90       100
                   ....*....|....*....|....*...
gi 1958660828  113 DSYTLIVQASDKSLE-FEALTQVVVHIL 139
Cdd:pfam00028   65 GEYELTVEATDSGGPpLSSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
3992-4024 2.78e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 2.78e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1958660828  3992 CTSA-PCQEGGTCVSSPEGTSCNCPHPYT-GDRCE 4024
Cdd:smart00179    5 CASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
1973-2061 4.92e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.90  E-value: 4.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1973 YRARVTENTPHRKALVILGVH----GnhLNDTLSYFLLNGT--DLFHMIESAGVLQTRGgTFDREQQDTHEVAVEVRDNR 2046
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlG--PNGRIFYSILGGGpgGNFRIDPDTGDISTTK-PLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1958660828 2047 VPQRVAQALVRVSVE 2061
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1877-1959 2.19e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1877 YEVAVVEPIHPGMGLLTVQAEDND----SRVTYSIKTSNADEAVTIHPTTGQISVVNP---ATLRLFQkFSIRASDGLYH 1949
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgpnGRIFYSILGGGPGGNFRIDPDTGDISTTKPldrESIGEYE-LTVEATDSGGP 79

                           90
                   ....*....|...
gi 1958660828 1950 ---DTAVVKISLT 1959
Cdd:pfam00028   80 plsSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3328-3424 6.86e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 127.04  E-value: 6.86e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3328 YTVRVLENAVVGDVILTVSASDDDGPVNSAITYSLVGGNQLGHFTINPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPP 3407
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958660828 3408 LHEDTEVAVEVVDVNDN 3424
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1141-1238 4.10e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 4.10e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1141 VFYPSVLEDAPLGTSVLQLEAWDPDSSSQGKLTFNLTSGNHLGHFIVHPFTGLLTTAKQLDRENKDEYVLEVTVQDNGDP 1220
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958660828 1221 SLRSTSRVVVCILDVNDN 1238
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2276-2375 9.44e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 9.44e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2276 VYTTSVSEGSPAQTPVIQLLASDQDSGQNQDVSYQIVEDGSDvsKFFRINGSTGEIFTIQELDYETHQHFRVKVRAMDKG 2355
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED--GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958660828 2356 DPPLTGETLVVVNVSDINDN 2375
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1036-1133 1.39e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 1.39e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1036 VYQGQVQENSPAGTPVMVVTAQDDDSGLDGELQYFLRAGTGLETFSINQDTGMLETLAPLDREFTPYYWLTVLAVDRGSV 1115
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958660828 1116 PLSAVTEVYIEVTDINDN 1133
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3018-3111 1.82e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 1.82e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3018 YTGKVREDVTPGHFILKVSAIDVDMDTNAQITYSLHGPGAQE-FKLDPHTGELTTLTVLDRERKDVYNLVAKATDGGG-- 3094
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 1958660828 3095 QSCQAEVTLHIEDVNDN 3111
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2803-2904 2.64e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.03  E-value: 2.64e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2803 PYKAFLTENMPGGTTVIQVTANDQDTGSDGQVSYRLSvepGSNIHELFAVDSESGWITTLQELDCETQQTYSFYVVAFDH 2882
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|..
gi 1958660828 2883 GqTIQLSSQALVEVSITDENDN 2904
Cdd:cd11304     78 G-GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 719-816 3.08e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 3.08e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  719 PQSIDILEQVPINTPLARLAATDPDTGFHGKLVYVISDGNEEGCFDIELETGLLMVAAALDYETTSFYVLNVTVYDLGTP 798
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1958660828  799 PKSSWKLLTVTVKDWNDN 816
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 462-560 4.45e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 4.45e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  462 SYEGTLDENIPPGTSVLTVTATDQDHGDNGHITYSI-AGPKAVPFSIDPLLGVISTTKPMDYELMKRiYTFRVRASDWGS 540
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 1958660828  541 PfRQEKEVSVSLRLKNLNDN 560
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3346-3426 9.02e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 103.58  E-value: 9.02e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  3346 SASDDDGPVNSAITYSLVGGNQLGHFTINPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPPLHEDTEVAVEVVDVNDNP 3425
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958660828  3426 P 3426
Cdd:smart00112   81 P 81
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3802-3923 1.34e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 104.81  E-value: 1.34e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3802 LKTLQPWALLMFTN--ETASISLKLANGFSHLEYHCPGGFYGNLSSRYPVNDGQWHSMLLEERDTSVHLLVDITDNASLV 3879
Cdd:pfam02210    1 FRTRQPNGLLLYAGggGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958660828 3880 IPEECQGLRTERQLLLGGLVPSNPSSNVSL--GFEGCLDAVVVNGE 3923
Cdd:pfam02210   81 PPGESLLLNLNGPLYLGGLPPLLLLPALPVraGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 825-921 4.73e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 4.73e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  825 YQLTISEDTEVGTTIAELKTEDADSEDNRRVRYTLL--TPTEKFSLHPFTGELVVTGHLDRESESQYILKAEARDQPtkG 902
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG--G 79

