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Conserved domains on  [gi|1958770778|ref|XP_038964023|]
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peroxisomal ATPase PEX1 isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEX-2N pfam09263
Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a Cdc48 domain 2-like ...
 17-98 1.44e-43

Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a Cdc48 domain 2-like fold, with a beta-alpha-beta(3) arrangement. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation.


:

Pssm-ID: 462730  Cd Length: 83  Bit Score: 151.37  E-value: 1.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778  17 VTVAFTNARDCFLHLPRHLVAQLHLLQNQAIEVTGDH-QPTYLSWVEGRHFNDQSENVAEINRQVGQKLGLSSGDQVFLR 95
Cdd:pfam09263   1 VTVVFNNAKNCFLHLPSKLVSQLSLQENQALELSWGHgQPVFLSWTEGRHSSDQDENVVELNRQLGEKLGLKDGEQVFLR 80


                  ...
gi 1958770778  96 PCS 98
Cdd:pfam09263  81 PCS 83
PEX-1N pfam09262
Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a double psi ...
 104-179 1.83e-30

Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a double psi beta-barrel fold, similar in structure to the Cdc48 N-terminal domain. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation.


:

Pssm-ID: 462729  Cd Length: 77  Bit Score: 114.13  E-value: 1.83e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958770778 104 QQVEVEPLSADDWEILELHAISLEEHLLDQIRIVFPKAIVPIWVDQQTYIFIQIVALMP-TAPYGRLETNTKLLIQP 179
Cdd:pfam09262   1 TTVEVEPLTSDDWEILELHAEFLEDNLLSQVRVVSPGQILPVWVSGTTVARFRVTSIEPaNSPFARLSPDTEVIVAP 77
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 595-686 1.82e-12

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


:

Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 64.92  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 595 LLITGGKGSGKSTLAKAICKEahdaLDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSTP 674
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKE----LGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSG 76

                          90
                  ....*....|..
gi 1958770778 675 EHEHSpEAVQSQ 686
Cdd:pfam00004  77 GDSES-RRVVNQ 87
 
Name Accession Description Interval E-value
PEX-2N pfam09263
Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a Cdc48 domain 2-like ...
 17-98 1.44e-43

Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a Cdc48 domain 2-like fold, with a beta-alpha-beta(3) arrangement. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation.


Pssm-ID: 462730  Cd Length: 83  Bit Score: 151.37  E-value: 1.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778  17 VTVAFTNARDCFLHLPRHLVAQLHLLQNQAIEVTGDH-QPTYLSWVEGRHFNDQSENVAEINRQVGQKLGLSSGDQVFLR 95
Cdd:pfam09263   1 VTVVFNNAKNCFLHLPSKLVSQLSLQENQALELSWGHgQPVFLSWTEGRHSSDQDENVVELNRQLGEKLGLKDGEQVFLR 80


                  ...
gi 1958770778  96 PCS 98
Cdd:pfam09263  81 PCS 83
PEX-1N pfam09262
Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a double psi ...
 104-179 1.83e-30

Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a double psi beta-barrel fold, similar in structure to the Cdc48 N-terminal domain. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation.


Pssm-ID: 462729  Cd Length: 77  Bit Score: 114.13  E-value: 1.83e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958770778 104 QQVEVEPLSADDWEILELHAISLEEHLLDQIRIVFPKAIVPIWVDQQTYIFIQIVALMP-TAPYGRLETNTKLLIQP 179
Cdd:pfam09262   1 TTVEVEPLTSDDWEILELHAEFLEDNLLSQVRVVSPGQILPVWVSGTTVARFRVTSIEPaNSPFARLSPDTEVIVAP 77
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 595-686 1.82e-12

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 64.92  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 595 LLITGGKGSGKSTLAKAICKEahdaLDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSTP 674
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKE----LGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSG 76

                          90
                  ....*....|..
gi 1958770778 675 EHEHSpEAVQSQ 686
Cdd:pfam00004  77 GDSES-RRVVNQ 87
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 595-689 3.68e-09

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 56.15  E-value: 3.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 595 LLITGGKGSGKSTLAKAICKEAhdalDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAglpstP 674
Cdd:cd19503    37 VLLHGPPGTGKTLLARAVANEA----GANFLSISGPSIVSKYLGESEKNLREIFEEARSHAPSIIFIDEIDALA-----P 107

