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Conserved domains on  [gi|1958725020|ref|XP_038952062|]
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protein patched homolog 1 isoform X1 [Rattus norvegicus]

Protein Classification

2A060602 and PHA03377 domain-containing protein( domain architecture ID 11489962)

2A060602 and PHA03377 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
178-1253 0e+00

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


:

Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 1931.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  178 QVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELI 257
Cdd:TIGR00918   91 EVGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPS 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  258 TETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHG 337
Cdd:TIGR00918  171 TEGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSQVESWEEMLKKAAVGQG 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  338 YMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPK 417
Cdd:TIGR00918  251 YMERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPK 330
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  418 QMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLML 497
Cdd:TIGR00918  331 QMYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLML 410
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  498 AYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNkr 577
Cdd:TIGR00918  411 AYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQN-- 488
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  578 IPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDI 657
Cdd:TIGR00918  489 IPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDI 568
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  658 FCCFTSPCVSRVIQVEPQAYTEPHSntrysppppySSHSFAHethitMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPv 737
Cdd:TIGR00918  569 FCCFFSPCSARVIQIEPQAYADGSA----------PPVYSSH-----MQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQP- 632
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  738 titQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTR 817
Cdd:TIGR00918  633 ---SDPLSCQSPDIAGSTRDLLSQFEDSKAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTR 709
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  818 VRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQK-ADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFR 896
Cdd:TIGR00918  710 VQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYNMYAVTQGnFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFR 789
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  897 DWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 976
Cdd:TIGR00918  790 DWLQGLQKAFDEDWRDGRITKENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSN 869
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  977 DPVAYAASQANIRPHRPEWVHDKADYMPETrLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSY 1056
Cdd:TIGR00918  870 DPVAYAASQANIYPHPPEWLHDKNDYDPEN-LRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSY 948
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1057 PNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIAS 1136
Cdd:TIGR00918  949 PSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIAS 1028
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1137 VGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLV 1216
Cdd:TIGR00918 1029 VGIGVEFTVHIALGFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLV 1108
                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 1958725020 1217 LLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVR 1253
Cdd:TIGR00918 1109 LLPVLLSMFGPEPEVSPAEGRSRLPTPSPEPPPGGVR 1145
 
Name Accession Description Interval E-value
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
178-1253 0e+00

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 1931.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  178 QVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELI 257
Cdd:TIGR00918   91 EVGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPS 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  258 TETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHG 337
Cdd:TIGR00918  171 TEGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSQVESWEEMLKKAAVGQG 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  338 YMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPK 417
Cdd:TIGR00918  251 YMERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPK 330
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  418 QMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLML 497
Cdd:TIGR00918  331 QMYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLML 410
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  498 AYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNkr 577
Cdd:TIGR00918  411 AYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQN-- 488
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  578 IPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDI 657
Cdd:TIGR00918  489 IPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDI 568
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  658 FCCFTSPCVSRVIQVEPQAYTEPHSntrysppppySSHSFAHethitMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPv 737
Cdd:TIGR00918  569 FCCFFSPCSARVIQIEPQAYADGSA----------PPVYSSH-----MQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQP- 632
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  738 titQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTR 817
Cdd:TIGR00918  633 ---SDPLSCQSPDIAGSTRDLLSQFEDSKAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTR 709
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  818 VRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQK-ADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFR 896
Cdd:TIGR00918  710 VQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYNMYAVTQGnFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFR 789
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  897 DWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 976
Cdd:TIGR00918  790 DWLQGLQKAFDEDWRDGRITKENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSN 869
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  977 DPVAYAASQANIRPHRPEWVHDKADYMPETrLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSY 1056
Cdd:TIGR00918  870 DPVAYAASQANIYPHPPEWLHDKNDYDPEN-LRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSY 948
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1057 PNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIAS 1136
Cdd:TIGR00918  949 PSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIAS 1028
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1137 VGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLV 1216
Cdd:TIGR00918 1029 VGIGVEFTVHIALGFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLV 1108
                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 1958725020 1217 LLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVR 1253
Cdd:TIGR00918 1109 LLPVLLSMFGPEPEVSPAEGRSRLPTPSPEPPPGGVR 1145
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
509-663 4.22e-49

