|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
178-1201 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 1801.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 178 QVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELI 257
Cdd:TIGR00918 91 EVGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPS 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 258 TETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHG 337
Cdd:TIGR00918 171 TEGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSQVESWEEMLKKAAVGQG 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 338 YMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPK 417
Cdd:TIGR00918 251 YMERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPK 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 418 QMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLM- 496
Cdd:TIGR00918 331 QMYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMl 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 497 ---------------------------------------------------VLPFLALGVGVDDVFLLAHAFSETGQNkr 525
Cdd:TIGR00918 411 ayacltmlrwdcaksqgsvglagvllvalsvaaglglcallgisfnaattqVLPFLALGVGVDDVFLLAHAFSETGQN-- 488
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 526 IPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDI 605
Cdd:TIGR00918 489 IPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDI 568
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 606 FCCFTSPCVSRVIQVEPQAYTEPHSntrysppppySSHSFAHethitMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPv 685
Cdd:TIGR00918 569 FCCFFSPCSARVIQIEPQAYADGSA----------PPVYSSH-----MQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQP- 632
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 686 titQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTR 765
Cdd:TIGR00918 633 ---SDPLSCQSPDIAGSTRDLLSQFEDSKAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTR 709
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 766 VRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQK-ADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFR 844
Cdd:TIGR00918 710 VQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYNMYAVTQGnFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFR 789
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 845 DWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 924
Cdd:TIGR00918 790 DWLQGLQKAFDEDWRDGRITKENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSN 869
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 925 DPVAYAASQANIRPHRPEWVHDKADYMPETrLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSY 1004
Cdd:TIGR00918 870 DPVAYAASQANIYPHPPEWLHDKNDYDPEN-LRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSY 948
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1005 PNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIAS 1084
Cdd:TIGR00918 949 PSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIAS 1028
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1085 VGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLV 1164
Cdd:TIGR00918 1029 VGIGVEFTVHIALGFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLV 1108
|
1050 1060 1070
....*....|....*....|....*....|....*..
gi 1958725032 1165 LLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVR 1201
Cdd:TIGR00918 1109 LLPVLLSMFGPEPEVSPAEGRSRLPTPSPEPPPGGVR 1145
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
477-1136 |
5.55e-39 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 157.52 E-value: 5.55e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 477 ILKSFSDVSVIRVASGYLLMVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTGECLKRTGASVALTSISNVTAFFM 556
Cdd:pfam02460 263 IVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRT--TATLSVKKRMGEALSEAGVSITITSLTDVLSFGI 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 557 AALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdlyrredrrldifccftspcvsrviqvepqaytephsntrysp 636
Cdd:pfam02460 341 GTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI------------------------------------------- 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 637 pppysshsfahethitmqstvqlrteydphthvyytTAEPrsEISVQPVTITQDTLSCQSPESTSSTRDllsqfsdsSLH 716
Cdd:pfam02460 378 ------------------------------------CAKP--EAEGRHCLFVWATSSPQRIDSEGSEPD--------KSH 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 717 CLEPPctkwtLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFY 796
Cdd:pfam02460 412 NIEQL-----KSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFWPE 486
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 797 --NMYIVTQKADYPNIQHLLYDLHK---SFSSVKYVMleeNKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMpnnykng 871
Cdd:pfam02460 487 glQIQVAVNNPPNLTIPESRDRMNEmvdEFENTPYSL---GPNSTLFWLREYENFLSTLNMEEEEDEEKEWSY------- 556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 872 sddGVLAYKLLVQTGSrdkpidisqltkqrlvdadgiinpsafyiyltAWVSNdpvayaasqanirphrpeWVHDKADYM 951
Cdd:pfam02460 557 ---GNLPSFLKAPGNS--------------------------------HWAGD------------------LVWDDNTTM 583
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 952 petrlripaaepIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLfwEQYISLRHWLLLAISVVL 1031
Cdd:pfam02460 584 ------------VTKFRFTLAGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDAPFA--DQYLTILPSTIQNIVITL 649
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1032 ACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNH-RA 1110
Cdd:pfam02460 650 ICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAeRV 729
|
650 660
....*....|....*....|....*.
