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Conserved domains on  [gi|1958782593|ref|XP_038967982|]
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intraflagellar transport protein 43 homolog isoform X7 [Rattus norvegicus]

Protein Classification

intraflagellar transport protein 43( domain architecture ID 10633880)

intraflagellar transport protein 43 (IFT43) is a component of the IFT complex A (IFT-A), which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), and is involved in ciliogenesis

Gene Symbol:  IFT43
Gene Ontology:  GO:0030991
PubMed:  28207750

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IFT43 pfam15305
Intraflagellar transport protein 43; Intraflagellar transport protein 43 (IFT43) is a subunit ...
 2-112 8.81e-59

Intraflagellar transport protein 43; Intraflagellar transport protein 43 (IFT43) is a subunit of the IFT complex A (IFT-A) machinery of primary cilia.


:

Pssm-ID: 464631  Cd Length: 136  Bit Score: 177.97  E-value: 8.81e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782593   2 EDRRLRQQNLTGT-EEGEDIPVIPDLEDVQEEDFVLQVASPPSIQVNRVMTYRDLDNDLMKYSAFQTLDGEIDLKLLTKV 80
Cdd:pfam15305  24 EDERLRKQTPYESdDEDEDIPVIPDLEEVQEEDLTTQVAAAPSIQVNRVQTYRELDNDLKKTAALQTLDGGIDLSLLTKV 103

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958782593  81 LAPEHEVREDDVGWDWDHLYTEVSSELLTEWD 112
Cdd:pfam15305 104 LSPEEEVREDDVPWDWDHLFTEVSSELQAEWD 135
 
Name Accession Description Interval E-value
IFT43 pfam15305
Intraflagellar transport protein 43; Intraflagellar transport protein 43 (IFT43) is a subunit ...
 2-112 8.81e-59

Intraflagellar transport protein 43; Intraflagellar transport protein 43 (IFT43) is a subunit of the IFT complex A (IFT-A) machinery of primary cilia.


Pssm-ID: 464631  Cd Length: 136  Bit Score: 177.97  E-value: 8.81e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782593   2 EDRRLRQQNLTGT-EEGEDIPVIPDLEDVQEEDFVLQVASPPSIQVNRVMTYRDLDNDLMKYSAFQTLDGEIDLKLLTKV 80
Cdd:pfam15305  24 EDERLRKQTPYESdDEDEDIPVIPDLEEVQEEDLTTQVAAAPSIQVNRVQTYRELDNDLKKTAALQTLDGGIDLSLLTKV 103

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958782593  81 LAPEHEVREDDVGWDWDHLYTEVSSELLTEWD 112
Cdd:pfam15305 104 LSPEEEVREDDVPWDWDHLFTEVSSELQAEWD 135
START_STARD13-like cd08909
C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also ...
 36-96 5.84e-03

C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. The precise function of the START domain in this subgroup is unclear.


Pssm-ID: 176918  Cd Length: 205  Bit Score: 34.89  E-value: 5.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958782593  36 LQVASPPSIQVNRVMTYRDL-DNDLMKYSAFQTLDGEIDLKLLTKVLAPEHEVREDDVGWDW 96
Cdd:cd08909    58 VEVEAPPSVVLNRVLRERHLwDEDFLQWKVVETLDKQTEVYQYVLNCMAPHPSRDFVVLRSW 119
 
Name Accession Description Interval E-value
IFT43 pfam15305
Intraflagellar transport protein 43; Intraflagellar transport protein 43 (IFT43) is a subunit ...
 2-112 8.81e-59

Intraflagellar transport protein 43; Intraflagellar transport protein 43 (IFT43) is a subunit of the IFT complex A (IFT-A) machinery of primary cilia.


Pssm-ID: 464631  Cd Length: 136  Bit Score: 177.97  E-value: 8.81e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782593   2 EDRRLRQQNLTGT-EEGEDIPVIPDLEDVQEEDFVLQVASPPSIQVNRVMTYRDLDNDLMKYSAFQTLDGEIDLKLLTKV 80
Cdd:pfam15305  24 EDERLRKQTPYESdDEDEDIPVIPDLEEVQEEDLTTQVAAAPSIQVNRVQTYRELDNDLKKTAALQTLDGGIDLSLLTKV 103

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958782593  81 LAPEHEVREDDVGWDWDHLYTEVSSELLTEWD 112
Cdd:pfam15305 104 LSPEEEVREDDVPWDWDHLFTEVSSELQAEWD 135
START_STARD13-like cd08909
C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also ...
 36-96 5.84e-03

C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD13 (also known as DLC-2, Arhgap37, and SDCCAG13) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. Proteins belonging to this subfamily also have a RhoGAP domain. The precise function of the START domain in this subgroup is unclear.


Pssm-ID: 176918  Cd Length: 205  Bit Score: 34.89  E-value: 5.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958782593  36 LQVASPPSIQVNRVMTYRDL-DNDLMKYSAFQTLDGEIDLKLLTKVLAPEHEVREDDVGWDW 96
Cdd:cd08909    58 VEVEAPPSVVLNRVLRERHLwDEDFLQWKVVETLDKQTEVYQYVLNCMAPHPSRDFVVLRSW 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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