                           90
                   ....*....|....*....
gi 1958660828  903 HQLFSVTDLIVTLEDINDN 921
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2074-2163 8.97e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 8.97e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2074 PYYTVIQDGTEPGDVLFQVSATDKDLGANGSVTYGFAEDYA--YFRIDPYVGDISLKKPFDYQALNKYHLRVIARDSGIP 2151
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|..
gi 1958660828 2152 PLQTEVEVHVTV 2163
Cdd:cd11304     81 PLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2296-2377 1.13e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.12  E-value: 1.13e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2296 ASDQDSGQNQDVSYQIVedGSDVSKFFRINGSTGEIFTIQELDYETHQHFRVKVRAMDKGDPPLTGETLVVVNVSDINDN 2375
Cdd:smart00112    2 ATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1958660828  2376 PP 2377
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1560-1650 1.43e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.47  E-value: 1.43e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1560 YEANVPDTTAPGTELLQVRAVDADRGANAEIHYSFLKGNSDGFFNIDSLLGIITVAQRLYHVHLTRHALTVKAEDQGSPR 1639
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|.
gi 1958660828 1640 RHDLALVVIHV 1650
Cdd:cd11304     82 LSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 931-1026 2.85e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 2.85e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  931 RLKVPEDMPLGTVLTFLDASDPDLGPAGEVKYILVE-DAHGTFQVHPMTGALSLEKELDFERRAGYNLSFWASDSGKPlS 1009
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-P 81

                           90
                   ....*....|....*..
gi 1958660828 1010 RRTLCHVEVLVMDVNEN 1026
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
3797-3923 2.88e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 100.88  E-value: 2.88e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  3797 QIHFYLKTLQPWALLMFT---NETASISLKLANGFSHLEYHCPGGFYGNLSSRYPVNDGQWHSMLLEERDTSVHLLVDIT 3873
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgskGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1958660828  3874 DNASLVIPEECQGLRTERQLLLGGLVPS--NPSSNVSLGFEGCLDAVVVNGE 3923
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDlkLPPLPVTPGFRGCIRNLKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1161-1240 4.46e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.58  E-value: 4.46e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  1161 AWDPDSSSQGKLTFNLTSGNHLGHFIVHPFTGLLTTAKQLDRENKDEYVLEVTVQDNGDPSLRSTSRVVVCILDVNDNPP 1240
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2277-2369 1.07e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 97.76  E-value: 1.07e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2277 YTTSVSEGSPAQTPVIQLLASDQDSGQNQDVSYQIVEDGSDvsKFFRINGSTGEIFTIQELDYETHQHFRVKVRAMDKGD 2356
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG--GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1958660828 2357 PPLTGETLVVVNV 2369
Cdd:pfam00028   79 PPLSSTATVTITV 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3777-3921 1.25e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 99.80  E-value: 1.25e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3777 TLRFSGQSYVRYRPLEA--QNWQIHFYLKTLQPWALLMFT---NETASISLKLANGFSHLEYHCpGGFYGNLSSRYPVND 3851
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAprTRLSISFSFRTTSPNGLLLYAgsqNGGDFLALELEDGRLVLRYDL-GSGSLVLSSKTPLND 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958660828 3852 GQWHSMLLEERDTSVHLLVDITDNASLVIPEECQGLRTERQLLLGGLVPS--NPSSNVSLGFEGCLDAVVVN 3921
Cdd:cd00110     80 GQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDlkSPGLPVSPGFVGCIRDLKVN 151
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1055-1135 5.12e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.49  E-value: 5.12e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  1055 TAQDDDSGLDGELQYFLRAGTGLETFSINQDTGMLETLAPLDREFTPYYWLTVLAVDRGSVPLSAVTEVYIEVTDINDNI 1134
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958660828  1135 P 1135
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2485-2581 6.53e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 6.53e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2485 VYEAELAENAKVGTKVIELLAIDKDSGPYGTVDYTIINKLAGERFFINPR-GQITTLQKLDREnsTERVIAIKVMARDGG 2563
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDRE--EQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1958660828 2564 G--KVAFCTVKIILTDENDN 2581
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1766-1867 6.53e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 6.53e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1766 HISEAAPLHSLILgednsplVVRASDSDREANSLLVYKILEPEALKFFKIDPSMGTLTTTSELDFEDTPLFQFNIYVHDQ 1845
Cdd:cd11304      5 SVPENAPPGTVVL-------TVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|..
gi 1958660828 1846 GTPILFAprSAKVIIHVRDVND 1867
Cdd:cd11304     78 GGPPLSS--TATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 739-818 7.13e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 7.13e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   739 ATDPDTGFHGKLVYVISDGNEEGCFDIELETGLLMVAAALDYETTSFYVLNVTVYDLGTPPKSSWKLLTVTVKDWNDNPP 818
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
3328-3418 2.32e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.90  E-value: 2.32e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3328 YTVRVLENAVVGDVILTVSASDDDGPVNSAITYSLVGGNQLGHFTINPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPP 3407
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1958660828 3408 LHEDTEVAVEV 3418
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3036-3113 3.04e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 3.04e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  3036 SAIDVDMDTNAQITYSLHGPGAQE-FKLDPHTGELTTLTVLDRERKDVYNLVAKATDGGGQ--SCQAEVTLHIEDVNDNA 3112
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNA 80


                    .
gi 1958660828  3113 P 3113
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2822-2906 3.62e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 3.62e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2822 TANDQDTGSDGQVSYRLSvepGSNIHELFAVDSESGWITTLQELDCETQQTYSFYVVAFDHGQTiQLSSQALVEVSITDE 2901
Cdd:smart00112    1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDV 76


