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Conserved domains on  [gi|1958784403|ref|XP_038968737|]
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latent-transforming growth factor beta-binding protein 2 isoform X3 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 687-730 1.63e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 66.15  E-value: 1.63e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958784403  687 GTCTLPLVQRITKQICCCSRVGKAWGSKCEHCPLPGTEAFREIC 730
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1392-1432 9.38e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 52.67  E-value: 9.38e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958784403 1392 CSQILGQNSTQAECCC-TQGARWGETCDPCPSEDSVEFSELC 1432
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1562-1605 1.95e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 1.95e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958784403 1562 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1605
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1272-1305 2.80e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.80e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1958784403  1272 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFET 1305
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
940-979 2.30e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.30e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958784403   940 DVDECEQPGVCS-GGRCSNTEGSYHCECDQGYvmVRRGHCQ 979
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY--TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1104-1134 2.33e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.69  E-value: 2.33e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403 1104 DVDECEGPQNSC-LGGECKNTDGSYQCLCPQG 1134
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1145-1186 4.90e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.90e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958784403  1145 DVDECVGEEHCAPHGECLNSPGSFFCLCAPGFasaEGGTRCQ 1186
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1187-1218 7.04e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 7.04e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958784403  1187 DVDECATTEPCL-GGHCVNTEGSFNCLCETGFQ 1218
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 897-931 1.57e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958784403  897 DDNECL-RNPCEGRGRCVNSVGSYSCLCYPGYTLAT 931
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1743-1777 4.64e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.64e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958784403  1743 DVNECEDLNgpaaLCAHG-HCENTEGSYRCHCSPGY 1777
Cdd:smart00179    1 DIDECASGN----PCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
628-657 1.87e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.87e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1958784403   628 DINECLTLGLCK-DSECVNTRGSYLCTCRPG 657
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 980-1015 3.13e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.13e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958784403  980 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYIGQS 1015
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1062-1092 4.27e-04

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 4.27e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1062 DLDECAFPG-VCP-TGVCTNTVGSFSCKdCDRG 1092
Cdd:pfam07645    1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1020-1061 6.46e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.46e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958784403  1020 DVDECASRASCPTG-LCLNTEGSFTCSaCQSGYwvnEDGTACE 1061
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1454-1487 1.85e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.85e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1958784403  1454 DADECILFGPalCQNG-RCLNTVPGYICLCNPGYH 1487
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33
PHA03378 super family cl33729
EBNA-3B; Provisional
 756-854 2.04e-03

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 2.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784403  756 ASPVREQRQQSSGPPPGAAERQPLRAATATWIEAETLPDKGDSRAIQITTSAPHlPARVPGDATGRPTPSLPGQGIPE-- 833
Cdd:PHA03378   709 APPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPG-RARPPAAAPGAPTPQPPPQAPPApq 787

                           90       100
                   ....*....|....*....|....*....
gi 1958784403  834 -----GPA---EEQVIPSSDVLVTHGPPG 854
Cdd:PHA03378   788 qrprgAPTpqpPPQAGPTSMQLMPRAAPG 816
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 567-601 7.05e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 7.05e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958784403  567 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 601
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 687-730 1.63e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 66.15  E-value: 1.63e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958784403  687 GTCTLPLVQRITKQICCCSRVGKAWGSKCEHCPLPGTEAFREIC 730
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1392-1432 9.38e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 52.67  E-value: 9.38e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958784403 1392 CSQILGQNSTQAECCC-TQGARWGETCDPCPSEDSVEFSELC 1432
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1562-1605 1.95e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 1.95e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958784403 1562 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1605
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1272-1305 2.80e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.80e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1958784403  1272 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFET 1305
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1272-1304 3.69e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.69e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1272 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1304
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
940-979 2.30e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.30e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958784403   940 DVDECEQPGVCS-GGRCSNTEGSYHCECDQGYvmVRRGHCQ 979
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY--TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1104-1134 2.33e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.69  E-value: 2.33e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403 1104 DVDECEGPQNSC-LGGECKNTDGSYQCLCPQG 1134
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1145-1186 4.90e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.90e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958784403  1145 DVDECVGEEHCAPHGECLNSPGSFFCLCAPGFasaEGGTRCQ 1186
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 940-970 5.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.64e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403  940 DVDECEQPGVCS-GGRCSNTEGSYHCECDQGY 970
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1187-1218 7.04e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 7.04e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958784403  1187 DVDECATTEPCL-GGHCVNTEGSFNCLCETGFQ 1218
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1104-1144 1.43e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.43e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958784403  1104 DVDECEGPQNSCLGGECKNTDGSYQCLCPQGFQlaNGTVCE 1144
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 897-931 1.57e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958784403  897 DDNECL-RNPCEGRGRCVNSVGSYSCLCYPGYTLAT 931
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1187-1218 2.66e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.66e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1187 DVDECATTEPCL-GGHCVNTEGSFNCLCETGFQ 1218
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1145-1186 3.33e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.33e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958784403 1145 DVDECVGEEHCAPHGECLNSPGSFFCLCAPGFAsaegGTRCQ 1186
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
897-928 3.66e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.66e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958784403   897 DDNECL-RNPCEGRGRCVNSVGSYSCLCYPGYT 928
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1743-1777 4.64e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.64e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958784403  1743 DVNECEDLNgpaaLCAHG-HCENTEGSYRCHCSPGY 1777
Cdd:smart00179    1 DIDECASGN----PCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1104-1139 7.91e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 7.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958784403 1104 DVDECEGPQNSCLGGECKNTDGSYQCLCPQGFQLAN 1139
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
628-657 1.87e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.87e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1958784403   628 DINECLTLGLCK-DSECVNTRGSYLCTCRPG 657
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
1187-1216 2.10e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 2.10e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403 1187 DVDECAT-TEPC-LGGHCVNTEGSFNCLCETG 1216
Cdd:pfam07645    1 DVDECATgTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1272-1302 2.15e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 2.15e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403 1272 DIDECANDT-VCGNHGFCDNTDGSFRCLCDQG 1302
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 980-1015 3.13e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.13e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958784403  980 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYIGQS 1015
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1062-1092 4.27e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 4.27e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1062 DLDECAFPG-VCP-TGVCTNTVGSFSCKdCDRG 1092
Cdd:pfam07645    1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 628-661 4.92e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 4.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958784403  628 DINECLTLGLCK-DSECVNTRGSYLCTCRPGLMLD 661
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1743-1777 6.36e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 6.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958784403 1743 DVNECEDLNgpaaLCAHGH-CENTEGSYRCHCSPGY 1777
Cdd:cd00054      1 DIDECASGN----PCQNGGtCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1020-1061 6.46e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.46e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958784403  1020 DVDECASRASCPTG-LCLNTEGSFTCSaCQSGYwvnEDGTACE 1061
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
940-969 1.10e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403  940 DVDECEQPG-VC-SGGRCSNTEGSYHCECDQG 969
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1743-1776 1.43e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.43e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958784403 1743 DVNECEDlngPAALC-AHGHCENTEGSYRCHCSPG 1776
Cdd:pfam07645    1 DVDECAT---GTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1454-1487 1.85e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.85e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1958784403  1454 DADECILFGPalCQNG-RCLNTVPGYICLCNPGYH 1487
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33
PHA03378 PHA03378
EBNA-3B; Provisional
 756-854 2.04e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 2.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784403  756 ASPVREQRQQSSGPPPGAAERQPLRAATATWIEAETLPDKGDSRAIQITTSAPHlPARVPGDATGRPTPSLPGQGIPE-- 833
Cdd:PHA03378   709 APPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPG-RARPPAAAPGAPTPQPPPQAPPApq 787

                           90       100
                   ....*....|....*....|....*....
gi 1958784403  834 -----GPA---EEQVIPSSDVLVTHGPPG 854
Cdd:PHA03378   788 qrprgAPTpqpPPQAGPTSMQLMPRAAPG 816
EGF_CA smart00179
Calcium-binding EGF-like domain;
1062-1103 2.23e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.23e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958784403  1062 DLDECAFPGVCPTG-VCTNTVGSFSCkDCDRGFRPsplGNSCE 1103
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRC-ECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
980-1011 2.56e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.56e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958784403   980 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGY 1011
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGY 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 901-928 3.97e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.97e-03
                           10        20
                   ....*....|....*....|....*...