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 432497 [Multi-domain]  Cd Length: 153  Bit Score: 171.62  E-value: 4.22e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  509 CSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTGECL 588
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRT--PRSLDVSERIAEAL 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958725020  589 KRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTS 663
Cdd:pfam12349   79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCLRY 153
COG1033 COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
516-653 2.45e-09

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 223964 [Multi-domain]  Cd Length: 727  Bit Score: 61.94  E-value: 2.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  516 VGLAGVLLVALSVAAGLGLCSLIGISFNAATtQVLPFLALGVGVDDVFLLAHAFSETGQNKriPFEDRTGECLKRTGASV 595
Cdd:COG1033    594 KAIIPLIPIAIVVGWNFGLMGLLGIPLTPAT-ATLGAIILGIGVDYSIHITERYREERKKG--GPKEAIETTVERTGKAI 670
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  596 ALTSISnvTAFFMAALI--PIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdLYRREDR 653
Cdd:COG1033    671 LASALT--TAIGFLALIfsPFPIISNFGLLTVIGILLSLLASLVLLPALLVL-LDGRRKR 727
 
Name Accession Description Interval E-value
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
178-1253 0e+00

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 1931.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  178 QVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELI 257
Cdd:TIGR00918   91 EVGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPS 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  258 TETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHG 337
Cdd:TIGR00918  171 TEGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSQVESWEEMLKKAAVGQG 250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  338 YMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPK 417
Cdd:TIGR00918  251 YMERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPK 330
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  418 QMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLML 497
Cdd:TIGR00918  331 QMYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLML 410
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  498 AYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNkr 577
Cdd:TIGR00918  411 AYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQN-- 488
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  578 IPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDI 657
Cdd:TIGR00918  489 IPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDI 568
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  658 FCCFTSPCVSRVIQVEPQAYTEPHSntrysppppySSHSFAHethitMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPv 737
Cdd:TIGR00918  569 FCCFFSPCSARVIQIEPQAYADGSA----------PPVYSSH-----MQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQP- 632
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  738 titQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTR 817
Cdd:TIGR00918  633 ---SDPLSCQSPDIAGSTRDLLSQFEDSKAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTR 709
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  818 VRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQK-ADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFR 896
Cdd:TIGR00918  710 VQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYNMYAVTQGnFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFR 789
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  897 DWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 976
Cdd:TIGR00918  790 DWLQGLQKAFDEDWRDGRITKENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSN 869
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  977 DPVAYAASQANIRPHRPEWVHDKADYMPETrLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSY 1056
Cdd:TIGR00918  870 DPVAYAASQANIYPHPPEWLHDKNDYDPEN-LRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSY 948
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1057 PNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIAS 1136
Cdd:TIGR00918  949 PSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIAS 1028
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1137 VGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLV 1216
Cdd:TIGR00918 1029 VGIGVEFTVHIALGFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLV 1108
                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 1958725020 1217 LLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVR 1253
Cdd:TIGR00918 1109 LLPVLLSMFGPEPEVSPAEGRSRLPTPSPEPPPGGVR 1145
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
445-1226 5.20e-68

