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Conserved domains on  [gi|1958764160|ref|XP_038961845|]
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inositol-trisphosphate 3-kinase A isoform X1 [Rattus norvegicus]

Protein Classification

inositol polyphosphate kinase family protein (domain architecture ID 10510177)

inositol polyphosphate kinase family protein such as inositol hexakisphosphate kinase, which converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) and 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
116-326 1.07e-58

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


:

Pssm-ID: 397715  Cd Length: 190  Bit Score: 187.38  E-value: 1.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160 116 YLQLQDLLDGFDGPCVLDCKMGVRTYleeeltkarerpklrkdmykkmlavDPEAPTEeehaqravtKPRYMQWREGISS 195
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTY-------------------------GDDASEE---------KRRRQQKKCRETT 46
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160 196 STTLGFRIEGIK----KADG--SCSTDFKTTRSREQVTRVFEEFMQ------GDAEVLKRYLNRLQQIRDTLEISDFFRr 263
Cdd:pfam03770  47 SASLGFRICGMKvwnvDTDGyiFRDKYYGRSLSAEEFKEALKRFFSngkslrRKKKIIPRFLERLQELRNVLESQESYR- 125
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958764160 264 heVIGSSLLFVHDHC---------HRAGVWLIDFGKTTPLPDGqildhrRPWEEGNREDGYLLGLDNLIGIL 326
Cdd:pfam03770 126 --FYSSSLLFVYDGDpesaeedppPKVKVKLIDFAHTVPLPDG------PPWPGGGPDEGYLFGLRSLIKIL 189
 
Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
116-326 1.07e-58

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


Pssm-ID: 397715  Cd Length: 190  Bit Score: 187.38  E-value: 1.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160 116 YLQLQDLLDGFDGPCVLDCKMGVRTYleeeltkarerpklrkdmykkmlavDPEAPTEeehaqravtKPRYMQWREGISS 195
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTY-------------------------GDDASEE---------KRRRQQKKCRETT 46
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160 196 STTLGFRIEGIK----KADG--SCSTDFKTTRSREQVTRVFEEFMQ------GDAEVLKRYLNRLQQIRDTLEISDFFRr 263
Cdd:pfam03770  47 SASLGFRICGMKvwnvDTDGyiFRDKYYGRSLSAEEFKEALKRFFSngkslrRKKKIIPRFLERLQELRNVLESQESYR- 125
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958764160 264 heVIGSSLLFVHDHC---------HRAGVWLIDFGKTTPLPDGqildhrRPWEEGNREDGYLLGLDNLIGIL 326
Cdd:pfam03770 126 --FYSSSLLFVYDGDpesaeedppPKVKVKLIDFAHTVPLPDG------PPWPGGGPDEGYLFGLRSLIKIL 189
PLN02667 PLN02667
inositol polyphosphate multikinase
61-330 2.56e-14

inositol polyphosphate multikinase


Pssm-ID: 215359  Cd Length: 286  Bit Score: 72.06  E-value: 2.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160  61 QLAGHTGSFKAAGT----SGLILK------RSS-EPEHYCLVRLMADV---LRGCVPAFHGVVE---RDGESYLQLQDLL 123
Cdd:PLN02667    8 QVAGHRASDGKLGPlvddSGRFYKplqddsRGErEAAFYESFSSDTRVpdhIRRFFPVFHGTQLveaSDGSGLLVLEDLL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160 124 DGFDGPCVLDCKMGVRTYleeeltkarerpklrkdmYkkmlavdPEAPteEEHAQRAVTKPRymqwregISSSTTLGFRI 203
Cdd:PLN02667   88 AGYTKPCVMDVKMGSRTW------------------Y-------PEAS--EEYIQKCLKKDR-------ETTTVSLGFRV 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160 204 EGIKKADGSCSTDFKTTRSR------EQVTRVFEEFMQGDAEVLKRY---------------LNRLQQIRDTLEISDFFR 262
Cdd:PLN02667  134 SGFKVYDHKESEFWKAERKLvkgldaDGVRLALRKFVSSNSPADPNPdcafasavyggshgiLAQLLELKSWFEEQTLYH 213
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958764160 263 RHeviGSSLLFVHD-HCHRAG--------VWLIDFGKTTplPDGQILDHrrpweegnredGYLLGLDNLIGILANLA 330
Cdd:PLN02667  214 FF---SASILIVYEgEAILKGnpedsrveVKLVDFAHVL--DGNGVIDH-----------NFLGGLCSLIKFISEIL 274
 
Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
116-326 1.07e-58

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


Pssm-ID: 397715  Cd Length: 190  Bit Score: 187.38  E-value: 1.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160 116 YLQLQDLLDGFDGPCVLDCKMGVRTYleeeltkarerpklrkdmykkmlavDPEAPTEeehaqravtKPRYMQWREGISS 195
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTY-------------------------GDDASEE---------KRRRQQKKCRETT 46
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160 196 STTLGFRIEGIK----KADG--SCSTDFKTTRSREQVTRVFEEFMQ------GDAEVLKRYLNRLQQIRDTLEISDFFRr 263
Cdd:pfam03770  47 SASLGFRICGMKvwnvDTDGyiFRDKYYGRSLSAEEFKEALKRFFSngkslrRKKKIIPRFLERLQELRNVLESQESYR- 125
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958764160 264 heVIGSSLLFVHDHC---------HRAGVWLIDFGKTTPLPDGqildhrRPWEEGNREDGYLLGLDNLIGIL 326
Cdd:pfam03770 126 --FYSSSLLFVYDGDpesaeedppPKVKVKLIDFAHTVPLPDG------PPWPGGGPDEGYLFGLRSLIKIL 189
PLN02667 PLN02667
inositol polyphosphate multikinase
61-330 2.56e-14

inositol polyphosphate multikinase


Pssm-ID: 215359  Cd Length: 286  Bit Score: 72.06  E-value: 2.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160  61 QLAGHTGSFKAAGT----SGLILK------RSS-EPEHYCLVRLMADV---LRGCVPAFHGVVE---RDGESYLQLQDLL 123
Cdd:PLN02667    8 QVAGHRASDGKLGPlvddSGRFYKplqddsRGErEAAFYESFSSDTRVpdhIRRFFPVFHGTQLveaSDGSGLLVLEDLL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160 124 DGFDGPCVLDCKMGVRTYleeeltkarerpklrkdmYkkmlavdPEAPteEEHAQRAVTKPRymqwregISSSTTLGFRI 203
Cdd:PLN02667   88 AGYTKPCVMDVKMGSRTW------------------Y-------PEAS--EEYIQKCLKKDR-------ETTTVSLGFRV 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958764160 204 EGIKKADGSCSTDFKTTRSR------EQVTRVFEEFMQGDAEVLKRY---------------LNRLQQIRDTLEISDFFR 262
Cdd:PLN02667  134 SGFKVYDHKESEFWKAERKLvkgldaDGVRLALRKFVSSNSPADPNPdcafasavyggshgiLAQLLELKSWFEEQTLYH 213
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958764160 263 RHeviGSSLLFVHD-HCHRAG--------VWLIDFGKTTplPDGQILDHrrpweegnredGYLLGLDNLIGILANLA 330
Cdd:PLN02667  214 FF---SASILIVYEgEAILKGnpedsrveVKLVDFAHVL--DGNGVIDH-----------NFLGGLCSLIKFISEIL 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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