|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
178-1253 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 1931.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 178 QVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELI 257
Cdd:TIGR00918 91 EVGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPS 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 258 TETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHG 337
Cdd:TIGR00918 171 TEGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSQVESWEEMLKKAAVGQG 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 338 YMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPK 417
Cdd:TIGR00918 251 YMERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPK 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 418 QMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLML 497
Cdd:TIGR00918 331 QMYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLML 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 498 AYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNkr 577
Cdd:TIGR00918 411 AYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQN-- 488
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 578 IPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDI 657
Cdd:TIGR00918 489 IPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDI 568
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 658 FCCFTSPCVSRVIQVEPQAYTEPHSntrysppppySSHSFAHethitMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPv 737
Cdd:TIGR00918 569 FCCFFSPCSARVIQIEPQAYADGSA----------PPVYSSH-----MQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQP- 632
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 738 titQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTR 817
Cdd:TIGR00918 633 ---SDPLSCQSPDIAGSTRDLLSQFEDSKAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTR 709
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 818 VRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQK-ADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFR 896
Cdd:TIGR00918 710 VQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYNMYAVTQGnFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFR 789
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 897 DWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 976
Cdd:TIGR00918 790 DWLQGLQKAFDEDWRDGRITKENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSN 869
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 977 DPVAYAASQANIRPHRPEWVHDKADYMPETrLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSY 1056
Cdd:TIGR00918 870 DPVAYAASQANIYPHPPEWLHDKNDYDPEN-LRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSY 948
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1057 PNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIAS 1136
Cdd:TIGR00918 949 PSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIAS 1028
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1137 VGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLV 1216
Cdd:TIGR00918 1029 VGIGVEFTVHIALGFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLV 1108
|
1050 1060 1070
....*....|....*....|....*....|....*..
gi 1958725020 1217 LLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVR 1253
Cdd:TIGR00918 1109 LLPVLLSMFGPEPEVSPAEGRSRLPTPSPEPPPGGVR 1145
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
445-1226 |
5.20e-68 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 252.14 E-value: 5.20e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 445 AWQRTYVEVVHQSVAPNsTQKVLSFTT-TTLDDILKSFSDVSVIRVASGYLLMLAYACLTM-----LRWDCSKSQGAVGL 518
Cdd:TIGR00917 533 AWEKAFIQLAKDELLPM-VQATISFSAeRSIEDELKRESTADVITIAISYLVMFAYISLTLgdsprLKSLYVTSKVLLGL 611
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 519 AGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF---------SETGQNKRIPFEDRTGECLK 589
Cdd:TIGR00917 612 SGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqVGVDNEQELTLERRLSRALM 691
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 590 RTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCftspcvsrv 669
Cdd:TIGR00917 692 EVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPC--------- 762
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 670 iqvepqaytephsntrysppppysshsfahethitmqstvqLRTEYDphthvyyttaeprseisvqpvTITQDTLSCQSP 749
Cdd:TIGR00917 763 -----------------------------------------IKTSKS---------------------SISAEKGSGQRK 780
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 750 EStsstrdllsqfsdsslhcleppctkwTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVP 829
Cdd:TIGR00917 781 AG--------------------------LLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLP 834
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 830 RETREYDFIAAQFKYFSFYNMYIVTQKADYPniqhllYDLHKSFSSVKYVMLEENKQLPQM-------------WLHYFR 896
Cdd:TIGR00917 835 QDSYLQIYFASLTPLLEVGPPFYIVIKGDYN------YTDFESQNKLCTMGGCDKDSIVNVfnnlsyiakpassWLDDYL 908
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 897 DWLQGLQDAFDSDWETGRimpnnYKNGSDDGVLAYKllvqtgsrdkpiDISQLTKQRlvdadgiINPSAFYIYLTAWVSN 976
Cdd:TIGR00917 909 VWLSPQASCCCRKFTNGT-----FCNGPDPQCFRCA------------DLSSDAQGR-------PSTTQFKEKLPWFLNA 964
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 977 DP--------VAYAASQANIRPHrpewvhdkadympetrlripaAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNY 1048
Cdd:TIGR00917 965 LPsadcakggHAAYSSAVDLQGY---------------------ATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKV 1023
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1049 T-SLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVELFGMMGLIGIKLS 1126
Cdd:TIGR00917 1024 SrSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLN 1103
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1127 AVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNHRAMLALEHMFAPVLDGAVST-LLGVLMLAGSEFDFIVRYFFAVLA 1204
Cdd:TIGR00917 1104 AVSVVNSVMHKGIAIEFCTHINAQFSTGKhFSRNHRAKEALGGMGSSVFSGITLTkLVGVVVLGFSRSEIFVVYYFRMYL 1183
|
810 820
....*....|....*....|..