gi 1958725032 1111 MLALEHMFAPVLDGAVSTLLGVLMLA 1136
Cdd:pfam02460 730 VDALEALGWPVFQGGLSTILGVLVLL 755
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
493-1155 |
6.34e-16 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 83.37 E-value: 6.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 493 YLLMVLPFLALGVGVDD-VFLLAHAFSETGQNKriPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQ 571
Cdd:COG1033 272 PLTILVPPLLLAIGIDYgIHLLNRYREERRKGL--DKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIV 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 572 AAVVVVFNFAMVLLIFPAILSMdLYRREDRRldifccftspcvsrviqvepqaytephsntrysppppysshsfahethi 651
Cdd:COG1033 350 AAIGVLLAFLTSLTLLPALLSL-LPRPKPKT------------------------------------------------- 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 652 tmqstvqlrteydphthvyyttaeprseisvqpvtitqdtlscQSPESTSSTRDLLSQFSDsslhcleppctkwtlssFA 731
Cdd:COG1033 380 -------------------------------------------RRLKKPPELGRLLAKLAR-----------------FV 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 732 EKHYapfllrpkakVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREY---DFIAAQFKYFSFYNMYIVTQKADYP 808
Cdd:COG1033 400 LRRP----------KVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRqdlDFIEENFGGSDPLEVVVDTGEPDGL 469
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 809 NIQHLLYDLHKsfssvkyvMLEENKQLPQ----MWLHYFRDWLQGLQDAFDSDWETgriMPNNykngsDDGVLAYKLLVQ 884
Cdd:COG1033 470 KDPEVLKEIDR--------LQDYLESLPEvgkvLSLADLVKELNQALNEGDPKYYA---LPES-----RELLAQLLLLLS 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 885 TGSRDkpidisqlTKQRLVDADGiinpsafyiyltawvsndpvayaaSQANIRphrpewvhdkadympetrlripaaepi 964
Cdd:COG1033 534 SPPGD--------DLSRFVDEDY------------------------SAARVT--------------------------- 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 965 eyaqfpFYLNGLrDTSDFVEAIEKVR-VICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLL 1043
Cdd:COG1033 555 ------VRLKDL-DSEEIKALVEEVRaFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR 627
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1044 NpWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI--GDKNHRAML-ALEHMFA 1119
Cdd:COG1033 628 S-LRLGLISLIPNLLPILLtFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERrkGGDLEEAIRrALRTTGK 706
|
650 660 670
....*....|....*....|....*....|....*.
gi 1958725032 1120 PVLDGAVSTLLGVLMLAGSEFDFIVRyfFAVLAILT 1155
Cdd:COG1033 707 AILFTSLTLAAGFGVLLFSSFPPLAD--FGLLLALG 740
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
178-1201 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 1801.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 178 QVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELI 257
Cdd:TIGR00918 91 EVGGRVSQELAYTRQKIGEEAMFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPS 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 258 TETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHG 337
Cdd:TIGR00918 171 TEGGYIEQILEKLIPCLIITPLDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSQVESWEEMLKKAAVGQG 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 338 YMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPK 417
Cdd:TIGR00918 251 YMERPCLNPADPDCPDTAPNKNSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPK 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 418 QMYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLM- 496
Cdd:TIGR00918 331 QMYEHFKGYYKVHHIGWNEEKAAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMl 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 497 ---------------------------------------------------VLPFLALGVGVDDVFLLAHAFSETGQNkr 525
Cdd:TIGR00918 411 ayacltmlrwdcaksqgsvglagvllvalsvaaglglcallgisfnaattqVLPFLALGVGVDDVFLLAHAFSETGQN-- 488
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 526 IPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDI 605
Cdd:TIGR00918 489 IPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDI 568
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 606 FCCFTSPCVSRVIQVEPQAYTEPHSntrysppppySSHSFAHethitMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPv 685
Cdd:TIGR00918 569 FCCFFSPCSARVIQIEPQAYADGSA----------PPVYSSH-----MQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQP- 632
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 686 titQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTR 765
Cdd:TIGR00918 633 ---SDPLSCQSPDIAGSTRDLLSQFEDSKAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTR 709