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 252.14  E-value: 5.20e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  445 AWQRTYVEVVHQSVAPNsTQKVLSFTT-TTLDDILKSFSDVSVIRVASGYLLMLAYACLTM-----LRWDCSKSQGAVGL 518
Cdd:TIGR00917  533 AWEKAFIQLAKDELLPM-VQATISFSAeRSIEDELKRESTADVITIAISYLVMFAYISLTLgdsprLKSLYVTSKVLLGL 611
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  519 AGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF---------SETGQNKRIPFEDRTGECLK 589
Cdd:TIGR00917  612 SGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqVGVDNEQELTLERRLSRALM 691
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  590 RTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCftspcvsrv 669
Cdd:TIGR00917  692 EVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPC--------- 762
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  670 iqvepqaytephsntrysppppysshsfahethitmqstvqLRTEYDphthvyyttaeprseisvqpvTITQDTLSCQSP 749
Cdd:TIGR00917  763 -----------------------------------------IKTSKS---------------------SISAEKGSGQRK 780
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  750 EStsstrdllsqfsdsslhcleppctkwTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVP 829
Cdd:TIGR00917  781 AG--------------------------LLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLP 834
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  830 RETREYDFIAAQFKYFSFYNMYIVTQKADYPniqhllYDLHKSFSSVKYVMLEENKQLPQM-------------WLHYFR 896
Cdd:TIGR00917  835 QDSYLQIYFASLTPLLEVGPPFYIVIKGDYN------YTDFESQNKLCTMGGCDKDSIVNVfnnlsyiakpassWLDDYL 908
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  897 DWLQGLQDAFDSDWETGRimpnnYKNGSDDGVLAYKllvqtgsrdkpiDISQLTKQRlvdadgiINPSAFYIYLTAWVSN 976
Cdd:TIGR00917  909 VWLSPQASCCCRKFTNGT-----FCNGPDPQCFRCA------------DLSSDAQGR-------PSTTQFKEKLPWFLNA 964
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  977 DP--------VAYAASQANIRPHrpewvhdkadympetrlripaAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNY 1048
Cdd:TIGR00917  965 LPsadcakggHAAYSSAVDLQGY---------------------ATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKV 1023
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1049 T-SLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVELFGMMGLIGIKLS 1126
Cdd:TIGR00917 1024 SrSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLN 1103
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1127 AVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNHRAMLALEHMFAPVLDGAVST-LLGVLMLAGSEFDFIVRYFFAVLA 1204
Cdd:TIGR00917 1104 AVSVVNSVMHKGIAIEFCTHINAQFSTGKhFSRNHRAKEALGGMGSSVFSGITLTkLVGVVVLGFSRSEIFVVYYFRMYL 1183
                          810       820
                   ....*....|....*....|..
gi 1958725020 1205 ILTVLGVLNGLVLLPVLLSFFG 1226
Cdd:TIGR00917 1184 ALVLLGFLHGLVFLPVLLSVLG 1205
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
509-663 4.22e-49

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 432497 [Multi-domain]  Cd Length: 153  Bit Score: 171.62  E-value: 4.22e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  509 CSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTGECL 588
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRT--PRSLDVSERIAEAL 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958725020  589 KRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTS 663
Cdd:pfam12349   79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCLRY 153
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
431-1188 1.02e-46