gi 1958725020 1205 ILTVLGVLNGLVLLPVLLSFFG 1226
Cdd:TIGR00917 1184 ALVLLGFLHGLVFLPVLLSVLG 1205
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
509-663 |
4.22e-49 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 432497 [Multi-domain] Cd Length: 153 Bit Score: 171.62 E-value: 4.22e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 509 CSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTGECL 588
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRT--PRSLDVSERIAEAL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958725020 589 KRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTS 663
Cdd:pfam12349 79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCLRY 153
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
431-1188 |
1.02e-46 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 181.40 E-value: 1.02e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 431 HINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQkVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT-----ML 505
Cdd:pfam02460 162 FLKFDEEEVEEDSKEWEDELSQLLHNKYASEHIQ-FTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlsSY 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 506 RWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTqVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTG 585
Cdd:pfam02460 241 TIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRT--TATLSVKKRMG 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 586 ECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdlyrredrrldifccftspc 665
Cdd:pfam02460 318 EALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI-------------------- 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 666 vsrviqvepqaytephsntrysppppysshsfahethitmqstvqlrteydphthvyytTAEPrsEISVQPVTITQDTLS 745
Cdd:pfam02460 378 -----------------------------------------------------------CAKP--EAEGRHCLFVWATSS 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 746 CQSPESTSSTRDllsqfsdsSLHCLEPPctkwtLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLT 825
Cdd:pfam02460 397 PQRIDSEGSEPD--------KSHNIEQL-----KSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPD 463
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 826 DIVPRETREYDFIAAQFKYFSFY--NMYIVTQKADYPNIQHLLYDLHK---SFSSVKYVMleeNKQLPQMWLHYFRDWLQ 900
Cdd:pfam02460 464 KLVLEDSPLVEYLSLREKHFWPEglQIQVAVNNPPNLTIPESRDRMNEmvdEFENTPYSL---GPNSTLFWLREYENFLS 540
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 901 GLQDAFDSDWETGRIMpnnykngsddGVLAYKLLVQTGSrdkpidisqltkqrlvdadgiinpsafyiyltAWVSNdpva 980
Cdd:pfam02460 541 TLNMEEEEDEEKEWSY----------GNLPSFLKAPGNS--------------------------------HWAGD---- 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 981 yaasqanirphrpeWVHDKADYMpetrlripaaepIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGY 1060
Cdd:pfam02460 575 --------------LVWDDNTTM------------VTKFRFTLAGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDA 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1061 PFLfwEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIG 1140
Cdd:pfam02460 629 PFA--DQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFS 706
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 1958725020 1141 VEFTVHVALAFLTAIGDKNH-RAMLALEHMFAPVLDGAVSTLLGVLMLA 1188
Cdd:pfam02460 707 VDFSAHIAYHFVRSRGDTPAeRVVDALEALGWPVFQGGLSTILGVLVLL 755
|
|
| COG1033 |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
516-653 |
2.45e-09 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 223964 [Multi-domain] Cd Length: 727 Bit Score: 61.94 E-value: 2.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 516 VGLAGVLLVALSVAAGLGLCSLIGISFNAATtQVLPFLALGVGVDDVFLLAHAFSETGQNKriPFEDRTGECLKRTGASV 595
Cdd:COG1033 594 KAIIPLIPIAIVVGWNFGLMGLLGIPLTPAT-ATLGAIILGIGVDYSIHITERYREERKKG--GPKEAIETTVERTGKAI 670
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 596 ALTSISnvTAFFMAALI--PIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdLYRREDR 653
