2XPK: Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases

PDB ID: 2XPKDownload
MMDB ID: 89148
PDB Deposition Date: 2010/8/26
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 2XPK: dimeric; determined by author and by software (PISA)
Molecular Components in 2XPK
Label Count Molecule
Proteins (2 molecules)
2
O-glcnacase Nagj
(Gene symbol: CPF_RS07030)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
N-[(5R,6R,7R,8S)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDIN-8-YL]-3-SULFANYLPROPANAMIDEN-[(5R,6R,7R,8S)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDIN-8-YL]-3-SULFANYLPROPANAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303