NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1958759450|ref|XP_038960025|]
View 

integrin alpha-6 isoform X2 [Rattus norvegicus]

Protein Classification

integrin alpha( domain architecture ID 12192641)

integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 465-939 1.62e-168

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 502.62  E-value: 1.62e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  465 RPVINILKTITVTPSRIDLRQKSmCGSPSG--ICLKVKACFEYTAKPsGYNPPISILGILEAEKERRKsGLSSRVQFrNQ 542
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKP-IPNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  543 GSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSNEAKTVQTDVHFL 622
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  623 KEgCGDDNVCNSNLKLEYKFGTREGNqdkfsylpiqkgiPELVLKDQKDIALEITVTNgpsdprnprkDGDDAHEAKLIA 702
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  703 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQD 780
Cdd:pfam08441  211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  781 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPlkNLGTATLNIQWPK 857
Cdd:pfam08441  289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  858 EISNGKWLLYLMKVEskGLEQVVCEPHNEINFLKLKESHNSRKKRELPEKQIDDSRKFSLFSERKYQT----LNCSVNVR 933
Cdd:pfam08441  366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                   ....*.
gi 1958759450  934 CVNIRC 939
Cdd:pfam08441  444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 374-425 4.71e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 67.40  E-value: 4.71e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958759450   374 DSMFGIAVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSPTGIITKPTQVL 425
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 316-354 1.26e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.44  E-value: 1.26e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958759450  316 FGYDVAVVDLNADGWQDIVIGAPQYFDRDgevGGAVYVY 354
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-100 1.28e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.28e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958759450    40 PGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEAlplqkANRTGGLYSCDITSRG-PCTRIVFD 100
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAND-----AGETGAVYVYFGSSGGgNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 254-292 8.99e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.51  E-value: 8.99e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958759450   254 ANSYLGFSLDSGkGIVSKDDIT-FVSGAPRANHS---GAVVLL 292
Cdd:smart00191    1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVY 42
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1038-1052 2.43e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


:

Pssm-ID: 459778  Cd Length: 15  Bit Score: 36.32  E-value: 2.43e-03
                           10
                   ....*....|....*
gi 1958759450 1038 KCGFFKRNKKDHYDA 1052
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 465-939 1.62e-168

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 502.62  E-value: 1.62e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  465 RPVINILKTITVTPSRIDLRQKSmCGSPSG--ICLKVKACFEYTAKPsGYNPPISILGILEAEKERRKsGLSSRVQFrNQ 542
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKP-IPNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  543 GSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSNEAKTVQTDVHFL 622
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  623 KEgCGDDNVCNSNLKLEYKFGTREGNqdkfsylpiqkgiPELVLKDQKDIALEITVTNgpsdprnprkDGDDAHEAKLIA 702
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  703 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQD 780
Cdd:pfam08441  211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  781 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPlkNLGTATLNIQWPK 857
Cdd:pfam08441  289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  858 EISNGKWLLYLMKVEskGLEQVVCEPHNEINFLKLKESHNSRKKRELPEKQIDDSRKFSLFSERKYQT----LNCSVNVR 933
Cdd:pfam08441  366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                   ....*.
gi 1958759450  934 CVNIRC 939
Cdd:pfam08441  444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 374-425 4.71e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 67.40  E-value: 4.71e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958759450   374 DSMFGIAVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSPTGIITKPTQVL 425
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 316-354 1.26e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.44  E-value: 1.26e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958759450  316 FGYDVAVVDLNADGWQDIVIGAPQYFDRDgevGGAVYVY 354
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 314-364 1.47e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.47e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1958759450   314 SSFGYDVA-VVDLNADGWQDIVIGAPQYFdrDGEVGGAVYVYINQQ--GRWSNV 364
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSggGNSIPL 54
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-100 1.28e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.28e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958759450    40 PGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEAlplqkANRTGGLYSCDITSRG-PCTRIVFD 100
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAND-----AGETGAVYVYFGSSGGgNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 377-410 5.25e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 44.04  E-value: 5.25e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958759450  377 FGIAVkNIGDINQDGYPDIAVGAPYDDL---GKVFIY 410
Cdd:pfam01839    1 FGYSV-AVGDLNGDGYADLAVGAPGEGGagaGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 254-292 8.99e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.51  E-value: 8.99e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958759450   254 ANSYLGFSLDSGkGIVSKDDIT-FVSGAPRANHS---GAVVLL 292
Cdd:smart00191    1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVY 42
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1038-1052 2.43e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 36.32  E-value: 2.43e-03
                           10
                   ....*....|....*
gi 1958759450 1038 KCGFFKRNKKDHYDA 1052
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 465-939 1.62e-168

