NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2024459298|ref|XP_040540011|]
View 

MHC class II transactivator isoform X3 [Gallus gallus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 778-1103 6.50e-35

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 136.33  E-value: 6.50e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  778 YIKRLQIDNLCPERLLELLHCIYETQNSYLLQHVAlrlkaDLSFLGIVLTPP--DVHVLSSTLKRSRKEFSLDLQnssid 855
Cdd:cd00116      4 SLKGELLKTERATELLPKLLCLQVLRLEGNTLGEE-----AAKALASALRPQpsLKELCLSLNETGRIPRGLQSL----- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  856 THGLKDLVGLKNVVSFRASLS-DTIRLWKYLEQTKDYELLRVSTEKFVLD--PFKAKTMRDII-DLSDLVEMQeiiiNRV 931
Cdd:cd00116     74 LQGLTKGCGLQELDLSDNALGpDGCGVLESLLRSSSLQELKLNNNGLGDRglRLLAKGLKDLPpALEKLVLGR----NRL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  932 QDDSGCS-SYQIPAIKNLRKLEFALGPAcGLQGFLKLVEILAAFPSLQHLDLDalsENGIGDEGAKSLSEVFPTLTSLET 1010
Cdd:cd00116    150 EGASCEAlAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298 1011 LNLSQNKITDVGAEKLATALPSLSSL-TTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLtDSLRKC 1089
Cdd:cd00116    226 LNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLL-AESLLE 304

                          330
                   ....*....|....
gi 2024459298 1090 PHIKNLVMWNPTIP 1103
Cdd:cd00116    305 PGNELESLWVKDDS 318
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 389-557 3.32e-32

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 123.18  E-value: 3.32e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  389 VIVVLGKAGMGKSILVQKICQDWSNGEFPQ-FEFVFWFDCKQISLPEKWYSLKDLLLDFFVRPQEGSKEIFEYILQNSTK 467
Cdd:pfam05729    2 TVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPER 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  468 VLLVFDGLEGLhghensphCSASQPNKDLCRVKELLSGLIQKKILNGCTLLLTARTK--EKVCQYVSKVDkTIEIVGFSP 545
Cdd:pfam05729   82 LLLILDGLDEL--------VSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalRDLRRGLEEPR-YLEVRGFSE 152

                          170
                   ....*....|..
gi 2024459298  546 WQRELYITKYFE 557
Cdd:pfam05729  153 SDRKQYVRKYFS 164
NLRC4_HD2 super family cl39284
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 701-810 3.97e-11

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


The actual alignment was detected with superfamily member pfam17776:

Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 61.54  E-value: 3.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  701 IQNFLGALHLILTEGIKNKSLIKYLsFPSKKKKPY-------------NWLHFVpRFLAGLL------FLQDdTYFCSLS 761
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLkslldkalkskngHLDLFL-RFLFGLLneenqrLLEG-LLGCKLS 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2024459298  762 nkgvkkSTKKQKmLLKYIKRLQIDNLCPERLLELLHCIYETQNSYLLQH 810
Cdd:pfam17776   81 ------SEIKQE-LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 778-1103 6.50e-35

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 136.33  E-value: 6.50e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  778 YIKRLQIDNLCPERLLELLHCIYETQNSYLLQHVAlrlkaDLSFLGIVLTPP--DVHVLSSTLKRSRKEFSLDLQnssid 855
Cdd:cd00116      4 SLKGELLKTERATELLPKLLCLQVLRLEGNTLGEE-----AAKALASALRPQpsLKELCLSLNETGRIPRGLQSL----- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  856 THGLKDLVGLKNVVSFRASLS-DTIRLWKYLEQTKDYELLRVSTEKFVLD--PFKAKTMRDII-DLSDLVEMQeiiiNRV 931
Cdd:cd00116     74 LQGLTKGCGLQELDLSDNALGpDGCGVLESLLRSSSLQELKLNNNGLGDRglRLLAKGLKDLPpALEKLVLGR----NRL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  932 QDDSGCS-SYQIPAIKNLRKLEFALGPAcGLQGFLKLVEILAAFPSLQHLDLDalsENGIGDEGAKSLSEVFPTLTSLET 1010
Cdd:cd00116    150 EGASCEAlAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298 1011 LNLSQNKITDVGAEKLATALPSLSSL-TTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLtDSLRKC 1089
Cdd:cd00116    226 LNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLL-AESLLE 304

