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Conserved domains on  [gi|1958763821|ref|XP_038961709|]
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sodium channel protein type 7 subunit alpha isoform X3 [Rattus norvegicus]

Protein Classification

Ion_trans and Na_channel_gate domain-containing protein (domain architecture ID 11998195)

protein containing domains Na_trans_assoc, Ion_trans, and Na_channel_gate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
504-738 6.11e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 154.35  E-value: 6.11e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  504 HPLFDLFLVICIILNICFLALEH-FPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHP-YGYFQISWHIFDSILVVLGL 581
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETyFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  582 TEMLLADIEEITVFILVPLIFI----KLGKYAPPFKNLMRILGRALVALKDLVLLVSIFIYFSAVFGMKLFGRSYKdcvc 657
Cdd:pfam00520   81 ISLVLSSVGSLSGLRVLRLLRLlrllRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---- 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  658 hVDQDCQRQRWHMSDFLHAYVTVFRILCGE-WIETLWECMEVAGEAWCIPFYMMVILIGNLLILYLFVALV-SSFASYDA 735
Cdd:pfam00520  157 -TWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIiDNFQELTE 235

                   ...
gi 1958763821  736 TTE 738
Cdd:pfam00520  236 RTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
932-1167 3.02e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 126.23  E-value: 3.02e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  932 NSWFECFIGLVTLLCTGTLALEDIYIDQRKTiKIFLEYGDMIFAYIFILEMLLKWVAYGF-KAYFSNNWYKLDFMVVI-- 1008
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLps 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1009 -------------------------------------VVLRALIKTTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECI 1051
Cdd:pfam00520   80 lislvlssvgslsglrvlrllrllrllrlirrleglrTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1052 DPtrgerfsvfevmnksqcenlvfnesmpwENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDSvgvymqpsfEHSLH 1131
Cdd:pfam00520  160 NP----------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG---------KGEFW 202
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1958763821 1132 MYTYFIIFVVFGLFLPLCMLIGVIIRNFNKQKIKQG 1167
Cdd:pfam00520  203 AYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1213-1460 4.27e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 125.84  E-value: 4.27e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1213 HRVFNVIIILLICFQATTIMIQNDEQSPQIETAV-FWMNSLFTMLFTLECILKLTAFRC--HYFTSAWNVHDFMVVVFSI 1289
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVlEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1290 TGLLLPLSIGQYFVppSLVQLLLLSRIIHVLRPGKGPKVFhdlMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYV- 1368
Cdd:pfam00520   81 ISLVLSSVGSLSGL--RVLRLLRLLRLLRLIRRLEGLRTL---VNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKl 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1369 -KKEAGINDVSNFETFGSSMLCLFQVTTFSGWDGMLDAIFNSQwsdcdpdkinpgtqvrgdcgSPSVGIFYFVSYILISW 1447
Cdd:pfam00520  156 kTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------------------GEFWAYIYFVSFIILGG 215
                          250
                   ....*....|...
gi 1958763821 1448 LIIVNMYVVLIME 1460
Cdd:pfam00520  216 FLLLNLFIAVIID 228
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
117-405 9.11e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 125.07  E-value: 9.11e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  117 HPLFRLLILISVLTDSILMCMSNLPE-------WILAVENTLLGIYTFEILVKVIARGIWagsFSFLGDLWNWLDFSVTL 189
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  190 FELIT----RSSPLSSLPMFKTIRTLRILKIIPLNHGLQSIVVTLVQCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKH 265
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  266 kcvrwpqedgndvmyngtgsqyhilerenfyymegaryallcgnktdaglcpegymcvkeGSNPDNGFTSFDNFGWALLA 345
Cdd:pfam00520  158 ------------------------------------------------------------WENPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763821  346 MFRLMTQ-DYPELLYHQILYASGKIYMIFFVLISFWFAFYMASLFLGILTMAYEQEKQRAS 405
Cdd:pfam00520  178 LFQTMTTeGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1158-1209 2.16e-20

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 85.69  E-value: 2.16e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958763821 1158 NFNKQKIKQGGS-NIFITVKQKKQYRALKKLLYADSQKPAARPRNKFQGFICD 1209
Cdd:cd13433      2 NFNQLKKKYGGGlDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
Na_trans_assoc super family cl05828
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
742-926 5.31e-17

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


The actual alignment was detected with superfamily member pfam06512:

