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Conserved domains on  [gi|1958775036|ref|XP_038965321|]
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myb-related protein A isoform X1 [Rattus norvegicus]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 13851053)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor; also contains a LMSTEN motif and Cmyb C-terminal domain

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 508-664 6.87e-75

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 239.57  E-value: 6.87e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036 508 FSPSQFFNTCPGSEQLNIENPSFTSTPICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAA 587
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958775036 588 QEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRKSLALESWDKEEPGTQLL 664
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
PLN03091 super family cl33633
hypothetical protein; Provisional
 107-215 3.32e-28

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 118.93  E-value: 3.32e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036 107 ELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKhLKG--RIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRW 184
Cdd:PLN03091   11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958775036 185 AEIAKLLPGRTDNSIKNHWNSTMRRKVEQEG 215
Cdd:PLN03091   90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRG 120
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 263-308 1.12e-19

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


:

Pssm-ID: 462332  Cd Length: 47  Bit Score: 82.62  E-value: 1.12e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958775036 263 GNCVEHVQTS-AFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKR 308
Cdd:pfam07988   1 LNCLEHPQHStAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 61-121 1.83e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 73.88  E-value: 1.83e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775036  61 WTRDEDDKLKKLVEQHGtDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRV 121
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 508-664 6.87e-75

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 239.57  E-value: 6.87e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036 508 FSPSQFFNTCPGSEQLNIENPSFTSTPICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAA 587
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958775036 588 QEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRKSLALESWDKEEPGTQLL 664
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
PLN03091 PLN03091
hypothetical protein; Provisional
 107-215 3.32e-28

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 118.93  E-value: 3.32e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036 107 ELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKhLKG--RIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRW 184
Cdd:PLN03091   11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958775036 185 AEIAKLLPGRTDNSIKNHWNSTMRRKVEQEG 215
Cdd:PLN03091   90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRG 120
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 107-209 4.60e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 116.04  E-value: 4.60e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036 107 ELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAE 186
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100
                  ....*....|....*....|...
gi 1958775036 187 IAKLLPGRTDNSIKNHWNSTMRR 209
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLED 119
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 263-308 1.12e-19

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 82.62  E-value: 1.12e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958775036 263 GNCVEHVQTS-AFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKR 308
Cdd:pfam07988   1 LNCLEHPQHStAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 113-171 4.07e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 78.89  E-value: 4.07e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958775036 113 WTKEEDQRVIELVQKYGPKrWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDR 171
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 61-121 1.83e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 73.88  E-value: 1.83e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775036  61 WTRDEDDKLKKLVEQHGtDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRV 121
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
110-158 1.87e-16

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 73.80  E-value: 1.87e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958775036  110 KGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNP 158
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 112-156 3.42e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 72.61  E-value: 3.42e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958775036 112 PWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHL 156
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
58-106 5.11e-15

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 69.56  E-value: 5.11e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958775036   58 RVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNP 106
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 60-104 1.45e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 67.99  E-value: 1.45e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958775036  60 KWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVL 104
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 508-664 6.87e-75

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 239.57  E-value: 6.87e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036 508 FSPSQFFNTCPGSEQLNIENPSFTSTPICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAA 587
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958775036 588 QEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRKSLALESWDKEEPGTQLL 664
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
PLN03091 PLN03091
hypothetical protein; Provisional
 107-215 3.32e-28

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 118.93  E-value: 3.32e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036 107 ELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKhLKG--RIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRW 184
Cdd:PLN03091   11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958775036 185 AEIAKLLPGRTDNSIKNHWNSTMRRKVEQEG 215
Cdd:PLN03091   90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRG 120
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 110-215 5.94e-28

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 113.25  E-value: 5.94e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036 110 KGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKG-RIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIA 188
Cdd:PLN03212   25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                          90       100
                  ....*....|....*....|....*..
gi 1958775036 189 KLLPGRTDNSIKNHWNSTMRRKVEQEG 215
Cdd:PLN03212  105 GRIPGRTDNEIKNYWNTHLRKKLLRQG 131
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 107-209 4.60e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 116.04  E-value: 4.60e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036 107 ELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAE 186
Cdd:COG5147    17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                          90       100
                  ....*....|....*....|...
gi 1958775036 187 IAKLLPGRTDNSIKNHWNSTMRR 209
Cdd:COG5147    97 IADYKDRRTAQQCVERYVNTLED 119
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 263-308 1.12e-19

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 82.62  E-value: 1.12e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958775036 263 GNCVEHVQTS-AFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKR 308
Cdd:pfam07988   1 LNCLEHPQHStAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 113-171 4.07e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 78.89  E-value: 4.07e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958775036 113 WTKEEDQRVIELVQKYGPKrWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDR 171
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 110-156 3.25e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 75.62  E-value: 3.25e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958775036 110 KGPWTKEEDQRVIELVQKYGpKRWSLIAKHLKGRIGKQCRERWHNHL 156
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 162-205 3.76e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 75.62  E-value: 3.76e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958775036 162 KSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNS 205
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 61-121 1.83e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 73.88  E-value: 1.83e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775036  61 WTRDEDDKLKKLVEQHGtDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRV 121
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
110-158 1.87e-16

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 73.80  E-value: 1.87e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958775036  110 KGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNP 158
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 112-156 3.42e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 72.61  E-value: 3.42e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958775036 112 PWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHL 156
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
58-106 5.11e-15

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 69.56  E-value: 5.11e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958775036   58 RVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNP 106
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 58-104 1.19e-14

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 68.30  E-value: 1.19e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958775036  58 RVKWTRDEDDKLKKLVEQHGtDDWTLIASHLQNRSDFQCQHRWQKVL 104
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 60-104 1.45e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 67.99  E-value: 1.45e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958775036  60 KWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVL 104
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
162-209 3.47e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.17  E-value: 3.47e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1958775036  162 KSSWTEEEDRIIYEAHKRLG-NRWAEIAKLLPGRTDNSIKNHWNSTMRR 209
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 164-204 3.97e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 64.13  E-value: 3.97e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1958775036 164 SWTEEEDRIIYEAHKRLG-NRWAEIAKLLPGRTDNSIKNHWN 204
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 165-218 5.88e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 50.00  E-value: 5.88e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1958775036 165 WTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQ 218
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSK 54
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 106-152 6.74e-07

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 46.53  E-value: 6.74e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958775036 106 PELIKGPWTKEEDQRVIELVQKYgPKRWSLIAKhLKGRIGKQCRERW 152
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLL-PTQWRTIAP-IVGRTAQQCLERY 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 112-154 7.04e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 46.41  E-value: 7.04e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958775036 112 PWTKEEDQRVIELVQKYGPKRWSLIAKH---LKGRIGKQCRERWHN 154
Cdd:cd11660     2 KWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKWRN 47
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 158-204 4.69e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 41.53  E-value: 4.69e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1958775036 158 PEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLpGRTDNSIKNHWN 204
Cdd:cd11659     1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQQCLERYN 46
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 58-200 5.98e-05

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 46.32  E-value: 5.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036  58 RVKWTRDEDDKLKKLVEQHGTdDWTLIaSHLQNRSDFQCQHRWQ--KVLNPELIKGPWTKEEDQRVIELV-------QKY 128
Cdd:COG5147   291 RGKWTKEEEQELAKLVVEHGG-SWTEI-GKLLGRMPNDCRDRWRdyVKCGDTLKRNRWSIEEEELLDKVVnemrleaQQS 368

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958775036 129 GPKRWSLIAKHLKGRIGKQCreRWHNHLNPEVKK----SSWTEEEDRiIYEAHKRLGNR--WAEIAKLLPGRTDNSIK 200
Cdd:COG5147   369 SRILWLLIAQNIRNRLQHHC--RDKYGVLISNSSpfdaGAAIWLIER-YSNRKIQNGDLikWRNSVLDSARRRMRDLK 443
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 59-100 4.10e-04

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 38.70  E-value: 4.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1958775036  59 VKWTRDEDDKLKKLVEQHGTDDWTLIASH---LQNRSDFQCQHRW 100
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKW 45
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 98-195 3.81e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 40.54  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775036  98 HRWQKVLNPELIKGPWTKEEDQRVIELVQKYGpKRWSLIAKhLKGRIGKQCRERWHNHLNP--EVKKSSWT-EEEDRII- 173
Cdd:COG5147   279 KHLRRKYNIFEQRGKWTKEEEQELAKLVVEHG-GSWTEIGK-LLGRMPNDCRDRWRDYVKCgdTLKRNRWSiEEEELLDk 356

                          90       100
                  ....*....|....*....|....*...
gi 1958775036 174 ------YEAHKRLGNRWAEIAKLLPGRT 195
Cdd:COG5147   357 vvnemrLEAQQSSRILWLLIAQNIRNRL 384
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 57-105 4.84e-03

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 35.75  E-value: 4.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958775036  57 NRVKWTRDEDDKLKKLVeQHGTDDWTLIAShLQNRSDFQCQHRWQKVLN 105
Cdd:cd11659     4 KKTEWTREEDEKLLHLA-KLLPTQWRTIAP-IVGRTAQQCLERYNKLLD 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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