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 766 VRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQK-ADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFR 844
Cdd:TIGR00918 710 VQDGLDLTDIVPRDTNEHDFLDAQFRYFSFYNMYAVTQGnFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFR 789
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 845 DWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSN 924
Cdd:TIGR00918 790 DWLQGLQKAFDEDWRDGRITKENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSN 869
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 925 DPVAYAASQANIRPHRPEWVHDKADYMPETrLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSY 1004
Cdd:TIGR00918 870 DPVAYAASQANIYPHPPEWLHDKNDYDPEN-LRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSY 948
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1005 PNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIAS 1084
Cdd:TIGR00918 949 PSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIAS 1028
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1085 VGIGVEFTVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLV 1164
Cdd:TIGR00918 1029 VGIGVEFTVHIALGFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLV 1108
|
1050 1060 1070
....*....|....*....|....*....|....*..
gi 1958725032 1165 LLPVLLSFFGPCPEVSPANGLNRLPTPSPEPPPSVVR 1201
Cdd:TIGR00918 1109 LLPVLLSMFGPEPEVSPAEGRSRLPTPSPEPPPGGVR 1145
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
497-1174 |
1.96e-51 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 199.37 E-value: 1.96e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 497 VLPFLALGVGVDDVFLLAHAF---------SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRA 567
Cdd:TIGR00917 642 VIPFLVLAVGVDNIFILVFFYfyleyfyrqVGVDNEQELTLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRV 721
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 568 FSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCftspcvsrviqvepqaytephsntrysppppysshsfah 647
Cdd:TIGR00917 722 FSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPC--------------------------------------- 762
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 648 ethitmqstvqLRTEYDPHTHvyYTTAEPRSEisvqpvtitqdtlSCqspestsstrdllsqfsdsslhcleppctkwtL 727
Cdd:TIGR00917 763 -----------IKTSKSSISA--EKGSGQRKA-------------GL--------------------------------L 784
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 728 SSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADY 807
Cdd:TIGR00917 785 TRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLEVGPPFYIVIKGDY 864
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 808 PniqhllYDLHKSFSSVKYVMLEENKQLPQM-------------WLHYFRDWLQGLQDAFDSDWETGRimpnnYKNGSDD 874
Cdd:TIGR00917 865 N------YTDFESQNKLCTMGGCDKDSIVNVfnnlsyiakpassWLDDYLVWLSPQASCCCRKFTNGT-----FCNGPDP 933
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 875 GVLAYKllvqtgsrdkpiDISQLTKQRlvdadgiINPSAFYIYLTAWVSNDP--------VAYAASQANIRPHrpewvhd 946
Cdd:TIGR00917 934 QCFRCA------------DLSSDAQGR-------PSTTQFKEKLPWFLNALPsadcakggHAAYSSAVDLQGY------- 987
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 947 kadympetrlripaAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYT-SLGLSSYPNGYPFLFWEQYISLRHWLLL 1025
Cdd:TIGR00917 988 --------------ATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSrSSKMEVYPYSVFYVFFEQYLTIWKTAII 1053
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1026 AISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI- 1103
Cdd:TIGR00917 1054 NLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKh 1133
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958725032 1104 GDKNHRAMLALEHMFAPVLDGAVST-LLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFG 1174
Cdd:TIGR00917 1134 FSRNHRAKEALGGMGSSVFSGITLTkLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
477-1136 |
5.55e-39 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 157.52 E-value: 5.55e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 477 ILKSFSDVSVIRVASGYLLMVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTGECLKRTGASVALTSISNVTAFFM 556
Cdd:pfam02460 263 IVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRT--TATLSVKKRMGEALSEAGVSITITSLTDVLSFGI 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 557 AALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdlyrredrrldifccftspcvsrviqvepqaytephsntrysp 636
Cdd:pfam02460 341 GTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI------------------------------------------- 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 637 pppysshsfahethitmqstvqlrteydphthvyytTAEPrsEISVQPVTITQDTLSCQSPESTSSTRDllsqfsdsSLH 716
Cdd:pfam02460 378 ------------------------------------CAKP--EAEGRHCLFVWATSSPQRIDSEGSEPD--------KSH 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 717 CLEPPctkwtLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFY 796
Cdd:pfam02460 412 NIEQL-----KSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFWPE 486
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 797 --NMYIVTQKADYPNIQHLLYDLHK---SFSSVKYVMleeNKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMpnnykng 871
Cdd:pfam02460 487 glQIQVAVNNPPNLTIPESRDRMNEmvdEFENTPYSL---GPNSTLFWLREYENFLSTLNMEEEEDEEKEWSY------- 556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 872 sddGVLAYKLLVQTGSrdkpidisqltkqrlvdadgiinpsafyiyltAWVSNdpvayaasqanirphrpeWVHDKADYM 951
Cdd:pfam02460 557 ---GNLPSFLKAPGNS--------------------------------HWAGD------------------LVWDDNTTM 583
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 952 petrlripaaepIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLfwEQYISLRHWLLLAISVVL 1031
Cdd:pfam02460 584 ------------VTKFRFTLAGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDAPFA--DQYLTILPSTIQNIVITL 649
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1032 ACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNH-RA 1110
Cdd:pfam02460 650 ICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAeRV 729
|
650 660
....*....|....*....|....*.
gi 1958725032 1111 MLALEHMFAPVLDGAVSTLLGVLMLA 1136
Cdd:pfam02460 730 VDALEALGWPVFQGGLSTILGVLVLL 755
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
497-611 |
3.32e-36 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 134.63 E-value: 3.32e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 497 VLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVV 576
Cdd:pfam12349 41 VIPFLVLAIGVDNIFLLVKAVVRT--PRSLDVSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAV 118
|
90 100 110
....*....|....*....|....*....|....*
gi 1958725032 577 VFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTS 611
Cdd:pfam12349 119 LFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
493-1155 |
6.34e-16 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 83.37 E-value: 6.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 493 YLLMVLPFLALGVGVDD-VFLLAHAFSETGQNKriPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQ 571
Cdd:COG1033 272 PLTILVPPLLLAIGIDYgIHLLNRYREERRKGL--DKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIV 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 572 AAVVVVFNFAMVLLIFPAILSMdLYRREDRRldifccftspcvsrviqvepqaytephsntrysppppysshsfahethi 651
Cdd:COG1033 350 AAIGVLLAFLTSLTLLPALLSL-LPRPKPKT------------------------------------------------- 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 652 tmqstvqlrteydphthvyyttaeprseisvqpvtitqdtlscQSPESTSSTRDLLSQFSDsslhcleppctkwtlssFA 731
Cdd:COG1033 380 -------------------------------------------RRLKKPPELGRLLAKLAR-----------------FV 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 732 EKHYapfllrpkakVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREY---DFIAAQFKYFSFYNMYIVTQKADYP 808
Cdd:COG1033 400 LRRP----------KVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRqdlDFIEENFGGSDPLEVVVDTGEPDGL 469
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 809 NIQHLLYDLHKsfssvkyvMLEENKQLPQ----MWLHYFRDWLQGLQDAFDSDWETgriMPNNykngsDDGVLAYKLLVQ 884
Cdd:COG1033 470 KDPEVLKEIDR--------LQDYLESLPEvgkvLSLADLVKELNQALNEGDPKYYA---LPES-----RELLAQLLLLLS 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 885 TGSRDkpidisqlTKQRLVDADGiinpsafyiyltawvsndpvayaaSQANIRphrpewvhdkadympetrlripaaepi 964
Cdd:COG1033 534 SPPGD--------DLSRFVDEDY------------------------SAARVT--------------------------- 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 965 eyaqfpFYLNGLrDTSDFVEAIEKVR-VICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLL 1043
Cdd:COG1033 555 ------VRLKDL-DSEEIKALVEEVRaFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR 627
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1044 NpWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI--GDKNHRAML-ALEHMFA 1119
Cdd:COG1033 628 S-LRLGLISLIPNLLPILLtFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERrkGGDLEEAIRrALRTTGK 706
|
650 660 670
....*....|....*....|....*....|....*.