gi 1958784403  901 CLRNPCEGRGRCVNSVGSYSCLCYPGYT 928
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1062-1103 5.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 5.18e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958784403 1062 DLDECAFPGVC-PTGVCTNTVGSFSCkDCDRGFRpsplGNSCE 1103
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRC-SCPPGYT----GRNCE 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 567-601 7.05e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 7.05e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958784403  567 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 601
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1454-1487 8.99e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.99e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958784403 1454 DADECILFGPalCQN-GRCLNTVPGYICLCNPGYH 1487
Cdd:cd00054      1 DIDECASGNP--CQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1020-1050 9.64e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 9.64e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1020 DVDECAS-RASCP-TGLCLNTEGSFTCSaCQSG 1050
Cdd:pfam07645    1 DVDECATgTHNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1020-1051 9.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.92e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1020 DVDECASRASC-PTGLCLNTEGSFTCSaCQSGY 1051
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGY 32
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 687-730 1.63e-13

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 66.15  E-value: 1.63e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1958784403  687 GTCTLPLVQRITKQICCCSRVGKAWGSKCEHCPLPGTEAFREIC 730
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1392-1432 9.38e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 52.67  E-value: 9.38e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958784403 1392 CSQILGQNSTQAECCC-TQGARWGETCDPCPSEDSVEFSELC 1432
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1562-1605 1.95e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 1.95e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1958784403 1562 DVCSQPLrGHHTTYTECCCQD-GEAWSQQCALCPPRSSEVYAQLC 1605
Cdd:pfam00683    1 GRCSNPL-PGNVTKSECCCTSvGRAWGSPCELCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
1272-1305 2.80e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 2.80e-07
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1958784403  1272 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFET 1305
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1272-1304 3.69e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 3.69e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1272 DIDECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1304
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
940-979 2.30e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.30e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958784403   940 DVDECEQPGVCS-GGRCSNTEGSYHCECDQGYvmVRRGHCQ 979
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGY--TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1104-1134 2.33e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.69  E-value: 2.33e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403 1104 DVDECEGPQNSC-LGGECKNTDGSYQCLCPQG 1134
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1145-1186 4.90e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 4.90e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958784403  1145 DVDECVGEEHCAPHGECLNSPGSFFCLCAPGFasaEGGTRCQ 1186
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 940-970 5.64e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.64e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403  940 DVDECEQPGVCS-GGRCSNTEGSYHCECDQGY 970
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1187-1218 7.04e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 7.04e-06
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958784403  1187 DVDECATTEPCL-GGHCVNTEGSFNCLCETGFQ 1218
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1104-1144 1.43e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 1.43e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958784403  1104 DVDECEGPQNSCLGGECKNTDGSYQCLCPQGFQlaNGTVCE 1144
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 897-931 1.57e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958784403  897 DDNECL-RNPCEGRGRCVNSVGSYSCLCYPGYTLAT 931
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1187-1218 2.66e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 2.66e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1187 DVDECATTEPCL-GGHCVNTEGSFNCLCETGFQ 1218
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1145-1186 3.33e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.33e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958784403 1145 DVDECVGEEHCAPHGECLNSPGSFFCLCAPGFAsaegGTRCQ 1186
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
897-928 3.66e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 3.66e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958784403   897 DDNECL-RNPCEGRGRCVNSVGSYSCLCYPGYT 928
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1743-1777 4.64e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 4.64e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958784403  1743 DVNECEDLNgpaaLCAHG-HCENTEGSYRCHCSPGY 1777
Cdd:smart00179    1 DIDECASGN----PCQNGgTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1104-1139 7.91e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 7.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958784403 1104 DVDECEGPQNSCLGGECKNTDGSYQCLCPQGFQLAN 1139
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
628-657 1.87e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.87e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1958784403   628 DINECLTLGLCK-DSECVNTRGSYLCTCRPG 657
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
1187-1216 2.10e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 2.10e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403 1187 DVDECAT-TEPC-LGGHCVNTEGSFNCLCETG 1216
Cdd:pfam07645    1 DVDECATgTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1272-1302 2.15e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 2.15e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403 1272 DIDECANDT-VCGNHGFCDNTDGSFRCLCDQG 1302
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 980-1015 3.13e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.13e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958784403  980 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGYIGQS 1015
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1062-1092 4.27e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 4.27e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1062 DLDECAFPG-VCP-TGVCTNTVGSFSCKdCDRG 1092
Cdd:pfam07645    1 DVDECATGThNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 628-661 4.92e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 4.92e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958784403  628 DINECLTLGLCK-DSECVNTRGSYLCTCRPGLMLD 661
Cdd:cd00054      1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1743-1777 6.36e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 6.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958784403 1743 DVNECEDLNgpaaLCAHGH-CENTEGSYRCHCSPGY 1777
Cdd:cd00054      1 DIDECASGN----PCQNGGtCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1020-1061 6.46e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 6.46e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958784403  1020 DVDECASRASCPTG-LCLNTEGSFTCSaCQSGYwvnEDGTACE 1061
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCE-CPPGY---TDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
940-969 1.10e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1958784403  940 DVDECEQPG-VC-SGGRCSNTEGSYHCECDQG 969
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1743-1776 1.43e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.43e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958784403 1743 DVNECEDlngPAALC-AHGHCENTEGSYRCHCSPG 1776
Cdd:pfam07645    1 DVDECAT---GTHNCpANTVCVNTIGSFECRCPDG 32
EGF smart00181
Epidermal growth factor-like domain;
943-975 1.46e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.88  E-value: 1.46e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958784403   943 ECEQPGVCSGGRCSNTEGSYHCECDQGYVMVRR 975
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1454-1487 1.85e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.85e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1958784403  1454 DADECILFGPalCQNG-RCLNTVPGYICLCNPGYH 1487
Cdd:smart00179    1 DIDECASGNP--CQNGgTCVNTVGSYRCECPPGYT 33
PHA03378 PHA03378
EBNA-3B; Provisional
 756-854 2.04e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 2.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958784403  756 ASPVREQRQQSSGPPPGAAERQPLRAATATWIEAETLPDKGDSRAIQITTSAPHlPARVPGDATGRPTPSLPGQGIPE-- 833
Cdd:PHA03378   709 APPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPG-RARPPAAAPGAPTPQPPPQAPPApq 787

                           90       100
                   ....*....|....*....|....*....
gi 1958784403  834 -----GPA---EEQVIPSSDVLVTHGPPG 854
Cdd:PHA03378   788 qrprgAPTpqpPPQAGPTSMQLMPRAAPG 816
EGF_CA smart00179
Calcium-binding EGF-like domain;
1062-1103 2.23e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.23e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1958784403  1062 DLDECAFPGVCPTG-VCTNTVGSFSCkDCDRGFRPsplGNSCE 1103
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRC-ECPPGYTD---GRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
980-1011 2.56e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.56e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1958784403   980 DINECRHPGTC-PDGRCVNSPGSYTCLaCEEGY 1011
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGY 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 901-928 3.97e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.97e-03
                           10        20
                   ....*....|....*....|....*...
gi 1958784403  901 CLRNPCEGRGRCVNSVGSYSCLCYPGYT 928
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1275-1304 4.11e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 4.11e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958784403 1275 ECANDTVCGNHGFCDNTDGSFRCLCDQGFE 1304
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYT 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1062-1103 5.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 5.18e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1958784403 1062 DLDECAFPGVC-PTGVCTNTVGSFSCkDCDRGFRpsplGNSCE 1103
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRC-SCPPGYT----GRNCE 38
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 567-601 7.05e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 7.05e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958784403  567 GQCANPL-GELTSQEDCCGSVGTFWGvTSCAPCPPR 601
Cdd:pfam00683    1 GRCSNPLpGNVTKSECCCTSVGRAWG-SPCELCPPP 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1454-1487 8.99e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.99e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958784403 1454 DADECILFGPalCQN-GRCLNTVPGYICLCNPGYH 1487
Cdd:cd00054      1 DIDECASGNP--CQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1020-1050 9.64e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 9.64e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1020 DVDECAS-RASCP-TGLCLNTEGSFTCSaCQSG 1050
Cdd:pfam07645    1 DVDECATgTHNCPaNTVCVNTIGSFECR-CPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1020-1051 9.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 9.92e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958784403 1020 DVDECASRASC-PTGLCLNTEGSFTCSaCQSGY 1051
Cdd:cd00054      1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGY 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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