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 181.40  E-value: 1.02e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  431 HINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQkVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT-----ML 505
Cdd:pfam02460  162 FLKFDEEEVEEDSKEWEDELSQLLHNKYASEHIQ-FTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlsSY 240
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  506 RWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTqVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTG 585
Cdd:pfam02460  241 TIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRT--TATLSVKKRMG 317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  586 ECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdlyrredrrldifccftspc 665
Cdd:pfam02460  318 EALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI-------------------- 377
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  666 vsrviqvepqaytephsntrysppppysshsfahethitmqstvqlrteydphthvyytTAEPrsEISVQPVTITQDTLS 745
Cdd:pfam02460  378 -----------------------------------------------------------CAKP--EAEGRHCLFVWATSS 396
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  746 CQSPESTSSTRDllsqfsdsSLHCLEPPctkwtLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLT 825
Cdd:pfam02460  397 PQRIDSEGSEPD--------KSHNIEQL-----KSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPD 463
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  826 DIVPRETREYDFIAAQFKYFSFY--NMYIVTQKADYPNIQHLLYDLHK---SFSSVKYVMleeNKQLPQMWLHYFRDWLQ 900
Cdd:pfam02460  464 KLVLEDSPLVEYLSLREKHFWPEglQIQVAVNNPPNLTIPESRDRMNEmvdEFENTPYSL---GPNSTLFWLREYENFLS 540
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  901 GLQDAFDSDWETGRIMpnnykngsddGVLAYKLLVQTGSrdkpidisqltkqrlvdadgiinpsafyiyltAWVSNdpva 980
Cdd:pfam02460  541 TLNMEEEEDEEKEWSY----------GNLPSFLKAPGNS--------------------------------HWAGD---- 574
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  981 yaasqanirphrpeWVHDKADYMpetrlripaaepIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGY 1060
Cdd:pfam02460  575 --------------LVWDDNTTM------------VTKFRFTLAGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDA 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1061 PFLfwEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIG 1140
Cdd:pfam02460  629 PFA--DQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFS 706
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*....
gi 1958725020 1141 VEFTVHVALAFLTAIGDKNH-RAMLALEHMFAPVLDGAVSTLLGVLMLA 1188
Cdd:pfam02460  707 VDFSAHIAYHFVRSRGDTPAeRVVDALEALGWPVFQGGLSTILGVLVLL 755
COG1033 COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
516-653 2.45e-09

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 223964 [Multi-domain]  Cd Length: 727  Bit Score: 61.94  E-value: 2.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  516 VGLAGVLLVALSVAAGLGLCSLIGISFNAATtQVLPFLALGVGVDDVFLLAHAFSETGQNKriPFEDRTGECLKRTGASV 595
Cdd:COG1033    594 KAIIPLIPIAIVVGWNFGLMGLLGIPLTPAT-ATLGAIILGIGVDYSIHITERYREERKKG--GPKEAIETTVERTGKAI 670
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  596 ALTSISnvTAFFMAALI--PIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdLYRREDR 653
Cdd:COG1033    671 LASALT--TAIGFLALIfsPFPIISNFGLLTVIGILLSLLASLVLLPALLVL-LDGRRKR 727
COG1033 COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
447-644 5.28e-09

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 223964 [Multi-domain]  Cd Length: 727  Bit Score: 60.78  E-value: 5.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  447 QRTYVEVVHQSVAPNSTQKVLSFTTTTL-------DDILKSF-SDVSVIRVASGYLLMLA-YACLTMLRWdcsksqgavG 517
Cdd:COG1033    153 DAQKEEIYEEIERIIEIAKFPSGVKLYLtgdpairYQILREIqKDMVVLLALAVILMVIVlYYVFRSVRR---------A 223
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  518 LAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLaLGVGVDDVFLLAHAFSETGQNKRIPFEdRTGECLKRTGASVAL 597
Cdd:COG1033    224 LLPLIIVLVSVLWTLGAMGLLGIPLTITTSAVPPLL-IGIGIDYGVHFHNRYEEERRKGRTVEE-AVVEAIKHTGPAVLI 301
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1958725020  598 TSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILS 644
Cdd:COG1033    302 AALTTAAGFLSLLTSSIPAIKEFGILLSIGIILAFLSSLTVLPALLI 348
COG1033 COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1033-1205 1.17e-08