Cdd:COG1033 671 LASALT--TAIGFLALIfsPFPIISNFGLLTVIGILLSLLASLVLLPALLVL-LDGRRKR 727
|
|
| COG1033 |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
447-644 |
5.28e-09 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 223964 [Multi-domain] Cd Length: 727 Bit Score: 60.78 E-value: 5.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 447 QRTYVEVVHQSVAPNSTQKVLSFTTTTL-------DDILKSF-SDVSVIRVASGYLLMLA-YACLTMLRWdcsksqgavG 517
Cdd:COG1033 153 DAQKEEIYEEIERIIEIAKFPSGVKLYLtgdpairYQILREIqKDMVVLLALAVILMVIVlYYVFRSVRR---------A 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 518 LAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLaLGVGVDDVFLLAHAFSETGQNKRIPFEdRTGECLKRTGASVAL 597
Cdd:COG1033 224 LLPLIIVLVSVLWTLGAMGLLGIPLTITTSAVPPLL-IGIGIDYGVHFHNRYEEERRKGRTVEE-AVVEAIKHTGPAVLI 301
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1958725020 598 TSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILS 644
Cdd:COG1033 302 AALTTAAGFLSLLTSSIPAIKEFGILLSIGIILAFLSSLTVLPALLI 348
|
|
| COG1033 |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1033-1205 |
1.17e-08 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 223964 [Multi-domain] Cd Length: 727 Bit Score: 59.62 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1033 DFVEAIEKVrvicnnYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTV 1112
Cdd:COG1033 534 EILRDIEKE------NIPTGVKVYVTGESVIYVEMNELLTSSQLISTVLGIILVFALLLIIFRSPLKAIIPLIPIAIVVG 607
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1113 ELFGMMGLIGIKLSavPVVILIAS--VGIGVEFTVHVALAFLTAIgDKNHRA---MLALEHMFAPVLDGAVSTLLGVLML 1187
Cdd:COG1033 608 WNFGLMGLLGIPLT--PATATLGAiiLGIGVDYSIHITERYREER-KKGGPKeaiETTVERTGKAILASALTTAIGFLAL 684
|
170
....*....|....*...
gi 1958725020 1188 AGSEFDFIvRYFFAVLAI 1205
Cdd:COG1033 685 IFSPFPII-SNFGLLTVI 701
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
476-659 |
2.58e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 55.23 E-value: 2.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 476 DILKSFSDVSVIRVASGYLLMLAYACLTMLRWdcsksqgAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLaL 555
Cdd:TIGR00921 186 DIEREFGKDMGTTMAISGILVVLVLLLDFKRW-------WRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPML-I 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 556 GVGVDDVFLLAHAFSETGQNKRiPFEDRTGECLKRTGASVALTSISNVtAFFMAALIPI-PALRAFSLQAAVVVVFNFAM 634
Cdd:TIGR00921 258 GVGIDYGIQTLNRYEEERDIGR-AKGEAIVTAVRRTGRAVLIALLTTS-AGFAALALSEfPMVSEFGLGLVAGLITAYLL 335
|
170 180
....*....|....*....|....*.
gi 1958725020 635 VLLIFPAIL-SMDLYRREDRRLDIFC 659
Cdd:TIGR00921 336 TLLVLPALLqSIDIGREKVKKEIIAI 361
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
516-643 |
3.66e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 51.76 E-value: 3.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 516 VGLAGVLLVALSVAAGLGLCSLIGISFNAaTTQVLPFLALGVGVDDVFLLAHAFSETgQNKRIPFEDRTgECLKRTGASV 595
Cdd:TIGR00921 593 KAVFPLIAIGSGILWAIGLMGLRGIPSFL-AMATTISIILGLGMDYSIHLAERYFEE-RKEHGPKEAIT-HTMERTGPGI 669
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1958725020 596 ALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAIL 643
Cdd:TIGR00921 670 LFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
448-643 |
1.91e-05 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 49.23 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 448 RTYVEVVhQSVAPNSTQKVLSFTTTTlDDILKSFsdvsvIRVASGYLLMLAYACLTMLRwdcSKSQGAVGLAGVLLVALS 527
Cdd:TIGR03480 683 RRFVRAV-RKVAPDATGAPVSILESG-DTVVGAF-----LQAFIYALVAITVLLLLTLR---RVRDVLLVLAPLLLAGLL 752
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 528 VAAglgLCSLIGISFNAATTQVLPFLaLGVGVDDVFLLAHAFSEtGQNKRIPFEDRTGEclkrtgaSVALTSISNVTAFF 607
Cdd:TIGR03480 753 TVA---AMVLLGIPFNFANIIALPLL-LGLGVDFGIYMVHRWRN-GVDSGNLLQSSTAR-------AVFFSALTTATAFG 820
|
170 180 190
....*....|....*....|....*....|....*.