                          330
                   ....*....|....
gi 2024459298 1090 PHIKNLVMWNPTIP 1103
Cdd:cd00116    305 PGNELESLWVKDDS 318
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 389-557 3.32e-32

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 123.18  E-value: 3.32e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  389 VIVVLGKAGMGKSILVQKICQDWSNGEFPQ-FEFVFWFDCKQISLPEKWYSLKDLLLDFFVRPQEGSKEIFEYILQNSTK 467
Cdd:pfam05729    2 TVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPER 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  468 VLLVFDGLEGLhghensphCSASQPNKDLCRVKELLSGLIQKKILNGCTLLLTARTK--EKVCQYVSKVDkTIEIVGFSP 545
Cdd:pfam05729   82 LLLILDGLDEL--------VSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalRDLRRGLEEPR-YLEVRGFSE 152

                          170
                   ....*....|..
gi 2024459298  546 WQRELYITKYFE 557
Cdd:pfam05729  153 SDRKQYVRKYFS 164
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
369-921 4.96e-21

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 99.88  E-value: 4.96e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  369 AVIERSQIFQMPGGKELETKVIVVLGKAGMGKSILVQKICQD-WSNGEFPQFEFVFWFDCKQISlpeKWYSLKDLLLDFF 447
Cdd:COG5635    162 NLLERIESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALElAERYLDAEDPIPILIELRDLA---EEASLEDLLAEAL 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  448 VRPQEGSKEIFEYILQNStKVLLVFDGL-EGLHGHENSphcsasqpnkdlcRVKELLSGLIQKkiLNGCTLLLTARTKEk 526
Cdd:COG5635    239 EKRGGEPEDALERLLRNG-RLLLLLDGLdEVPDEADRD-------------EVLNQLRRFLER--YPKARVIITSRPEG- 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  527 vcqYVSKVD---KTIEIVGFSPWQRELYITKYFEGLPSC-DNALNLIKEHEYLFSHCYSPVMCRFVCFLCETilemgDQG 602
Cdd:COG5635    302 ---YDSSELegfEVLELAPLSDEQIEEFLKKWFEATERKaERLLEALEENPELRELARNPLLLTLLALLLRE-----RGE 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  603 LPSTLTTLFLKFVQQKI-----MPTQTDVTDVTLAQNQENLATLACIAWYLGEKHLSA------MKSDLLPSKEVKEF-- 669
Cdd:COG5635    374 LPDTRAELYEQFVELLLerwdeQRGLTIYRELSREELRELLSELALAMQENGRTEFAReeleeiLREYLGRRKDAEALld 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  670 --ALKNGFFLPfafpkhsdTGEEEYGtmFSDFVIQNFLGALHLI-LTEGIKNKSLIKYLSFPSkkkkpynWlHFVPRFLA 746
Cdd:COG5635    454 elLLRTGLLVE--------RGEGRYS--FAHRSFQEYLAARALVeELDEELLELLAEHLEDPR-------W-REVLLLLA 515

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  747 GLlfLQDDTYFCSLSNKGVKKSTKKQKMLLKYIKRLQIDNLCPERLLEL-LHCIYETQNSYLLQHVALRLKADLSFLGIV 825
Cdd:COG5635    516 GL--LDDVKQIKELIDALLARDDAAALALAAALLLALLLALALLALLALlLLLRLLLALLALLLLALLLLLLLALLLALL 593