Pssm-ID: 399489  Cd Length: 201  Bit Score: 81.25  E-value: 5.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  742 EAKNLQLAVA-------WIKMVINCVLLKILCKEKTVSTE--ATDQTCDPSVKEN-ISGHTLselsntqtflRYKDQSSG 811
Cdd:pfam06512    3 EMNNLQIALAriqrgirFVKRTLRDFCCRLCLLEPQKLPEkkPLDESKDASKKTNqIANHTS----------APKELKKA 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  812 TEKTPVTESESQSLIASPSVSETVPIASGESDIENLDNKETrskSANGSSKEKMKQ---------SSSSECSTVDIAISe 882
Cdd:pfam06512   73 PGGKYGVDEDHMSFITNPNLTVCVPIAEGESDLENEEDEDE---SSQSSDEEKSKQqeqlqqvddSSSSEGSTVDLTDP- 148
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958763821  883 eeemvYEHEKSKLHKN------------GYERKSSAGQVSRESRNGKIWRNIRKTC 926
Cdd:pfam06512  149 -----EEELEQIPEEAedlkepedcfpeGCVRRFPCCAVDITKGPWKIWWNLRKTC 199
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
504-738 6.11e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 154.35  E-value: 6.11e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  504 HPLFDLFLVICIILNICFLALEH-FPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHP-YGYFQISWHIFDSILVVLGL 581
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETyFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  582 TEMLLADIEEITVFILVPLIFI----KLGKYAPPFKNLMRILGRALVALKDLVLLVSIFIYFSAVFGMKLFGRSYKdcvc 657
Cdd:pfam00520   81 ISLVLSSVGSLSGLRVLRLLRLlrllRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---- 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  658 hVDQDCQRQRWHMSDFLHAYVTVFRILCGE-WIETLWECMEVAGEAWCIPFYMMVILIGNLLILYLFVALV-SSFASYDA 735
Cdd:pfam00520  157 -TWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIiDNFQELTE 235

                   ...
gi 1958763821  736 TTE 738
Cdd:pfam00520  236 RTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
932-1167 3.02e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 126.23  E-value: 3.02e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  932 NSWFECFIGLVTLLCTGTLALEDIYIDQRKTiKIFLEYGDMIFAYIFILEMLLKWVAYGF-KAYFSNNWYKLDFMVVI-- 1008
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLps 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1009 -------------------------------------VVLRALIKTTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECI 1051
Cdd:pfam00520   80 lislvlssvgslsglrvlrllrllrllrlirrleglrTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1052 DPtrgerfsvfevmnksqcenlvfnesmpwENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDSvgvymqpsfEHSLH 1131
Cdd:pfam00520  160 NP----------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG---------KGEFW 202
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1958763821 1132 MYTYFIIFVVFGLFLPLCMLIGVIIRNFNKQKIKQG 1167
Cdd:pfam00520  203 AYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1213-1460 4.27e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 125.84  E-value: 4.27e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1213 HRVFNVIIILLICFQATTIMIQNDEQSPQIETAV-FWMNSLFTMLFTLECILKLTAFRC--HYFTSAWNVHDFMVVVFSI 1289
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVlEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1290 TGLLLPLSIGQYFVppSLVQLLLLSRIIHVLRPGKGPKVFhdlMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYV- 1368
Cdd:pfam00520   81 ISLVLSSVGSLSGL--RVLRLLRLLRLLRLIRRLEGLRTL---VNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKl 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1369 -KKEAGINDVSNFETFGSSMLCLFQVTTFSGWDGMLDAIFNSQwsdcdpdkinpgtqvrgdcgSPSVGIFYFVSYILISW 1447
Cdd:pfam00520  156 kTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------------------GEFWAYIYFVSFIILGG 215
                          250
                   ....*....|...
gi 1958763821 1448 LIIVNMYVVLIME 1460
Cdd:pfam00520  216 FLLLNLFIAVIID 228
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
117-405 9.11e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 125.07  E-value: 9.11e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  117 HPLFRLLILISVLTDSILMCMSNLPE-------WILAVENTLLGIYTFEILVKVIARGIWagsFSFLGDLWNWLDFSVTL 189
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  190 FELIT----RSSPLSSLPMFKTIRTLRILKIIPLNHGLQSIVVTLVQCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKH 265
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  266 kcvrwpqedgndvmyngtgsqyhilerenfyymegaryallcgnktdaglcpegymcvkeGSNPDNGFTSFDNFGWALLA 345
Cdd:pfam00520  158 ------------------------------------------------------------WENPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763821  346 MFRLMTQ-DYPELLYHQILYASGKIYMIFFVLISFWFAFYMASLFLGILTMAYEQEKQRAS 405
Cdd:pfam00520  178 LFQTMTTeGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1158-1209 2.16e-20