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 502.62  E-value: 1.62e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  465 RPVINILKTITVTPSRIDLRQKSmCGSPSG--ICLKVKACFEYTAKPsGYNPPISILGILEAEKERRKsGLSSRVQFrNQ 542
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKP-IPNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  543 GSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSNEAKTVQTDVHFL 622
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  623 KEgCGDDNVCNSNLKLEYKFGTREGNqdkfsylpiqkgiPELVLKDQKDIALEITVTNgpsdprnprkDGDDAHEAKLIA 702
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  703 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQD 780
Cdd:pfam08441  211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  781 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPlkNLGTATLNIQWPK 857
Cdd:pfam08441  289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759450  858 EISNGKWLLYLMKVEskGLEQVVCEPHNEINFLKLKESHNSRKKRELPEKQIDDSRKFSLFSERKYQT----LNCSVNVR 933
Cdd:pfam08441  366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                   ....*.
gi 1958759450  934 CVNIRC 939
Cdd:pfam08441  444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 374-425 4.71e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 67.40  E-value: 4.71e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958759450   374 DSMFGIAVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSPTGIITKPTQVL 425
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 316-354 1.26e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.44  E-value: 1.26e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958759450  316 FGYDVAVVDLNADGWQDIVIGAPQYFDRDgevGGAVYVY 354
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 314-364 1.47e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.47e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1958759450   314 SSFGYDVA-VVDLNADGWQDIVIGAPQYFdrDGEVGGAVYVYINQQ--GRWSNV 364
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSggGNSIPL 54
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 324-397 1.17e-08

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 52.23  E-value: 1.17e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958759450  324 DLNADGWQDIVIGAPqyfdrdgevgGAVYVYINQ-QGRWSNVKPVRLNGTKDSMfGIAVkniGDINQDGYPDIAV 397
Cdd:pfam13517    1 DLDGDGKLDLVVAND----------GGLRLYLNNgDGTFTFITSVSLGGGGGGL-SVAV---GDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-100 1.28e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.28e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958759450    40 PGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEAlplqkANRTGGLYSCDITSRG-PCTRIVFD 100
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAND-----AGETGAVYVYFGSSGGgNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 377-410 5.25e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 44.04  E-value: 5.25e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958759450  377 FGIAVkNIGDINQDGYPDIAVGAPYDDL---GKVFIY 410
Cdd:pfam01839    1 FGYSV-AVGDLNGDGYADLAVGAPGEGGagaGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 386-452 4.43e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.21  E-value: 4.43e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958759450  386 DINQDGYPDIAVGAPyddlGKVFIYHGSPTGIITKPTQVLeGTTPFFGYSIAGnMDLDRNSYPDVAV 452
Cdd:pfam13517    1 DLDGDGKLDLVVAND----GGLRLYLNNGDGTFTFITSVS-LGGGGGGLSVAV-GDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 254-292 8.99e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.51  E-value: 8.99e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958759450   254 ANSYLGFSLDSGkGIVSKDDIT-FVSGAPRANHS---GAVVLL 292
Cdd:smart00191    1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVY 42
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1038-1052 2.43e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 36.32  E-value: 2.43e-03
                           10
                   ....*....|....*
gi 1958759450 1038 KCGFFKRNKKDHYDA 1052
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH