2VH0: Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs

PDB ID: 2VH0Download
MMDB ID: 68086
PDB Deposition Date: 2007/11/16
Updated in MMDB: 2012/11
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 2VH0: dimeric; determined by author and by software (PQS)
Molecular Components in 2VH0
Label Count Molecule
Proteins (2 molecules)
1
Activated Factor XA Heavy Chain
(Gene symbol: F10)
Molecule annotation
1
Activated Factor XA Light Chain
(Gene symbol: F10)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
CALCIUM IONCALCIUM ION
2
1
MAGNESIUM IONMAGNESIUM ION
3
1
2-(5-chlorothiophen-2-yl)-N-[(3S)-1-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-2-oxopyrrolidin-3-yl]ethanesulfonamide2-(5-chlorothiophen-2-yl)-N-[(3S)-1-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-2-oxopyrrolidin-3-yl]ethanesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303