|
Name |
Accession |
Description |
Interval |
E-value |
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
830-1155 |
5.22e-35 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 136.33 E-value: 5.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 830 YIKRLQIDNLCPERLLELLHCIYETQNSYLLQHVAlrlkaDLSFLGIVLTPP--DVHVLSSTLKRSRKEFSLDLQnssid 907
Cdd:cd00116 4 SLKGELLKTERATELLPKLLCLQVLRLEGNTLGEE-----AAKALASALRPQpsLKELCLSLNETGRIPRGLQSL----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 908 THGLKDLVGLKNVVSFRASLS-DTIRLWKYLEQTKDYELLRVSTEKFVLD--PFKAKTMRDII-DLSDLVEMQeiiiNRV 983
Cdd:cd00116 74 LQGLTKGCGLQELDLSDNALGpDGCGVLESLLRSSSLQELKLNNNGLGDRglRLLAKGLKDLPpALEKLVLGR----NRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 984 QDDSGCS-SYQIPAIKNLRKLEFALGPAcGLQGFLKLVEILAAFPSLQHLDLDalsENGIGDEGAKSLSEVFPTLTSLET 1062
Cdd:cd00116 150 EGASCEAlAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 1063 LNLSQNKITDVGAEKLATALPSLSSL-TTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLtDSLRKC 1141
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLL-AESLLE 304
|
330
....*....|....
gi 2024459292 1142 PHIKNLVMWNPTIP 1155
Cdd:cd00116 305 PGNELESLWVKDDS 318
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
441-609 |
3.52e-32 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 123.18 E-value: 3.52e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 441 VIVVLGKAGMGKSILVQKICQDWSNGEFPQ-FEFVFWFDCKQISLPEKWYSLKDLLLDFFVRPQEGSKEIFEYILQNSTK 519
Cdd:pfam05729 2 TVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 520 VLLVFDGLEGLhghensphCSASQPNKDLCRVKELLSGLIQKKILNGCTLLLTARTK--EKVCQYVSKVDkTIEIVGFSP 597
Cdd:pfam05729 82 LLLILDGLDEL--------VSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalRDLRRGLEEPR-YLEVRGFSE 152
|
170
....*....|..
gi 2024459292 598 WQRELYITKYFE 609
Cdd:pfam05729 153 SDRKQYVRKYFS 164
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
753-862 |
3.50e-11 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 61.54 E-value: 3.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 753 IQNFLGALHLILTEGIKNKSLIKYLsFPSKKKKPY-------------NWLHFVpRFLAGLL------FLQDdTYFCSLS 813
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLkslldkalkskngHLDLFL-RFLFGLLneenqrLLEG-LLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2024459292 814 nkgvkkSTKKQKmLLKYIKRLQIDNLCPERLLELLHCIYETQNSYLLQH 862
Cdd:pfam17776 81 ------SEIKQE-LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
830-1155 |
5.22e-35 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 136.33 E-value: 5.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 830 YIKRLQIDNLCPERLLELLHCIYETQNSYLLQHVAlrlkaDLSFLGIVLTPP--DVHVLSSTLKRSRKEFSLDLQnssid 907
Cdd:cd00116 4 SLKGELLKTERATELLPKLLCLQVLRLEGNTLGEE-----AAKALASALRPQpsLKELCLSLNETGRIPRGLQSL----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 908 THGLKDLVGLKNVVSFRASLS-DTIRLWKYLEQTKDYELLRVSTEKFVLD--PFKAKTMRDII-DLSDLVEMQeiiiNRV 983
Cdd:cd00116 74 LQGLTKGCGLQELDLSDNALGpDGCGVLESLLRSSSLQELKLNNNGLGDRglRLLAKGLKDLPpALEKLVLGR----NRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 984 QDDSGCS-SYQIPAIKNLRKLEFALGPAcGLQGFLKLVEILAAFPSLQHLDLDalsENGIGDEGAKSLSEVFPTLTSLET 1062
Cdd:cd00116 150 EGASCEAlAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 1063 LNLSQNKITDVGAEKLATALPSLSSL-TTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLtDSLRKC 1141
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLL-AESLLE 304
|
330
....*....|....