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 223964 [Multi-domain]  Cd Length: 727  Bit Score: 59.62  E-value: 1.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1033 DFVEAIEKVrvicnnYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTV 1112
Cdd:COG1033    534 EILRDIEKE------NIPTGVKVYVTGESVIYVEMNELLTSSQLISTVLGIILVFALLLIIFRSPLKAIIPLIPIAIVVG 607
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1113 ELFGMMGLIGIKLSavPVVILIAS--VGIGVEFTVHVALAFLTAIgDKNHRA---MLALEHMFAPVLDGAVSTLLGVLML 1187
Cdd:COG1033    608 WNFGLMGLLGIPLT--PATATLGAiiLGIGVDYSIHITERYREER-KKGGPKeaiETTVERTGKAILASALTTAIGFLAL 684
                          170
                   ....*....|....*...
gi 1958725020 1188 AGSEFDFIvRYFFAVLAI 1205
Cdd:COG1033    685 IFSPFPII-SNFGLLTVI 701
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
476-659 2.58e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 55.23  E-value: 2.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  476 DILKSFSDVSVIRVASGYLLMLAYACLTMLRWdcsksqgAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLaL 555
Cdd:TIGR00921  186 DIEREFGKDMGTTMAISGILVVLVLLLDFKRW-------WRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPML-I 257
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  556 GVGVDDVFLLAHAFSETGQNKRiPFEDRTGECLKRTGASVALTSISNVtAFFMAALIPI-PALRAFSLQAAVVVVFNFAM 634
Cdd:TIGR00921  258 GVGIDYGIQTLNRYEEERDIGR-AKGEAIVTAVRRTGRAVLIALLTTS-AGFAALALSEfPMVSEFGLGLVAGLITAYLL 335
                          170       180
                   ....*....|....*....|....*.
gi 1958725020  635 VLLIFPAIL-SMDLYRREDRRLDIFC 659
Cdd:TIGR00921  336 TLLVLPALLqSIDIGREKVKKEIIAI 361
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
516-643 3.66e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 51.76  E-value: 3.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  516 VGLAGVLLVALSVAAGLGLCSLIGISFNAaTTQVLPFLALGVGVDDVFLLAHAFSETgQNKRIPFEDRTgECLKRTGASV 595
Cdd:TIGR00921  593 KAVFPLIAIGSGILWAIGLMGLRGIPSFL-AMATTISIILGLGMDYSIHLAERYFEE-RKEHGPKEAIT-HTMERTGPGI 669
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958725020  596 ALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAIL 643
Cdd:TIGR00921  670 LFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
448-643 1.91e-05

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 49.23  E-value: 1.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  448 RTYVEVVhQSVAPNSTQKVLSFTTTTlDDILKSFsdvsvIRVASGYLLMLAYACLTMLRwdcSKSQGAVGLAGVLLVALS 527
Cdd:TIGR03480  683 RRFVRAV-RKVAPDATGAPVSILESG-DTVVGAF-----LQAFIYALVAITVLLLLTLR---RVRDVLLVLAPLLLAGLL 752
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  528 VAAglgLCSLIGISFNAATTQVLPFLaLGVGVDDVFLLAHAFSEtGQNKRIPFEDRTGEclkrtgaSVALTSISNVTAFF 607
Cdd:TIGR03480  753 TVA---AMVLLGIPFNFANIIALPLL-LGLGVDFGIYMVHRWRN-GVDSGNLLQSSTAR-------AVFFSALTTATAFG 820
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1958725020  608 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAIL 643
Cdd:TIGR03480  821 SLAVSSHPGTASMGILLSLGLGLTLLCTLIFLPALL 856
COG1033 COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1075-1206 1.13e-04

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 223964 [Multi-domain]  Cd Length: 727  Bit Score: 46.91  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1075 LLLAISVvlactFLVCAVFLL--NPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAF 1151
Cdd:COG1033    200 VLLALAV-----ILMVIVLYYvfRSVRRALLPLIIVLVSVLWtLGAMGLLGIPLTITTSAVPPLLIGIGIDYGVHFHNRY 274
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958725020 1152 L--TAIGDKNHRAML-ALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRyfFAVLAIL 1206
Cdd:COG1033    275 EeeRRKGRTVEEAVVeAIKHTGPAVLIAALTTAAGFLSLLTSSIPAIKE--FGILLSI 330
YdfJ COG2409
Uncharacterized membrane protein YdfJ, MMPL/SSD domain [Function unknown];
514-645 2.58e-04

Uncharacterized membrane protein YdfJ, MMPL/SSD domain [Function unknown];


