NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958745363|ref|XP_038953279|]
View 

zinc finger protein 236 isoform X7 [Rattus norvegicus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-618 3.62e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 3.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  213 EADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRG--FVSAGVLKAHVRTHTGLKSFKCLICNG-AFTTGGSL 289
Cdd:COG5048     29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPlSNSKASSS 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  290 RRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQEASSMDEESTvdqqsiqvSAPMPVEIESAELQQ 369
Cdd:COG5048    109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--------SLHPPLPANSLSKDP 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  370 TPETVAADPESILELGPQHvvgtEDTALGQQLADQPLEADDEdgfaaSQAPLPGHMDQFEEQGTPQPSFESAgLPQGFTV 449
Cdd:COG5048    181 SSNLSLLISSNVSTSIPSS----SENSPLSSSYSIPSSSSDQ-----NLENSSSSLPLTTNSQLSPKSLLSQ-SPSSLSS 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  450 TDTYSQQTSFPPVQQLQDSSTLESQALSTSFHQQNLLQVPSSDAINvatrllPESSQEDlDLQTHRPQFLGDSEDQSRRS 529
Cdd:COG5048    251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCN------ISFSRSS-PLTRHLRSVNHSGESLKPFS 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  530 YRCDYCHKGFKKSSHLKQHVRSHTGEKPYKCKLCGRGFVSSGVLKS-------HEKTHTGVKAFSCSV--CSASFTTNGS 600
Cdd:COG5048    324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSN 403

                          410
                   ....*....|....*...
gi 1958745363  601 LTRHMATHMSMKPYKCPF 618
Cdd:COG5048    404 LSLHIITHLSFRPYNCKN 421
FhaB super family cl27105
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 900-1176 1.02e-07

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG3210:

Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 57.08  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  900 ASVSAGGDLTVSL--TDGSLATLEGIQLQLAANLVGPNVQIS--GIDASSINNITLQIDPSILQQTLQQSSLLAQPITGE 975
Cdd:COG3210    802 GTITAAGTTAINVtgSGGTITINTATTGLTGTGDTTSGAGGSntTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGS 881

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  976 SSTASQNSSLQTSDSTVPASVVIQPISGLSLQPTVTSANLTIGPLSEQDSVLTTSNTGTQDLPQVMTSQGLVSTSTGphe 1055
Cdd:COG3210    882 GGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAAS--- 958

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1056 ITLTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSNGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLA 1135
Cdd:COG3210    959 ASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAA 1038

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1958745363 1136 DTQGMLPGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGS 1176
Cdd:COG3210   1039 TAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGG 1079
zf-H2C2_2 pfam13465
Zinc-finger double domain;
744-768 1.28e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.83  E-value: 1.28e-06
                           10        20
                   ....*....|....*....|....*
gi 1958745363  744 DLVRHVRIHTGEKPYKCDECGKSFT 768
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
522-865 6.64e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 6.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  522 SEDQSRRSYRCDYCHKGFKKSSHLKQHVRSHTGEKPYKCKLCGRGFVSSGVLKSH---EKTHTGVKAFSCSVCSASFTTN 598
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSrhlRTHHNNPSDLNSKSLPLSNSKA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  599 GSLTRHMATHMSMKPYKCPFC----EEGFRTAIHCRKHMK-RHQAVSSVASAVAETEG-------GDTCVEEDEENSDRS 666
Cdd:COG5048    106 SSSSLSSSSSNSNDNNLLSSHslppSSRDPQLPDLLSISNlRNNPLPGNNSSSVNTPQsnslhppLPANSLSKDPSSNLS 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  667 ASRKPRPEVITFTEEETAQLaKIQPQESATVSEKVLVQSAAEKDRISEMKDKQAELEAEPKHANC----CTYCPKSFKKP 742
Cdd:COG5048    186 LLISSNVSTSIPSSSENSPL-SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSssdsSSSASESPRSS 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  743 SDLVRHVRIH----------TGEKPYKCDECGKSFTVKSTLDCHVKT--HTGQKL--FSCHV--CSNAFSTKGSLKVHMR 806
Cdd:COG5048    265 LPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCPYslCGKLFSRNDALKRHIL 344