                    ....*
gi 1958660828  2902 NDNPP 2906
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
1037-1128 4.62e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.13  E-value: 4.62e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1037 YQGQVQENSPAGTPVMVVTAQDDDSGLDGELQYFLRAGTGLETFSINQDTGMLETLAPLDREFTPYYWLTVLAVDRGSVP 1116
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1958660828 1117 LSAVTEVYIEVT 1128
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2913-3009 1.10e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 1.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2913 YRGSVVENNEPGELVATLKTLDADvSDQNRQVTCYITEGDPLGQFSISQvgDEWRISSRKTLDREHIAKYLLRVTASDG- 2991
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDP--STGEITTAKPLDREEQSSYTLTVTATDGg 78

                           90       100
                   ....*....|....*....|
gi 1958660828 2992 --KFQASVPVEVFVVDINDN 3009
Cdd:cd11304     79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3122-3211 1.73e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.73e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3122 VAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLT-DSADGQFSIDATSGVIRLEKPLQVRASSAVELTVRASDLGTPiPL 3200
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PL 82

                           90
                   ....*....|.
gi 1958660828 3201 STLGTVTVSVV 3211
Cdd:cd11304     83 SSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2176-2268 5.60e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 5.60e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2176 YKVKVPENITLYTPILHTQAR---SPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTALGS 2252
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958660828 2253 FS-EATVEVLVEDINDN 2268
Cdd:cd11304     82 LSsTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1664-1754 5.77e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 5.77e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1664 EYFIEIPESVPIGSPILLLSA-----GSSSEVTYELREGNKDSVFSMNSYSGLISTQKRLDHEKVPSYRLRIRGSNMAG- 1737
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1958660828 1738 -VFTEVVALVYIIDENDN 1754
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1145-1233 9.25e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 9.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1145 SVLEDAPLGTSVLQLEAWDPDSSSQGKLTFNLTSGNHLGHFIVHPFTGLLTTAKQLDRENKDEYVLEVTVQDNGDPSLRS 1224
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1958660828 1225 TSRVVVCIL 1233
Cdd:pfam00028   84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
720-810 3.06e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 3.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  720 QSIDILEQVPINTPLARLAATDPDTGFHGKLVYVISDGNEEGCFDIELETGLLMVAAALDYETTSFYVLNVTVYDLGTPP 799
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1958660828  800 KSSWKLLTVTV 810
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2075-2163 7.13e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 7.13e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2075 YYTVIQDGTEPGDVLFQVSATDKDLGANGSVTYGFAEDYAY--FRIDPYVGDISLKKPFDYQALNKYHLRVIARDSGIPP 2152
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1958660828 2153 LQTEVEVHVTV 2163
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2383-2475 9.22e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.98  E-value: 9.22e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2383 QYEANVSELATCGHLVLKVQALDPDIGDTSRLEYLILSGNQDRHFSINSTSGIISMfnlcKKQLD----SSYNLRVGASD 2458
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT----AKPLDreeqSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|
gi 1958660828 2459 G---VFRATVPVYINTTNAN 2475
Cdd:cd11304     77 GggpPLSSTATVTITVLDVN 96
Cadherin pfam00028
Cadherin domain;
3433-3524 1.87e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 1.87e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3433 YSTSVQENSPIGIKVLQLILDDPDSPQNGPPyFFRITEGNTGSVFRVTPD-GWLVTAASLSKKAREWYQLHIEVSDSGLP 3511
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1958660828 3512 PLSSSTLVRVQVT 3524
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3018-3106 1.89e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 1.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3018 YTGKVREDVTPGHFILKVSAIDVDMDTNAQITYSL--HGPGAQeFKLDPHTGELTTLTVLDRERKDVYNLVAKATDGGGQ 3095
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGN-FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|.
gi 1958660828 3096 SCQAEVTLHIE 3106
Cdd:pfam00028   80 PLSSTATVTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3433-3524 3.81e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 3.81e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3433 YSTSVQENSPIGIKVLQLILDDPDSPQNGPpYFFRITEGNTGSVFRVTPD-GWLVTAASLSKKAREWYQLHIEVSDSGLP 3511
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|...
gi 1958660828 3512 PLSSSTLVRVQVT 3524
Cdd:cd11304     81 PLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
463-552 1.61e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 1.61e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  463 YEGTLDENIPPGTSVLTVTATDQDHGDNGHITYSIA-GPKAVPFSIDPLLGVISTTKPMDYELMkRIYTFRVRASDWGSP 541
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESI-GEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1958660828  542 FR-QEKEVSVSL 552
Cdd:pfam00028   80 PLsSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1247-1335 1.84e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.84e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1247 FNVRLSERLSPlsPEPVYRLVASDPDEGLNGSVTYSIEESDEES-FRIDPVTGVVSSSSTF---AAGEYNiLTIKATDSG 1322
Cdd:cd11304      2 YEVSVPENAPP--GTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLdreEQSSYT-LTVTATDGG 78

                           90
                   ....*....|...
gi 1958660828 1323 QPALSTSVRLHIE 1335
Cdd:cd11304     79 GPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-249 1.88e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.13  E-value: 1.88e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  152 SYRVTISEDRPLKSPICKVTATDADLGQNAEFYYAF--NARSEVFAIHPTSGVVTVAGKLNVTRRGKYELQVLAVDrmrk 229
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD---- 76

