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Conserved domains on  [gi|2038274900|ref|XP_041427824|]
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tRNA methyltransferase 61A L homeolog isoform X1 [Xenopus laevis]

Protein Classification

tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A( domain architecture ID 10554888)

tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 64-300 6.22e-156

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


:

Pssm-ID: 312288  Cd Length: 242  Bit Score: 435.00  E-value: 6.22e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  64 GWVYILYPTPELWTLNLPHRTQILYSTDISLITMMLELKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEK 143
Cdd:pfam08704   1 GFVYVLQPTPELWTLNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900 144 ATEEFRQHKVDHLVTVKNQDVCKHGF--GVSDIADAVFLDIPSPWEAIGHAKSAMKTEGGRICSFSPCIEQVQRTCLALE 221
Cdd:pfam08704  81 AREEFREHGIDQLVTVTHRDVCKEGFltEVSGKADAVFLDLPSPWEAVPHAWKALKVEGGRFCSFSPCIEQVQRTCQALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900 222 EHGFTEINTLEILLRVYDVRTVNLQVPDLGRAAEEKSSLDVIDRPKqipagQHASALFKSGV--------PPRETVGHTG 293
Cdd:pfam08704 161 ELGFTEISTLEVLLRVYDVRTVSLPVIDLGIDREKENERTRTEGLS-----NDDKSEDNSGNsmlgtalkPMSEAVGHTG 235


                  ....*..
gi 2038274900 294 YLTFATK 300
Cdd:pfam08704 236 YLTFATK 242
 
Name Accession Description Interval E-value
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 64-300 6.22e-156

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 435.00  E-value: 6.22e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  64 GWVYILYPTPELWTLNLPHRTQILYSTDISLITMMLELKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEK 143
Cdd:pfam08704   1 GFVYVLQPTPELWTLNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900 144 ATEEFRQHKVDHLVTVKNQDVCKHGF--GVSDIADAVFLDIPSPWEAIGHAKSAMKTEGGRICSFSPCIEQVQRTCLALE 221
Cdd:pfam08704  81 AREEFREHGIDQLVTVTHRDVCKEGFltEVSGKADAVFLDLPSPWEAVPHAWKALKVEGGRFCSFSPCIEQVQRTCQALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900 222 EHGFTEINTLEILLRVYDVRTVNLQVPDLGRAAEEKSSLDVIDRPKqipagQHASALFKSGV--------PPRETVGHTG 293
Cdd:pfam08704 161 ELGFTEISTLEVLLRVYDVRTVSLPVIDLGIDREKENERTRTEGLS-----NDDKSEDNSGNsmlgtalkPMSEAVGHTG 235


                  ....*..
gi 2038274900 294 YLTFATK 300
Cdd:pfam08704 236 YLTFATK 242
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 13-300 5.01e-75

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 230.05  E-value: 5.01e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  13 GDTAIVFLGHDSMFPITIQNGSQTQTKYGVIRHStDLIGKKFGSKVTCSKGGWVYILYPTPELWTLNLPHRTQILYSTDI 92
Cdd:COG2519     2 GDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHD-DLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  93 SLITMMLELKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEKATEEFRQHKVDHLVTVKNQDVcKHGFGVS 172
Cdd:COG2519    81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDI-REGIDEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900 173 DiADAVFLDIPSPWEAIGHAKSAMKTeGGRICSFSPCIEQVQRTCLALEEHGFTEINTLEILLRVYDVRtvnlqvpdlGR 252
Cdd:COG2519   160 D-VDAVFLDMPDPWEALEAVAKALKP-GGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVE---------GL 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2038274900 253 AAeekssldvidRPKQIpagqhasalfksgvppreTVGHTGYLTFATK 300
Cdd:COG2519   229 AV----------RPEHR------------------MVGHTGFLVFARK 248
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 86-150 7.85e-05

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 43.08  E-value: 7.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038274900  86 ILYSTDISLITM------MLELKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEKATEEFRQ 150
Cdd:PRK13942   53 IGYGQTISAIHMvaimceLLDLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK 123
 
Name Accession Description Interval E-value
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 64-300 6.22e-156

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 435.00  E-value: 6.22e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  64 GWVYILYPTPELWTLNLPHRTQILYSTDISLITMMLELKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEK 143
Cdd:pfam08704   1 GFVYVLQPTPELWTLNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900 144 ATEEFRQHKVDHLVTVKNQDVCKHGF--GVSDIADAVFLDIPSPWEAIGHAKSAMKTEGGRICSFSPCIEQVQRTCLALE 221
Cdd:pfam08704  81 AREEFREHGIDQLVTVTHRDVCKEGFltEVSGKADAVFLDLPSPWEAVPHAWKALKVEGGRFCSFSPCIEQVQRTCQALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900 222 EHGFTEINTLEILLRVYDVRTVNLQVPDLGRAAEEKSSLDVIDRPKqipagQHASALFKSGV--------PPRETVGHTG 293
Cdd:pfam08704 161 ELGFTEISTLEVLLRVYDVRTVSLPVIDLGIDREKENERTRTEGLS-----NDDKSEDNSGNsmlgtalkPMSEAVGHTG 235


                  ....*..
gi 2038274900 294 YLTFATK 300
Cdd:pfam08704 236 YLTFATK 242
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 13-300 5.01e-75

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 230.05  E-value: 5.01e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  13 GDTAIVFLGHDSMFPITIQNGSQTQTKYGVIRHStDLIGKKFGSKVTCSKGGWVYILYPTPELWTLNLPHRTQILYSTDI 92
Cdd:COG2519     2 GDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHD-DLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  93 SLITMMLELKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEKATEEFRQHKVDHLVTVKNQDVcKHGFGVS 172
Cdd:COG2519    81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDI-REGIDEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900 173 DiADAVFLDIPSPWEAIGHAKSAMKTeGGRICSFSPCIEQVQRTCLALEEHGFTEINTLEILLRVYDVRtvnlqvpdlGR 252
Cdd:COG2519   160 D-VDAVFLDMPDPWEALEAVAKALKP-GGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVE---------GL 228

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 2038274900 253 AAeekssldvidRPKQIpagqhasalfksgvppreTVGHTGYLTFATK 300
Cdd:COG2519   229 AV----------RPEHR------------------MVGHTGFLVFARK 248
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 101-212 5.19e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.57  E-value: 5.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900 101 LKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEKATEEFRQHKVDHlVTVKNQDVCKHGFGVSD------I 174
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFDN-VEFEQGDIEELPELLEDdkfdvvI 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2038274900 175 ADAVFLDIPSPWEAIGHAKSAMKtEGGRICSFSPCIEQ 212
Cdd:pfam13847  80 SNCVLNHIPDPDKVLQEILRVLK-PGGRLIISDPDSLA 116
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 99-185 3.36e-05

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 44.77  E-value: 3.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  99 LELKPGSVVCESGTGSGSLSHAIIRTvAPTGHLYTVEFHQQRAEKATEEFRQHKVDHLVTVknqdvckHGFgvsdiADAV 178
Cdd:COG2242   243 LALRPGDVLWDIGAGSGSVSIEAARL-APGGRVYAIERDPERAALIRANARRFGVPNVEVV-------EGE-----APEA 309


                  ....*..
gi 2038274900 179 FLDIPSP 185
Cdd:COG2242   310 LADLPDP 316
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
39-203 7.46e-05

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 43.13  E-value: 7.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  39 KYGVIRHstDLIGKKFGSK-----VTCSKGGWVYILYPTPelwtlnlphrtqILYSTDISLITMM------LELKPGSVV 107
Cdd:pfam01135  12 NYGVIKS--DKVAEAMLAVdreefVPESFKSYAYEDIPLS------------IGYGQTISAPHMHammlelLELKPGMRV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900 108 CESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEKATEEFRQHKVDHLVTvknqdVCKHG-FGVSDIA--DAVFL---- 180
Cdd:pfam01135  78 LEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLENVIV-----VVGDGrQGWPEFApyDAIHVgaaa 152

                         170       180
                  ....*....|....*....|....
gi 2038274900 181 -DIPSPWeaIGHAKsamktEGGRI 203
Cdd:pfam01135 153 pEIPEAL--IDQLK-----EGGRL 169
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 86-150 7.85e-05

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 43.08  E-value: 7.85e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038274900  86 ILYSTDISLITM------MLELKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEKATEEFRQ 150
Cdd:PRK13942   53 IGYGQTISAIHMvaimceLLDLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK 123
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
102-164 2.65e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 41.56  E-value: 2.65e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2038274900 102 KPGSVVCESGTGSGSLSHAIIRTVAptGHLYTVEFHQQRAEKATEEFRQHKVDHLVTVKNQDV 164
Cdd:COG4076    34 KPGDVVLDIGTGSGLLSMLAARAGA--KKVYAVEVNPDIAAVARRIIAANGLSDRITVINADA 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 98-226 5.47e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 39.59  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  98 MLELKPGSVVCESGTGSGSLSHAIIRTvapTGHLYTVEFHQQRAEKATEEFRQHKVDhlVTVKNQDVCKHGFGvSDIADA 177
Cdd:COG2226    17 ALGLRPGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAEAGLN--VEFVVGDAEDLPFP-DGSFDL 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2038274900 178 VFL-----DIPSPWEAIGHAKSAMKtEGGRICSFSPCIEQVQRTCLALEEHGFT 226
Cdd:COG2226    91 VISsfvlhHLPDPERALAEIARVLK-PGGRLVVVDFSPPDLAELEELLAEAGFE 143
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 93-163 6.23e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 39.78  E-value: 6.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2038274900  93 SLITMMLELKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEKATEEFRQHKVDHLVTVKNQD 163
Cdd:COG4122     6 RLLYLLARLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGD 76
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
94-185 1.28e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 39.42  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  94 LITMMLELKPGSVVCESGTGSGS----LSHaIIRtvaptgHLYTVEFHQQRAEKATEEFRQHKVdHLVTVKNQDVCK--H 167
Cdd:PRK00312   69 RMTELLELKPGDRVLEIGTGSGYqaavLAH-LVR------RVFSVERIKTLQWEAKRRLKQLGL-HNVSVRHGDGWKgwP 140

                          90       100
                  ....*....|....*....|
gi 2038274900 168 GFGVSD--IADAVFLDIPSP 185
Cdd:PRK00312  141 AYAPFDriLVTAAAPEIPRA 160
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 89-203 6.77e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 37.52  E-value: 6.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2038274900  89 STDISLITMMLE---LKPGSVVCESGTGSGSLSHAIIRTVAPTGHLYTVEFHQQRAEKATEEFRQHKVDHLVTvknqdVC 165
Cdd:PRK13943   63 SSQPSLMALFMEwvgLDKGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRRLGIENVIF-----VC 137

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2038274900 166 KHG-FGVSDIA--DAVFL-----DIPSPWeaIGHAKsamktEGGRI 203
Cdd:PRK13943  138 GDGyYGVPEFApyDVIFVtvgvdEVPETW--FTQLK-----EGGRV 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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