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958745363  807 LHTGAKPFKCP--HCELRFRTSGRRKTHMQFHYKSDPKKARKPVTRSSSENLQSVNLLNSS 865
Cdd:COG5048    345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLS 405
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1300-1324 1.22e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 1.22e-05
                           10        20
                   ....*....|....*....|....*
gi 1958745363 1300 LERHSRIHTGERPFHCTLCEKAFNQ 1324
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-138 1.08e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958745363  113 SLKVHIRLHTGVRPFACPHCDKKFRT 138
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1327-1352 1.57e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.57e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958745363 1327 ALQVHMKKHTGERPYRCDYCVMGFTQ 1352
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1222-1270 1.37e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 1.37e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958745363 1222 CLDCDRAFSSAAVLMHHSKEVHGKerihgCRVCRKAFKRATHLKEHMLT 1270
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKHFK-----CHICHKKLYTAGGLAVHCLQ 47
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 43-65 1.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|...
gi 1958745363   43 HVCPYCTKEFRKPSDLVRHIRIH 65
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 69-117 1.77e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 1.77e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958745363   69 KPFkCPQCFRAFAVKSTLTAHIKTHTgikaFKCQYCMKSFSTSGSLKVH 117
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-618 3.62e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 3.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  213 EADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRG--FVSAGVLKAHVRTHTGLKSFKCLICNG-AFTTGGSL 289
Cdd:COG5048     29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPlSNSKASSS 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  290 RRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQEASSMDEESTvdqqsiqvSAPMPVEIESAELQQ 369
Cdd:COG5048    109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--------SLHPPLPANSLSKDP 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  370 TPETVAADPESILELGPQHvvgtEDTALGQQLADQPLEADDEdgfaaSQAPLPGHMDQFEEQGTPQPSFESAgLPQGFTV 449
Cdd:COG5048    181 SSNLSLLISSNVSTSIPSS----SENSPLSSSYSIPSSSSDQ-----NLENSSSSLPLTTNSQLSPKSLLSQ-SPSSLSS 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  450 TDTYSQQTSFPPVQQLQDSSTLESQALSTSFHQQNLLQVPSSDAINvatrllPESSQEDlDLQTHRPQFLGDSEDQSRRS 529
Cdd:COG5048    251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCN------ISFSRSS-PLTRHLRSVNHSGESLKPFS 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  530 YRCDYCHKGFKKSSHLKQHVRSHTGEKPYKCKLCGRGFVSSGVLKS-------HEKTHTGVKAFSCSV--CSASFTTNGS 600
Cdd:COG5048    324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSN 403

                          410
                   ....*....|....*...
gi 1958745363  601 LTRHMATHMSMKPYKCPF 618
Cdd:COG5048    404 LSLHIITHLSFRPYNCKN 421
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 900-1176 1.02e-07

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 57.08  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  900 ASVSAGGDLTVSL--TDGSLATLEGIQLQLAANLVGPNVQIS--GIDASSINNITLQIDPSILQQTLQQSSLLAQPITGE 975
Cdd:COG3210    802 GTITAAGTTAINVtgSGGTITINTATTGLTGTGDTTSGAGGSntTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGS 881

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  976 SSTASQNSSLQTSDSTVPASVVIQPISGLSLQPTVTSANLTIGPLSEQDSVLTTSNTGTQDLPQVMTSQGLVSTSTGphe 1055
Cdd:COG3210    882 GGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAAS--- 958

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1056 ITLTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSNGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLA 1135
Cdd:COG3210    959 ASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAA 1038

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1958745363 1136 DTQGMLPGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGS 1176
Cdd:COG3210   1039 TAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGG 1079
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 969-1212 7.90e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 53.43  E-value: 7.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  969 AQPITGESSTASQNSSLQTSDSTVPASVViqPISglslqPTVTSANLTIGPlseqdsvltTSNTGTQDLPQVMTSQGLVS 1048
Cdd:pfam17823  179 ASSTTAASSTTAASSAPTTAASSAPATLT--PAR-----GISTAATATGHP---------AAGTALAAVGNSSPAAGTVT 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1049 TSTGPHEITLTINNSSLSQVLAQAAGptaSSSSGSPQEITLTISELNPSNGSLPS-TAPMSPSA------ISAQNLVMSS 1121
Cdd:pfam17823  243 AAVGTVTPAALATLAAAAGTVASAAG---TINMGDPHARRLSPAKHMPSDTMARNpAAPMGAQAqgpiiqVSTDQPVHNT 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1122 SGVGADASVTLTLADTQGMLPGGLDTVTLNITSQGQQFPALLTDPSLSgqgGAGSPQVILVSHTPQPS------SAAG-- 1193
Cdd:pfam17823  320 AGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLH---TSMIPEVEATSPTTQPSpllptqGAAGpg 396

                          250       260
                   ....*....|....*....|....
gi 1958745363 1194 -----EEIAYQVTDVSAQLSPNSQ 1212
Cdd:pfam17823  397 illapEQVATEATAGTASAGPTPR 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
744-768 1.28e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.83  E-value: 1.28e-06
                           10        20
                   ....*....|....*....|....*
gi 1958745363  744 DLVRHVRIHTGEKPYKCDECGKSFT 768
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
522-865 6.64e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 6.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  522 SEDQSRRSYRCDYCHKGFKKSSHLKQHVRSHTGEKPYKCKLCGRGFVSSGVLKSH---EKTHTGVKAFSCSVCSASFTTN 598
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSrhlRTHHNNPSDLNSKSLPLSNSKA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  599 GSLTRHMATHMSMKPYKCPFC----EEGFRTAIHCRKHMK-RHQAVSSVASAVAETEG-------GDTCVEEDEENSDRS 666
Cdd:COG5048    106 SSSSLSSSSSNSNDNNLLSSHslppSSRDPQLPDLLSISNlRNNPLPGNNSSSVNTPQsnslhppLPANSLSKDPSSNLS 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  667 ASRKPRPEVITFTEEETAQLaKIQPQESATVSEKVLVQSAAEKDRISEMKDKQAELEAEPKHANC----CTYCPKSFKKP 742
Cdd:COG5048    186 LLISSNVSTSIPSSSENSPL-SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSssdsSSSASESPRSS 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  743 SDLVRHVRIH----------TGEKPYKCDECGKSFTVKSTLDCHVKT--HTGQKL--FSCHV--CSNAFSTKGSLKVHMR 806
Cdd:COG5048    265 LPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCPYslCGKLFSRNDALKRHIL 344

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958745363  807 LHTGAKPFKCP--HCELRFRTSGRRKTHMQFHYKSDPKKARKPVTRSSSENLQSVNLLNSS 865
Cdd:COG5048    345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLS 405
zf-H2C2_2 pfam13465
Zinc-finger double domain;
232-257 8.56e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 8.56e-06
                           10        20
                   ....*....|....*....|....*.
gi 1958745363  232 HLKQHIRSHTGEKPFKCSQCGRGFVS 257
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1300-1324 1.22e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 1.22e-05
                           10        20
                   ....*....|....*....|....*
gi 1958745363 1300 LERHSRIHTGERPFHCTLCEKAFNQ 1324
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03255 PHA03255
BDLF3; Provisional
 969-1106 4.90e-05

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 46.44  E-value: 4.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  969 AQPITGESSTASQNSSLQTSDSTVPASVVIQPISGLSLQPTVTSANLTIGPLSeqdsvlTTSNTGTQDLPQVMTSQGLVS 1048
Cdd:PHA03255    40 TTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPVP------TTSNASTINVTTKVTAQNITA 113