                           90       100
                   ....*....|....*....|
gi 1958660828  230 iSEGNGFGNLASLVIRVEPV 249
Cdd:cd11304     77 -GGGPPLSSTATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
1560-1651 2.39e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 2.39e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1560 YEANVPDTTAPGTELLQVRAVDADRGANAEIHYSFLKGNSDGFFNIDSLLGIITVAQRLYHVHLTRHALTVKAEDQGSPR 1639
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1958660828 1640 RHDLALVVIHVH 1651
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2697-2795 2.47e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 2.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2697 YTFSAPEDLPEGSEIGSVKAV----AAQDPIIYSLVQGttpesNSDDVFSLDQDTGVLKVRKAMDHESTKWYQIDLMAHC 2772
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                           90       100
                   ....*....|....*....|...
gi 1958660828 2773 PHEDtDLVSLVSVSIQVEDVNDN 2795
Cdd:cd11304     77 GGGP-PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1788-1870 2.62e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 2.62e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  1788 RASDSDREANSLLVYKILEPEALKFFKIDPSMGTLTTTSELDFEDTPLFQFNIYVHDQGTPILFAPrsAKVIIHVRDVND 1867
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSST--ATVTITVLDVND 78


                    ...
gi 1958660828  1868 SPP 1870
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 846-923 2.80e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 2.80e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   846 DADSEDNRRVRYTLL--TPTEKFSLHPFTGELVVTGHLDRESESQYILKAEARDQPtkGHQLFSVTDLIVTLEDINDNPP 923
Cdd:smart00112    4 DADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1452-1551 4.38e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 4.38e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1452 HYEIRVPQDTLPGVELLRVQATDQDHGKG--LIYTILSSQDPGsanLFQLDPSSGVLVTVGTL--ELHsgpSQHILTVMV 1527
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDG---LFSIDPSTGEITTAKPLdrEEQ---SSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 1958660828 1528 RDQEMPIKRNFVWVTIHVEDGNLH 1551
Cdd:cd11304     75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2804-2899 1.19e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.19e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2804 YKAFLTENMPGGTTVIQVTANDQDTGSDGQVSYRLSvepGSNIHELFAVDSESGWITTLQELDCETQQTYSFYVVAFDHG 2883
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL---GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*.
gi 1958660828 2884 QTiQLSSQALVEVSIT 2899
Cdd:pfam00028   78 GP-PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3226-3319 1.96e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.44  E-value: 1.96e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3226 STQVPEDAPIDMEVLHLaTLTRPGSEKTG---YHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSS 3302
Cdd:cd11304      3 EVSVPENAPPGTVVLTV-SATDPDSGENGevtYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1958660828 3303 LSDVTTIVINVTDVNEH 3319
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3127-3210 2.40e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 2.40e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3127 NTTVKTPVAVVFARDPDQGANAQVVYSLT-DSADGQFSIDATSGVIRLEKPLQVRASSAVELTVRASDLGTPiPLSTLGT 3205
Cdd:pfam00028    8 NAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTAT 86


                   ....*
gi 1958660828 3206 VTVSV 3210
Cdd:pfam00028   87 VTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2093-2163 5.91e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 5.91e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958660828  2093 SATDKDLGANGSVTYGFAEDYA--YFRIDPYVGDISLKKPFDYQALNKYHLRVIARDSGIPPLQTEVEVHVTV 2163
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 481-562 1.03e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 1.03e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   481 TATDQDHGDNGHITYSIA-GPKAVPFSIDPLLGVISTTKPMDYELMKRiYTFRVRASDWGSPfRQEKEVSVSLRLKNLND 559
Cdd:smart00112    1 SATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1958660828   560 NQP 562
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2590-2683 4.54e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.20  E-value: 4.54e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2590 YTVSIPSNVSRDSPIIQVLAYDADEGRNADVTYSVDSTEDlaEEIIEVNPTTGVVKVKESLVGLENRAVDFNIKAQDGGP 2669
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE--DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....
gi 1958660828 2670 PHWDSLVPVRLQVV 2683
Cdd:cd11304     80 PPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2505-2583 8.21e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 8.21e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2505 AIDKDSGPYGTVDYTIINKLAGERFFINPR-GQITTLQKLDREnsTERVIAIKVMARDGGG--KVAFCTVKIILTDENDN 2581
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDRE--EQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                    ..
gi 1958660828  2582 AP 2583
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2193-2270 9.98e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.69  E-value: 9.98e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660828  2193 TQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTALGSFS-EATVEVLVEDINDNPP 2270
Cdd:smart00112    3 TDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSsTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
825-916 2.00e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 2.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  825 YQLTISEDTEVGTTIAELKTEDADSEDNRRVRYTLLTPTEK--FSLHPFTGELVVTGHLDRESESQYILKAEARDQPTKG 902
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....
gi 1958660828  903 hqLFSVTDLIVTLE 916
Cdd:pfam00028   81 --LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1972-2066 3.54e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 3.54e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1972 VYRARVTENTPHRKALVILGVH--GNHLNDTLSYFLLNGTD--LFHMIESAGVLQTRGgTFDREQQDTHEVAVEVRDNRV 2047
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1958660828 2048 PQRVAQALVRVSVEDVNDN 2066
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3139-3211 3.79e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 3.79e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958660828  3139 ARDPDQGANAQVVYSLTD-SADGQFSIDATSGVIRLEKPLQVRASSAVELTVRASDLGTPiPLSTLGTVTVSVV 3211
Cdd:smart00112    2 ATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVL 74
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-661 6.35e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 6.35e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  570 TVSLRQDVPVGKSIMAVSAIDMDELQN--LKYEIVSGNEQDYFHLNHFSGVISLKRSfmnLTAVRPTIYSLKITASDGKN 647
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKP---LDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*
gi 1958660828  648 YASPTTLKVTV-VKD 661
Cdd:cd11304     80 PPLSSTATVTItVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 366-454 7.00e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 7.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  366 VYRVKLSEFSPPGSRVALVKVT----TALPNLRYSLKPSSRNTAFKLNARTGLITTTKLVDFHEQNQYQLHVK-TSLGQ- 439
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTaTDGGGp 80