                          90
                  ....*....|....*
gi 1958770778 675 EHEHSPEAVQSQRLA 689
Cdd:cd19503   108 KREEDQREVERRVVA 122
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 591-668 1.68e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 48.14  E-value: 1.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778  591 RNGALLITGGKGSGKSTLAKAICKEAhDALDAHVEMVDCKALRGKRLESIQ--------------KALEVAFSEAAWRQP 656
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALAREL-GPPGGGVIYIDGEDILEEVLDQLLliivggkkasgsgeLRLRLALALARKLKP 79

                           90
                   ....*....|..
gi 1958770778  657 SVILLDDLDLIA 668
Cdd:smart00382  80 DVLILDEITSLL 91
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 566-669 1.41e-05

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 47.98  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 566 AMEHITHSLLGRPLSRQLMALVAGLRngaLLITGGKGSGKSTLAKAICKEahdaLDAHVEMVDCKALRGKRLESIQKALE 645
Cdd:COG0464   168 ELRELVALPLKRPELREEYGLPPPRG---LLLYGPPGTGKTLLARALAGE----LGLPLIEVDLSDLVSKYVGETEKNLR 240

                          90       100
                  ....*....|....*....|....
gi 1958770778 646 VAFSEAAWRQPSVILLDDLDLIAG 669
Cdd:COG0464   241 EVFDKARGLAPCVLFIDEADALAG 264
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 595-668 7.61e-03

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 39.51  E-value: 7.61e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958770778 595 LLITGGKGSGKSTLAKAICKEAhdalDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIA 668
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEA----GAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIA 284
 
Name Accession Description Interval E-value
PEX-2N pfam09263
Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a Cdc48 domain 2-like ...
 17-98 1.44e-43

Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a Cdc48 domain 2-like fold, with a beta-alpha-beta(3) arrangement. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation.


Pssm-ID: 462730  Cd Length: 83  Bit Score: 151.37  E-value: 1.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778  17 VTVAFTNARDCFLHLPRHLVAQLHLLQNQAIEVTGDH-QPTYLSWVEGRHFNDQSENVAEINRQVGQKLGLSSGDQVFLR 95
Cdd:pfam09263   1 VTVVFNNAKNCFLHLPSKLVSQLSLQENQALELSWGHgQPVFLSWTEGRHSSDQDENVVELNRQLGEKLGLKDGEQVFLR 80


                  ...
gi 1958770778  96 PCS 98
Cdd:pfam09263  81 PCS 83
PEX-1N pfam09262
Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a double psi ...
 104-179 1.83e-30

Peroxisome biogenesis factor 1, N-terminal; Members of this family adopt a double psi beta-barrel fold, similar in structure to the Cdc48 N-terminal domain. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation.


Pssm-ID: 462729  Cd Length: 77  Bit Score: 114.13  E-value: 1.83e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958770778 104 QQVEVEPLSADDWEILELHAISLEEHLLDQIRIVFPKAIVPIWVDQQTYIFIQIVALMP-TAPYGRLETNTKLLIQP 179
Cdd:pfam09262   1 TTVEVEPLTSDDWEILELHAEFLEDNLLSQVRVVSPGQILPVWVSGTTVARFRVTSIEPaNSPFARLSPDTEVIVAP 77
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 595-686 1.82e-12

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 64.92  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 595 LLITGGKGSGKSTLAKAICKEahdaLDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSTP 674
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKE----LGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSG 76

                          90
                  ....*....|..
gi 1958770778 675 EHEHSpEAVQSQ 686
Cdd:pfam00004  77 GDSES-RRVVNQ 87
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 595-689 3.68e-09

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 56.15  E-value: 3.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 595 LLITGGKGSGKSTLAKAICKEAhdalDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAglpstP 674
Cdd:cd19503    37 VLLHGPPGTGKTLLARAVANEA----GANFLSISGPSIVSKYLGESEKNLREIFEEARSHAPSIIFIDEIDALA-----P 107

                          90
                  ....*....|....*
gi 1958770778 675 EHEHSPEAVQSQRLA 689
Cdd:cd19503   108 KREEDQREVERRVVA 122
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 581-668 4.02e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 56.00  E-value: 4.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 581 RQLMALVAGLRNGALLITGGKGSGKSTLAKAICKEAHDAlDAHVEMVDCKALRGKRLESIQK---ALEVAFSEAAWRQPS 657
Cdd:cd00009     8 EALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRP-GAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKPG 86

                          90
                  ....*....|.
gi 1958770778 658 VILLDDLDLIA 668
Cdd:cd00009    87 VLFIDEIDSLS 97
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 579-694 4.73e-09

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 55.75  E-value: 4.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 579 LSRQLMALVAGLRNGALLItGGKGSGKSTLAKAICKEahdaLDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSV 658
Cdd:cd19481    14 RGSRLRRYGLGLPKGILLY-GPPGTGKTLLAKALAGE----LGLPLIVVKLSSLLSKYVGESEKNLRKIFERARRLAPCI 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958770778 659 ILLDDLDLIAGLPSTPEHEHSPEAVQSQRLahgTEM 694
Cdd:cd19481    89 LFIDEIDAIGRKRDSSGESGELRRVLNQLL---TEL 121
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 594-679 3.56e-07

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 50.43  E-value: 3.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 594 ALLITGGKGSGKSTLAKAICKEahdaLDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPST 673
Cdd:cd19509    34 GILLYGPPGTGKTLLARAVASE----SGSTFFSISASSLVSKWVGESEKIVRALFALARELQPSIIFIDEIDSLLSERGS 109


                  ....*.
gi 1958770778 674 PEHEHS 679
Cdd:cd19509   110 GEHEAS 115
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 591-668 1.68e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 48.14  E-value: 1.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778  591 RNGALLITGGKGSGKSTLAKAICKEAhDALDAHVEMVDCKALRGKRLESIQ--------------KALEVAFSEAAWRQP 656
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALAREL-GPPGGGVIYIDGEDILEEVLDQLLliivggkkasgsgeLRLRLALALARKLKP 79

                           90
                   ....*....|..
gi 1958770778  657 SVILLDDLDLIA 668
Cdd:smart00382  80 DVLILDEITSLL 91
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 586-679 5.40e-06

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 47.15  E-value: 5.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 586 LVAGLRNGA--LLITGGKGSGKSTLAKAICKEAhdalDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDD 663
Cdd:cd19524    25 LFTGLRAPArgLLLFGPPGNGKTMLAKAVAAES----NATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDE 100

                          90
                  ....*....|....*.
gi 1958770778 664 LDLIAGLPSTPEHEHS 679
Cdd:cd19524   101 VDSLLSERSEGEHEAS 116
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 566-669 1.41e-05

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 47.98  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 566 AMEHITHSLLGRPLSRQLMALVAGLRngaLLITGGKGSGKSTLAKAICKEahdaLDAHVEMVDCKALRGKRLESIQKALE 645
Cdd:COG0464   168 ELRELVALPLKRPELREEYGLPPPRG---LLLYGPPGTGKTLLARALAGE----LGLPLIEVDLSDLVSKYVGETEKNLR 240

                          90       100
                  ....*....|....*....|....
gi 1958770778 646 VAFSEAAWRQPSVILLDDLDLIAG 669
Cdd:COG0464   241 EVFDKARGLAPCVLFIDEADALAG 264
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 594-689 5.93e-05

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 44.10  E-value: 5.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 594 ALLITGGKGSGKSTLAKAICKEahdaLDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIagLPST 673
Cdd:cd19523    35 SILLFGPRGTGKTLLGRCLASQ----LGATFLRLRGSTLVAKWAGEGEKILQASFLAARCRQPSVLFISDLDAL--LSSQ 108

                          90
                  ....*....|....*..
gi 1958770778 674 PEhEHSP-EAVQSQRLA 689
Cdd:cd19523   109 DD-EASPvGRLQVELLA 124
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 595-677 2.76e-04

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 42.03  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 595 LLITGGKGSGKSTLAKAICKEAhdalDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSTP 674
Cdd:cd19520    38 VLLYGPPGCGKTMLAKATAKEA----GARFINLQVSSLTDKWYGESQKLVAAVFSLASKLQPSIIFIDEIDSFLRQRSST 113


                  ...
gi 1958770778 675 EHE 677
Cdd:cd19520   114 DHE 116
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 594-679 1.32e-03

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 40.23  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 594 ALLITGGKGSGKSTLAKAICKEAHDALDAhvemVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPST 673
Cdd:cd19521    42 GILLYGPPGTGKSYLAKAVATEANSTFFS----VSSSDLVSKWMGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGE 117


                  ....*.
gi 1958770778 674 PEHEHS 679
Cdd:cd19521   118 GESEAS 123
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 595-668 2.23e-03

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 39.34  E-value: 2.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958770778 595 LLITGGKGSGKSTLAKAICKEAhdalDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIA 668
Cdd:cd19519    37 ILLYGPPGTGKTLIARAVANET----GAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDEIDAIA 106
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 596-694 2.68e-03

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 39.19  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 596 LITGGKGSGKSTLAKAICKEAHdaldAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSTPE 675
Cdd:cd19511    31 LLYGPPGCGKTLLAKALASEAG----LNFISVKGPELFSKYVGESERAVREIFQKARQAAPCIIFFDEIDSLAPRRGQSD 106

                          90
                  ....*....|....*....
gi 1958770778 676 HEHSPEAVQSQRLahgTEM 694
Cdd:cd19511   107 SSGVTDRVVSQLL---TEL 122
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 589-679 3.64e-03

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 39.20  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 589 GLRN--GALLITGGKGSGKSTLAKAICKEAhdalDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDL 666
Cdd:cd19525    50 GLRGppKGILLFGPPGTGKTLIGKCIASQS----GATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDS 125

                          90
                  ....*....|...
gi 1958770778 667 IAGLPSTPEHEHS 679
Cdd:cd19525   126 LLSQRGEGEHESS 138
AAA_29 pfam13555
P-loop containing region of AAA domain;
591-612 4.50e-03

P-loop containing region of AAA domain;


Pssm-ID: 433304 [Multi-domain]  Cd Length: 61  Bit Score: 36.04  E-value: 4.50e-03
                          10        20
                  ....*....|....*....|..
gi 1958770778 591 RNGALLITGGKGSGKSTLAKAI 612
Cdd:pfam13555  21 PRGNTLLTGPSGSGKSTLLDAI 42
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
595-675 4.63e-03

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 39.79  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958770778 595 LLITGGKGSGKSTLAKAICKEAHDAL-DAHV----------EMVdcKALRGKRLESIQKALevafseaawRQPSVILLDD 663
Cdd:COG0593    37 LFLYGGVGLGKTHLLHAIGNEALENNpGARVvyltaeeftnDFI--NAIRNNTIEEFKEKY---------RSVDVLLIDD 105

                          90
                  ....*....|..
gi 1958770778 664 LDLIAGLPSTPE 675
Cdd:COG0593   106 IQFLAGKEATQE 117
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 595-668 7.61e-03

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 39.51  E-value: 7.61e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958770778 595 LLITGGKGSGKSTLAKAICKEAhdalDAHVEMVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIA 668
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEA----GAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIA 284
AAA_19 pfam13245
AAA domain;
582-616 8.45e-03

AAA domain;


Pssm-ID: 433059 [Multi-domain]  Cd Length: 136  Bit Score: 37.20  E-value: 8.45e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1958770778 582 QLMALVAGLRNGALLITGGKGSGKSTLAKAICKEA 616
Cdd:pfam13245   1 QREAVRTALPSKVVLLTGGPGTGKTTTIRHIVALL 35
AAA_14 pfam13173
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 591-662 9.70e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 463799 [Multi-domain]  Cd Length: 128  Bit Score: 36.80  E-value: 9.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958770778 591 RNGALLITGGKGSGKSTLAKAICKEAHDalDAHVEMVDCKALRgkRLESIQKALEVAFSEAAWRQPSVILLD 662
Cdd:pfam13173   1 SRKILVITGPRQVGKTTLLLQLIKELLP--PENILYINLDDPR--LLKLADFELLELFLELLYPGKTYLFLD 68
VirB4 COG3451
Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and ...
 588-638 9.75e-03

Type IV secretory pathway, VirB4 component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442674 [Multi-domain]  Cd Length: 546  Bit Score: 39.16  E-value: 9.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958770778 588 AGLRNGALLITGGKGSGKSTLAKAICKEAHdALDAHVEMVD--------CKALRGKRLE 638
Cdd:COG3451   200 DGLDNGNTLILGPSGSGKSFLLKLLLLQLL-RYGARIVIFDpggsyeilVRALGGTYID 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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