gi 2024459292 1142 PHIKNLVMWNPTIP 1155
Cdd:cd00116 305 PGNELESLWVKDDS 318
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
441-609 |
3.52e-32 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 123.18 E-value: 3.52e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 441 VIVVLGKAGMGKSILVQKICQDWSNGEFPQ-FEFVFWFDCKQISLPEKWYSLKDLLLDFFVRPQEGSKEIFEYILQNSTK 519
Cdd:pfam05729 2 TVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 520 VLLVFDGLEGLhghensphCSASQPNKDLCRVKELLSGLIQKKILNGCTLLLTARTK--EKVCQYVSKVDkTIEIVGFSP 597
Cdd:pfam05729 82 LLLILDGLDEL--------VSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalRDLRRGLEEPR-YLEVRGFSE 152
|
170
....*....|..
gi 2024459292 598 WQRELYITKYFE 609
Cdd:pfam05729 153 SDRKQYVRKYFS 164
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
931-1147 |
5.13e-21 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 97.55 E-value: 5.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 931 IRLWKYLEQTKDYELLRV-----STEKFVLDPFKAKTMRDIIDLSDlvemqeiiiNRVQDDsGCSSY--QIPAIKNLRKL 1003
Cdd:COG5238 144 IQVLKDPLGGNAVHLLGLaarlgLLAAISMAKALQNNSVETVYLGC---------NQIGDE-GIEELaeALTQNTTVTTL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 1004 EFALGPAcGLQGFLKLVEILAAFPSLQHLDLdalSENGIGDEGAKSLSEVFPTLTSLETLNLSQNKITDVGAEKLATALP 1083
Cdd:COG5238 214 WLKRNPI-GDEGAEILAEALKGNKSLTTLDL---SNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024459292 1084 SLSSLTTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLTDSLRKCPHIKNL 1147
Cdd:COG5238 290 GNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSL 353
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
753-862 |
3.50e-11 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 61.54 E-value: 3.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 753 IQNFLGALHLILTEGIKNKSLIKYLsFPSKKKKPY-------------NWLHFVpRFLAGLL------FLQDdTYFCSLS 813
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLkslldkalkskngHLDLFL-RFLFGLLneenqrLLEG-LLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2024459292 814 nkgvkkSTKKQKmLLKYIKRLQIDNLCPERLLELLHCIYETQNSYLLQH 862
Cdd:pfam17776 81 ------SEIKQE-LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| LRR_6 |
pfam13516 |
Leucine Rich repeat; |
1056-1079 |
6.71e-04 |
|
Leucine Rich repeat;
Pssm-ID: 463907 [Multi-domain] Cd Length: 24 Bit Score: 37.99 E-value: 6.71e-04
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1057-1082 |
1.10e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.39 E-value: 1.10e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
830-1155 |
5.22e-35 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 136.33 E-value: 5.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 830 YIKRLQIDNLCPERLLELLHCIYETQNSYLLQHVAlrlkaDLSFLGIVLTPP--DVHVLSSTLKRSRKEFSLDLQnssid 907
Cdd:cd00116 4 SLKGELLKTERATELLPKLLCLQVLRLEGNTLGEE-----AAKALASALRPQpsLKELCLSLNETGRIPRGLQSL----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 908 THGLKDLVGLKNVVSFRASLS-DTIRLWKYLEQTKDYELLRVSTEKFVLD--PFKAKTMRDII-DLSDLVEMQeiiiNRV 983
Cdd:cd00116 74 LQGLTKGCGLQELDLSDNALGpDGCGVLESLLRSSSLQELKLNNNGLGDRglRLLAKGLKDLPpALEKLVLGR----NRL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 984 QDDSGCS-SYQIPAIKNLRKLEFALGPAcGLQGFLKLVEILAAFPSLQHLDLDalsENGIGDEGAKSLSEVFPTLTSLET 1062
Cdd:cd00116 150 EGASCEAlAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 1063 LNLSQNKITDVGAEKLATALPSLSSL-TTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLtDSLRKC 1141
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLL-AESLLE 304
|
330
....*....|....
