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Conserved domains on  [gi|1958699485|ref|XP_038951366|]
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nucleotide sugar transporter SLC35D2 isoform X3 [Rattus norvegicus]

Protein Classification

triose-phosphate transporter family protein( domain architecture ID 706146)

triose-phosphate transporter family protein belongs to the RhaT/DMT (drug/metabolite transporter) superfamily

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPT super family cl26744
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 16-186 3.25e-09

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


The actual alignment was detected with superfamily member pfam03151:

Pssm-ID: 474852 [Multi-domain]  Cd Length: 290  Bit Score: 54.99  E-value: 3.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  16 LLSALFYGTCSFLIVLvNKALLTTygFPSPIVLGIGQMTTTIMILYVSKLNKIIHFPDFDKKIPGKLFPLPLLYVGNHIS 95
Cdd:pfam03151   5 LLFGLWYFLNIYFNIY-NKKILNA--FPYPMTVSSVQLFVGSVYILVLWGTGLRKRPKISSPFLKNILPLALCHTLGHVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  96 GLSSTSKLSLPmFTVLRKFTIPL-TLLLEAIILGKQYSLSIILSVLAIVLGAFIAAGSDLTFNWEGYVFVFLNDIFTAAN 174
Cdd:pfam03151  82 ANVSLGKVAVS-FTHTVKAMEPFfTVILSRLFLGEYPPLLVYLSLLPIVGGVALASVTELSFNWIGFISAMISNLGFSLR 160

                         170
                  ....*....|..
gi 1958699485 175 GVYTKQKMDPKE 186
Cdd:pfam03151 161 NIFSKKLMKGKD 172
 
Name Accession Description Interval E-value
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 16-186 3.25e-09

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 54.99  E-value: 3.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  16 LLSALFYGTCSFLIVLvNKALLTTygFPSPIVLGIGQMTTTIMILYVSKLNKIIHFPDFDKKIPGKLFPLPLLYVGNHIS 95
Cdd:pfam03151   5 LLFGLWYFLNIYFNIY-NKKILNA--FPYPMTVSSVQLFVGSVYILVLWGTGLRKRPKISSPFLKNILPLALCHTLGHVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  96 GLSSTSKLSLPmFTVLRKFTIPL-TLLLEAIILGKQYSLSIILSVLAIVLGAFIAAGSDLTFNWEGYVFVFLNDIFTAAN 174
Cdd:pfam03151  82 ANVSLGKVAVS-FTHTVKAMEPFfTVILSRLFLGEYPPLLVYLSLLPIVGGVALASVTELSFNWIGFISAMISNLGFSLR 160

                         170
                  ....*....|..
gi 1958699485 175 GVYTKQKMDPKE 186
Cdd:pfam03151 161 NIFSKKLMKGKD 172
tpt TIGR00817
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
 16-187 5.34e-08

Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]


Pssm-ID: 129898 [Multi-domain]  Cd Length: 302  Bit Score: 51.65  E-value: 5.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  16 LLSALFYGTCSFLIV---LVNKALLTTygFPSPIVLGIGQMTTTIMILYVSKLNKIIHFPDFDKKIPGKLFPLPLLYVGN 92
Cdd:TIGR00817   1 LQTGLLFGLWYFLNVyfnIYNKKLLNV--FPYPYFKTLISLAVGSLYCLLSWSSGLPKRLKISSALLKLLLPVAIVHTIG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  93 HISGLSSTSKLSLPMFTVLRKFTIPLTLLLEAIILGKQYSLSIILSVLAIVLGAFIAAGSDLTFNWEGYVFVFLNDIFTA 172
Cdd:TIGR00817  79 HVTSNVSLSKVAVSFTHTIKAMEPFFSVVLSAFFLGQEFPSTLWLSLLPIVGGVALASDTELSFNWAGFLSAMISNITFV 158

                         170
                  ....*....|....*
gi 1958699485 173 ANGVYTKQKMDPKEM 187
Cdd:TIGR00817 159 SRNIFSKKAMTIKSL 173
VRG4 COG5070
Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational ...
 16-173 1.22e-07

Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227402  Cd Length: 309  Bit Score: 50.66  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  16 LLSALFYGTCSFLIVLVNKALLTTYGFPSPIVLGIGQMTTTIMILYVSKLNKIIHFPDFDKKipgKLFPLPLLYVGNHIS 95
Cdd:COG5070     8 LTASLSYCFSSILMTLTNKYVLSNLGFNMNFLLLAVQSLVCVVGLLILKFLRLVEFRLTKAK---KWFPISFLLVVMIYT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  96 GLSSTSKLSLPMFTVLRKFTIPLTLLLEAIILGKQYSLSIILSVLAIVLGAFIAAGSD--------LTFNwEGYVFVFLN 167
Cdd:COG5070    85 SSKSLQYLAVPIYTIFKNLTIILIAYGEVLFFGGRVTSLELLSFILMVLSSVVATWGDqqasafkaQILN-PGYLWMFTN 163


                  ....*.
gi 1958699485 168 DIFTAA 173
Cdd:COG5070   164 CLSSAA 169
PTZ00343 PTZ00343
triose or hexose phosphate/phosphate translocator; Provisional
 57-186 3.62e-04

triose or hexose phosphate/phosphate translocator; Provisional


Pssm-ID: 240371 [Multi-domain]  Cd Length: 350  Bit Score: 40.49  E-value: 3.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  57 IMILYVSKLNKIIHFPDFDKKIPgKLFPLPLLYVGNHISGLSSTSKLSLPMFTVLRKFTIPLTLLLEAIILGKQYSLSII 136
Cdd:PTZ00343   93 ALLYWATGFRKIPRIKSLKLFLK-NFLPQGLCHLFVHFGAVISMGLGAVSFTHVVKAAEPVFTALLSILFLKQFLNLYAY 171

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958699485 137 LSVLAIVLGAFIAAGSDLTFNWEGYVFVFLNDIFTAANGVYTKQKMDPKE 186
Cdd:PTZ00343  172 LSLIPIVGGVALASVKELHFTWLAFWCAMLSNLGSSLRSIFAKKTMKNKS 221
 
Name Accession Description Interval E-value
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 16-186 3.25e-09

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 54.99  E-value: 3.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  16 LLSALFYGTCSFLIVLvNKALLTTygFPSPIVLGIGQMTTTIMILYVSKLNKIIHFPDFDKKIPGKLFPLPLLYVGNHIS 95
Cdd:pfam03151   5 LLFGLWYFLNIYFNIY-NKKILNA--FPYPMTVSSVQLFVGSVYILVLWGTGLRKRPKISSPFLKNILPLALCHTLGHVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  96 GLSSTSKLSLPmFTVLRKFTIPL-TLLLEAIILGKQYSLSIILSVLAIVLGAFIAAGSDLTFNWEGYVFVFLNDIFTAAN 174
Cdd:pfam03151  82 ANVSLGKVAVS-FTHTVKAMEPFfTVILSRLFLGEYPPLLVYLSLLPIVGGVALASVTELSFNWIGFISAMISNLGFSLR 160

                         170
                  ....*....|..
gi 1958699485 175 GVYTKQKMDPKE 186
Cdd:pfam03151 161 NIFSKKLMKGKD 172
tpt TIGR00817
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
 16-187 5.34e-08

Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]


Pssm-ID: 129898 [Multi-domain]  Cd Length: 302  Bit Score: 51.65  E-value: 5.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  16 LLSALFYGTCSFLIV---LVNKALLTTygFPSPIVLGIGQMTTTIMILYVSKLNKIIHFPDFDKKIPGKLFPLPLLYVGN 92
Cdd:TIGR00817   1 LQTGLLFGLWYFLNVyfnIYNKKLLNV--FPYPYFKTLISLAVGSLYCLLSWSSGLPKRLKISSALLKLLLPVAIVHTIG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  93 HISGLSSTSKLSLPMFTVLRKFTIPLTLLLEAIILGKQYSLSIILSVLAIVLGAFIAAGSDLTFNWEGYVFVFLNDIFTA 172
Cdd:TIGR00817  79 HVTSNVSLSKVAVSFTHTIKAMEPFFSVVLSAFFLGQEFPSTLWLSLLPIVGGVALASDTELSFNWAGFLSAMISNITFV 158

                         170
                  ....*....|....*
gi 1958699485 173 ANGVYTKQKMDPKEM 187
Cdd:TIGR00817 159 SRNIFSKKAMTIKSL 173
VRG4 COG5070
Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational ...
 16-173 1.22e-07

Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion];


Pssm-ID: 227402  Cd Length: 309  Bit Score: 50.66  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  16 LLSALFYGTCSFLIVLVNKALLTTYGFPSPIVLGIGQMTTTIMILYVSKLNKIIHFPDFDKKipgKLFPLPLLYVGNHIS 95
Cdd:COG5070     8 LTASLSYCFSSILMTLTNKYVLSNLGFNMNFLLLAVQSLVCVVGLLILKFLRLVEFRLTKAK---KWFPISFLLVVMIYT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  96 GLSSTSKLSLPMFTVLRKFTIPLTLLLEAIILGKQYSLSIILSVLAIVLGAFIAAGSD--------LTFNwEGYVFVFLN 167
Cdd:COG5070    85 SSKSLQYLAVPIYTIFKNLTIILIAYGEVLFFGGRVTSLELLSFILMVLSSVVATWGDqqasafkaQILN-PGYLWMFTN 163


                  ....*.
gi 1958699485 168 DIFTAA 173
Cdd:COG5070   164 CLSSAA 169
PTZ00343 PTZ00343
triose or hexose phosphate/phosphate translocator; Provisional
 57-186 3.62e-04

triose or hexose phosphate/phosphate translocator; Provisional


Pssm-ID: 240371 [Multi-domain]  Cd Length: 350  Bit Score: 40.49  E-value: 3.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958699485  57 IMILYVSKLNKIIHFPDFDKKIPgKLFPLPLLYVGNHISGLSSTSKLSLPMFTVLRKFTIPLTLLLEAIILGKQYSLSII 136
Cdd:PTZ00343   93 ALLYWATGFRKIPRIKSLKLFLK-NFLPQGLCHLFVHFGAVISMGLGAVSFTHVVKAAEPVFTALLSILFLKQFLNLYAY 171

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958699485 137 LSVLAIVLGAFIAAGSDLTFNWEGYVFVFLNDIFTAANGVYTKQKMDPKE 186
Cdd:PTZ00343  172 LSLIPIVGGVALASVKELHFTWLAFWCAMLSNLGSSLRSIFAKKTMKNKS 221
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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