gi 1958725020 608 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAIL 643
Cdd:TIGR03480 821 SLAVSSHPGTASMGILLSLGLGLTLLCTLIFLPALL 856
|
|
| COG1033 |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1075-1206 |
1.13e-04 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 223964 [Multi-domain] Cd Length: 727 Bit Score: 46.91 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1075 LLLAISVvlactFLVCAVFLL--NPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAF 1151
Cdd:COG1033 200 VLLALAV-----ILMVIVLYYvfRSVRRALLPLIIVLVSVLWtLGAMGLLGIPLTITTSAVPPLLIGIGIDYGVHFHNRY 274
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1958725020 1152 L--TAIGDKNHRAML-ALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRyfFAVLAIL 1206
Cdd:COG1033 275 EeeRRKGRTVEEAVVeAIKHTGPAVLIAALTTAAGFLSLLTSSIPAIKE--FGILLSI 330
|
|
| YdfJ |
COG2409 |
Uncharacterized membrane protein YdfJ, MMPL/SSD domain [Function unknown]; |
514-645 |
2.58e-04 |
|
Uncharacterized membrane protein YdfJ, MMPL/SSD domain [Function unknown];
Pssm-ID: 225272 [Multi-domain] Cd Length: 937 Bit Score: 45.49 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 514 GAVGLAGVLL--VALSVAAGLGLCSLIGISFNAAT-TQVLPF---LALGVGVD-DVFLLA---HAFSEtGQNKripfEDR 583
Cdd:COG2409 206 RSVITAFLPLitVGLSLLVAQGIVALLAYAFGLGVsTFALSLlvaLGIGAGTDyALFLVSryrEELRE-GQDR----EAA 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958725020 584 TGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSM 645
Cdd:COG2409 281 VGTAYRTAGKTVAFSGLTVAIALLGLSFARLPFLKTLGIAAAIGVAVAVLAALTLLPALLAL 342
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
437-645 |
2.98e-04 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 44.59 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 437 DRAAAILEAwqrtyvevVHQSVAPNSTQKVLSFTTTTLDDILKSFS-DVSVIRVASgylLMLAYACLTMLRwdcsksqGA 515
Cdd:pfam03176 104 ESVAAVRDA--------VEQAPPPEGLKAYLTGPAATVADLRDAGDrDLGLIEAVT---LVVIFIILLIVY-------RS 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 516 VGLAGVLL--VALSVAAGLGLCS-LIGISFNAATTQVLPF---LALGVGVD-DVFLLA--HAFSETGQNKripfEDRTGE 586
Cdd:pfam03176 166 VVAALLPLltVGLSLGAAQGLVAiLAHILGIGLSTFALNLlvvLLIAVGTDyALFLVSryREELRAGEDR----EEAVIR 241
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1958725020 587 CLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSM 645
Cdd:pfam03176 242 AVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
1076-1198 |
4.98e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.83 E-value: 4.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1076 LLAISVVLactflVCAVFLL--NPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1152
Cdd:TIGR00921 198 TMAISGIL-----VVLVLLLdfKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYE 272
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1958725020 1153 TAIG---DKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRY 1198
Cdd:TIGR00921 273 EERDigrAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEF 321
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1077-1205 |
8.15e-04 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 223911 [Multi-domain] Cd Length: 1009 Bit Score: 44.14 E-value: 8.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 1077 LAISVVLActFLVCAVFLLNpWTAGIIVMV---LALMTVelFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLT 1153
Cdd:COG0841 335 LFEAIVLV--VLVMYLFLGN-LRATLIPALavpVSLLGT--FAVMYAFGFSLNTLTLFALVLAIGLLVDDAIVVVENIER 409
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1958725020 1154 AIGDKNHR--AMLALEHMFAPVLDGAVSTLLG---VLMLAGS--EFdfiVRYFFAVLAI 1205
Cdd:COG0841 410 HMRGLPPReaAEKAMGEIGGAVIAITLVLIAVflpMAFMGGStgEL---FRQFAITIAV 465
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
478-641 |
1.29e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 226709 [Multi-domain] Cd Length: 788 Bit Score: 43.32 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 478 LKSFSD---VSVIRVASGYLL--MLAYACLTMLRWDCSKsqGAVGLAGVLLVALSVAAGLGLCsliGISFNAATTQVLpF 552
Cdd:COG4258 633 RKSTFDrlfAAYRYVLAGLLAgaLALVLCLAVARRGWRR--GLRVLLPSVLALGCGLAVLAMA---GVPLNLFHLLAL-V 706
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725020 553 LALGVGVDdvflLAHAFSETGQNKRIPFedrtgeclkRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNF 632
Cdd:COG4258 707 LVLGVGIN----YALFFSNAGDPRAEPL---------TTLLALALAMLTTLLTFGLLAFSATPVLSSFGITLASGIILAF 773
|
....*....
gi 1958725020 633 AMVLLIFPA 641
Cdd:COG4258 774 VLAPLAMPD 782
|
|
|