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Conserved domains on  [gi|2024449525|ref|XP_040518313|]
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solute carrier organic anion transporter family member 1A2 [Gallus gallus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
31-546 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17458:

Pssm-ID: 452895 [Multi-domain]  Cd Length: 527  Bit Score: 925.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  31 IGKTMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLF 110
Cdd:cd17458    14 VAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLGCFLASLPHFLM 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 111 GRYHIESSVS-PQENSSVVSLCHANQSLTSLPTEEPStECEKEPESLLWIFVMVGNLIRGMGETPIVPLGISYLEDFAKT 189
Cdd:cd17458    94 GRYEYESTVStTSNSSSRVPLCLANQSLSHNVTQLPS-ECEKESMSLMWIFVLVGNLLRGIGETPVMPLGISYIDDFSKK 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 190 ENSPFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRS 269
Cdd:cd17458   173 ENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLAGLPFWFLPKS 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 270 LVKEGEISESEKTgKKEGVLLEGNEQKETKQSMYEIAKDFIPFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQ 349
Cdd:cd17458   253 LPKEGEENETEPS-KTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMISFMPKYLEQ 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 350 QFGKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGI 429
Cdd:cd17458   332 QYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVAGLTVSYEGI 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 430 DQLSYAENTLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVAAAEFPFQNTSAiLGQCD 509
Cdd:cd17458   412 DQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQNSSA-VGQCD 490
                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 2024449525 510 KGGNCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIRS 546
Cdd:cd17458   491 KGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
 
Name Accession Description Interval E-value
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
31-546 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 925.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  31 IGKTMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLF 110
Cdd:cd17458    14 VAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLGCFLASLPHFLM 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 111 GRYHIESSVS-PQENSSVVSLCHANQSLTSLPTEEPStECEKEPESLLWIFVMVGNLIRGMGETPIVPLGISYLEDFAKT 189
Cdd:cd17458    94 GRYEYESTVStTSNSSSRVPLCLANQSLSHNVTQLPS-ECEKESMSLMWIFVLVGNLLRGIGETPVMPLGISYIDDFSKK 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 190 ENSPFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRS 269
Cdd:cd17458   173 ENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLAGLPFWFLPKS 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 270 LVKEGEISESEKTgKKEGVLLEGNEQKETKQSMYEIAKDFIPFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQ 349
Cdd:cd17458   253 LPKEGEENETEPS-KTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMISFMPKYLEQ 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 350 QFGKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGI 429
Cdd:cd17458   332 QYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVAGLTVSYEGI 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 430 DQLSYAENTLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVAAAEFPFQNTSAiLGQCD 509
Cdd:cd17458   412 DQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQNSSA-VGQCD 490
                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 2024449525 510 KGGNCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIRS 546
Cdd:cd17458   491 KGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
31-633 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 666.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  31 IGKTMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLF 110
Cdd:TIGR00805  43 LQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLM 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 111 GRYHIESSVSPQENSSVVS--LCHANQSLTSLPTEEPStECEKEPESLLWIFVMVGNLIRGMGETPIVPLGISYLEDFAK 188
Cdd:TIGR00805 123 GRYSYSTTVSSTGNLSSANsfLCMENLTQTLRPTQDPS-ECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAK 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 189 TENSPFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPR 268
Cdd:TIGR00805 202 SKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPK 281
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 269 SLVKEGeiSESEKTGKKEGVLLEGNEQKETKQSMyeIAKDFIPFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLE 348
Cdd:TIGR00805 282 TLPKEG--KRVNVDVHEAEKLEKSRGEDRKKNSG--ITKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLE 357
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 349 QQFGKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVsyEG 428
Cdd:TIGR00805 358 NQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVNN--PS 435
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 429 IDQLSYAENTLlaDCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVAAAefpfQNTSAILGQC 508
Cdd:TIGR00805 436 NDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGSNMVFTNCSCIQTP----GNSSAKKGLC 509
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 509 DKggNCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIRSLKPEEKSFGVGIHELAARVFAGIPSPVFFGALIDTTCMKWGT 588
Cdd:TIGR00805 510 DP--PCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQT 587
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 2024449525 589 KSCGGEGACRIYDIVKYRWIYLGLPALLRGVSFIPGVITLFILKK 633
Cdd:TIGR00805 588 LKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
33-605 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 599.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  33 KTMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFlfgr 112
Cdd:pfam03137  13 QALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLILFVSYFGGKGHRPRWIGVGSLLMGLGSLLFALPHF---- 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 113 yhiessvspqenssvvslchanqsltslpteepstecekepesllwIFVMVGNLIRGMGETPIVPLGISYLEDFAKTENS 192
Cdd:pfam03137  89 ----------------------------------------------LSFFLGQLLLGIGGTPLYTLGISYIDDNVKKKNS 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 193 PFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVdagELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRSLVK 272
Cdd:pfam03137 123 PLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGSV---SLTLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLPG 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 273 EGEISESEKtgKKEGVLLEGNEQKETKQSMYEIAKDFIPFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFG 352
Cdd:pfam03137 200 TAKRRAEKK--KEPESHSIKDSEKTKSLKLGKSLKDFPRALKRLLKNPVYMLLTLASVSEFLLIAGYATFLPKYIETQFG 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 353 KSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGIDQL 432
Cdd:pfam03137 278 LSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAKGLAKFNLITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGTQQL 357
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 433 SyaeNTLLADCNRDCDCTLKVWDPVCANNG--ITYVSSCLAGCKASTGTGKSVVFENCTCVAAAEFPFQNTSAILGQCDK 510
Cdd:pfam03137 358 S---GNLTASCNSNCSCSTSFYSPVCGSDGigYTSPCPCGAGCSSSSGAGKSTYNCSCCCSCGSSTSGGNGSATPGKCPS 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 511 ggNCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIRSLKPEEKSFGVGIHELAARVFAGIPSPVFFGALIDTTCMKWgTKS 590
Cdd:pfam03137 435 --DCSNKLPLFLALLFLASFFSSLSSTPGTLIILRCVPPEDKSFALGLQFLILRLLGFIPGPIIFGALIDSTCLLW-TKT 511
                         570
                  ....*....|....*
gi 2024449525 591 CGGEGACRIYDIVKY 605
Cdd:pfam03137 512 CGGRGNCWLYDNDKL 526
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
442-483 3.67e-04