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 85.69  E-value: 2.16e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958763821 1158 NFNKQKIKQGGS-NIFITVKQKKQYRALKKLLYADSQKPAARPRNKFQGFICD 1209
Cdd:cd13433      2 NFNQLKKKYGGGlDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
742-926 5.31e-17

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 399489  Cd Length: 201  Bit Score: 81.25  E-value: 5.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  742 EAKNLQLAVA-------WIKMVINCVLLKILCKEKTVSTE--ATDQTCDPSVKEN-ISGHTLselsntqtflRYKDQSSG 811
Cdd:pfam06512    3 EMNNLQIALAriqrgirFVKRTLRDFCCRLCLLEPQKLPEkkPLDESKDASKKTNqIANHTS----------APKELKKA 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  812 TEKTPVTESESQSLIASPSVSETVPIASGESDIENLDNKETrskSANGSSKEKMKQ---------SSSSECSTVDIAISe 882
Cdd:pfam06512   73 PGGKYGVDEDHMSFITNPNLTVCVPIAEGESDLENEEDEDE---SSQSSDEEKSKQqeqlqqvddSSSSEGSTVDLTDP- 148
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958763821  883 eeemvYEHEKSKLHKN------------GYERKSSAGQVSRESRNGKIWRNIRKTC 926
Cdd:pfam06512  149 -----EEELEQIPEEAedlkepedcfpeGCVRRFPCCAVDITKGPWKIWWNLRKTC 199
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
504-738 6.11e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 154.35  E-value: 6.11e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  504 HPLFDLFLVICIILNICFLALEH-FPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHP-YGYFQISWHIFDSILVVLGL 581
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETyFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  582 TEMLLADIEEITVFILVPLIFI----KLGKYAPPFKNLMRILGRALVALKDLVLLVSIFIYFSAVFGMKLFGRSYKdcvc 657
Cdd:pfam00520   81 ISLVLSSVGSLSGLRVLRLLRLlrllRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---- 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  658 hVDQDCQRQRWHMSDFLHAYVTVFRILCGE-WIETLWECMEVAGEAWCIPFYMMVILIGNLLILYLFVALV-SSFASYDA 735
Cdd:pfam00520  157 -TWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIiDNFQELTE 235

                   ...
gi 1958763821  736 TTE 738
Cdd:pfam00520  236 RTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
932-1167 3.02e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 126.23  E-value: 3.02e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  932 NSWFECFIGLVTLLCTGTLALEDIYIDQRKTiKIFLEYGDMIFAYIFILEMLLKWVAYGF-KAYFSNNWYKLDFMVVI-- 1008
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLps 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1009 -------------------------------------VVLRALIKTTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECI 1051
Cdd:pfam00520   80 lislvlssvgslsglrvlrllrllrllrlirrleglrTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1052 DPtrgerfsvfevmnksqcenlvfnesmpwENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDSvgvymqpsfEHSLH 1131
Cdd:pfam00520  160 NP----------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG---------KGEFW 202
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1958763821 1132 MYTYFIIFVVFGLFLPLCMLIGVIIRNFNKQKIKQG 1167
Cdd:pfam00520  203 AYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1213-1460 4.27e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 125.84  E-value: 4.27e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1213 HRVFNVIIILLICFQATTIMIQNDEQSPQIETAV-FWMNSLFTMLFTLECILKLTAFRC--HYFTSAWNVHDFMVVVFSI 1289
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVlEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1290 TGLLLPLSIGQYFVppSLVQLLLLSRIIHVLRPGKGPKVFhdlMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYV- 1368
Cdd:pfam00520   81 ISLVLSSVGSLSGL--RVLRLLRLLRLLRLIRRLEGLRTL---VNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKl 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1369 -KKEAGINDVSNFETFGSSMLCLFQVTTFSGWDGMLDAIFNSQwsdcdpdkinpgtqvrgdcgSPSVGIFYFVSYILISW 1447
Cdd:pfam00520  156 kTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------------------GEFWAYIYFVSFIILGG 215
                          250
                   ....*....|...
gi 1958763821 1448 LIIVNMYVVLIME 1460
Cdd:pfam00520  216 FLLLNLFIAVIID 228
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
117-405 9.11e-32