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958745363 1049 TSTGPHEIT-LTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSNGSLPsTAP 1106
Cdd:PHA03255   114 TEAGTGTSTgVTSNVTTRSSSTTSATTRITNATTLAPTLSSKGTSNATKTTAELP-TVP 171
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-138 1.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958745363  113 SLKVHIRLHTGVRPFACPHCDKKFRT 138
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 216-267 1.23e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.77  E-value: 1.23e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958745363  216 RPYkCFYCHRAYKKSCHLKQHIRSHTgekpFKCSQCGRGFVSAGVLKAHVRT 267
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1327-1352 1.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.57e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958745363 1327 ALQVHMKKHTGERPYRCDYCVMGFTQ 1352
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
800-825 2.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.95e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958745363  800 SLKVHMRLHTGAKPFKCPHCELRFRT 825
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1222-1270 1.37e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 1.37e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958745363 1222 CLDCDRAFSSAAVLMHHSKEVHGKerihgCRVCRKAFKRATHLKEHMLT 1270
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKHFK-----CHICHKKLYTAGGLAVHCLQ 47
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 43-65 1.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|...
gi 1958745363   43 HVCPYCTKEFRKPSDLVRHIRIH 65
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 69-117 1.77e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 1.77e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958745363   69 KPFkCPQCFRAFAVKSTLTAHIKTHTgikaFKCQYCMKSFSTSGSLKVH 117
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 756-805 2.39e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 2.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958745363  756 KPYkCDECGKSFTVKSTLDCHVKTHTgqklFSCHVCSNAFSTKGSLKVHM 805
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
PHA00733 PHA00733
hypothetical protein
 96-146 3.40e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 3.40e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958745363   96 IKAFKCQYCMKSFSTSGSLKVHIRL--HTGVrpfaCPHCDKKFRTSGHRKTHV 146
Cdd:PHA00733    71 VSPYVCPLCLMPFSSSVSLKQHIRYteHSKV----CPVCGKEFRNTDSTLDHV 119
zf-H2C2_2 pfam13465
Zinc-finger double domain;
86-110 4.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 4.26e-03
                           10        20
                   ....*....|....*....|....*
gi 1958745363   86 LTAHIKTHTGIKAFKCQYCMKSFST 110
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-618 3.62e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 3.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  213 EADRPYKCFYCHRAYKKSCHLKQHIRSHTGEKPFKCSQCGRG--FVSAGVLKAHVRTHTGLKSFKCLICNG-AFTTGGSL 289
Cdd:COG5048     29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSLPlSNSKASSS 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  290 RRHMGIHNDLRPYMCPYCQKTFKTSLNCKKHMKTHRYELAQQLQQHQEASSMDEESTvdqqsiqvSAPMPVEIESAELQQ 369
Cdd:COG5048    109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSN--------SLHPPLPANSLSKDP 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  370 TPETVAADPESILELGPQHvvgtEDTALGQQLADQPLEADDEdgfaaSQAPLPGHMDQFEEQGTPQPSFESAgLPQGFTV 449
Cdd:COG5048    181 SSNLSLLISSNVSTSIPSS----SENSPLSSSYSIPSSSSDQ-----NLENSSSSLPLTTNSQLSPKSLLSQ-SPSSLSS 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  450 TDTYSQQTSFPPVQQLQDSSTLESQALSTSFHQQNLLQVPSSDAINvatrllPESSQEDlDLQTHRPQFLGDSEDQSRRS 529
Cdd:COG5048    251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCN------ISFSRSS-PLTRHLRSVNHSGESLKPFS 323

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  530 YRCDYCHKGFKKSSHLKQHVRSHTGEKPYKCKLCGRGFVSSGVLKS-------HEKTHTGVKAFSCSV--CSASFTTNGS 600
Cdd:COG5048    324 CPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSN 403

                          410
                   ....*....|....*...
gi 1958745363  601 LTRHMATHMSMKPYKCPF 618
Cdd:COG5048    404 LSLHIITHLSFRPYNCKN 421
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 900-1176 1.02e-07

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 57.08  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  900 ASVSAGGDLTVSL--TDGSLATLEGIQLQLAANLVGPNVQIS--GIDASSINNITLQIDPSILQQTLQQSSLLAQPITGE 975
Cdd:COG3210    802 GTITAAGTTAINVtgSGGTITINTATTGLTGTGDTTSGAGGSntTDTTTGTTSDGASGGGTAGANSGSLAATAASITVGS 881

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  976 SSTASQNSSLQTSDSTVPASVVIQPISGLSLQPTVTSANLTIGPLSEQDSVLTTSNTGTQDLPQVMTSQGLVSTSTGphe 1055
Cdd:COG3210    882 GGVATSTGTANAGTLTNLGTTTNAASGNGAVLATVTATGTGGGGLTGGNAAAGGTGAGNGTTALSGTQGNAGLSAAS--- 958

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1056 ITLTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSNGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLA 1135
Cdd:COG3210    959 ASDGAGDTGASSAAGSSAVGTSANSAGSTGGVIAATGILVAGNSGTTASTTGGSGAIVAGGNGVTGTTGTASATGTGTAA 1038

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1958745363 1136 DTQGMLPGGLDTVTLNITSQGQQFPALLTDPSLSGQGGAGS 1176
Cdd:COG3210   1039 TAGGQNGVGVNASGISGGNAAALTASGTAGTTGGTAASNGG 1079
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 969-1212 7.90e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 53.43  E-value: 7.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  969 AQPITGESSTASQNSSLQTSDSTVPASVViqPISglslqPTVTSANLTIGPlseqdsvltTSNTGTQDLPQVMTSQGLVS 1048
Cdd:pfam17823  179 ASSTTAASSTTAASSAPTTAASSAPATLT--PAR-----GISTAATATGHP---------AAGTALAAVGNSSPAAGTVT 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1049 TSTGPHEITLTINNSSLSQVLAQAAGptaSSSSGSPQEITLTISELNPSNGSLPS-TAPMSPSA------ISAQNLVMSS 1121
Cdd:pfam17823  243 AAVGTVTPAALATLAAAAGTVASAAG---TINMGDPHARRLSPAKHMPSDTMARNpAAPMGAQAqgpiiqVSTDQPVHNT 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1122 SGVGADASVTLTLADTQGMLPGGLDTVTLNITSQGQQFPALLTDPSLSgqgGAGSPQVILVSHTPQPS------SAAG-- 1193
Cdd:pfam17823  320 AGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLH---TSMIPEVEATSPTTQPSpllptqGAAGpg 396

                          250       260
                   ....*....|....*....|....
gi 1958745363 1194 -----EEIAYQVTDVSAQLSPNSQ 1212
Cdd:pfam17823  397 illapEQVATEATAGTASAGPTPR 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
744-768 1.28e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.83  E-value: 1.28e-06
                           10        20
                   ....*....|....*....|....*
gi 1958745363  744 DLVRHVRIHTGEKPYKCDECGKSFT 768
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
522-865 6.64e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 6.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  522 SEDQSRRSYRCDYCHKGFKKSSHLKQHVRSHTGEKPYKCKLCGRGFVSSGVLKSH---EKTHTGVKAFSCSVCSASFTTN 598
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSrhlRTHHNNPSDLNSKSLPLSNSKA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  599 GSLTRHMATHMSMKPYKCPFC----EEGFRTAIHCRKHMK-RHQAVSSVASAVAETEG-------GDTCVEEDEENSDRS 666
Cdd:COG5048    106 SSSSLSSSSSNSNDNNLLSSHslppSSRDPQLPDLLSISNlRNNPLPGNNSSSVNTPQsnslhppLPANSLSKDPSSNLS 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  667 ASRKPRPEVITFTEEETAQLaKIQPQESATVSEKVLVQSAAEKDRISEMKDKQAELEAEPKHANC----CTYCPKSFKKP 742
Cdd:COG5048    186 LLISSNVSTSIPSSSENSPL-SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSssdsSSSASESPRSS 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  743 SDLVRHVRIH----------TGEKPYKCDECGKSFTVKSTLDCHVKT--HTGQKL--FSCHV--CSNAFSTKGSLKVHMR 806
Cdd:COG5048    265 LPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLkpFSCPYslCGKLFSRNDALKRHIL 344

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958745363  807 LHTGAKPFKCP--HCELRFRTSGRRKTHMQFHYKSDPKKARKPVTRSSSENLQSVNLLNSS 865
Cdd:COG5048    345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLS 405
zf-H2C2_2 pfam13465
Zinc-finger double domain;
232-257 8.56e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 8.56e-06
                           10        20
                   ....*....|....*....|....*.
gi 1958745363  232 HLKQHIRSHTGEKPFKCSQCGRGFVS 257
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
544-569 9.25e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 9.25e-06
                           10        20
                   ....*....|....*....|....*.
gi 1958745363  544 HLKQHVRSHTGEKPYKCKLCGRGFVS 569
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1300-1324 1.22e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 1.22e-05
                           10        20
                   ....*....|....*....|....*
gi 1958745363 1300 LERHSRIHTGERPFHCTLCEKAFNQ 1324
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 934-1129 2.33e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 49.14  E-value: 2.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  934 PNVQISGIDASSINNITLQIDPSILQQTLQQSSLLA----QPITGESSTASQNSSLQTSDSTVPA---SVVIQPISGLSL 1006
Cdd:pfam05109  567 PNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQAnttnHTLGGTSSTPVVTSPPKNATSAVTTgqhNITSSSTSSMSL 646

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1007 QPTVTSAnlTIGPLSEQDS-----VLTTSN-TGTQDLPQVMTSqglvstSTGPHEITlTINNSSLSQVLAQAAGPTASSS 1080
Cdd:pfam05109  647 RPSSISE--TLSPSTSDNStshmpLLTSAHpTGGENITQVTPA------STSTHHVS-TSSPAPRPGTTSQASGPGNSST 717

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958745363 1081 SGSPQEITLTiselnpsNGSLP--STAPMSPSAISAQNLVMSSSGVGADAS 1129
Cdd:pfam05109  718 STKPGEVNVT-------KGTPPknATSPQAPSGQKTAVPTVTSTGGKANST 761
PHA03255 PHA03255
BDLF3; Provisional
 969-1106 4.90e-05

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 46.44  E-value: 4.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  969 AQPITGESSTASQNSSLQTSDSTVPASVVIQPISGLSLQPTVTSANLTIGPLSeqdsvlTTSNTGTQDLPQVMTSQGLVS 1048
Cdd:PHA03255    40 TTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPVP------TTSNASTINVTTKVTAQNITA 113

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958745363 1049 TSTGPHEIT-LTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSNGSLPsTAP 1106
Cdd:PHA03255   114 TEAGTGTSTgVTSNVTTRSSSTTSATTRITNATTLAPTLSSKGTSNATKTTAELP-TVP 171
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-138 1.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 1.08e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958745363  113 SLKVHIRLHTGVRPFACPHCDKKFRT 138
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 216-267 1.23e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.77  E-value: 1.23e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958745363  216 RPYkCFYCHRAYKKSCHLKQHIRSHTgekpFKCSQCGRGFVSAGVLKAHVRT 267
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 945-1221 1.37e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.11  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  945 SINNITLQIDPSILQQTLQQSSLLAQPITGESST--ASQNSSLQTSDSTVPASVVIQPISGLSLQPTVTSANLTIGPLSE 1022
Cdd:pfam17823   43 SGDAVPRADNKSSEQ*NFCAATAAPAPVTLTKGTsaAHLNSTEVTAEHTPHGTDLSEPATREGAADGAASRALAAAASSS 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1023 QDSVLTTSNTGTQDLPQVMTSQGLVSTSTGPHEIT-LTINNSSLSQVLAQAAGPTASSSSGSPQEITLTISELNPSNGSL 1101
Cdd:pfam17823  123 PSSAAQSLPAAIAALPSEAFSAPRAAACRANASAApRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSA 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1102 PST-APMSPSAISAQNLVMSSSG-VGADASVTLTLADTQGMLPGGLDTVTLNITSQGQQfpallTDPSLSGQGGAGSPqv 1179
Cdd:pfam17823  203 PATlTPARGISTAATATGHPAAGtALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAG-----TVASAAGTINMGDP-- 275

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1958745363 1180 ilVSHTPQPSSaageeiaYQVTDVSAQ-LSPNSQPEKEGPLHQ 1221
Cdd:pfam17823  276 --HARRLSPAK-------HMPSDTMARnPAAPMGAQAQGPIIQ 309
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1327-1352 1.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.57e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958745363 1327 ALQVHMKKHTGERPYRCDYCVMGFTQ 1352
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
600-625 1.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.91e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958745363  600 SLTRHMATHMSMKPYKCPFCEEGFRT 625
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 244-293 2.52e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.00  E-value: 2.52e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958745363  244 KPFkCSQCGRGFVSAGVLKAHVRTHTglksFKCLICNGAFTTGGSLRRHM 293
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
800-825 2.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.95e-04
                           10        20
                   ....*....|....*....|....*.
gi 1958745363  800 SLKVHMRLHTGAKPFKCPHCELRFRT 825
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
FhaB COG3210
Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, ...
 848-1175 4.14e-04

Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442443 [Multi-domain]  Cd Length: 1698  Bit Score: 45.14  E-value: 4.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  848 VTRSSSENLQSVNLLNSSATDPNVFIMNNSVLTGQFDQNMLQPGLVGQAILPASVSAGGDLTVSLTDGSLATLEGIQLQL 927
Cdd:COG3210    509 GIATGLTGITAGGGGGGNATSGGTGGDGTTLSGSGLTTTVSGGASGTTAASGSNTANTLGVLAATGGTSNATTAGNSTSA 588

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363  928 AANLVGPNVQISGIDASSINNITLQIDPSILQQTLQQSSLLAQPITGESSTASQNSSLQTSDSTVPASVVIQPISGLSLQ 1007
Cdd:COG3210    589 TGGTGTNSGGTVLSIGTGSAGATGTITLGAGTSGAGANATGGGAGLTGSAVGAALSGTGSGTTGTASANGSNTTGVNTAG 668

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1008 PTVTSANLTIGPLSEQDSVLTTSNTGTQDLP--------------QVMTSQGLVSTSTGpheITLTINNSSLSQVLAQAA 1073
Cdd:COG3210    669 GTGGGTTGTVTSGATGGTTGTTLNAATGGTLnnagntltistgsiTVTGQIGALANANG---DTVTFGNLGTGATLTLNA 745

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958745363 1074 GPTAssSSGSPQEITLTISE----------LNPSNGSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLADTQGmlpg 1143
Cdd:COG3210    746 GVTI--TSGNAGTLSIGLTAnttasgttltLANANGNTSAGATLDNAGAEISIDITADGTITAAGTTAINVTGSGG---- 819

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1958745363 1144 gldTVTLNITSQGQQFPALLTDPSLSGQGGAG 1175
Cdd:COG3210    820 ---TITINTATTGLTGTGDTTSGAGGSNTTDT 848
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 530-552 4.98e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 4.98e-04
                           10        20
                   ....*....|....*....|...
gi 1958745363  530 YRCDYCHKGFKKSSHLKQHVRSH 552
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 1222-1270 1.37e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 1.37e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958745363 1222 CLDCDRAFSSAAVLMHHSKEVHGKerihgCRVCRKAFKRATHLKEHMLT 1270
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKHFK-----CHICHKKLYTAGGLAVHCLQ 47
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 43-65 1.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|...
gi 1958745363   43 HVCPYCTKEFRKPSDLVRHIRIH 65
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 69-117 1.77e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 1.77e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958745363   69 KPFkCPQCFRAFAVKSTLTAHIKTHTgikaFKCQYCMKSFSTSGSLKVH 117
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-313 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 2.31e-03
                           10        20
                   ....*....|....*....|....*.
gi 1958745363  288 SLRRHMGIHNDLRPYMCPYCQKTFKT 313
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 756-805 2.39e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 2.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1958745363  756 KPYkCDECGKSFTVKSTLDCHVKTHTgqklFSCHVCSNAFSTKGSLKVHM 805
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
PHA00733 PHA00733
hypothetical protein
 96-146 3.40e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 3.40e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958745363   96 IKAFKCQYCMKSFSTSGSLKVHIRL--HTGVrpfaCPHCDKKFRTSGHRKTHV 146
Cdd:PHA00733    71 VSPYVCPLCLMPFSSSVSLKQHIRYteHSKV----CPVCGKEFRNTDSTLDHV 119
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1277-1346 3.52e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 3.52e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958745363 1277 LSSQKPRVFKCDTCEKAFAKPSQLERHSRIHTGERPFHCTLCEKAFNQK--SALQVHMKKHTGERPYRCDYC 1346
Cdd:COG5048     26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKS 97
zf-H2C2_2 pfam13465
Zinc-finger double domain;
86-110 4.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 4.26e-03
                           10        20
                   ....*....|....*....|....*
gi 1958745363   86 LTAHIKTHTGIKAFKCQYCMKSFST 110
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1313-1335 4.67e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 4.67e-03
                           10        20
                   ....*....|....*....|...
gi 1958745363 1313 FHCTLCEKAFNQKSALQVHMKKH 1335
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 732-752 5.79e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 5.79e-03
                           10        20
                   ....*....|....*....|.
gi 1958745363  732 CTYCPKSFKKPSDLVRHVRIH 752
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
57-81 6.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 6.56e-03
                           10        20
                   ....*....|....*....|....*
gi 1958745363   57 DLVRHIRIHTHEKPFKCPQCFRAFA 81
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 532-576 6.64e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 6.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958745363  532 CDYCHKGFKKSSHLKQHVRSHTgekpYKCKLCGRGFVSSGVLKSH 576
Cdd:cd20908      4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 218-240 6.98e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 6.98e-03
                           10        20
                   ....*....|....*....|...
gi 1958745363  218 YKCFYCHRAYKKSCHLKQHIRSH 240
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH