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Conserved domains on  [gi|2052688444|ref|XP_041911973|]
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dimethylaniline monooxygenase [N-oxide-forming] 4-like [Arvicola amphibius]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 3-107 1.32e-64

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 203.86  E-value: 1.32e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052688444   3 KKVAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGLWKFAETSNDGMTRVYRSLVTNVCKEMSSYSDFPYQEYYPNFM 82
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100
                  ....*....|....*....|....*
gi 2052688444  83 DHKKFWEYLREFAEHFDLLKYIRFK 107
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFK 106
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 3-107 1.32e-64

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 203.86  E-value: 1.32e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052688444   3 KKVAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGLWKFAETSNDGMTRVYRSLVTNVCKEMSSYSDFPYQEYYPNFM 82
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100
                  ....*....|....*....|....*
gi 2052688444  83 DHKKFWEYLREFAEHFDLLKYIRFK 107
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFK 106
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-106 1.40e-24

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 95.70  E-value: 1.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052688444   5 VAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGLWKFaetsndgmtRVYRSLVTNVCKEMSSYSDFPYQEYYPNFMDH 84
Cdd:COG2072     9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRD---------NRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                          90       100
                  ....*....|....*....|..
gi 2052688444  85 KKFWEYLREFAEHFDLLKYIRF 106
Cdd:COG2072    80 DEILAYLEAYADKFGLRRPIRF 101
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-107 5.72e-14

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 66.42  E-value: 5.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052688444   3 KKVAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGLWKFA-ETSNDGM----------TRVYRSLVTNVCKEMSSYSD 71
Cdd:PLN02172   11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTpKSESDPLsldptrsivhSSVYESLRTNLPRECMGYRD 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2052688444  72 FPY----------QEYYPNfmdHKKFWEYLREFAEHFDLLKYIRFK 107
Cdd:PLN02172   91 FPFvprfddesrdSRRYPS---HREVLAYLQDFAREFKIEEMVRFE 133
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 3-39 4.36e-03

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 35.20  E-value: 4.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2052688444   3 KKVAVIGAGVSGLSSI----KCCLDEDLEPTCFERSDDFGG 39
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAyyleKEIPELPVELTLVEASDRVGG 43
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 3-107 1.32e-64

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 203.86  E-value: 1.32e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052688444   3 KKVAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGLWKFAETSNDGMTRVYRSLVTNVCKEMSSYSDFPYQEYYPNFM 82
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100
                  ....*....|....*....|....*
gi 2052688444  83 DHKKFWEYLREFAEHFDLLKYIRFK 107
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFK 106
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-106 1.40e-24

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 95.70  E-value: 1.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052688444   5 VAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGLWKFaetsndgmtRVYRSLVTNVCKEMSSYSDFPYQEYYPNFMDH 84
Cdd:COG2072     9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRD---------NRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                          90       100
                  ....*....|....*....|..
gi 2052688444  85 KKFWEYLREFAEHFDLLKYIRF 106
Cdd:COG2072    80 DEILAYLEAYADKFGLRRPIRF 101
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-107 5.72e-14

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 66.42  E-value: 5.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2052688444   3 KKVAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGLWKFA-ETSNDGM----------TRVYRSLVTNVCKEMSSYSD 71
Cdd:PLN02172   11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTpKSESDPLsldptrsivhSSVYESLRTNLPRECMGYRD 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2052688444  72 FPY----------QEYYPNfmdHKKFWEYLREFAEHFDLLKYIRFK 107
Cdd:PLN02172   91 FPFvprfddesrdSRRYPS---HREVLAYLQDFAREFKIEEMVRFE 133
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-40 1.84e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 42.13  E-value: 1.84e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2052688444   3 KKVAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGL 40
Cdd:COG1232     2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGL 39
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 3-40 4.19e-05

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 40.92  E-value: 4.19e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2052688444   3 KKVAVIGAGVSGLSsikcCLDEdL-----EPTCFERSDDFGGL 40
Cdd:PRK12810  144 KKVAVVGSGPAGLA----AADQ-LaraghKVTVFERADRIGGL 181
PRK07233 PRK07233
hypothetical protein; Provisional
 4-40 6.93e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 40.26  E-value: 6.93e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2052688444   4 KVAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGL 40
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGL 37
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 3-40 1.29e-04

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 39.35  E-value: 1.29e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2052688444   3 KKVAVIGAGVSGLSsikcCLDeDL-----EPTCFERSDDFGGL 40
Cdd:COG0493   122 KKVAVVGSGPAGLA----AAY-QLaraghEVTVFEALDKPGGL 159
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
3-39 3.66e-04

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 38.17  E-value: 3.66e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2052688444   3 KKVAVIGAGVSGLSSiKCCLDEDLEPTCFERSDDFGG 39
Cdd:COG2907     4 MRIAVIGSGISGLTA-AWLLSRRHDVTLFEANDRLGG 39
PRK07208 PRK07208
hypothetical protein; Provisional
 3-40 6.20e-04

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 37.56  E-value: 6.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2052688444   3 KKVAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGL 40
Cdd:PRK07208    5 KSVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVGGI 42
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-39 9.00e-04

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 37.14  E-value: 9.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2052688444   1 MVKKVAVIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGG 39
Cdd:COG3349     2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGG 40
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-41 2.41e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 34.04  E-value: 2.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2052688444   7 VIGAGVSGLSSIKCCLDEDLEPTCFERSDDFGGLW 41
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNA 35
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 3-39 4.36e-03

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 35.20  E-value: 4.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2052688444   3 KKVAVIGAGVSGLSSI----KCCLDEDLEPTCFERSDDFGG 39
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAyyleKEIPELPVELTLVEASDRVGG 43
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-36 5.00e-03

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 35.06  E-value: 5.00e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2052688444   3 KKVAVIGAGVSGLSSIKCCLDEDLEPTCFERSDD 36
Cdd:COG0771     5 KKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPA 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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