                           90
                   ....*....|....*...
gi 1958660828  440 ---ATTTVIIDIVDCNNH 454
Cdd:cd11304     81 plsSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1578-1658 1.09e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.00  E-value: 1.09e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  1578 RAVDADRGANAEIHYSFLKGNSDGFFNIDSLLGIITVAQRLYHVHLTRHALTVKAEDQGSPRRHDLALVVIHVHPSDSSA 1657
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1958660828  1658 P 1658
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1354-1444 1.12e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 1.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1354 YSFTVMETDPVNHMVGVISV----EGRPGLFWFHISDGDKDMDFDIEKTTGSIVIARPLDTRRKSSYNLTVEVTDG---- 1425
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpp 81

                           90
                   ....*....|....*....
gi 1958660828 1426 FHTIATqVHIFmIANINHH 1444
Cdd:cd11304     82 LSSTAT-VTIT-VLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2934-3011 1.36e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 1.36e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2934 DADvSDQNRQVTCYITEGDPLGQFSISQVGDEwrISSRKTLDREHIAKYLLRVTASDG---KFQASVPVEVFVVDINDNS 3010
Cdd:smart00112    4 DAD-SGENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 1958660828  3011 P 3011
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3255-3321 1.46e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 1.46e-14
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958660828  3255 YHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSSLSDVTTIVINVTDVNEHHP 3321
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1684-1756 2.26e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.84  E-value: 2.26e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958660828  1684 AGSSSEVTYELREGNKDSVFSMNSYSGLISTQKRLDHEKVPSYRLRIRGSNMAGV--FTEVVALVYIIDENDNPP 1756
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1763-1862 4.42e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 4.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1763 FLGHISEAAPLHSLILgednsplVVRASDSDREANSLLVYKILEPEALKFFKIDPSMGTLTTTSELDFEDTPLFQFNIYV 1842
Cdd:pfam00028    1 YSASVPENAPVGTEVL-------TVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90       100
                   ....*....|....*....|
gi 1958660828 1843 HDQGTPILFAPrsAKVIIHV 1862
Cdd:pfam00028   74 TDSGGPPLSST--ATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 949-1026 7.27e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 7.27e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660828   949 ASDPDLGPAGEVKYILV-EDAHGTFQVHPMTGALSLEKELDFERRAGYNLSFWASDSGKPlSRRTLCHVEVLVMDVNEN 1026
Cdd:smart00112    2 ATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79
Cadherin pfam00028
Cadherin domain;
2486-2576 1.08e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.08e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2486 YEAELAENAKVGTKVIELLAIDKDSGPYGTVDYTIINKLAGERFFINPR-GQITTLQKLDRENSTERVIAIKVMARDGGG 2564
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1958660828 2565 KVAFCTVKIILT 2576
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2384-2470 4.76e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 4.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2384 YEANVSELATCGHLVLKVQALDPDIGDTSRLEYLILSGNQDRHFSINSTSGIISMfnlcKKQLD----SSYNLRVGASDG 2459
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDIST----TKPLDresiGEYELTVEATDS 76

                           90
                   ....*....|....
gi 1958660828 2460 VFRA---TVPVYIN 2470
Cdd:pfam00028   77 GGPPlssTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1267-1335 5.42e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 5.42e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958660828  1267 VASDPDEGLNGSVTYSIEESDEES-FRIDPVTGVVSSSSTF---AAGEYNiLTIKATDSGQPALSTSVRLHIE 1335
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
934-1019 1.36e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 1.36e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  934 VPEDMPLGTVLTFLDASDPDLGPAGEVKY-ILVEDAHGTFQVHPMTGALSLEKELDFERRAGYNLSFWASDSG-KPLSRR 1011
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgPPLSST 84


                   ....*...
gi 1958660828 1012 TLCHVEVL 1019
Cdd:pfam00028   85 ATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1247-1335 2.09e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 2.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1247 FNVRLSERlSPLSPEpVYRLVASDPDEGLNGSVTYSIEESDEE-SFRIDPVTGVVSSSSTF---AAGEYNiLTIKATDSG 1322
Cdd:pfam00028    1 YSASVPEN-APVGTE-VLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLdreSIGEYE-LTVEATDSG 77

                           90
                   ....*....|...
gi 1958660828 1323 QPALSTSVRLHIE 1335
Cdd:pfam00028   78 GPPLSSTATVTIT 90
Cadherin pfam00028
Cadherin domain;
153-226 5.23e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.63  E-value: 5.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660828  153 YRVTISEDRPLKSPICKVTATDADLGQNAEFYYAF--NARSEVFAIHPTSGVVTVAGKLNVTRRGKYELQVLAVDR 226
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 38-143 8.79e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 8.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   38 YNATIYENSAPKTYVespvkmGMYLA-----EPHWVVKYRIISGDAAGVFKTEEHVvGNfcflrIRTKSSntalLNREVR 112
Cdd:cd11304      2 YEVSVPENAPPGTVV------LTVSAtdpdsGENGEVTYSIVSGNEDGLFSIDPST-GE-----ITTAKP----LDREEQ 65

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958660828  113 DSYTLIVQASDK-SLEFEALTQVVVHILDQND 143
Cdd:cd11304     66 SSYTLTVTATDGgGPPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2723-2797 2.43e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.37  E-value: 2.43e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2723 IIYSLVQGttpesNSDDVFSLDQDTGVLKVRKAMDHESTKWYQIDLMAhcphedTD-----LVSLVSVSIQVEDVNDNRP 2797
Cdd:smart00112   13 VTYSILSG-----NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEA------TDgggppLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1998-2068 3.53e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 3.53e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958660828  1998 NDTLSYFLLNGTD--LFHMIESAGVLQTRGgTFDREQQDTHEVAVEVRDNRVPQRVAQALVRVSVEDVNDNIP 2068
Cdd:smart00112   10 NGKVTYSILSGNDdgLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3454-3531 3.60e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.98  E-value: 3.60e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660828  3454 DPDSPQNGPpYFFRITEGNTGSVFRVTPD-GWLVTAASLSKKAREWYQLHIEVSDSGLPPLSSSTLVRVQVTEQSRYPP 3531
Cdd:smart00112    4 DADSGENGK-VTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2176-2263 5.16e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 5.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2176 YKVKVPENITLYTPILHTQARSP-EGL--RLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTAL-G 2251
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPdLGPngRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpP 80

                           90
                   ....*....|..
gi 1958660828 2252 SFSEATVEVLVE 2263
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1665-1748 5.32e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.93  E-value: 5.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1665 YFIEIPESVPIGSPILLLSA-----GSSSEVTYELREGNKDSVFSMNSYSGLISTQKRLDHEKVPSYRLRIRGSNMAGVF 1739
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTAtdpdlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                   ....*....
gi 1958660828 1740 TEVVALVYI 1748
Cdd:pfam00028   81 LSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
3226-3314 7.05e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 7.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3226 STQVPEDAPIDMEVLHLATLTR--PGSEKTGYHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSSL 3303
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPdlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1958660828 3304 SDVTTIVINVT 3314
Cdd:pfam00028   82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1471-1553 8.33e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 8.33e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  1471 QATDQDHGKG--LIYTILSSQDPGsanLFQLDPSSGVLVTVGTLELHSGPsQHILTVMVRDQEMPIKRNFVWVTIHVEDG 1548
Cdd:smart00112    1 SATDADSGENgkVTYSILSGNDDG---LFSIDPETGEITTTKPLDREEQP-EYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 1958660828  1549 NLHSP 1553
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
2697-2790 2.61e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.62  E-value: 2.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2697 YTFSAPEDLPEGSEIGSVKAVAAQDP----IIYSLVQGttpesNSDDVFSLDQDTGVLKVRKAMDHESTKWYQIDLMAhc 2772
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngrIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA-- 73

                           90       100
                   ....*....|....*....|.
gi 1958660828 2773 phEDTDLVSLVS---VSIQVE 2790
Cdd:pfam00028   74 --TDSGGPPLSStatVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2402-2475 3.40e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 3.40e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  2402 QALDPDIGDTSRLEYLILSGNQDRHFSINSTSGIISmfnlCKKQLD----SSYNLRVGASDG---VFRATVPVYINTTNA 2474
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEIT----TTKPLDreeqPEYTLTVEATDGggpPLSSTATVTITVLDV 76


                    .
gi 1958660828  2475 N 2475
Cdd:smart00112   77 N 77
Cadherin pfam00028
Cadherin domain;
2590-2682 3.77e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 3.77e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 2590 YTVSIPSNVSRDSPIIQVLAYDADEGRNADVTYSVdsTEDLAEEIIEVNPTTGVVKVKESLVGLENRAVDFNIKAQDGGP 2669
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1958660828 2670 PHWDSLVPVRLQV 2682
Cdd:pfam00028   79 PPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 392-456 4.17e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 4.17e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   392 NLRYSLKPSSRNTAFKLNARTGLITTTKLVDFHEQNQYQLHVKTSLG-----QATTTVIIDIVDCNNHAP 456
Cdd:smart00112   12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2913-2991 8.48e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 8.48e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958660828 2913 YRGSVVENNEPGELVATLKTLDADvSDQNRQVTCYITEGDPLGQFSISQVGDEwrISSRKTLDREHIAKYLLRVTASDG 2991
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGD--ISTTKPLDRESIGEYELTVEATDS 76
Cadherin pfam00028
Cadherin domain;
1453-1546 2.63e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 2.63e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1453 YEIRVPQDTLPGVELLRVQATDQDHG--KGLIYTILSsqdPGSANLFQLDPSSGVLVTVGTLELHSgPSQHILTVMVRDQ 1530
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpnGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRES-IGEYELTVEATDS 76

                           90
                   ....*....|....*.
gi 1958660828 1531 EMPIKRNFVWVTIHVE 1546
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3535-3621 4.48e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 4.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3535 PLEISITkgEEEFQGGMIGKIHATDRD--PQDTLTYSLEqEGGLDRYFTVGASDGKIIASQGLPH---GRYSFNVTVSDG 3609
Cdd:cd11304      1 SYEVSVP--ENAPPGTVVLTVSATDPDsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDReeqSSYTLTVTATDG 77

                           90
                   ....*....|....*
gi 1958660828 3610 ---TFTTTTGVHVHV 3621
Cdd:cd11304     78 ggpPLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1374-1446 5.18e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 5.18e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660828  1374 EGRPGLFWFHISDGDKDMDFDIEKTTGSIVIARPLDTRRKSSYNLTVEVTDG---FHTIATQVHIFmIANINHHRP 1446
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTIT-VLDVNDNAP 81
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3992-4022 8.40e-09

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 53.54  E-value: 8.40e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1958660828 3992 CTSAPCQEGGTCVSSPEGTSCNCPHPYTGDR 4022
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 171-254 2.29e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 2.29e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   171 TATDADLGQNAEFYYAFNARSE--VFAIHPTSGVVTVAGKLNVTRRGKYELQVLAVDrmrkiSEGNGFGNLASLVIRVEP 248
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-----GGGPPLSSTATVTITVLD 75


                    ....*.
gi 1958660828   249 VHRKPP 254
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
570-658 5.35e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 5.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  570 TVSLRQDVPVGKSIMAVSAIDMDELQN--LKYEIVSGNEQDYFHLNHFSGVISLKRsfmNLTAVRPTIYSLKITASDGKN 647
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTK---PLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1958660828  648 YA--SPTTLKVTV 658
Cdd:pfam00028   79 PPlsSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-146 7.32e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.35  E-value: 7.32e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828    65 PHWVVKYRIISGDAAGVFkteehvvgnfcflRIRTKS---SNTALLNREVRDSYTLIVQASDK-SLEFEALTQVVVHILD 140
Cdd:smart00112    9 ENGKVTYSILSGNDDGLF-------------SIDPETgeiTTTKPLDREEQPEYTLTVEATDGgGPPLSSTATVTITVLD 75


                    ....*.
gi 1958660828   141 QNDLKP 146
Cdd:smart00112   76 VNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3953-3986 7.45e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.10  E-value: 7.45e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958660828 3953 C-SQSPCLNGGSCSPALGSgYLCRCPPPFSGRNCE 3986
Cdd:cd00054      5 CaSGNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3992-4024 1.28e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 1.28e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958660828 3992 CTSA-PCQEGGTCVSSPEGTSCNCPHPYTGDRCE 4024
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
367-448 1.88e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828  367 YRVKLSEFSPPGSRVALVKVT----TALPNLRYSLKPSSRNTAFKLNARTGLITTTKLVDFHEQNQYQLHVK-TSLGQ-- 439
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEaTDSGGpp 80

                           90
                   ....*....|.
gi 1958660828  440 --ATTTVIIDI 448
Cdd:pfam00028   81 lsSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1354-1425 1.90e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.90e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660828 1354 YSFTVMETDPVNHMVGVISV----EGRPGLFWFHISDGDKDMDFDIEKTTGSIVIARPLDTRRKSSYNLTVEVTDG 1425
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTAtdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2609-2683 2.93e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.81  E-value: 2.93e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958660828  2609 AYDADEGRNADVTYSVDSTEDlaEEIIEVNPTTGVVKVKESLVgLENRAV-DFNIKAQDGGPPHWDSLVPVRLQVV 2683
Cdd:smart00112    2 ATDADSGENGKVTYSILSGND--DGLFSIDPETGEITTTKPLD-REEQPEyTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 587-661 3.64e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 3.64e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958660828   587 SAIDMDELQN--LKYEIVSGNEQDYFHLNHFSGVISLKRSfmnLTAVRPTIYSLKITASDGKNYASPTTLKVTV-VKD 661
Cdd:smart00112    1 SATDADSGENgkVTYSILSGNDDGLFSIDPETGEITTTKP---LDREEQPEYTLTVEATDGGGPPLSSTATVTItVLD 75
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3953-3984 7.42e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 48.15  E-value: 7.42e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958660828 3953 CSQSPCLNGGSCSPaLGSGYLCRCPPPFSGRN 3984
Cdd:pfam00008    1 CAPNPCSNGGTCVD-TPGGYTCICPEGYTGKR 31
Laminin_G_1 pfam00054
Laminin G domain;
3803-3926 2.47e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 2.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 3803 KTLQPWALLMFT---NETASISLKLANGFSHLEYHcPGGFYGNLSSRYPVNDGQWHSMLLEERDTSVHLLVDitDNASLV 3879
Cdd:pfam00054    2 RTTEPSGLLLYNgtqTERDFLALELRDGRLEVSYD-LGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVD--GEARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958660828 3880 IPEEC---QGLRTERQLLLGGLvPSNPSSN----VSLGFEGCLDAVVVNGERLE 3926
Cdd:pfam00054   79 GESPLgatTDLDVDGPLYVGGL-PSLGVKKrrlaISPSFDGCIRDVIVNGKPLD 131
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3953-3986 3.97e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 46.32  E-value: 3.97e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958660828 3953 CSQS-PCLNGGSCSPALGSgYLCRCPPPFSG-RNCE 3986
Cdd:cd00053      2 CAASnPCSNGGTCVNTPGS-YRCVCPPGYTGdRSCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3992-4024 5.22e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 45.93  E-value: 5.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958660828 3992 C-TSAPCQEGGTCVSSPEGTSCNCPHPYTGD-RCE 4024
Cdd:cd00053      2 CaASNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
3953-3986 1.32e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 1.32e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958660828  3953 C-SQSPCLNGGSCSPALGSgYLCRCPPPFS-GRNCE 3986
Cdd:smart00179    5 CaSGNPCQNGGTCVNTVGS-YRCECPPGYTdGRNCE 39
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 4084-4268 1.60e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.31  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 4084 EDPDLLARSIGVDTQASPAIELDPLNTSSCNNlnQPEPSKTSVPNE-LVTFGPSSKQRPMVCSVPPRLPpaavSSHPGHE 4162
Cdd:pfam03154  177 QSGAASPPSPPPPGTTQAATAGPTPSAPSVPP--QGSPATSQPPNQtQSTAAPHTLIQQTPTLHPQRLP----SPHPPLQ 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 4163 PIIKrtwsgeelvypsgaavwPPTYSRKKHWEYPHPeTMQGTLPPSPRR-HVGPAVMPDPtGLYGGFPFPLELENKRAPL 4241
Cdd:pfam03154  251 PMTQ-----------------PPPPSQVSPQPLPQP-SLHGQMPPMPHSlQTGPSHMQHP-VPPQPFPLTPQSSQSQVPP 311

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1958660828 4242 PPRYSNQNLEDLMPPRPPS---------PREHLLAP 4268
Cdd:pfam03154  312 GPSPAAPGQSQQRIHTPPSqsqlqsqqpPREQPLPP 347
Cadherin pfam00028
Cadherin domain;
38-139 6.98e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.21  E-value: 6.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828   38 YNATIYENSAPKTyveSPVKMGMYLA--EPHWVVKYRIISGDAAGVFkteehvvgnfcflRIRTKS---SNTALLNREVR 112
Cdd:pfam00028    1 YSASVPENAPVGT---EVLTVTATDPdlGPNGRIFYSILGGGPGGNF-------------RIDPDTgdiSTTKPLDRESI 64

                           90       100
                   ....*....|....*....|....*...
gi 1958660828  113 DSYTLIVQASDKSLE-FEALTQVVVHIL 139
Cdd:pfam00028   65 GEYELTVEATDSGGPpLSSTATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
3992-4024 2.78e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 2.78e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1958660828  3992 CTSA-PCQEGGTCVSSPEGTSCNCPHPYT-GDRCE 4024
Cdd:smart00179    5 CASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
1973-2061 4.92e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.90  E-value: 4.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1973 YRARVTENTPHRKALVILGVH----GnhLNDTLSYFLLNGT--DLFHMIESAGVLQTRGgTFDREQQDTHEVAVEVRDNR 2046
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlG--PNGRIFYSILGGGpgGNFRIDPDTGDISTTK-PLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1958660828 2047 VPQRVAQALVRVSVE 2061
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1877-1959 2.19e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.98  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958660828 1877 YEVAVVEPIHPGMGLLTVQAEDND----SRVTYSIKTSNADEAVTIHPTTGQISVVNP---ATLRLFQkFSIRASDGLYH 1949
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgpnGRIFYSILGGGPGGNFRIDPDTGDISTTKPldrESIGEYE-LTVEATDSGGP 79

                           90
                   ....*....|...
gi 1958660828 1950 ---DTAVVKISLT 1959
Cdd:pfam00028   80 plsSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1080-1133 2.59e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.02  E-value: 2.59e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958660828 1080 FSINQDTGMLETLAPLDREFTPYYWLTVLAVDRGSVPLSAVTEVYIEVTDINDN 1133
Cdd:cd00031     45 LHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
EGF smart00181
Epidermal growth factor-like domain;
3947-3986 3.06e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.88  E-value: 3.06e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958660828  3947 CWPGTACSQSPCLNggscspaLGSGYLCRCPPPFSG-RNCE 3986
Cdd:smart00181    2 CASGGPCSNGTCIN-------TPGSYTCSCPPGYTGdKRCE 35
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 3958-3978 6.02e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.93  E-value: 6.02e-03
                           10        20
                   ....*....|....*....|.
gi 1958660828 3958 CLNGGSCSPALGsGYLCRCPP 3978
Cdd:pfam12661    1 CQNGGTCVDGVN-GYKCQCPP 20
EGF smart00181
Epidermal growth factor-like domain;
3992-4024 6.22e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.11  E-value: 6.22e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1958660828  3992 CTS-APCQEGgTCVSSPEGTSCNCPHPYTGD-RCE 4024
Cdd:smart00181    2 CASgGPCSNG-TCINTPGSYTCSCPPGYTGDkRCE 35
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3250-3319 6.48e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.86  E-value: 6.48e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958660828 3250 SEKTGYHITG-GNEQ--GKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSSLSDVTTIVINVTDVNEH 3319
Cdd:cd00031     26 SSGEIIKISAaGKEAlpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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