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 38.43  E-value: 3.67e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024449525  442 DCNRDCDctlKVWDPVCANNGITYVSSCLAgCKASTGTGKSV 483
Cdd:smart00280   1 DCPEACP---REYDPVCGSDGVTYSNECHL-CKAACESGKSI 38
 
Name Accession Description Interval E-value
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
31-546 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 925.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  31 IGKTMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLF 110
Cdd:cd17458    14 VAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLGCFLASLPHFLM 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 111 GRYHIESSVS-PQENSSVVSLCHANQSLTSLPTEEPStECEKEPESLLWIFVMVGNLIRGMGETPIVPLGISYLEDFAKT 189
Cdd:cd17458    94 GRYEYESTVStTSNSSSRVPLCLANQSLSHNVTQLPS-ECEKESMSLMWIFVLVGNLLRGIGETPVMPLGISYIDDFSKK 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 190 ENSPFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRS 269
Cdd:cd17458   173 ENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNFLAGLPFWFLPKS 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 270 LVKEGEISESEKTgKKEGVLLEGNEQKETKQSMYEIAKDFIPFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQ 349
Cdd:cd17458   253 LPKEGEENETEPS-KTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSGMISFMPKYLEQ 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 350 QFGKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGI 429
Cdd:cd17458   332 QYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSPVAGLTVSYEGI 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 430 DQLSYAENTLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVAAAEFPFQNTSAiLGQCD 509
Cdd:cd17458   412 DQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPSQNSSA-VGQCD 490
                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 2024449525 510 KGGNCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIRS 546
Cdd:cd17458   491 KGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
31-633 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 666.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  31 IGKTMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLF 110
Cdd:TIGR00805  43 LQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLM 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 111 GRYHIESSVSPQENSSVVS--LCHANQSLTSLPTEEPStECEKEPESLLWIFVMVGNLIRGMGETPIVPLGISYLEDFAK 188
Cdd:TIGR00805 123 GRYSYSTTVSSTGNLSSANsfLCMENLTQTLRPTQDPS-ECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAK 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 189 TENSPFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPR 268
Cdd:TIGR00805 202 SKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPK 281
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 269 SLVKEGeiSESEKTGKKEGVLLEGNEQKETKQSMyeIAKDFIPFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLE 348
Cdd:TIGR00805 282 TLPKEG--KRVNVDVHEAEKLEKSRGEDRKKNSG--ITKDFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLE 357
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 349 QQFGKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVsyEG 428
Cdd:TIGR00805 358 NQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVNN--PS 435
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 429 IDQLSYAENTLlaDCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVAAAefpfQNTSAILGQC 508
Cdd:TIGR00805 436 NDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSVGTGSNMVFTNCSCIQTP----GNSSAKKGLC 509
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 509 DKggNCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIRSLKPEEKSFGVGIHELAARVFAGIPSPVFFGALIDTTCMKWGT 588
Cdd:TIGR00805 510 DP--PCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQT 587
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 2024449525 589 KSCGGEGACRIYDIVKYRWIYLGLPALLRGVSFIPGVITLFILKK 633
Cdd:TIGR00805 588 LKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
33-605 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 599.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  33 KTMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFlfgr 112
Cdd:pfam03137  13 QALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLILFVSYFGGKGHRPRWIGVGSLLMGLGSLLFALPHF---- 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 113 yhiessvspqenssvvslchanqsltslpteepstecekepesllwIFVMVGNLIRGMGETPIVPLGISYLEDFAKTENS 192
Cdd:pfam03137  89 ----------------------------------------------LSFFLGQLLLGIGGTPLYTLGISYIDDNVKKKNS 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 193 PFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVdagELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRSLVK 272
