|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
1-1055 |
0e+00 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 1889.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 1 MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITP 80
Cdd:TIGR00918 112 MFTPQLLIQTPHQEGANVLTPEALLQHLDSALKASRVHVYLYNRQWGLEHLCYKSGEPSTEGGYIEQILEKLIPCLIITP 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 81 LDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNK 160
Cdd:TIGR00918 192 LDCFWEGAKLQGGTAYLPGKPPLQWTNLDPASFLEELKQKMSQVESWEEMLKKAAVGQGYMERPCLNPADPDCPDTAPNK 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 161 NSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDR 240
Cdd:TIGR00918 272 NSTQPPDVAAVLSGGCYGLSAKYMHWQEELIVGGTKRNRSGKLLSAQALQSMFQLMTPKQMYEHFKGYYKVHHIGWNEEK 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 241 AAAILEAWQRTYVEVVHQSVAPNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGL 320
Cdd:TIGR00918 352 AAAVLEAWQRNFSEEVQQSLPKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTMLRWDCAKSQGSVGL 431
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 321 AGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNkrIPFEDRTGECLKRTGASVALT 400
Cdd:TIGR00918 432 AGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQN--IPFEERTGECLKRTGASVVLT 509
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 401 SISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYT 480
Cdd:TIGR00918 510 SISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSPCSARVIQIEPQAYA 589
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 481 EPHSntrysppppySSHSFAHethitMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPvtitQDTLSCQSPESTSSTRDL 560
Cdd:TIGR00918 590 DGSA----------PPVYSSH-----MQSTVQLRTEYDPGTQHYYTTNEPRSHLSVQP----SDPLSCQSPDIAGSTRDL 650
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 561 LSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Cdd:TIGR00918 651 LSQFEDSKAACLSLPCARWTLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFL 730
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 641 AAQFKYFSFYNMYIVTQK-ADYPNIQHLLYDLHKSFSSVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMP 719
Cdd:TIGR00918 731 DAQFRYFSFYNMYAVTQGnFDYPTQQQLLYDLHQSFSSVKYVLKEDNGQLPRMWLHYFRDWLQGLQKAFDEDWRDGRITK 810
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 720 NNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVH 799
Cdd:TIGR00918 811 ENYRNGSDDAVLAYKLLVQTGHRDKPVDKEQLTTQRLVNADGIINPNAFYIYLSAWVSNDPVAYAASQANIYPHPPEWLH 890
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 800 DKADYMPETrLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLL 879
Cdd:TIGR00918 891 DKNDYDPEN-LRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSYPSGYPFLFWEQYMGLRHWLLL 969
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 880 AISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGD 959
Cdd:TIGR00918 970 SISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIGD 1049
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 960 KNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGPCPEVSPANGL 1039
Cdd:TIGR00918 1050 RNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPEPEVSPAEGR 1129
|
1050
....*....|....*.
gi 1958725055 1040 NRLPTPSPEPPPSVVR 1055
Cdd:TIGR00918 1130 SRLPTPSPEPPPGGVR 1145
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
247-1028 |
1.45e-67 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 249.83 E-value: 1.45e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 247 AWQRTYVEVVHQSVAPNsTQKVLSFTT-TTLDDILKSFSDVSVIRVASGYLLMLAYACLTM-----LRWDCSKSQGAVGL 320
Cdd:TIGR00917 533 AWEKAFIQLAKDELLPM-VQATISFSAeRSIEDELKRESTADVITIAISYLVMFAYISLTLgdsprLKSLYVTSKVLLGL 611
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 321 AGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAF---------SETGQNKRIPFEDRTGECLK 391
Cdd:TIGR00917 612 SGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqVGVDNEQELTLERRLSRALM 691
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 392 RTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCftspcvsrv 471
Cdd:TIGR00917 692 EVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPC--------- 762
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 472 iqvepqaytephsntrysppppysshsfahethitmqstvqLRTEYDphthvyyttaeprseisvqpvTITQDTLSCQSP 551
Cdd:TIGR00917 763 -----------------------------------------IKTSKS---------------------SISAEKGSGQRK 780
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 552 EStsstrdllsqfsdsslhcleppctkwTLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVP 631
Cdd:TIGR00917 781 AG--------------------------LLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLP 834
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 632 RETREYDFIAAQFKYFSFYNMYIVTQKADYPniqhllYDLHKSFSSVKYVMLEENKQLPQMWLHYFR------DWLQGLQ 705
Cdd:TIGR00917 835 QDSYLQIYFASLTPLLEVGPPFYIVIKGDYN------YTDFESQNKLCTMGGCDKDSIVNVFNNLSYiakpasSWLDDYL 908
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 706 DAFDSDWETGRIMPNN--YKNGSDDGVLAYKllvqtgsrdkpiDISQLTKQRlvdadgiINPSAFYIYLTAWVSNDP--- 780
Cdd:TIGR00917 909 VWLSPQASCCCRKFTNgtFCNGPDPQCFRCA------------DLSSDAQGR-------PSTTQFKEKLPWFLNALPsad 969
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 781 -----VAYAASQANIRPHrpewvhdkadympetrlripaAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYT-SLG 854
Cdd:TIGR00917 970 cakggHAAYSSAVDLQGY---------------------ATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSrSSK 1028
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 855 LSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVV 933
Cdd:TIGR00917 1029 MEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLqLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVV 1108
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 934 ILIASVGIGVEFTVHVALAFLTAI-GDKNHRAMLALEHMFAPVLDGAVST-LLGVLMLAGSEFDFIVRYFFAVLAILTVL 1011
Cdd:TIGR00917 1109 NSVMHKGIAIEFCTHINAQFSTGKhFSRNHRAKEALGGMGSSVFSGITLTkLVGVVVLGFSRSEIFVVYYFRMYLALVLL 1188
|
810
....*....|....*..
gi 1958725055 1012 GVLNGLVLLPVLLSFFG 1028
Cdd:TIGR00917 1189 GFLHGLVFLPVLLSVLG 1205
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
311-465 |
2.07e-49 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 172.00 E-value: 2.07e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 311 CSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTGECL 390
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRT--PRSLDVSERIAEAL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958725055 391 KRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTS 465
Cdd:pfam12349 79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
233-990 |
1.21e-45 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 177.93 E-value: 1.21e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 233 HINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQkVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLT-----ML 307
Cdd:pfam02460 162 FLKFDEEEVEEDSKEWEDELSQLLHNKYASEHIQ-FTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVsvtlsSY 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 308 RWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTqVLPFLALGVGVDDVFLLAHAFSETgqNKRIPFEDRTG 387
Cdd:pfam02460 241 TIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVC-VTPFLVLAIGVDDMFLMVAAWQRT--TATLSVKKRMG 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 388 ECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdlyrredrrldifccftspc 467
Cdd:pfam02460 318 EALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI-------------------- 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 468 vsrviqvepqaytephsntrysppppysshsfahethitmqstvqlrteydphthvyytTAEPrsEISVQPVTITQDTLS 547
Cdd:pfam02460 378 -----------------------------------------------------------CAKP--EAEGRHCLFVWATSS 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 548 CQSPESTSSTRDllsqfsdsSLHCLEPPctkwtLSSFAEKHYAPFLLRPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLT 627
Cdd:pfam02460 397 PQRIDSEGSEPD--------KSHNIEQL-----KSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPD 463
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 628 DIVPRETREYDFIAAQFKYFSFY--NMYIVTQKADYPNIQHLLYDLHK---SFSSVKYVMleeNKQLPQMWLHYFRDWLQ 702
Cdd:pfam02460 464 KLVLEDSPLVEYLSLREKHFWPEglQIQVAVNNPPNLTIPESRDRMNEmvdEFENTPYSL---GPNSTLFWLREYENFLS 540
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 703 GLQDAFDSDWETGRIMpnnykngsddGVLAYKLLVQTGSrdkpidisqltkqrlvdadgiinpsafyiyltAWVSNdpva 782
Cdd:pfam02460 541 TLNMEEEEDEEKEWSY----------GNLPSFLKAPGNS--------------------------------HWAGD---- 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 783 yaasqanirphrpeWVHDKADYMpetrlripaaepIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGY 862
Cdd:pfam02460 575 --------------LVWDDNTTM------------VTKFRFTLAGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDA 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 863 PFLfwEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIG 942
Cdd:pfam02460 629 PFA--DQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFS 706
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 1958725055 943 VEFTVHVALAFLTAIGDKNH-RAMLALEHMFAPVLDGAVSTLLGVLMLA 990
Cdd:pfam02460 707 VDFSAHIAYHFVRSRGDTPAeRVVDALEALGWPVFQGGLSTILGVLVLL 755
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
277-1009 |
1.37e-19 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 94.93 E-value: 1.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 277 DDILKSFSDVSVIRVASGYLLMLAYACLTMLRWdcsksqgAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTqVLPFLA 356
Cdd:COG1033 210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL-------RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 357 LGVGVDD-VFLLAHAFSETGQNKriPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFA 435
Cdd:COG1033 282 LAIGIDYgIHLLNRYREERRKGL--DKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFL 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 436 MVLLIFPAILSMdLYRREDRRldifccftspcvsrviqvepqaytephsntrysppppysshsfahethitmqstvqlrt 515
Cdd:COG1033 360 TSLTLLPALLSL-LPRPKPKT----------------------------------------------------------- 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 516 eydphthvyyttaeprseisvqpvtitqdtlscQSPESTSSTRDLLSQFSDsslhcleppctkwtlssFAEKHYapfllr 595
Cdd:COG1033 380 ---------------------------------RRLKKPPELGRLLAKLAR-----------------FVLRRP------ 403
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 596 pkakVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREY---DFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLH 672
Cdd:COG1033 404 ----KVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRqdlDFIEENFGGSDPLEVVVDTGEPDGLKDPEVLKEID 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 673 KsfssvkyvMLEENKQLPQ----MWLHYFRDWLQGLQDAFDSDWETgriMPNNykngsDDGVLAYKLLVQTGSRDkpidi 748
Cdd:COG1033 480 R--------LQDYLESLPEvgkvLSLADLVKELNQALNEGDPKYYA---LPES-----RELLAQLLLLLSSPPGD----- 538
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 749 sqlTKQRLVDADGiinpsafyiyltawvsndpvayaaSQANIRphrpewvhdkadympetrlripaaepieyaqfpFYLN 828
Cdd:COG1033 539 ---DLSRFVDEDY------------------------SAARVT---------------------------------VRLK 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 829 GLrDTSDFVEAIEKVR-VICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNpWTAGIIVM 907
Cdd:COG1033 559 DL-DSEEIKALVEEVRaFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRS-LRLGLISL 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 908 VLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI--GDKNHRAML-ALEHMFAPVLDGAVSTL 983
Cdd:COG1033 637 IPNLLPILLtFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERrkGGDLEEAIRrALRTTGKAILFTSLTLA 716
|
730 740
....*....|....*....|....*.
gi 1958725055 984 LGVLMLAGSEFDFIVRyfFAVLAILT 1009
Cdd:COG1033 717 AGFGVLLFSSFPPLAD--FGLLLALG 740
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
318-456 |
5.69e-13 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 73.74 E-value: 5.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 318 VGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPfLALGVGVDDVFLLAHAFSEtGQNKRIPFEDRTGECLKRTGASV 397
Cdd:COG1033 631 LGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYTIHFLSRYRE-ERRKGGDLEEAIRRALRTTGKAI 708
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1958725055 398 ALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMdLYRREDRR 456
Cdd:COG1033 709 LFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLL-LDPRIAKK 766
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
822-1029 |
2.21e-12 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 71.81 E-value: 2.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 822 QFPFYLNGLRDTSDFVEAIEKVRVICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLAISVVLACTFLVCAVFLLNPWT 901
Cdd:COG1033 165 VVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRG 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 902 AGIIVMVLALMTVELFGMMGLIGIKLS----AVPVVILiasvGIGVEFTVHVALAFLTAI---GDKNHRAMLALEHMFAP 974
Cdd:COG1033 245 VLLPLLVVLLAVIWTLGLMGLLGIPLSpltiLVPPLLL----AIGIDYGIHLLNRYREERrkgLDKREALREALRKLGPP 320
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958725055 975 VLDGAVSTLLGVLMLAGSEFDfIVRYF---------FAVLAILTvlgvlnglvLLPVLLSFFGP 1029
Cdd:COG1033 321 VLLTSLTTAIGFLSLLFSDIP-PIRDFgivaaigvlLAFLTSLT---------LLPALLSLLPR 374
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
278-461 |
2.27e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 55.23 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 278 DILKSFSDVSVIRVASGYLLMLAYACLTMLRWdcsksqgAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLaL 357
Cdd:TIGR00921 186 DIEREFGKDMGTTMAISGILVVLVLLLDFKRW-------WRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPML-I 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 358 GVGVDDVFLLAHAFSETGQNKRiPFEDRTGECLKRTGASVALTSISNVtAFFMAALIPI-PALRAFSLQAAVVVVFNFAM 436
Cdd:TIGR00921 258 GVGIDYGIQTLNRYEEERDIGR-AKGEAIVTAVRRTGRAVLIALLTTS-AGFAALALSEfPMVSEFGLGLVAGLITAYLL 335
|
170 180
....*....|....*....|....*.
gi 1958725055 437 VLLIFPAIL-SMDLYRREDRRLDIFC 461
Cdd:TIGR00921 336 TLLVLPALLqSIDIGREKVKKEIIAI 361
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
318-445 |
3.24e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 51.76 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 318 VGLAGVLLVALSVAAGLGLCSLIGISFNAaTTQVLPFLALGVGVDDVFLLAHAFSETgQNKRIPFEDRTgECLKRTGASV 397
Cdd:TIGR00921 593 KAVFPLIAIGSGILWAIGLMGLRGIPSFL-AMATTISIILGLGMDYSIHLAERYFEE-RKEHGPKEAIT-HTMERTGPGI 669
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1958725055 398 ALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAIL 445
Cdd:TIGR00921 670 LFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
872-992 |
6.78e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 50.62 E-value: 6.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 872 SLRH--WLLLAISVVLActFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFtvhv 949
Cdd:COG4258 636 RYRNdaLWLLLLALLLI--LLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDY---- 709
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1958725055 950 ALAFLTAIGDKNHRAmlalEHMFAPVLdGAVSTLLGVLMLAGS 992
Cdd:COG4258 710 ALFFTEGLLDKGELA----RTLLSILL-AALTTLLGFGLLAFS 747
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
290-443 |
7.31e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 50.62 E-value: 7.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 290 RVASGYLLMLAYA---CLTMLRwdcskSQGAVGLAGVLLV-ALSVAAGLGLCSLIGISFNAATTQVLpFLALGVGVD-DV 364
Cdd:COG4258 638 RNDALWLLLLALLlilLLLLLR-----LRSLRRALRVLLPpLLAVLLTLAILGLLGIPLNLFHLIAL-LLVLGIGIDyAL 711
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958725055 365 FllahaFSETGQNKRIpfedrtgecLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPA 443
Cdd:COG4258 712 F-----FTEGLLDKGE---------LARTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLLAPLLAPR 776
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
250-445 |
2.00e-05 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 49.23 E-value: 2.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 250 RTYVEVVhQSVAPNSTQKVLSFTTTTlDDILKSFsdvsvIRVASGYLLMLAYACLTMLRwdcSKSQGAVGLAGVLLVALS 329
Cdd:TIGR03480 683 RRFVRAV-RKVAPDATGAPVSILESG-DTVVGAF-----LQAFIYALVAITVLLLLTLR---RVRDVLLVLAPLLLAGLL 752
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 330 VAAglgLCSLIGISFNAATTQVLPFLaLGVGVDDVFLLAHAFSEtGQNKRIPFEDRTGEclkrtgaSVALTSISNVTAFF 409
Cdd:TIGR03480 753 TVA---AMVLLGIPFNFANIIALPLL-LGLGVDFGIYMVHRWRN-GVDSGNLLQSSTAR-------AVFFSALTTATAFG 820
|
170 180 190
....*....|....*....|....*....|....*.
gi 1958725055 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAIL 445
Cdd:TIGR03480 821 SLAVSSHPGTASMGILLSLGLGLTLLCTLIFLPALL 856
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
316-447 |
4.05e-05 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 47.84 E-value: 4.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 316 GAVGLAGV--LLVALSVAAGLGLCSLIG--ISFNAATTQVLPFLALGVGVD-DVFLLAhAFSE---TGQNKripfEDRTG 387
Cdd:COG2409 191 RSLVAALLplLTAGLAVGVALGLLALLAafTDVSSFAPNLLTMLGLGVGIDyALFLVS-RYREelrAGEDR----EEAVA 265
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958725055 388 ECLKRTGASVAltsISNVT---AFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSM 447
Cdd:COG2409 266 RAVATAGRAVL---FSGLTvaiALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPALLAL 325
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
284-456 |
1.80e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 46.00 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 284 SDVSVIRVASGY----LLMLAYACLTMLrwdcsksqgavgLAGVLLVALSVAAGLGLCSLI-----GISFNAATTqvlpf 354
Cdd:COG4258 249 HDISTIGLISLLgillLLLLVFRSLRPL------------LLGLLPVAVGALAGLAAVSLVfgsvhGITLGFGSS----- 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 355 LaLGVGVD-DVFLLAHAFSETGQNKRIPfedrtgecLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFN 433
Cdd:COG4258 312 L-IGVAVDySLHYLTHRRAAGEWDPRAA--------LRRIWPTLLLGLLTTVLGYLALLFSPFPGLRQLGVFAAAGLLAA 382
|
170 180
....*....|....*....|...
gi 1958725055 434 FAMVLLIFPAilsmdLYRREDRR 456
Cdd:COG4258 383 ALTTLLWLPL-----LLPRAAPR 400
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
239-447 |
2.62e-04 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 44.59 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 239 DRAAAILEAwqrtyvevVHQSVAPNSTQKVLSFTTTTLDDILKSFS-DVSVIRVASgylLMLAYACLTMLRwdcsksqGA 317
Cdd:pfam03176 104 ESVAAVRDA--------VEQAPPPEGLKAYLTGPAATVADLRDAGDrDLGLIEAVT---LVVIFIILLIVY-------RS 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 318 VGLAGVLL--VALSVAAGLGLCS-LIGISFNAATTQVLPF---LALGVGVD-DVFLLA--HAFSETGQNKripfEDRTGE 388
Cdd:pfam03176 166 VVAALLPLltVGLSLGAAQGLVAiLAHILGIGLSTFALNLlvvLLIAVGTDyALFLVSryREELRAGEDR----EEAVIR 241
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1958725055 389 CLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSM 447
Cdd:pfam03176 242 AVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
878-1000 |
4.42e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.83 E-value: 4.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958725055 878 LLAISVVLactflVCAVFLL--NPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 954
Cdd:TIGR00921 198 TMAISGIL-----VVLVLLLdfKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYE 272
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1958725055 955 TAIG---DKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRY 1000
Cdd:TIGR00921 273 EERDigrAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEF 321
|
|
| |