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 125.07  E-value: 9.11e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  117 HPLFRLLILISVLTDSILMCMSNLPE-------WILAVENTLLGIYTFEILVKVIARGIWagsFSFLGDLWNWLDFSVTL 189
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  190 FELIT----RSSPLSSLPMFKTIRTLRILKIIPLNHGLQSIVVTLVQCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKH 265
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  266 kcvrwpqedgndvmyngtgsqyhilerenfyymegaryallcgnktdaglcpegymcvkeGSNPDNGFTSFDNFGWALLA 345
Cdd:pfam00520  158 ------------------------------------------------------------WENPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958763821  346 MFRLMTQ-DYPELLYHQILYASGKIYMIFFVLISFWFAFYMASLFLGILTMAYEQEKQRAS 405
Cdd:pfam00520  178 LFQTMTTeGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1158-1209 2.16e-20

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 85.69  E-value: 2.16e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958763821 1158 NFNKQKIKQGGS-NIFITVKQKKQYRALKKLLYADSQKPAARPRNKFQGFICD 1209
Cdd:cd13433      2 NFNQLKKKYGGGlDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
742-926 5.31e-17

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 399489  Cd Length: 201  Bit Score: 81.25  E-value: 5.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  742 EAKNLQLAVA-------WIKMVINCVLLKILCKEKTVSTE--ATDQTCDPSVKEN-ISGHTLselsntqtflRYKDQSSG 811
Cdd:pfam06512    3 EMNNLQIALAriqrgirFVKRTLRDFCCRLCLLEPQKLPEkkPLDESKDASKKTNqIANHTS----------APKELKKA 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  812 TEKTPVTESESQSLIASPSVSETVPIASGESDIENLDNKETrskSANGSSKEKMKQ---------SSSSECSTVDIAISe 882
Cdd:pfam06512   73 PGGKYGVDEDHMSFITNPNLTVCVPIAEGESDLENEEDEDE---SSQSSDEEKSKQqeqlqqvddSSSSEGSTVDLTDP- 148
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958763821  883 eeemvYEHEKSKLHKN------------GYERKSSAGQVSRESRNGKIWRNIRKTC 926
Cdd:pfam06512  149 -----EEELEQIPEEAedlkepedcfpeGCVRRFPCCAVDITKGPWKIWWNLRKTC 199
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
1252-1460 1.36e-04

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 46.18  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1252 LFTMLFTLECILKLTAFRCHYFTSAWNVHDFMVVVFSItgLLLPLSIGQYFVPPSLVQLLL-----------LSRIIHVL 1320
Cdd:pfam08016  218 VFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSV--VLIVLNIYRDFLVDRLIKSVEaspvtfidfdrVAQLDNLY 295
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821 1321 RPGKG----------------PKVFHDLMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAyvkkeagiNDVSNFETFG 1384
Cdd:pfam08016  296 RIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--------TQAPNFSNFV 367
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958763821 1385 SSMLCLFQVttfsgwdgMLDAIfnsQWSDcdpdkINPGTQVrgdcgspsVGIFYFVSYILISWLIIVNMYVVLIME 1460
Cdd:pfam08016  368 KSILTLFRT--------ILGDF---GYNE-----IFSGNRV--------LGPLLFLTFVFLVIFILLNLFLAIIND 419
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
542-739 9.48e-03

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 40.41  E-value: 9.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  542 LVFIGIYTIEMILKIiAMHPYGYFQISWHIFDSILVVL----------------GLTEMLLADIEEITVF---------- 595
Cdd:pfam08016  217 VVFFLYFVVEEILKI-RKHRPSYLRSVWNLLDLAIVILsvvlivlniyrdflvdRLIKSVEASPVTFIDFdrvaqldnly 295
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958763821  596 -----ILVPLIFIKLGKY---APPFKNLMRILGRALVALKDLVLLVSIFIYFSAVFGMKLFGRsykdcvchvdqdcqrQR 667
Cdd:pfam08016  296 riilaFLVFLTWLKLFKVlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGT---------------QA 360
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958763821  668 WHMSDFLHAYVTVFRILCGEW-IETLWECMEVAGEAWCIPFYMMVILIgnllILYLFVALVssfasYDATTEV 739
Cdd:pfam08016  361 PNFSNFVKSILTLFRTILGDFgYNEIFSGNRVLGPLLFLTFVFLVIFI----LLNLFLAII-----NDSYVEV 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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