gi 1958725032 1120 PVLDGAVSTLLGVLMLAGSEFDFIVRyfFAVLAILT 1155
Cdd:COG1033 707 AILFTSLTLAAGFGVLLFSSFPPLAD--FGLLLALG 740
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
968-1175 |
7.36e-13 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 73.36 E-value: 7.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 968 QFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWT 1047
Cdd:COG1033 165 VVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRG 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1048 AGIIVMVLALMTVELFGMMGLIGIKLS----AVPVVILiasvGIGVEFTVHVALAFLTAI---GDKNHRAMLALEHMFAP 1120
Cdd:COG1033 245 VLLPLLVVLLAVIWTLGLMGLLGIPLSpltiLVPPLLL----AIGIDYGIHLLNRYREERrkgLDKREALREALRKLGPP 320
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958725032 1121 VLDGAVSTLLGVLMLAGSEFDfIVRYF---------FAVLAILTvlgvlnglvLLPVLLSFFGP 1175
Cdd:COG1033 321 VLLTSLTTAIGFLSLLFSDIP-PIRDFgivaaigvlLAFLTSLT---------LLPALLSLLPR 374
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
495-602 |
1.20e-08 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 59.87 E-value: 1.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 495 LMVLPfLALGVGVDDVFLLAHAFSE---TGQNKRIPFEdrtgECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQ 571
Cdd:COG1033 662 AVVAS-IALGIGVDYTIHFLSRYREerrKGGDLEEAIR----RALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLL 736
|
90 100 110
....*....|....*....|....*....|.
gi 1958725032 572 AAVVVVFNFAMVLLIFPAILSMdLYRREDRR 602
Cdd:COG1033 737 LALGLLVALLAALLLLPALLLL-LDPRIAKK 766
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
1018-1138 |
5.42e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 51.01 E-value: 5.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1018 SLRH--WLLLAISVVLActFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFtvhv 1095
Cdd:COG4258 636 RYRNdaLWLLLLALLLI--LLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDY---- 709
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1958725032 1096 ALAFLTAIGDKNHRAmlalEHMFAPVLdGAVSTLLGVLMLAGS 1138
Cdd:COG4258 710 ALFFTEGLLDKGELA----RTLLSILL-AALTTLLGFGLLAFS 747
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
485-591 |
2.71e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 45.60 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 485 SVIRVASGYL-LMVLPF---------LALGVGVDDVFLLAHAFSETgQNKRIPFEDRTgECLKRTGASVALTSISNVTAF 554
Cdd:TIGR00921 603 SGILWAIGLMgLRGIPSflamattisIILGLGMDYSIHLAERYFEE-RKEHGPKEAIT-HTMERTGPGILFSGLTTAGGF 680
|
90 100 110
....*....|....*....|....*....|....*..
gi 1958725032 555 FMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAIL 591
Cdd:TIGR00921 681 LSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
1024-1146 |
4.99e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.83 E-value: 4.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725032 1024 LLAISVVLactflVCAVFLL--NPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1100
Cdd:TIGR00921 198 TMAISGIL-----VVLVLLLdfKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYE 272
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1958725032 1101 TAIG---DKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRY 1146
Cdd:TIGR00921 273 EERDigrAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEF 321
|
|
| |