gi 2024459292 1142 PHIKNLVMWNPTIP 1155
Cdd:cd00116 305 PGNELESLWVKDDS 318
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
441-609 |
3.52e-32 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 123.18 E-value: 3.52e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 441 VIVVLGKAGMGKSILVQKICQDWSNGEFPQ-FEFVFWFDCKQISLPEKWYSLKDLLLDFFVRPQEGSKEIFEYILQNSTK 519
Cdd:pfam05729 2 TVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 520 VLLVFDGLEGLhghensphCSASQPNKDLCRVKELLSGLIQKKILNGCTLLLTARTK--EKVCQYVSKVDkTIEIVGFSP 597
Cdd:pfam05729 82 LLLILDGLDEL--------VSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalRDLRRGLEEPR-YLEVRGFSE 152
|
170
....*....|..
gi 2024459292 598 WQRELYITKYFE 609
Cdd:pfam05729 153 SDRKQYVRKYFS 164
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
931-1147 |
5.13e-21 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 97.55 E-value: 5.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 931 IRLWKYLEQTKDYELLRV-----STEKFVLDPFKAKTMRDIIDLSDlvemqeiiiNRVQDDsGCSSY--QIPAIKNLRKL 1003
Cdd:COG5238 144 IQVLKDPLGGNAVHLLGLaarlgLLAAISMAKALQNNSVETVYLGC---------NQIGDE-GIEELaeALTQNTTVTTL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 1004 EFALGPAcGLQGFLKLVEILAAFPSLQHLDLdalSENGIGDEGAKSLSEVFPTLTSLETLNLSQNKITDVGAEKLATALP 1083
Cdd:COG5238 214 WLKRNPI-GDEGAEILAEALKGNKSLTTLDL---SNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024459292 1084 SLSSLTTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLTDSLRKCPHIKNL 1147
Cdd:COG5238 290 GNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSL 353
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
421-973 |
5.33e-21 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 99.88 E-value: 5.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 421 AVIERSQIFQMPGGKELETKVIVVLGKAGMGKSILVQKICQD-WSNGEFPQFEFVFWFDCKQISlpeKWYSLKDLLLDFF 499
Cdd:COG5635 162 NLLERIESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALElAERYLDAEDPIPILIELRDLA---EEASLEDLLAEAL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 500 VRPQEGSKEIFEYILQNStKVLLVFDGL-EGLHGHENSphcsasqpnkdlcRVKELLSGLIQKkiLNGCTLLLTARTKEk 578
Cdd:COG5635 239 EKRGGEPEDALERLLRNG-RLLLLLDGLdEVPDEADRD-------------EVLNQLRRFLER--YPKARVIITSRPEG- 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 579 vcqYVSKVD---KTIEIVGFSPWQRELYITKYFEGLPSC-DNALNLIKEHEYLFSHCYSPVMCRFVCFLCETilemgDQG 654
Cdd:COG5635 302 ---YDSSELegfEVLELAPLSDEQIEEFLKKWFEATERKaERLLEALEENPELRELARNPLLLTLLALLLRE-----RGE 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 655 LPSTLTTLFLKFVQQKI-----MPTQTDVTDVTLAQNQENLATLACIAWYLGEKHLSA------MKSDLLPSKEVKEF-- 721
Cdd:COG5635 374 LPDTRAELYEQFVELLLerwdeQRGLTIYRELSREELRELLSELALAMQENGRTEFAReeleeiLREYLGRRKDAEALld 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 722 --ALKNGFFLPfafpkhsdTGEEEYGtmFSDFVIQNFLGALHLI-LTEGIKNKSLIKYLSFPSkkkkpynWlHFVPRFLA 798
Cdd:COG5635 454 elLLRTGLLVE--------RGEGRYS--FAHRSFQEYLAARALVeELDEELLELLAEHLEDPR-------W-REVLLLLA 515
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 799 GLlfLQDDTYFCSLSNKGVKKSTKKQKMLLKYIKRLQIDNLCPERLLEL-LHCIYETQNSYLLQHVALRLKADLSFLGIV 877
Cdd:COG5635 516 GL--LDDVKQIKELIDALLARDDAAALALAAALLLALLLALALLALLALlLLLRLLLALLALLLLALLLLLLLALLLALL 593
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 878 LTPPDVHVLSSTLKRSRKEFSLDLQNSSIDTHGLKDLVGLKNVVSFRASLSDTIRLWKYLEQTKDYELLRVSTEKFVLDP 957
Cdd:COG5635 594 ALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAASAALLLL 673
|
570
....*....|....*.
gi 2024459292 958 FKAKTMRDIIDLSDLV 973
Cdd:COG5635 674 LLLLLAELLLALLALA 689
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1012-1140 |
2.88e-19 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 92.16 E-value: 2.88e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 1012 GLQGFLKLVEILAAFPSLQHLDLdalSENGIGDEGAKSLSEVFPTLTSLETLNLSQNKITDVGAEKLATALPSLSSLTTL 1091
Cdd:COG5238 277 GAEGAIALAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSL 353
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2024459292 1092 SLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLTDSLRK 1140
Cdd:COG5238 354 DLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT 402
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
992-1164 |
2.03e-14 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 77.14 E-value: 2.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 992 YQIPAIKNLRKLEFALG-PACGLQGFLKLVEILAAF-----PSLQHLDLDALSENGIGDEGAKSLSEVFPTLTSLETLNL 1065
Cdd:COG5238 136 ALPRRINLIQVLKDPLGgNAVHLLGLAARLGLLAAIsmakaLQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWL 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 1066 SQNKITDVGAEKLATALPSLSSLTTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLTDSLRKCPHIK 1145
Cdd:COG5238 216 KRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLT 295
|
170 180
....*....|....*....|...
gi 2024459292 1146 NLVMW-NPTIPYGVL---EHLQQ 1164
Cdd:COG5238 296 SLDLSvNRIGDEGAIalaEGLQG 318
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
753-862 |
3.50e-11 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 61.54 E-value: 3.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 753 IQNFLGALHLILTEGIKNKSLIKYLsFPSKKKKPY-------------NWLHFVpRFLAGLL------FLQDdTYFCSLS 813
Cdd:pfam17776 4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLkslldkalkskngHLDLFL-RFLFGLLneenqrLLEG-LLGCKLS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2024459292 814 nkgvkkSTKKQKmLLKYIKRLQIDNLCPERLLELLHCIYETQNSYLLQH 862
Cdd:pfam17776 81 ------SEIKQE-LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
886-1166 |
9.80e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 62.26 E-value: 9.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 886 LSSTLKRSRKEFSLDLQNSSIDTHGLKDLVGLKNVVSFRASLSDTIRLWKYLEQTKDYELLRVSTEKFVLDPFKAKTMRD 965
Cdd:COG4886 6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 966 IIDLSDLVEMQEIiinRVQDDSGCSSyqIPAIKNLRKLEfalgpaCGLQGFLKLVEILAAFPSLQHLDLdalSENGIgde 1045
Cdd:COG4886 86 LLGLTDLGDLTNL---TELDLSGNEE--LSNLTNLESLD------LSGNQLTDLPEELANLTNLKELDL---SNNQL--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459292 1046 gaKSLSEVFPTLTSLETLNLSQNKITDVGAE--KLaTALpslsslTTLSLYNNSIcdfgaENLAKVLPAMASLRVLDIQY 1123
Cdd:COG4886 149 --TDLPEPLGNLTNLKSLDLSNNQLTDLPEElgNL-TNL------KELDLSNNQI-----TDLPEPLGNLTNLEELDLSG 214
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 2024459292 1124 NKITDvgaqqLTDSLRKCPHIKNLVMWN---PTIPY-GVLEHLQQLD 1166
Cdd:COG4886 215 NQLTD-----LPEPLANLTNLETLDLSNnqlTDLPElGNLTNLEELD 256
|
|
| LRR_6 |
pfam13516 |
Leucine Rich repeat; |
1056-1079 |
6.71e-04 |
|
Leucine Rich repeat;
Pssm-ID: 463907 [Multi-domain] Cd Length: 24 Bit Score: 37.99 E-value: 6.71e-04
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1057-1082 |
1.10e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 37.39 E-value: 1.10e-03
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1113-1139 |
4.84e-03 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 35.46 E-value: 4.84e-03
|
| |