Cdd:pfam03137 123 PLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGSV---SLTLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLPG 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 273 EGEISESEKtgKKEGVLLEGNEQKETKQSMYEIAKDFIPFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFG 352
Cdd:pfam03137 200 TAKRRAEKK--KEPESHSIKDSEKTKSLKLGKSLKDFPRALKRLLKNPVYMLLTLASVSEFLLIAGYATFLPKYIETQFG 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 353 KSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGIDQL 432
Cdd:pfam03137 278 LSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAKGLAKFNLITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGTQQL 357
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 433 SyaeNTLLADCNRDCDCTLKVWDPVCANNG--ITYVSSCLAGCKASTGTGKSVVFENCTCVAAAEFPFQNTSAILGQCDK 510
Cdd:pfam03137 358 S---GNLTASCNSNCSCSTSFYSPVCGSDGigYTSPCPCGAGCSSSSGAGKSTYNCSCCCSCGSSTSGGNGSATPGKCPS 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 511 ggNCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIRSLKPEEKSFGVGIHELAARVFAGIPSPVFFGALIDTTCMKWgTKS 590
Cdd:pfam03137 435 --DCSNKLPLFLALLFLASFFSSLSSTPGTLIILRCVPPEDKSFALGLQFLILRLLGFIPGPIIFGALIDSTCLLW-TKT 511
                         570
                  ....*....|....*
gi 2024449525 591 CGGEGACRIYDIVKY 605
Cdd:pfam03137 512 CGGRGNCWLYDNDKL 526
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
33-546 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 599.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  33 KTMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLFGR 112
Cdd:cd17459    15 KALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAIGTFLIALPHFFMGR 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 113 YHIESSVSPQENSSVV---SLCHANQSLTSLPTEE--PSTECEKEPESLLWIFVMVGNLIRGMGETPIVPLGISYLEDFA 187
Cdd:cd17459    95 YKYETAIQSSSNSTVSispCSLEPSPQLHSIESSDskTGTGCEKEPGSSMWIYVFLGNLLRGIGETPVQPLGISYIDDFA 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 188 KTENSPFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLP 267
Cdd:cd17459   175 KEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLIAGVITLLSAVPFWFLP 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 268 RSLvkegeisesektgkkegvllegneqketkqsmyeiAKDFIPFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYL 347
Cdd:cd17459   255 KSL-----------------------------------PKDFLPSLKNLLGNPVYFLYLCTSILQFNSLIGMVTYKPKYI 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 348 EQQFGKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYE 427
Cdd:cd17459   300 EQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLLSFFAMGCENSDVAGLTVSYN 379
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 428 GIDQLSYAENTLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVAAAEFPFQNTSAILGQ 507
Cdd:cd17459   380 GTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVFHNCSCIGIPSSASGSSSAILGQ 459
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 2024449525 508 CDKGGNCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIRS 546
Cdd:cd17459   460 CPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
31-545 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 537.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  31 IGKTMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLF 110
Cdd:cd17400    13 VAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGLGCFLKALPHFFM 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 111 GRYHIessvspqenssvvslchanqsltslpteepstecekepeSLLWIFVMVGNLIRGMGETPIVPLGISYLEDFAKTE 190
Cdd:cd17400    93 NQYEY---------------------------------------SLMWIYVFVGNILRGIGETPILPLGISYIDDFAKEE 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 191 NSPFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPrsl 270
Cdd:cd17400   134 NSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWLGFLICGGVSVLTAIPFFFLP--- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 271 vkegeisesektgkkegvllegneqketkqsmyeiakdfipflkallrnPVYMLFIVISVLQFSAFIGMISFMPKYLEQQ 350
Cdd:cd17400   211 -------------------------------------------------PIYMLFILVSVIQFNSFVGMITYMPKYLEQQ 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 351 FGKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGID 430
Cdd:cd17400   242 YGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTCENSSVAGLTTSYEGIP 321
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 431 QLSYAENTLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVAAAEFPFQNTSAILGQCDK 510
Cdd:cd17400   322 PVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGKNIVFYNCSCIQTSGNSSANLSLCDGGCPR 401
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 2024449525 511 GGNCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIR 545
Cdd:cd17400   402 DPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
31-545 1.84e-168

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 488.97  E-value: 1.84e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  31 IGKTMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLF 110
Cdd:cd17457    13 FAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGLGSVLTALPHFFM 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 111 GRYHIEssvspqenssvvslchanqsltslpteepsteCEKEPESLLWIFVMVGNLIRGMGETPIVPLGISYLEDFAKTE 190
Cdd:cd17457    93 GYYKYG--------------------------------CLKESGSYMWVYVLMGNMLRGIGETPIVPLGISYLDDFAKEE 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 191 NSPFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPrsl 270
Cdd:cd17457   141 NSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSIISAIPFFFLP--- 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 271 vkegeisesektgkkegvllegneqketkqsmyeiakDFIPFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQQ 350
Cdd:cd17457   218 -------------------------------------GFFQSLKSILTNRLYVMFVCLTLLQVSSFIGFFTYKPKYMEQQ 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 351 FGKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGID 430
Cdd:cd17457   261 YGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGCENKSVAGITMTYDGNN 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 431 QLSYAENTLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVAAAEFPFQNTSAILGQCDK 510
Cdd:cd17457   341 PVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVFHNCSCLEVTGSQNRNYSAHLGECPR 420
                         490       500       510
                  ....*....|....*....|....*....|....*
gi 2024449525 511 GGNCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIR 545
Cdd:cd17457   421 DDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
34-545 1.47e-119

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 362.33  E-value: 1.47e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  34 TMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLFgry 113
Cdd:cd17336    16 GAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFLLALPHFLF--- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 114 hiessvspqenssvvslchanqsltslpteepstecekepesllwifvmVGNLIRGMGETPIVPLGISYLEDFAKTENSP 193
Cdd:cd17336    93 -------------------------------------------------VGQFLLGIGSSPLYTLGITYIDDNVSKKNSP 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 194 FYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDageLTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPrslvke 273
Cdd:cd17336   124 LYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVP---LGITPDDPRWIGAWWLGFLILGILLLIVSIPLFFFP------ 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 274 geisesektgkkegvllegneqketkqsmyeiakdfipflkallrnPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFGK 353
Cdd:cd17336   195 ----------------------------------------------PIFILLLLAIVFESFAISGFSTFLPKYLETQFRL 228
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 354 SASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGIDqls 433
Cdd:cd17336   229 SASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGCDNPPIAGVTTPYGSSS--- 305
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 434 yaeNTLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVAAaefPFQNTSAILGQCDKGGN 513
Cdd:cd17336   306 ---SPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSSDAGNGTKTYSNCSCINS---GTATSSGCPPDCSVAPN 379
                         490       500       510
                  ....*....|....*....|....*....|..
gi 2024449525 514 CDKMLQYFLILQLVGSFIFSLAAMPGFMVLIR 545
Cdd:cd17336   380 CCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
38-545 6.38e-98

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 308.27  E-value: 6.38e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  38 AYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLFGRYHIEs 117
Cdd:cd17461    21 AYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLALGAFLLTLPHFLSEPYQYS- 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 118 svspqenssvvslchanqsltslpteepstecekepeslLWIFVMVGNLIRGMGETPIVPLGISYLEDFAKTENSPFYQG 197
Cdd:cd17461   100 ---------------------------------------MWVLMVVAQLLAGIGTVPIQPFGISYVDDFAEPSNSPLYIA 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 198 CLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRSLVKEgeis 277
Cdd:cd17461   141 ILFAISVFGPAFGYLLGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWLGLLISSGLLVLTSLPYFFFPREMLVG---- 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 278 esEKTGKKEGVLLEGNEQKETKQSMYEIAKDFIPFLKALLRNPVYMLfIVISVLQFSAFI-GMISFMPKYLEQQFGKSAS 356
Cdd:cd17461   217 --KKPSPEGDMLRKKEDEKKEEGSLLDFIKRFPKMFVKLLLNPLFML-LVLAQCTFSSVIaGLSTFLNKFLEKQYGASAS 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 357 DAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYegidqlSYAE 436
Cdd:cd17461   294 YANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVPLFFMGCSTQDVAGVYPKT------SNSS 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 437 NTLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKAST---GTGKSVVFENCTCVAAaefPFQNTSAILGQCdkGGN 513
Cdd:cd17461   368 DGPHLSCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNmdsSTYRQQIYSNCSCIPD---LSGEKPAKTGSC--PNS 442
                         490       500       510
                  ....*....|....*....|....*....|..
gi 2024449525 514 CDKMLQYFLILQLVGSFIFSLAAMPGFMVLIR 545
Cdd:cd17461   443 CSHLLLPVMFLISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
35-545 6.23e-97

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 305.93  E-value: 6.23e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  35 MTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLFGRYH 114
Cdd:cd17460    17 LVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLAGFLMALPHFISEPYE 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 115 iessvspqenssvvslchanqsltslpteepstecekepesllWIFVMVGNLIRGMGETPIVPLGISYLEDFAKTENSPF 194
Cdd:cd17460    97 -------------------------------------------YGILFLGQLLLGIGGVPIQPFGISYIDDFASESNSPL 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 195 YQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRSLVKEg 274
Cdd:cd17460   134 YLGILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWLGFLIAATLVALSAVPYFFFPREMPKE- 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 275 EISESEKTGKKEGVLLEG--NEQKETKQ-SMYEIAKDFIPFLKALLRNPVYMLfIVISVLQFSAFI-GMISFMPKYLEQQ 350
Cdd:cd17460   213 VVELQPREKKLAKTMLKKlkSLSDILQNlSLLQFIKKFPRILLRTLRNPIYLL-VVLAQVNLSAMVaGLATFMGKFLERQ 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 351 FGKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEgid 430
Cdd:cd17460   292 FSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAMCVLGMLLCLFFALPLLFIGCSTQKIAGITHRTS--- 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 431 qlSYAENTLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKA---STGTGKSVVFENCTCVAAAEFPfqnTSAILGQ 507
Cdd:cd17460   369 --SSPGLELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGCKSvnvQALDNSVVNYTDCSCVSEGGPV---GAASPGT 443
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 2024449525 508 CDKGgnCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIR 545
Cdd:cd17460   444 CGSG--CSHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
37-545 6.39e-96

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 302.23  E-value: 6.39e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  37 GAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLFGRYHIe 116
Cdd:cd17402    19 GAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALPEFLTHQYKT- 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 117 ssvspqenssvvslchanqsltslpteepstecekepeSLLWIFVMVGNLIRGMGETPIVPLGISYLEDFAKTENSPFYQ 196
Cdd:cd17402    98 --------------------------------------NMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYI 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 197 GCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRSLvkegei 276
Cdd:cd17402   140 GILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFFSALLMFGFPQSL------ 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 277 sesektgkkegvllegneqketkQSMYEIAKdfipFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFGKSAS 356
Cdd:cd17402   214 -----------------------QQLRVIPK----VTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTS 266
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 357 DAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYeGIDQLSYAE 436
Cdd:cd17402   267 SANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPY-GNDTAPGSS 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 437 NTLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGksvvfenCTCVAAaeFPFQNTSAILGQCDKGGnCDK 516
Cdd:cd17402   346 LDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSG-------CACLSS--VPAENATVVPGKCPSPG-CQE 415
                         490       500
                  ....*....|....*....|....*....
gi 2024449525 517 MLQYFLILQLVGSFIFSLAAMPGFMVLIR 545
Cdd:cd17402   416 AFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
34-545 7.34e-89

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 283.09  E-value: 7.34e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  34 TMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLfgry 113
Cdd:cd17404    16 ALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIALGSFLFSLPHFF---- 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 114 hiessvspqenssvvslchanqsltslpteepstecekepesllwifvMVGNLIRGMGETPIVPLGISYLEDFAKTENSP 193
Cdd:cd17404    92 ------------------------------------------------ILAQILIGMGGTPIFTLGTTYLDDHVKKESSS 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 194 FYQGCLHTATVIGPFLGYLLASFCAKLFVDLESVdagELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRslvke 273
Cdd:cd17404   124 LYLAIMYVMGALGPAAGFLLGGLLINFYVDPLST---PPDISPGDPRWIGAWWGGFLLCGIALLLVAFPFFTFPK----- 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 274 geisesektgkkegvllegneqketkqsmyeiakdfipflkallrnPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFGK 353
Cdd:cd17404   196 ----------------------------------------------MTFLVVSLGYCMELAIVSGFITFLPKYLETQFGI 229
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 354 SASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGIDQLS 433
Cdd:cd17404   230 PASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLAGITIPYTTGPSLS 309
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 434 YAENTLL-ADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVV-FENCTCVAAAEFPFQNTSAIlGQCDKG 511
Cdd:cd17404   310 STHGRNLtSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSVGNTSTGIRnYTNCACLQSRSSISPPTVGQ-GSQLQA 388
                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 2024449525 512 GNCDK---MLQYFLILQLVGSFIFSLAAMPGFMVLIR 545
Cdd:cd17404   389 GPCSRtcnTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
35-545 9.59e-85