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  826 LTPPDVHVLSSTLKRSRKEFSLDLQNSSIDTHGLKDLVGLKNVVSFRASLSDTIRLWKYLEQTKDYELLRVSTEKFVLDP 905
Cdd:COG5635    594 ALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAASAALLLL 673

                          570
                   ....*....|....*.
gi 2024459298  906 FKAKTMRDIIDLSDLV 921
Cdd:COG5635    674 LLLLLAELLLALLALA 689
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 701-810 3.97e-11

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 61.54  E-value: 3.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  701 IQNFLGALHLILTEGIKNKSLIKYLsFPSKKKKPY-------------NWLHFVpRFLAGLL------FLQDdTYFCSLS 761
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLkslldkalkskngHLDLFL-RFLFGLLneenqrLLEG-LLGCKLS 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2024459298  762 nkgvkkSTKKQKmLLKYIKRLQIDNLCPERLLELLHCIYETQNSYLLQH 810
Cdd:pfam17776   81 ------SEIKQE-LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
LRR_6 pfam13516
Leucine Rich repeat;
1004-1027 6.80e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.99  E-value: 6.80e-04
                           10        20
                   ....*....|....*....|....
gi 2024459298 1004 TLTSLETLNLSQNKITDVGAEKLA 1027
Cdd:pfam13516    1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
1005-1030 1.11e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 1.11e-03
                            10        20
                    ....*....|....*....|....*.
gi 2024459298  1005 LTSLETLNLSQNKITDVGAEKLATAL 1030
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEAL 26
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 778-1103 6.50e-35

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 136.33  E-value: 6.50e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  778 YIKRLQIDNLCPERLLELLHCIYETQNSYLLQHVAlrlkaDLSFLGIVLTPP--DVHVLSSTLKRSRKEFSLDLQnssid 855
Cdd:cd00116      4 SLKGELLKTERATELLPKLLCLQVLRLEGNTLGEE-----AAKALASALRPQpsLKELCLSLNETGRIPRGLQSL----- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  856 THGLKDLVGLKNVVSFRASLS-DTIRLWKYLEQTKDYELLRVSTEKFVLD--PFKAKTMRDII-DLSDLVEMQeiiiNRV 931
Cdd:cd00116     74 LQGLTKGCGLQELDLSDNALGpDGCGVLESLLRSSSLQELKLNNNGLGDRglRLLAKGLKDLPpALEKLVLGR----NRL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  932 QDDSGCS-SYQIPAIKNLRKLEFALGPAcGLQGFLKLVEILAAFPSLQHLDLDalsENGIGDEGAKSLSEVFPTLTSLET 1010
Cdd:cd00116    150 EGASCEAlAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298 1011 LNLSQNKITDVGAEKLATALPSLSSL-TTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLtDSLRKC 1089
Cdd:cd00116    226 LNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLL-AESLLE 304

                          330
                   ....*....|....
gi 2024459298 1090 PHIKNLVMWNPTIP 1103
Cdd:cd00116    305 PGNELESLWVKDDS 318
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 389-557 3.32e-32

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 123.18  E-value: 3.32e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  389 VIVVLGKAGMGKSILVQKICQDWSNGEFPQ-FEFVFWFDCKQISLPEKWYSLKDLLLDFFVRPQEGSKEIFEYILQNSTK 467
Cdd:pfam05729    2 TVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPER 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  468 VLLVFDGLEGLhghensphCSASQPNKDLCRVKELLSGLIQKKILNGCTLLLTARTK--EKVCQYVSKVDkTIEIVGFSP 545
Cdd:pfam05729   82 LLLILDGLDEL--------VSDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalRDLRRGLEEPR-YLEVRGFSE 152

                          170
                   ....*....|..
gi 2024459298  546 WQRELYITKYFE 557
Cdd:pfam05729  153 SDRKQYVRKYFS 164
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
369-921 4.96e-21

