3P33: Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity

PDB ID: 3P33Download
MMDB ID: 95198
PDB Deposition Date: 2010/10/4
Updated in MMDB: 2011/11
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 3P33: octameric; determined by author and by software (PISA)
Molecular Components in 3P33
Label Count Molecule
Proteins (8 molecules)
4
Insulin
(Gene symbol: INS)
Molecule annotation
4
Insulin
(Gene symbol: INS)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
4
PHENOLPHENOL
2
4
ZINC IONZINC ION
3
4
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303