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 272.87  E-value: 9.59e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  35 MTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLfgryh 114
Cdd:cd17401    17 LYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAAGAFLLTLPHFI----- 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 115 iessvspqenssvvslchanqsltSLPTEEPstecekepesllwiFVMVGNLIRGMGETPIVPLGISYLEDFAKTENSPF 194
Cdd:cd17401    92 ------------------------SEPYQYG--------------IMVVAQLLLGIGGVPIQPFGISYIDDFAEPSNSPL 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 195 YQGCLHTATVIGPFLGYLLASFCAKLFVDLESVDAGELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRSLvkeg 274
Cdd:cd17401   134 YLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWLGFLIAAALLVLTSFPYFFFPRFI---- 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 275 eisesektgkkegvllegneqketkqsmyeiaKDFIPFLKALLRNPVYMLfIVISVLQFSAFI-GMISFMPKYLEQQFGK 353
Cdd:cd17401   210 --------------------------------KRFPCIFLRTLRNPIFLL-VVLAQVTLSSMIaGLATFLNKFLEKQFGT 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 354 SASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLT--VSYEGIDQ 431
Cdd:cd17401   257 TASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFFIGCSTPTIAGVYppSSSSSIHP 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 432 LSYAentlladCNRDCDCTLKVWDPVCANNGITYVSSCLAGCK----ASTGTGKSVVFENCTCVAAAefpfqNTSAILGQ 507
Cdd:cd17401   337 QSPA-------CRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSninmSTSATSKQVIYTNCSCVTGG-----SASAKTGS 404
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 2024449525 508 CDKGgnCDKMLQYFLILQLVGSFIFSLAAMPGFMVLIR 545
Cdd:cd17401   405 CPSP--CSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
40-545 1.44e-83

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 269.12  E-value: 1.44e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  40 LNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLfgryhiessv 119
Cdd:cd17403    23 VNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGIGSLVFALPHFT---------- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 120 spqenssvvslchanqsltslpteepstecekepesllwIFvMVGNLIRGMGETPIVPLGISYLEDFAKTENSPFYQGCL 199
Cdd:cd17403    93 ---------------------------------------VF-ILAQLLHGAGATPLYTLGVTYLDENVSTKMSPLYIGIF 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 200 HTATVIGPFLGYLLASFCAKLFVDLESVDAgELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPrslvkegeises 279
Cdd:cd17403   133 YAMAILGPAIGYVLGGFLLNLYTDIDQVDS-ELGLTPDDPRWVGAWWLGFLISGALALIIAFPLLGFP------------ 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 280 ektgkkegvllegneqketkqsmyeiakdfipflkallrnPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFGKSASDAI 359
Cdd:cd17403   200 ----------------------------------------PTFMFLNLAGASEGMLLAGFATFLPKLIESQFSLSASLAA 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 360 FLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTiCDTSPVAGLTVSYEgiDQLSYAENTL 439
Cdd:cd17403   240 LLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLFSFILLIY-CPNAPFAGVTVPYG--NSPLEGTSNL 316
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 440 LADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVAAAEFpFQNTSAILGQCDKGGNCDKMLQ 519
Cdd:cd17403   317 TSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDDGQKVYSNCSCIQSNSS-KTSTAATGKACPCETCCQKLYL 395
                         490       500
                  ....*....|....*....|....*.
gi 2024449525 520 YFLILQLVGSFIFsLAAMPGFMVLIR 545
Cdd:cd17403   396 FLAVFFLLIVFTF-MSSTPALSATLR 420
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
32-545 6.55e-62

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 212.00  E-value: 6.55e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  32 GKTMTGaYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLfg 111
Cdd:cd17462    16 GMTVNG-FINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGSLVFALPHFT-- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 112 ryhiessvspqenssvvslchanqsltslpteepstecekepesllwIFvMVGNLIRGMGETPIVPLGISYLEDFAKTEN 191
Cdd:cd17462    93 -----------------------------------------------VF-MLGQFLHGIGATPLYTLGVTYLDENVKSNY 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 192 SPFYQGCLHTATVIGPFLGYLLASFCAKLFVDLESvdagELTITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRSLv 271
Cdd:cd17462   125 SPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIGR----QTELTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQL- 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 272 kegeisesektgkkegvllegneqketkqsmyeiakdfipflKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQQF 351
Cdd:cd17462   200 ------------------------------------------PGLLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQF 237
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 352 GKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFsAFWTICDTSPVAGLTVSYEGIDQ 431
Cdd:cd17462   238 SLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVSLLAIF-IFSLHCPNVPMAGVTASYRGSVL 316
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 432 LSYAENtLLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKS--VVFENCTCVAaaefpfQNTSAILGQCD 509
Cdd:cd17462   317 PEGSLN-LTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEAYSDIRNgqKVYQDCSCVA------GNLSVGFGEAS 389
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 2024449525 510 KGG---NCDKMLQYFLILQLVGSFIFsLAAMPGFMVLIR 545
Cdd:cd17462   390 AGKctsNCNHMPLLLAFVFLVILFTF-LCSIPALTATLR 427
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
47-545 7.56e-54