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 99.88  E-value: 4.96e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  369 AVIERSQIFQMPGGKELETKVIVVLGKAGMGKSILVQKICQD-WSNGEFPQFEFVFWFDCKQISlpeKWYSLKDLLLDFF 447
Cdd:COG5635    162 NLLERIESLKRLELLEAKKKRLLILGEPGSGKTTLLRYLALElAERYLDAEDPIPILIELRDLA---EEASLEDLLAEAL 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  448 VRPQEGSKEIFEYILQNStKVLLVFDGL-EGLHGHENSphcsasqpnkdlcRVKELLSGLIQKkiLNGCTLLLTARTKEk 526
Cdd:COG5635    239 EKRGGEPEDALERLLRNG-RLLLLLDGLdEVPDEADRD-------------EVLNQLRRFLER--YPKARVIITSRPEG- 301

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  527 vcqYVSKVD---KTIEIVGFSPWQRELYITKYFEGLPSC-DNALNLIKEHEYLFSHCYSPVMCRFVCFLCETilemgDQG 602
Cdd:COG5635    302 ---YDSSELegfEVLELAPLSDEQIEEFLKKWFEATERKaERLLEALEENPELRELARNPLLLTLLALLLRE-----RGE 373

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  603 LPSTLTTLFLKFVQQKI-----MPTQTDVTDVTLAQNQENLATLACIAWYLGEKHLSA------MKSDLLPSKEVKEF-- 669
Cdd:COG5635    374 LPDTRAELYEQFVELLLerwdeQRGLTIYRELSREELRELLSELALAMQENGRTEFAReeleeiLREYLGRRKDAEALld 453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  670 --ALKNGFFLPfafpkhsdTGEEEYGtmFSDFVIQNFLGALHLI-LTEGIKNKSLIKYLSFPSkkkkpynWlHFVPRFLA 746
Cdd:COG5635    454 elLLRTGLLVE--------RGEGRYS--FAHRSFQEYLAARALVeELDEELLELLAEHLEDPR-------W-REVLLLLA 515

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  747 GLlfLQDDTYFCSLSNKGVKKSTKKQKMLLKYIKRLQIDNLCPERLLEL-LHCIYETQNSYLLQHVALRLKADLSFLGIV 825
Cdd:COG5635    516 GL--LDDVKQIKELIDALLARDDAAALALAAALLLALLLALALLALLALlLLLRLLLALLALLLLALLLLLLLALLLALL 593

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  826 LTPPDVHVLSSTLKRSRKEFSLDLQNSSIDTHGLKDLVGLKNVVSFRASLSDTIRLWKYLEQTKDYELLRVSTEKFVLDP 905
Cdd:COG5635    594 ALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAASAALLLL 673

                          570
                   ....*....|....*.
gi 2024459298  906 FKAKTMRDIIDLSDLV 921
Cdd:COG5635    674 LLLLLAELLLALLALA 689
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 879-1095 5.00e-21

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 97.55  E-value: 5.00e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  879 IRLWKYLEQTKDYELLRV-----STEKFVLDPFKAKTMRDIIDLSDlvemqeiiiNRVQDDsGCSSY--QIPAIKNLRKL 951
Cdd:COG5238    144 IQVLKDPLGGNAVHLLGLaarlgLLAAISMAKALQNNSVETVYLGC---------NQIGDE-GIEELaeALTQNTTVTTL 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  952 EFALGPAcGLQGFLKLVEILAAFPSLQHLDLdalSENGIGDEGAKSLSEVFPTLTSLETLNLSQNKITDVGAEKLATALP 1031
Cdd:COG5238    214 WLKRNPI-GDEGAEILAEALKGNKSLTTLDL---SNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024459298 1032 SLSSLTTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLTDSLRKCPHIKNL 1095
Cdd:COG5238    290 GNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSL 353
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 960-1088 2.81e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 92.16  E-value: 2.81e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  960 GLQGFLKLVEILAAFPSLQHLDLdalSENGIGDEGAKSLSEVFPTLTSLETLNLSQNKITDVGAEKLATALPSLSSLTTL 1039
Cdd:COG5238    277 GAEGAIALAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSL 353

