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Conserved domains on  [gi|1958665564|ref|XP_038944296|]
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immunoglobulin superfamily member 5 isoform X3 [Rattus norvegicus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|8176743|23842991|10436082|3289571|9541533
SCOP:  3000071

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-124 2.39e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.81  E-value: 2.39e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665564   31 PRNVTALKGSEARFNCTVTHGWKLIMWalngiveLSLTSQKPIITSNRFTSasynSTDSFISEMIIHNVQLNDSGPVQCS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVT-------WYKQGGKLLAESGRFSV----SRSGSTSTLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*.
gi 1958665564  111 LQNSN--VFGFAFLSV 124
Cdd:smart00410  70 ATNSSgsASSGTTLTV 85
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-124 2.39e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.81  E-value: 2.39e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665564   31 PRNVTALKGSEARFNCTVTHGWKLIMWalngiveLSLTSQKPIITSNRFTSasynSTDSFISEMIIHNVQLNDSGPVQCS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVT-------WYKQGGKLLAESGRFSV----SRSGSTSTLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*.
gi 1958665564  111 LQNSN--VFGFAFLSV 124
Cdd:smart00410  70 ATNSSgsASSGTTLTV 85
I-set pfam07679
Immunoglobulin I-set domain;
26-114 3.37e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 44.17  E-value: 3.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665564  26 QIIEGPRNVTALKGSEARFNCTVThGWKL--IMWALNGivelsltsqKPIITSNRFtSASYnstDSFISEMIIHNVQLND 103
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVT-GTPDpeVSWFKDG---------QPLRSSDRF-KVTY---EGGTYTLTISNVQPDD 67

                          90
                  ....*....|.
gi 1958665564 104 SGPVQCSLQNS 114
Cdd:pfam07679  68 SGKYTCVATNS 78
IgI_Titin_like cd05747
Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the ...
 27-114 1.03e-03

Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain from the C-terminus of human titin x and similar proteins. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is gigantic; depending on isoform composition it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone and appears to function similar to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 143224 [Multi-domain]  Cd Length: 92  Bit Score: 37.34  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665564  27 IIEGPRNVTALKGSEARFNCTVT-HGWKLIMWALNGivelsltsqKPIITSNRF--TSASYNSTdsfiseMIIHNVQLND 103
Cdd:cd05747     6 ILTKPRSLTVSEGESARFSCDVDgEPAPTVTWMREG---------QIIVSSQRHqiTSTEYKST------FEISKVQMSD 70

                          90
                  ....*....|.
gi 1958665564 104 SGPVQCSLQNS 114
Cdd:cd05747    71 EGNYTVVVENS 81
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-124 2.39e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.81  E-value: 2.39e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665564   31 PRNVTALKGSEARFNCTVTHGWKLIMWalngiveLSLTSQKPIITSNRFTSasynSTDSFISEMIIHNVQLNDSGPVQCS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVT-------WYKQGGKLLAESGRFSV----SRSGSTSTLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*.
gi 1958665564  111 LQNSN--VFGFAFLSV 124
Cdd:smart00410  70 ATNSSgsASSGTTLTV 85
I-set pfam07679
Immunoglobulin I-set domain;
26-114 3.37e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 44.17  E-value: 3.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665564  26 QIIEGPRNVTALKGSEARFNCTVThGWKL--IMWALNGivelsltsqKPIITSNRFtSASYnstDSFISEMIIHNVQLND 103
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVT-GTPDpeVSWFKDG---------QPLRSSDRF-KVTY---EGGTYTLTISNVQPDD 67

                          90
                  ....*....|.
gi 1958665564 104 SGPVQCSLQNS 114
Cdd:pfam07679  68 SGKYTCVATNS 78
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 26-113 1.04e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.47  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665564  26 QIIEGPRNVTALKGSEARFNCTVTHGWK-LIMWALNGIVELSltsqkpiitsnrfTSASYNSTDSFISEMIIHNVQLNDS 104
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPpTITWYKNGEPISS-------------GSTRSRSLSGSNSTLTISNVTRSDA 69


                  ....*....
gi 1958665564 105 GPVQCSLQN 113
Cdd:pfam13927  70 GTYTCVASN 78
IgI_Titin_like cd05747
Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the ...
 27-114 1.03e-03

Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain from the C-terminus of human titin x and similar proteins. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is gigantic; depending on isoform composition it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone and appears to function similar to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 143224 [Multi-domain]  Cd Length: 92  Bit Score: 37.34  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958665564  27 IIEGPRNVTALKGSEARFNCTVT-HGWKLIMWALNGivelsltsqKPIITSNRF--TSASYNSTdsfiseMIIHNVQLND 103
Cdd:cd05747     6 ILTKPRSLTVSEGESARFSCDVDgEPAPTVTWMREG---------QIIVSSQRHqiTSTEYKST------FEISKVQMSD 70

                          90
                  ....*....|.
gi 1958665564 104 SGPVQCSLQNS 114
Cdd:cd05747    71 EGNYTVVVENS 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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