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 190.34  E-value: 7.56e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  47 IEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLfgryhiessvspqenss 126
Cdd:cd17463    30 IEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGSLVFSLPHFF----------------- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 127 vvslchanqsltslpteepstecekepesllwIFVMvGNLIRGMGETPIVPLGISYLEDFAKTENSPFYQGCLHTATVIG 206
Cdd:cd17463    93 --------------------------------VFIL-GQLLLGVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGYGMSVLG 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 207 PFLGYLLASFCAKLFVDlesVDAGELT-ITPADVRWVGAWWLGILICALVNFLAGLPFWFLPRslvkegeisesektgkk 285
Cdd:cd17463   140 PAIGYLLGGQLLNIYID---VNKGQSVdLTEEDPRWLGAWWIGFLMCWLIAWCLIAPFSCFPK----------------- 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 286 egvllegneqketkqsmyeiakdfipFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFGKSASDAIFLIGVY 365
Cdd:cd17463   200 --------------------------HLPGLLKNPVFMCLTISSCSEALITTGFATFLPKFIENQFGQTSSFAAILGGLV 253
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 366 NLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGIDQLsyaeNTLLADCNR 445
Cdd:cd17463   254 LIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSVFIFAKCGNDPFAGVSETYNGTGKI----GNLTAPCNA 329
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 446 DCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCVaaaEFPFQNTSAILGQCDKGGNCD---KMLQYFL 522
Cdd:cd17463   330 NCSCLSSFYYPVCGADGVQYFSPCFAGCTNENLHDKKKVYYNCSCI---GNFTEEFSANTTKCEEGKKCEttcKNLPIFL 406
                         490       500
                  ....*....|....*....|...
gi 2024449525 523 ILQLVGSFIFSLAAMPGFMVLIR 545
Cdd:cd17463   407 CFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
48-540 2.95e-34

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 135.36  E-value: 2.95e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  48 EKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLFgryHIessvspqenssv 127
Cdd:cd17405    30 QVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGLGSMLFAFPFFTF---HI------------ 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 128 vslchanqsltslpteepstecekepesllwifvmVGNLIRGMGETPIVPLGISYLEDFAKTENSPFYQGCLHTATVIGP 207
Cdd:cd17405    95 -----------------------------------AGQCIQGIAGMPIYILGITFIFDNIPTSSAGIYLGIAHSAYLIGY 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 208 FLGYLLASFCAKLFVDLESVDageltITPADV--RWVGAWWLGILICALVNFLAGLPFWFLPRSLvkegeisesektgkk 285
Cdd:cd17405   140 LLGYVGGLPNFQPPPNEKSVE-----IEVNKVyqLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSL--------------- 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 286 egvllegneqketkqsmyeiakdfipflKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFGKSASDAIFLIGVY 365
Cdd:cd17405   200 ----------------------------PGLLKNPLLLCQAICKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAF 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 366 NLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTICDTSPVAGLTVSYEGIDQLSyaenTLLADCNR 445
Cdd:cd17405   252 LIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGINEDYDGYGQLG----NLTAPCNE 327
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 446 DCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCV----AAAEFPFQNTSAILGQCDkgGNCDKMLQYF 521
Cdd:cd17405   328 YCDCTSSLYTSICGRDEIEYFSPCFAGCKASKVSNTEKTYYNCSCIkeglAAADDEGDFIDAIAGKCD--SKCYKLPLFF 405
                         490
                  ....*....|....*....
gi 2024449525 522 lilqlvgSFIFSLAAMPGF 540
Cdd:cd17405   406 -------AFYFSATVFSNM 417
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
439-491 1.21e-23

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 93.91  E-value: 1.21e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2024449525 439 LLADCNRDCDCTLKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTCV 491
Cdd:cd01330     1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCV 53
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
35-411 5.12e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 92.49  E-value: 5.12e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  35 MTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHflfgryh 114
Cdd:cd06174    10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP------- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 115 iessvspqenssvvslchanqsltslpteepstecekepeslLWIFVMVGNLIRGMGETPIVPLGISYLEDFAKTENSPF 194
Cdd:cd06174    83 ------------------------------------------SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGR 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 195 YQGCLHTATVIGPFLGYLLASFCAKLFVdlesvdageltitpadvrwvGAWWLGILICALVNFLAGLPFWFLPRSLVKEG 274
Cdd:cd06174   121 ALGLLQAFGSVGGILGPLLGGILASSLG--------------------FGWRAVFLIAAALALLAAILLLLVVPDPPESA 180
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 275 EISESEKTGKKegvllegneqketkqsmyeiakdFIPFLKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFGKS 354
Cdd:cd06174   181 RAKNEEASSKS-----------------------VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024449525 355 ASDAIFLIGVYNLPIIcLGYFFGGLFMKKFKINTY-QAAHIACWVTFLDYLLYFSAFW 411
Cdd:cd06174   238 VAVAGLLLSLFGLAGA-LGSLLLGLLSDRLIGRKPlLLIGLLLMALGLALLLLAPSLL 294
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
444-490 1.61e-11

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 59.43  E-value: 1.61e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2024449525 444 NRDCDCTLKVWDPVCANNGITYVSSC---LAGCKASTGTGKSVVFENCTC 490
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
MFS_1 pfam07690
Major Facilitator Superfamily;
34-413 2.57e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 65.52  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525  34 TMTGAYLNSMYTQIEKQFNIPASLVGIINGSFEIGNLLLIAFVSYFGGKFHRPKIIALGCTVFAFGCLLTSFPHFLFgry 113
Cdd:pfam07690  10 LGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW--- 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 114 hiessvspqenssvvslchanqsltslpteepstecekepesllwiFVMVGNLIRGMGETPIVPLGISYLEDFAKTENSP 193
Cdd:pfam07690  87 ----------------------------------------------LLLVLRVLQGLGAGALFPAALALIADWFPPEERG 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 194 FYQGCLHTATVIGPFLGYLLASFCAKLFvdlesvdageltitpadvRWVGAWWlgilICALVNFLAGLPFWFLPRSLVKE 273
Cdd:pfam07690 121 RALGLVSAGFGLGAALGPLLGGLLASLF------------------GWRAAFL----ILAILSLLAAVLLLLPRPPPESK 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 274 GEISESEKtgkkegvllegneqketkqsmyeiAKDFIPFLKALLRNPVYMLFIVIsVLQFSAFIGMISFMPKYLEqQFGK 353
Cdd:pfam07690 179 RPKPAEEA------------------------RLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQE-VLGL 232
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 354 SASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACWVTFLDYLLYFSAFWTI 413
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSL 292
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
449-490 3.55e-09

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 52.66  E-value: 3.55e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2024449525 449 CTlKVWDPVCANNGITYVSSCLAGCKASTGTGKSVVFENCTC 490
Cdd:cd00104     1 CP-KEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
158-425 2.96e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.80  E-value: 2.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 158 WIFVMVGNLIRGMGETPIVPLGISYLEDFAKTENSPFYQGCLHTATVIGPFLGYLLASFCAKLFvdlesvdageltitpa 237
Cdd:cd17325    84 YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL---------------- 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 238 DVRWVgawwlgILICALVNFLAGLPFWFLPRslvkegeisESEKTGKKEGVLlegneqketkqsmyeiAKDFIPFLKALL 317
Cdd:cd17325   148 GYRAP------FLVCAALALLALVLALLLLP---------EPRPPPNKRAVS----------------AARLRSGLRLLL 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 318 RNPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFGKSASDAIFLIGVYNLPIICLGYFFGGLFMKKFKINTYQAAHIACW 397
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
                         250       260
                  ....*....|....*....|....*...
gi 2024449525 398 VTFLdYLLYFSAFWTICDTSPVAGLTVS 425
Cdd:cd17325   277 VALL-LLPLATSFWLLLLLLALLGLGLG 303
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
442-483 3.67e-04

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 38.43  E-value: 3.67e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024449525  442 DCNRDCDctlKVWDPVCANNGITYVSSCLAgCKASTGTGKSV 483
Cdd:smart00280   1 DCPEACP---REYDPVCGSDGVTYSNECHL-CKAACESGKSI 38
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
313-379 7.77e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.15  E-value: 7.77e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024449525 313 LKALLRNPVYMLFIVISVLQFSAFIGMISFMPKYLEQQFGKSASDAIFLIGVYNLPIICLGYFFGGL 379
Cdd:cd17324   191 LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
241-370 7.61e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 39.15  E-value: 7.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024449525 241 WVGAWWLGILICALVNFLAglpFWFLPRSLVKEGEISESEKTGKKEGVLLEGNEQKETkqSMYEIakdfipFLKALLRNP 320
Cdd:cd17345   163 WRGAFIFPAIIAIIVAVIV---LFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQEL--SAWEI------FVKYVLKNK 231
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2024449525 321 VYMLFIVISVLQFSAFIGMISFMPKYLEQQFGKSASDAIFLIGVYNLPII 370
Cdd:cd17345   232 LLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAI 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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