Pssm-ID: 225272 [Multi-domain]  Cd Length: 937  Bit Score: 45.49  E-value: 2.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  514 GAVGLAGVLL--VALSVAAGLGLCSLIGISFNAAT-TQVLPF---LALGVGVD-DVFLLA---HAFSEtGQNKripfEDR 583
Cdd:COG2409    206 RSVITAFLPLitVGLSLLVAQGIVALLAYAFGLGVsTFALSLlvaLGIGAGTDyALFLVSryrEELRE-GQDR----EAA 280
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958725020  584 TGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSM 645
Cdd:COG2409    281 VGTAYRTAGKTVAFSGLTVAIALLGLSFARLPFLKTLGIAAAIGVAVAVLAALTLLPALLAL 342
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
437-645 2.98e-04

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 44.59  E-value: 2.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  437 DRAAAILEAwqrtyvevVHQSVAPNSTQKVLSFTTTTLDDILKSFS-DVSVIRVASgylLMLAYACLTMLRwdcsksqGA 515
Cdd:pfam03176  104 ESVAAVRDA--------VEQAPPPEGLKAYLTGPAATVADLRDAGDrDLGLIEAVT---LVVIFIILLIVY-------RS 165
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  516 VGLAGVLL--VALSVAAGLGLCS-LIGISFNAATTQVLPF---LALGVGVD-DVFLLA--HAFSETGQNKripfEDRTGE 586
Cdd:pfam03176  166 VVAALLPLltVGLSLGAAQGLVAiLAHILGIGLSTFALNLlvvLLIAVGTDyALFLVSryREELRAGEDR----EEAVIR 241
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958725020  587 CLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSM 645
Cdd:pfam03176  242 AVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
1076-1198 4.98e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.83  E-value: 4.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1076 LLAISVVLactflVCAVFLL--NPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1152
Cdd:TIGR00921  198 TMAISGIL-----VVLVLLLdfKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYE 272
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1958725020 1153 TAIG---DKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRY 1198
Cdd:TIGR00921  273 EERDigrAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEF 321
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
1077-1205 8.15e-04

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 223911 [Multi-domain]  Cd Length: 1009  Bit Score: 44.14  E-value: 8.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1077 LAISVVLActFLVCAVFLLNpWTAGIIVMV---LALMTVelFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLT 1153
Cdd:COG0841    335 LFEAIVLV--VLVMYLFLGN-LRATLIPALavpVSLLGT--FAVMYAFGFSLNTLTLFALVLAIGLLVDDAIVVVENIER 409
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958725020 1154 AIGDKNHR--AMLALEHMFAPVLDGAVSTLLG---VLMLAGS--EFdfiVRYFFAVLAI 1205
Cdd:COG0841    410 HMRGLPPReaAEKAMGEIGGAVIAITLVLIAVflpMAFMGGStgEL---FRQFAITIAV 465
COG4258 COG4258
Predicted exporter [General function prediction only];
478-641 1.29e-03

Predicted exporter [General function prediction only];


Pssm-ID: 226709 [Multi-domain]  Cd Length: 788  Bit Score: 43.32  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  478 LKSFSD---VSVIRVASGYLL--MLAYACLTMLRWDCSKsqGAVGLAGVLLVALSVAAGLGLCsliGISFNAATTQVLpF 552
Cdd:COG4258    633 RKSTFDrlfAAYRYVLAGLLAgaLALVLCLAVARRGWRR--GLRVLLPSVLALGCGLAVLAMA---GVPLNLFHLLAL-V 706
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020  553 LALGVGVDdvflLAHAFSETGQNKRIPFedrtgeclkRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNF 632
Cdd:COG4258    707 LVLGVGIN----YALFFSNAGDPRAEPL---------TTLLALALAMLTTLLTFGLLAFSATPVLSSFGITLASGIILAF 773

                   ....*....
gi 1958725020  633 AMVLLIFPA 641
Cdd:COG4258    774 VLAPLAMPD 782
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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