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2024459298 1040 SLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLTDSLRK 1088
Cdd:COG5238    354 DLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT 402
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 940-1112 1.96e-14

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 77.14  E-value: 1.96e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  940 YQIPAIKNLRKLEFALG-PACGLQGFLKLVEILAAF-----PSLQHLDLDALSENGIGDEGAKSLSEVFPTLTSLETLNL 1013
Cdd:COG5238    136 ALPRRINLIQVLKDPLGgNAVHLLGLAARLGLLAAIsmakaLQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWL 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298 1014 SQNKITDVGAEKLATALPSLSSLTTLSLYNNSICDFGAENLAKVLPAMASLRVLDIQYNKITDVGAQQLTDSLRKCPHIK 1093
Cdd:COG5238    216 KRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLT 295

                          170       180
                   ....*....|....*....|...
gi 2024459298 1094 NLVMW-NPTIPYGVL---EHLQQ 1112
Cdd:COG5238    296 SLDLSvNRIGDEGAIalaEGLQG 318
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 701-810 3.97e-11

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 61.54  E-value: 3.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  701 IQNFLGALHLILTEGIKNKSLIKYLsFPSKKKKPY-------------NWLHFVpRFLAGLL------FLQDdTYFCSLS 761
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLkslldkalkskngHLDLFL-RFLFGLLneenqrLLEG-LLGCKLS 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2024459298  762 nkgvkkSTKKQKmLLKYIKRLQIDNLCPERLLELLHCIYETQNSYLLQH 810
Cdd:pfam17776   81 ------SEIKQE-LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
834-1114 1.57e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 1.57e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  834 LSSTLKRSRKEFSLDLQNSSIDTHGLKDLVGLKNVVSFRASLSDTIRLWKYLEQTKDYELLRVSTEKFVLDPFKAKTMRD 913
Cdd:COG4886      6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  914 IIDLSDLVEMQEIiinRVQDDSGCSSyqIPAIKNLRKLEfalgpaCGLQGFLKLVEILAAFPSLQHLDLdalSENGIgde 993
Cdd:COG4886     86 LLGLTDLGDLTNL---TELDLSGNEE--LSNLTNLESLD------LSGNQLTDLPEELANLTNLKELDL---SNNQL--- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024459298  994 gaKSLSEVFPTLTSLETLNLSQNKITDVGAE--KLaTALpslsslTTLSLYNNSIcdfgaENLAKVLPAMASLRVLDIQY 1071
Cdd:COG4886    149 --TDLPEPLGNLTNLKSLDLSNNQLTDLPEElgNL-TNL------KELDLSNNQI-----TDLPEPLGNLTNLEELDLSG 214

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 2024459298 1072 NKITDvgaqqLTDSLRKCPHIKNLVMWN---PTIPY-GVLEHLQQLD 1114
Cdd:COG4886    215 NQLTD-----LPEPLANLTNLETLDLSNnqlTDLPElGNLTNLEELD 256
LRR_6 pfam13516
Leucine Rich repeat;
1004-1027 6.80e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.99  E-value: 6.80e-04
                           10        20
                   ....*....|....*....|....
gi 2024459298 1004 TLTSLETLNLSQNKITDVGAEKLA 1027
Cdd:pfam13516    1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
1005-1030 1.11e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 1.11e-03
                            10        20
                    ....*....|....*....|....*.
gi 2024459298  1005 LTSLETLNLSQNKITDVGAEKLATAL 1030
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
1061-1087 4.96e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 4.96e-03
                            10        20
                    ....*....|....*....|....*..
gi 2024459298  1061 MASLRVLDIQYNKITDVGAQQLTDSLR 1087
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH