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Conserved domains on  [gi|2077105344|ref|XP_042675444|]
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thrombopoietin receptor [Centrocercus urophasianus]

Protein Classification

EpoR_lig-bind and FN3 domain-containing protein( domain architecture ID 10557304)

EpoR_lig-bind and FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 82-182 2.60e-42

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


:

Pssm-ID: 401127  Cd Length: 104  Bit Score: 148.34  E-value: 2.60e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344  82 SQDAVLLAEVPEDILCFSRSFEDLTCFWDEEEASGI---HCFYYWYSRDAPTMCAVSTQRRGANGMRHICVFPSQDVRLF 158
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLpttYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 2077105344 159 TQLHVLVLDAATNRTRHRRELSVD 182
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-514 6.18e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344 423 EAPRDVQATAAQGR-LTLRWLPPLEVLAEQLEYQIRYATDDSLDWKVLQVPRAARKEVL--DLRPGARYRAQVRAqpcgp 499
Cdd:cd00063     2 SPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRA----- 76

                          90
                  ....*....|....*
gi 2077105344 500 QYRGSWSAWSQPVAV 514
Cdd:cd00063    77 VNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 189-314 4.47e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 4.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344 189 PPVNISAHWAGATgQLRVSWQPPLADYPNFFLYEVCYHPMTPTvtprgtapgdlpahptdgahppTARGAASSQGTgqgl 268
Cdd:cd00063     3 PPTNLRVTDVTST-SVTLSWTPPEDDGGPITGYVVEYREKGSG----------------------DWKEVEVTPGS---- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2077105344 269 vqaNTWVILRELQPGVKYHIQVRSKPDGTsmdgvWGPWSEVVVAET 314
Cdd:cd00063    56 ---ETSYTLTGLKPGTEYEFRVRAVNGGG-----ESPPSESVTVTT 93
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 82-182 2.60e-42

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 148.34  E-value: 2.60e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344  82 SQDAVLLAEVPEDILCFSRSFEDLTCFWDEEEASGI---HCFYYWYSRDAPTMCAVSTQRRGANGMRHICVFPSQDVRLF 158
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLpttYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 2077105344 159 TQLHVLVLDAATNRTRHRRELSVD 182
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-514 6.18e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344 423 EAPRDVQATAAQGR-LTLRWLPPLEVLAEQLEYQIRYATDDSLDWKVLQVPRAARKEVL--DLRPGARYRAQVRAqpcgp 499
Cdd:cd00063     2 SPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRA----- 76

                          90
                  ....*....|....*
gi 2077105344 500 QYRGSWSAWSQPVAV 514
Cdd:cd00063    77 VNGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
424-506 3.67e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 3.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344 424 APRDVQATAAQGR-LTLRWLPPLEVLAEQLEYQIRYATDDSLD-WKVLQVPRAARK-EVLDLRPGARYRAQVRAQPCGpq 500
Cdd:pfam00041   2 APSNLTVTDVTSTsLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSvTLTGLKPGTEYEVRVQAVNGG-- 79


                  ....*.
gi 2077105344 501 YRGSWS 506
Cdd:pfam00041  80 GEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 189-314 4.47e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 4.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344 189 PPVNISAHWAGATgQLRVSWQPPLADYPNFFLYEVCYHPMTPTvtprgtapgdlpahptdgahppTARGAASSQGTgqgl 268
Cdd:cd00063     3 PPTNLRVTDVTST-SVTLSWTPPEDDGGPITGYVVEYREKGSG----------------------DWKEVEVTPGS---- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2077105344 269 vqaNTWVILRELQPGVKYHIQVRSKPDGTsmdgvWGPWSEVVVAET 314
Cdd:cd00063    56 ---ETSYTLTGLKPGTEYEFRVRAVNGGG-----ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 424-494 2.13e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.37  E-value: 2.13e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2077105344  424 APRDVQATAAQGR-LTLRWLPPLE--VLAEQLEYQIRYATDDSlDWKVLQVPRAARKEVL-DLRPGARYRAQVRA 494
Cdd:smart00060   3 PPSNLRVTDVTSTsVTLSWEPPPDdgITGYIVGYRVEYREEGS-EWKEVNVTPSSTSYTLtGLKPGTEYEFRVRA 76
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 190-306 1.68e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 38.16  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344 190 PVNISAHWAGATGQLRVSWQPPLADYPNFFLYevcyhpmtptvtprGTAPGDLPAhptdgahppTARGAASSQGTGQGLV 269
Cdd:pfam16656   1 PEQVHLSLTGDSTSMTVSWVTPSAVTSPVVQY--------------GTSSSALTS---------TATATSSTYTTGDGGT 57

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2077105344 270 QANTWVILRELQPGVKYHIQVRSKpdgtsmDGVWGPW 306
Cdd:pfam16656  58 GYIHRATLTGLEPGTTYYYRVGDD------NGGWSEV 88
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 82-182 2.60e-42

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 148.34  E-value: 2.60e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344  82 SQDAVLLAEVPEDILCFSRSFEDLTCFWDEEEASGI---HCFYYWYSRDAPTMCAVSTQRRGANGMRHICVFPSQDVRLF 158
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLpttYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 2077105344 159 TQLHVLVLDAATNRTRHRRELSVD 182
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 423-514 6.18e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344 423 EAPRDVQATAAQGR-LTLRWLPPLEVLAEQLEYQIRYATDDSLDWKVLQVPRAARKEVL--DLRPGARYRAQVRAqpcgp 499
Cdd:cd00063     2 SPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRA----- 76

                          90
                  ....*....|....*
gi 2077105344 500 QYRGSWSAWSQPVAV 514
Cdd:cd00063    77 VNGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
424-506 3.67e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.96  E-value: 3.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344 424 APRDVQATAAQGR-LTLRWLPPLEVLAEQLEYQIRYATDDSLD-WKVLQVPRAARK-EVLDLRPGARYRAQVRAQPCGpq 500
Cdd:pfam00041   2 APSNLTVTDVTSTsLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSvTLTGLKPGTEYEVRVQAVNGG-- 79


                  ....*.
gi 2077105344 501 YRGSWS 506
Cdd:pfam00041  80 GEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 189-314 4.47e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 4.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344 189 PPVNISAHWAGATgQLRVSWQPPLADYPNFFLYEVCYHPMTPTvtprgtapgdlpahptdgahppTARGAASSQGTgqgl 268
Cdd:cd00063     3 PPTNLRVTDVTST-SVTLSWTPPEDDGGPITGYVVEYREKGSG----------------------DWKEVEVTPGS---- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2077105344 269 vqaNTWVILRELQPGVKYHIQVRSKPDGTsmdgvWGPWSEVVVAET 314
Cdd:cd00063    56 ---ETSYTLTGLKPGTEYEFRVRAVNGGG-----ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 424-494 2.13e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.37  E-value: 2.13e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2077105344  424 APRDVQATAAQGR-LTLRWLPPLE--VLAEQLEYQIRYATDDSlDWKVLQVPRAARKEVL-DLRPGARYRAQVRA 494
Cdd:smart00060   3 PPSNLRVTDVTSTsVTLSWEPPPDdgITGYIVGYRVEYREEGS-EWKEVNVTPSSTSYTLtGLKPGTEYEFRVRA 76
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 190-306 1.68e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 38.16  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077105344 190 PVNISAHWAGATGQLRVSWQPPLADYPNFFLYevcyhpmtptvtprGTAPGDLPAhptdgahppTARGAASSQGTGQGLV 269
Cdd:pfam16656   1 PEQVHLSLTGDSTSMTVSWVTPSAVTSPVVQY--------------GTSSSALTS---------TATATSSTYTTGDGGT 57

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2077105344 270 QANTWVILRELQPGVKYHIQVRSKpdgtsmDGVWGPW 306
Cdd:pfam16656  58 GYIHRATLTGLEPGTTYYYRVGDD------NGGWSEV 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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